2 results about "Long-term potentiation" patented technology

The application discloses application of methyl palmitate in preparation of a medicine for treating and / or preventing senility and related cognitive impairment, and belongs to the technical field of biological medicine. The application proves by a cell experiment that methyl palmitate can significantly inhibit D-galactose-induced SH-SY5Y cell senility, and effectively reduce the expression level of senility-related proteins P53 and P16. The application proves by a behavior experiment that methyl palmitate can significantly improve the cognitive index of a senility model mouse, shorten an escape latency, and effectively improve learning ability reduction, spatial memory decline and cognitive function impairment caused by senility. In addition, methyl palmitate can significantly enhance the long-term potentiation effect of the hippocampal CA1 region of the senility model mouse, and reverse senility-related synaptic transmission damage. The application discloses the application of methyl palmitate in resisting neural senility and improving senility-related cognitive impairment, and provides a new candidate molecule for preparing a medicine for treating neurodegenerative diseases.

The application relates to a Cs3Bi2Br9-MoS2 heterojunction-based dual-terminal neuromorphic device. A zero-dimensional / two-dimensional hybrid structure is constructed through in-situ deposition, and charge accumulation injection and slow release are realized by using energy level offset and interface electron potential well, so that synaptic plasticity with a high pair pulse promotion index (PPF index > 230%), a high long-term potentiation curve linearity (R 2 > 0.97 and a photocurrent lag time > 800 s is exhibited. The device can realize 96% handwriting recognition accuracy in a convolutional neural network, and the accuracy is kept to be > 85% in a 13-75% RH wide humidity range, so that the device is suitable for neural network calculation in a complex environment.