New use of ginsenoside Rg1

A technology of ginsenosides and new uses, applied in the field of ginsenoside Rg1 treatment/prevention of Alzheimer's disease, can solve unclear problems, achieve strong scientific and innovative, reduce inhibition, high development and application value Effect
CN101084909AInactive Publication Date: 2007-12-12FUJIAN MEDICAL UNIV UNION HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUJIAN MEDICAL UNIV UNION HOSPITAL
Publication Date
2007-12-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an application of ginsenoside Rg 1 for treating / preventing Alzheimer disease, and provides new use of ginsenoside Rg 1 in treating / preventing Alzheimer disease caused by A beta 1-42 induced neurotoxic effect. This provided Chinese medicinal monomer of ginsenoside Rg 1 has the following functions: protecting cytochondriome and reducing neuron apoptosis through relieving oligo-A beta 1-42 induced neuron stress injury, relieving inhibiting effect of A beta 1-42 on PKA-CREB signal passage, contributing to form long-term potentiation, and improving memory, thereby providing direct powerful experimental foundation and theoretical basis for ginsenoside Rg 1 in treating Alzheimer disease, and has high scientific and originality, and application value.
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Description

technical field

[0001] The present invention relates to the use of ginsenoside Rg1 in the treatment / prevention of Alzheimer's disease, in particular to the use of ginsenoside Rg1 in the treatment / prevention of Aβ 1-42 Novel uses of Alzheimer's disease mediated by neurotoxic effects. Background technique

[0002] Alzheimer's disease (AD) is a neurodegenerative disease with progressive cognitive impairment as the main clinical manifestation. A large number of neuroinflammatory plaques (Neuriteplaques, NP) accumulate outside the cells, intracellular Abnormal deposition of β-amyloid peptide (β-amyloidpeptide, Aβ), formation of neurofibrillary tangles (neurofibrillary tangle, NFT) and loss of synapses or neurons are the main neuropathological features of AD. Although the pathogenesis of AD has not been fully elucidated, the "Aβ cascade theory" has been accepted by most scholars, that is, the abnormal Aβ metabolism caused by various reasons causes the abnormal accumulation of Aβ ...

Claims

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