69 results about "Surgical pain" patented technology

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and inadequate pain relief. Embodiments of the invention relate to the association between genes, specific polymorphisms of genes, and non-genetic factors with inadequate pain relief and anesthesia-, analgesic, and / or opioid-related adverse effects. Embodiments of the invention can be used to determine and manage patient risk factors for development of adverse perioperative effects and can allow for personalized anesthesia and pain management for improvement of pain control and reduction of anesthesia-, analgesic-, and opioid-related adverse outcomes. These methods and compositions apply to non-surgical pain management with opioids. Therefore, patients who are genetically predisposed to risk of inadequate pain relief and / or serious side effects from anesthesia, analgesics, and / or opioids can be identified and individualized treatment plans developed for implementation by the clinician to improve clinical and economic outcomes.

The invention discloses application of Inonotus obliquus polysaccharide components in preventing and controlling chronic pancreatitis and belongs to the technical field of medicaments. The Inonotus obliquus polysaccharide components are applicable to preventing and controlling chronic pancreatitis. The Inonotus obliquus polysaccharide components which are 0.4g / kg of mouse weight are effective in increasing the content of superoxide dismutase in pancreatic glands of mice with chronic pancreatitis and decreasing accumulation of malondialdehyde and meanwhile are capable of reducing IL-1Beta and IFN-Nu in serum, and effective in decreasing the contents of amylase and lactic dehydrogenase and decreasing synthetic hydroxyproline. An application method of Inonotus obliquus polysaccharide components alleviate the condition of chronic pancreatitis in terms of immunity and metabolic regulation; compared with methods such as accumulated heat and dyspepsia conditioning in traditional Chinese medicine and medicated analgesia and surgery in western medicine, the method has the advantages that no toxic or side effect occurs, surgical pain is avoided, a treatment course is short, treatment is safe and convenient, and the effect of preventing and treating chronic pancreatitis in mice is significant.

Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and inadequate pain relief. Embodiments of the invention relate to the association between genes, specific polymorphisms of genes, and non-genetic factors with inadequate pain relief and anesthesia-, analgesic, and / or opioid-related adverse effects. Embodiments of the invention can be used to determine and manage patient risk factors for development of adverse perioperative effects and can allow for personalized anesthesia and pain management for improvement of pain control and reduction of anesthesia-, analgesic-, and opioid-related adverse outcomes. These methods and compositions apply to non-surgical pain management with opioids. Therefore, patients who are genetically predisposed to risk of inadequate pain relief and / or serious side effects from anesthesia, analgesics, and / or opioids can be identified and individualized treatment plans developed for implementation by the clinician to improve clinical and economic outcomes.

Methods and compositions of treating a subject for post-surgical pain are provided. In the subject methods, a subject is treated for post-surgical pain by administering to the subject an effective amount of a narcotic emulsion, e.g., fentanyl emulsion, formulation. In certain embodiments, the emulsion formulations include a narcotic active agent, oil, water and an surfactant. Also provided are methods of making the subject emulsion formulations as well as kits that include the emulsion formulations.

A method is provided for treating pain in patients recovering from post-surgical trauma by administering between about 13 to about 30 mg of diclofenac potassium in a liquid dispersible formulation over a period of at least 24 hours, wherein the daily total amount of diclofenac potassium administered is less than or equal to about 100 mg. The method is particularly useful in treating acute pain in bunionectomy patients.

The invention discloses a medicament for treating calculi and a preparation method thereof. The medicament comprises the raw materials in percentage by weight: chicken gizzard-membrane, stir-fired antlion, spora lygodii, cluster mallow fruit, longhairy antenoron herb, lalang grass rhizome, beautiful sweetgum fruit, grassleaf sweelflag rhizome, prepared twotooth achyranthes root, cicada slough, talcpowder, astragalus, szechwon tangshen root and liquoric root. The raw materials of the medicament have abundant source and are readily available. Compared with the conventional formula and means for treating urolithiasis and intra-hepatic cholelithiasis, a medicinal formula of the medicament is close to pathological change; and clinical tests prove that the medicament has the advantages of little dosage, short course of treatment, obviously curative effect and convenient administration, no need of surgical pain and no toxic or side effect, plays a role of preventing calculi regeneration, and promotes to achieve the effects of eliminating dampness and heat and dissolving and removing calculi through conditioning of Chinese patient medicaments. In addition, the medicament is simple and convenient to produce and wide in application, and is suitable for self-prepared prescriptions or self-prepared medicaments.

