5 results about "Long-term potentiation" patented technology

The application provides a brain-like synapse learning method and a brain-like technology neural morphological hardware system, and the method comprises the following steps: determining a pulse pair generated by a presynaptic neuron and a postsynaptic neuron in a brain-like synapse learning circuit, wherein the pulse pair comprises an input pulse generated by the presynaptic neuron and an output pulse generated by the postsynaptic neuron; determining an STDP mechanism corresponding to the pulse pair and a synapse weight corresponding to the STDP mechanism based on the pulse pair; and performing STDP learning corresponding to the brain-like synapse learning circuit based on the pulse pair and the synapse weight; wherein the STDP mechanism is a pulse time-dependent plasticity mechanism, and the front and rear pulses of the pulse pair correspond to a long-term potentiation process or a long-term depression process in the STDP mechanism according to the time sequence. The application realizes online learning of brain-like intelligence, and plays the environment self-adaptive characteristics of brain-like computing.

The invention discloses a two-dimensional layered perovskite type memristor, a preparation method and application thereof, and belongs to the technical field of perovskite type memristors. A high-quality Cs2Pb (SCN) 2I2 thin film is prepared through a low-temperature solution method, the Al / Cs2Pb (SCN) 2I2 / FTO vertical structure memristor device is constructed, the device has excellent stability and carrier transport characteristics, continuous, reversible and bidirectional symmetrical resistance regulation and control are achieved under low voltage, and the device has good application prospects. And the core characteristics of long-term enhancement / inhibition (LTP-LTD), time dependent plasticity (PPF), history dependent plasticity and the like of the biological synapses can be accurately reproduced. The device can stably realize addition, subtraction, multiplication and mixed arithmetic operation through voltage pulse sequence combination, and meets the requirements of exchange law, distribution law and reversibility. The invention provides a novel material selection and preparation scheme for the development of the high-performance memristor, lays an experimental and theoretical foundation for the hardware implementation of neuromorphic calculation, and has an important application prospect.

The invention belongs to the technical field of bionic synaptic devices, and particularly discloses a three-terminal voltage gating synaptic device based on a nanofluid channel and a preparation method of the three-terminal voltage gating synaptic device based on the nanofluid channel, and the three-terminal voltage gating synaptic device based on the nanofluid channel comprises a nanochannel layer; the gate control electrode layer is connected with the nano channel layer and is used for applying a gate voltage pulse and simulating a presynaptic membrane; and the epoxy resin layer is coated outside the nano channel layer and the gate control electrode layer. According to the application, independent grid control is introduced, multiple functions of biological synapses can be highly simulated, a device closer to a biological neuron function is provided for neuromorphic calculation, a complex and intelligent calculation system can be constructed, in addition, super-long time-history plasticity is realized by utilizing cation-pi bond interaction, and the calculation efficiency is improved. The method has excellent performance in long-time-history enhancement and long-time-history suppression, and the stability and durability of nonvolatile information storage and processing are improved.

The application discloses application of methyl palmitate in preparation of a medicine for treating and / or preventing senility and related cognitive impairment, and belongs to the technical field of biological medicine. The application proves by a cell experiment that methyl palmitate can significantly inhibit D-galactose-induced SH-SY5Y cell senility, and effectively reduce the expression level of senility-related proteins P53 and P16. The application proves by a behavior experiment that methyl palmitate can significantly improve the cognitive index of a senility model mouse, shorten an escape latency, and effectively improve learning ability reduction, spatial memory decline and cognitive function impairment caused by senility. In addition, methyl palmitate can significantly enhance the long-term potentiation effect of the hippocampal CA1 region of the senility model mouse, and reverse senility-related synaptic transmission damage. The application discloses the application of methyl palmitate in resisting neural senility and improving senility-related cognitive impairment, and provides a new candidate molecule for preparing a medicine for treating neurodegenerative diseases.

The application relates to a Cs3Bi2Br9-MoS2 heterojunction-based dual-terminal neuromorphic device. A zero-dimensional / two-dimensional hybrid structure is constructed through in-situ deposition, and charge accumulation injection and slow release are realized by using energy level offset and interface electron potential well, so that synaptic plasticity with a high pair pulse promotion index (PPF index > 230%), a high long-term potentiation curve linearity (R 2 > 0.97 and a photocurrent lag time > 800 s is exhibited. The device can realize 96% handwriting recognition accuracy in a convolutional neural network, and the accuracy is kept to be > 85% in a 13-75% RH wide humidity range, so that the device is suitable for neural network calculation in a complex environment.