A composition for reducing pain at a surgical wound site or trauma site comprising oxidized regenerated cellulose and a non-steroidal anti-inflammatory drug or pharmaceutically acceptable salt or ester thereof, where the non-steroidal anti-inflammatory drug is an acid having a secondary amine group; and a method of reducing localized pain at a surgical wound site or trauma site.

The invention provides a lidocaine medicine composition for preparing local anesthetic for preventing or treating surgical pain of human and mammals, and application of the lidocaine medicine composition in preparation and application of a medicine. Therefore, a corresponding product has a quicker and better treating effect, higher safety and higher treating compliance in a clinical process.

The invention relates to an external traditional Chinese medicine for relieving pain, particularly to an external traditional Chinese medicine for relieving pain in the fields of wind-damp pain, surgical pain (cut-free wound), traumatic injury, dysmenorrheal and the like. The traditional Chinese medicine contains medicines of rhizoma corydalis, caulis sinomenii, corydalis decumbens and the like, and the medicines can be combined to achieve the functions of activating blood, dispersing stasis, relieving swelling and pain, dispelling wind and eliminating dampness. The external traditional Chinese medicine can be used for effectively relieving pain of diseases of wind-damp ostealgia, rheumatoid arthritis, scapulohumeral periarthritis, sprain, sprain, traumatic injury, dysmenorrheal and the like, and has the definite pain relieving effect when being prepared from the following components in parts by weight: 10-40 parts of rhizoma corydalis, 10-30 parts of caulis sinomenii, 10-40 parts of corydalis decumbens and 0.5-5 parts of borneol. The external traditional Chinese medicine can be prepared into extract through extraction with 60-75% ethyl alcohol, and can be processed into external dosage forms of tincture, spray, ointment, external cream paste and the like according to pharmacy.

The invention discloses a traditional Chinese medicine preparation for treating functional uterine bleeding and a preparation method thereof. The traditional Chinese medicine preparation is prepared by combining Chinese herbal medicines such as pine branches, pelage, agrimonia eupatoria, ajuga pantantha hand.-mazz, mountain radix puerariae, herba leonuri, eucommia ulmoides, radix angelicae sinensis, flos carthami, root of pilose asiabell, radix arnebiae, dried buchnera cruciata ham, radix glycyrrhizae and the like; and the traditional Chinese medicine preparation can be soaked in water and extracted to form decoction and can also be prepared to form granules and tablets after being ground. Through clinical treatment and observation of 32 patients suffering from functional uterine bleeding, the efficiency of the traditional Chinese medicine preparation reaches 100%, and the traditional Chinese medicine preparation can effectively treat functional uterine bleeding and has the functions of stopping bleeding and regulating patient physical conditions; moreover, the traditional Chinese medicine preparation can also replenish qi and nourish blood while stopping bleeding, is convenient to take and has an exact curative effect, the surgical pain and economic load of patients can be relieved, and the traditional Chinese medicine preparation is a good medicine for treating functional uterine bleeding; and the functional uterine bleeding is suitable for pharmaceutical factory production, hospital clinical application and patient taking.

The present disclosure relates to compositions and methods for the promotion and maintenance of oral health. Specifically, the present disclosure relates to pain management, promoting healing, reducing post-surgical edemas, reducing the need for the opioids in post-surgical pain management, treating various inflammatory conditions in the oral cavity, general maintenance of a healthy oral cavity, and general dental care. The present disclosure presents compositions and methods for promoting and maintaining oral health, including decreasing pain, inflammation, swelling, and bruising associated with dental procedures, and accelerating recovery from dental procedures and other oral procedures or trauma.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

The invention discloses a tolfenamic acid injection and a preparation method and application thereof. The tolfenamic acid injection disclosed by the invention comprises a main drug, a cosolvent, a pH regulator, a preservative agent and a local analgetic agent. The tolfenamic acid injection disclosed by the invention is safe and convenient to use and controllable in quality; the preparation process of the tolfenamic acid injection is stable, suitable for industrial production and low in cost; and the tolfenamic acid injection enriches veterinary clinical drugs and has obvious effect if being used for treating arthritis, arthritic pain and surgical pain of dogs, cats and the like.

The invention belongs to the field of a medicine, relating to ointment for treating condyloma acuminatum, which contains the following components by mass: 3-40 parts of brucea javanica oil, 0.1-10 parts of aqueous matrix, 3-40 parts of emulsifier and 10-93.9 parts of water. The ointment disclosed by the invention is a new, non-toxic and harmless prescribed pure traditional Chinese medicine preparation which is free from untoward effects. The pharmacology and the clinical practice confirm that the ointment has the effects of removing putrid tissues and regenerating tissues, and promoting the necrotic tissues to liquefy, decompose and fall off, so that the condyloma acuminatum can be treated as soon as possible, the patients can avoid the surgical pain, other equipments are not needed, and the economic consumption of the patients is reduced as well. The ointment is safer, more effective and convenient to use. Simultaneously, the treatment effect of the ointment is identical to that of the current brucea javanica oil compound preparation by optimizing the prescription and the preparation technology, and the cost is lower, and the preparation technology is more convenient.

The invention discloses a head lymph massage instrument and a using method thereof, and relates to the field of neurosurgery, the head lymph massage instrument comprises a drainage pump and an inflation drainage head sleeve, and the drainage pump comprises an inflation module, a control module, a display module, a shell and a switch. According to the head lymph massage instrument and the using method thereof, a physical therapy is used for replacing manual massage, pressing type drainage is conducted on lymphatic systems in front of the ears, behind the ears and at the lower jaw of a patient, and drainage in front of the ears and behind the ears is drained to the clavicle from top to bottom in the jugular vein direction; the chin drainage starts from the chin and drains towards the inflection point of the mandibular angle from front to back along the mandible, so that a doctor can be helped to massage the head lymph of a patient by using a physical technique under the condition of not performing craniotomy or skull drilling and intubation, the intracranial pressure of the patient is reduced, the surgical pain of the patient is relieved, the intracardiac pressure is reduced, and the postoperative infection risk is avoided.

The invention discloses a needle-withdrawing and line-leading suture instrument, which comprises a suture instrument shell, lifting and pulling connecting rod mechanisms, annular needles and line-leading locking mechanisms, wherein the suture instrument shell is in a cylinder-shaped structure; the lifting and pulling connecting rod mechanisms are arranged in the suture instrument shell; driving operating ends of the lifting and pulling connecting rod mechanisms are arranged at the upper part of the suture instrument shell; and driven executing ends of the lifting and pulling connecting rod mechanisms are connected with the annular needles and are arranged on a bottom plate of the suture instrument shell; a needle going bottom hole is arranged in the bottom plate of the suture instrument shell; and the line-leading locking mechanisms are arranged in positions in the periphery of the bottom plate of the suture instrument shell, which are corresponding to the annular needles. During intestinal tract rerouting surgery, the suture instrument operates the annular needles outside an abdominal cavity through the lifting and pulling connecting rod mechanisms so as to thread the needles and lead lines in lumen tissue of an abdominal wall, multiple suture lines can be simultaneously led out of a human body around a cut wound, the line leading efficiency is improved, the surgical time is shortened and surgical pain of patients is reduced, so the needle-withdrawing and line-leading suture instrument can be widely used in surgery such as intestinal tract rerouting and the like.

The invention relates to a stent or catheter in-vivo dredging device. The device comprises a base body and a dredging structure arranged on the base body, and the base body is connected with the dredging structure. According to the stent or catheter in-vivo dredging device, by controlling the base body to move, the dredging structure is controlled to dredge a stent or a catheter, and blockage objects in the stent or the catheter are removed, so that a narrow or blocked pipeline gets smooth without replacing the stent or the catheter, the time and effort are saved, the surgical pain of patientsis relieved, and the treatment cost of the patient is greatly reduced.

Disclosed herein are compositions and methods for treating post-surgical pain in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a NK-1 receptor antagonist and a pain medication.

The invention discloses a clinical analgesic device for medical operation, which comprises a base and a fixed plate. A hollow sleeve is arranged on the top of the base. The top of the hollow sleeve is fixedly connected with a telescopic rod through an adjusting screw. A slide block is slidably connected to the inside of the chute, and one end of the slide block is provided with a one-way valve, and the liquid outlet of the one-way valve is fixedly connected with the liquid outlet of the infusion tube. The present invention is equipped with a bearing seat, a fixed plate and a liquid storage tank. When the liquid storage tank fails during the operation, the staff rotates the fixed plate to separate the faulty liquid storage tank from the lower liquid hose and make the lower liquid soft. The tube is connected to the liquid outlet control valve of the spare liquid storage tank to ensure the normal progress of the operation. The telescopic rod, chute and slider are provided to facilitate the medical staff to quickly adjust the height of the clinical analgesic device according to the needs of the site.

The invention provides a series-parallel connection type shape memory alloy vertebral body support, which belongs to the technical field of medical instruments, and comprises a plurality of parallel connection single bodies connected in series, each parallel connection single body comprises a plurality of support single bodies, and the support single bodies are connected in parallel in a crossed mode to form one parallel connection single body. The parallel monomer is made of a shape memory alloy material meeting the biocompatibility requirement, so that the parallel monomer can be in a contracted state or an expanded state at different temperatures. The support is simple in structure, convenient to operate and use and capable of being used in cooperation with an existing universal outer sleeve vertebral body forming instrument, the economic cost is obviously reduced, the effect of supporting the vertebral body can be achieved only through the support, bone cement does not need to be filled, and therefore the leakage problem of the bone cement is avoided; burning damage of bone cement to nerves and other tissues is effectively prevented, surgical pain of a patient can be effectively relieved, and postoperative complications of the patient are reduced.

The invention discloses a needle-withdrawing and line-leading suture instrument, which comprises a suture instrument shell, lifting and pulling connecting rod mechanisms, annular needles and line-leading locking mechanisms, wherein the suture instrument shell is in a cylinder-shaped structure; the lifting and pulling connecting rod mechanisms are arranged in the suture instrument shell; driving operating ends of the lifting and pulling connecting rod mechanisms are arranged at the upper part of the suture instrument shell; and driven executing ends of the lifting and pulling connecting rod mechanisms are connected with the annular needles and are arranged on a bottom plate of the suture instrument shell; a needle going bottom hole is arranged in the bottom plate of the suture instrument shell; and the line-leading locking mechanisms are arranged in positions in the periphery of the bottom plate of the suture instrument shell, which are corresponding to the annular needles. During intestinal tract rerouting surgery, the suture instrument operates the annular needles outside an abdominal cavity through the lifting and pulling connecting rod mechanisms so as to thread the needles and lead lines in lumen tissue of an abdominal wall, multiple suture lines can be simultaneously led out of a human body around a cut wound, the line leading efficiency is improved, the surgical time is shortened and surgical pain of patients is reduced, so the needle-withdrawing and line-leading suture instrument can be widely used in surgery such as intestinal tract rerouting and the like.

Methods and compositions using a combination of adenosine monophosphate protein kinase (AMPK) activators for treating pain such as post-surgical pain or development of chronic pain. The two or more AMPK activators work synergistically and may be administered in individually sub-efficacious doses. The AMPK activators may have different mechanisms of AMPK activation. The AMPK activators may be administered systemically and / or topically in, for example, as a gel, ointment, cream, lotion, suspension, liquid, or transdermal patch.

The invention relates to an otological repair material and a preparation method and application thereof; the otological repair material is made with intestinal submucosal matrix material with immunogens removed; the repair material comprises a base layer and one or more protrusion portions arranged on the base layer; the repair material can induce cell ingrowth of a patient, a template is provided for reconstructed damaged issues for cells, and the functional tissues or organs are repaired; the immunogen removal matrix may degrade gradually in substantial sync with the reconstructed tissue regeneration process, an immunogen-removed matrix patch is completely replaced by host tissues, and otological recovery is achieved accordingly. The repair material never causes immunogen reaction, and a required shape is easy to process. A patient has no need to bear extra surgical pain.

The invention discloses application of Inonotus obliquus polysaccharide components in preventing and controlling chronic pancreatitis and belongs to the technical field of medicaments. The Inonotus obliquus polysaccharide components are applicable to preventing and controlling chronic pancreatitis. The Inonotus obliquus polysaccharide components which are 0.4g / kg of mouse weight are effective in increasing the content of superoxide dismutase in pancreatic glands of mice with chronic pancreatitis and decreasing accumulation of malondialdehyde and meanwhile are capable of reducing IL-1Beta and IFN-Nu in serum, and effective in decreasing the contents of amylase and lactic dehydrogenase and decreasing synthetic hydroxyproline. An application method of Inonotus obliquus polysaccharide components alleviate the condition of chronic pancreatitis in terms of immunity and metabolic regulation; compared with methods such as accumulated heat and dyspepsia conditioning in traditional Chinese medicine and medicated analgesia and surgery in western medicine, the method has the advantages that no toxic or side effect occurs, surgical pain is avoided, a treatment course is short, treatment is safe and convenient, and the effect of preventing and treating chronic pancreatitis in mice is significant.

The invention discloses wearable electrocardiogram monitoring equipment. The electrocardiogram monitoring equipment comprises a single-lead electrocardiogram device and a wearable device, wherein thesingle-lead electrocardiogram device is used for being attached to the heart position; the wearable device is used for being worn on the wrist of a patient; the single-lead electrocardiogram device collects electrocardiogram signals and sends the electrocardiogram signals to a cloud end, and the cloud end analyzes the electrocardiogram signals and sends an analysis result back to the wearable device; and a display screen on the wearable device displays a judgment result, a prompt lamp flickers, a loudspeaker gives out a prompt tone and a vibrating head vibrates so that the patient with a heartdisease can be informed and reminded of the state of the heart and taking medicines in time to inhibit the heart disease. The wearable electrocardiogram monitoring equipment has the advantages that installation is convenient, and surgical pain of the patient is relieved; the wearable electrocardiogram monitoring equipment can be taken down quickly when needing to be replaced, and damage to the heart of the patient is small; and through the equipment, the patient can be reminded of taking medicines in time.

The invention provides a universal locking device of femoral neck and a femoral neck operation method. A femoral head fitting portion is provided with universal locking holes, including a first universal locking hole, a second universal locking hole, a third universal locking hole and a fourth universal locking hole; the first universal locking hole and the fourth universal locking hole are symmetrically arranged in spaced manner along the vertical direction; the second universal locking hole and the third universal locking hole are symmetrically arranged in spaced manner in the horizontal direction; a femoral shaft fitting portion is provided with two locking holes arranged evenly in spaced manner; fixing nails are tightened in the universal locking holes and the locking holes to fix thefemoral neck. The problem that an internal fixation system for femoral neck fracture operation has poor stability is solved. The femoral head fitting portion is fitted to the femoral head; the fixingnails are tightened in the four universal locking holes arranged in diamond form, and stable fixation is achieved; the fixing nails are tightened in the two locking holes for stable fixation; the femoral head experiences small sinking and horizontal displacements; the operations are simple, and less surgical pain is caused to patients.

The invention relates to the technical field of medical apparatuses and instruments, in particular to a spine vertebral pedicle set screw soft tissue protecting device. The protecting device comprisesa semi-opening sleeve and handheld mechanisms, the head of the semi-opening sleeve is open, a long-strip-shaped gap is formed in one side of the cylinder wall in the length direction of the sleeve, the diameter of the opening of the head end of the semi-opening sleeve is matched with the diameter of the tail of a pedicle screw, and the tail of the pedicle screw can be just sleeved with the head end of the semi-opening sleeve; the tail end of the semi-opening sleeve is closed; the handheld mechanisms are symmetrically and fixedly arranged on the two sides of the tail end of the semi-opening sleeve; according to the spine vertebral pedicle set screw soft tissue protecting device, the tail end of the semi-opening sleeve and a screw setter are cooperatively installed, spine peripheral soft tissue and a sharp medical instrument are isolated, and the phenomenon that the spine peripheral soft tissue is damaged by medical apparatuses and instruments in spine smell incision screw setting surgery is effectively avoided, so that the postoperative rehabilitation healing speed of a spine incision is ensured, and the surgical pain to a patient is relieved.