36results about How to "High development and application value" patented technology

The invention discloses milk-tea powder as well as a preparation method thereof, which is prepared by fresh milk, white sugar, non-dairy creamer, green brick tea, and solid essence powder according to a certain proportion. The preparation method comprises the following steps: A. comminution: the brick tea is comminuted into superfine tea powder; B. mixture: a proper amount of the fresh milk is taken and heated by a plate heat exchanger, via a water-powder mixer, the tea powder, the white sugar, the non-dairy creamer, and the solid essence powder are added and stirred circularly, and the rest raw milk is added; C. sterilization; D. concentration: the material is sterilized and concentrated by a double effect falling film vacuum evaporator to obtain the concentrated material; E. spray drying: the concentrated material is sprayed and dried by a high pressure pump; F. redrying by a fluidized bed to obtain the milk-tea powder. The milk-tea powder has reasonable formula, convenient drinking, easy method and simple technique, thereby minimizing the energy consumption in the milk-tea processing technique, shortening the productive time with enhanced stability of the milk-tea quality, and increasing the utility ratio of the tea in the milk-tea manufacturing process without waste and pollution.

The invention discloses a method for comprehensively extracting and purifying anthocyanin and general flavone which does not comprise the anthocyanin in sugarcane toppers or slag. The method comprises the steps of firstly extracting the sugarcane toppers or slag by an organic solvent, concentrating the extract and passing the extract through a chromatographic column filled with a macro-porous adsorptive resin, removing water-soluble impurities such as glucide by a gradient elution method, respectively collecting the ethanol eluent with a low concentration and the ethanol eluent with a high concentration to obtain two ingredients of the anthocyanin and the general flavone which does not comprise the anthocyanin, and respectively enriching and purifying the ingredients of the anthocyanin and the general flavone which does not comprise the anthocyanin by a solvent extraction method and an acid and alkali treatment method so as to obtain the anthocyanin and the general flavone which does not comprise the anthocyanin. Compared with the reported methods for extraction and separation of similar ingredients, the method of the invention can not only completely extract two main oxidation-resistant ingredients in the sugarcane toppers or slag, also the reagents consumed in the technological process can be recycled. The method has low production cost, high purity and mature technology, and is easily controlled and in favour of industrial production.

The invention relates to a method for preparing a temperature rise elastic force automatic compensation titanium spring of a pneumatic friction clutch brake. The method comprises the following steps of: 1, selecting and determining the range of phase transformation points of a titanium alloy; 2, measuring the phase transformation points of the selected titanium alloy material; 3, cold drawing the titanium alloy for filamentization; 4, winding to form a spring; 5, cutting, and processing the two ends of the spring to form planes; 6, putting the titanium spring into a furnace, heating, and preserving heat; and 7, cooling. The method has a simple preparing process, and the titanium spring is convenient to mount and use. When the pneumatic friction clutch brake is designed and manufactured, heat dissipation area and heat dissipation openings are not required to be increased specially. In the summer which has an extremely low heat dissipation effect and is extremely hot, instant clutching and quick braking of a clutch can be ensured. Therefore, the method is extremely high in development value and application value during actual application.

The invention belongs to the field of medical chemistry and relates to an arylbenzofuran derivative with alpha-glucosidase inhibitory activity as well as a preparation method and application of the derivative in a composition, a drug and a health-care product that are used for preventing and/or treating type 2 diabetes mellitus. In the invention, a series of arylbenzofuran compounds are designed and synthesized by taking a mother nucleus structure of an arylbenzofuran ring as a synthesis target through a chemical synthesis method. The biological activity and the structure-function relationshiprelated to the arylbenzofuran derivative are deeply evaluated and discussed by applying a computer-aided drug design method, combining in vitro and in vivo pharmacological activity evaluation experiments and taking alpha-glucosidase as a target protein, so that a solid material basis is provided for discovering a lead compound of an alpha-glucosidase inhibitor drug with high efficiency and low toxicity.

The present invention belongs to the technical field of genetic engineering and enzyme engineering, and particularly relates to a method for continuous production of c-di-AMP by using immobilized DisA protein. The method comprises: 1, DisA gene transformation, wherein DisA gene and cbm gene are fused through gene engineering to construct a recombinant plasmid vector; 2, recombinant plasmid transformation and CBM-DAC fusion protein expression; 3, one-step DAC enzyme purification and immobilization; 4, continuous c-di-AMP production; and 5, reaction product separation concentration and purification. According to the present invention, the characteristic that the CBM domain is combined with cellulose and no hydrolysis exists is specifically utilized, the process is mature, the production cost is low, the environmental protection is provided, the types of the prepared DAC enzyme are diversified, the sources are wide, the concentration and the purity are high, the enzymatic reaction efficiency is high, and the good development and application value is provided.

The invention relates to an application of tanshinone I shown in a formula I to the treatment of a microglia-mediated disease, in particular to an application of tanshinone I to the preparation of a medicament for treating and/or preventing the microglia-mediated disease, in particular to an application of tanshinone I to preparation of a medicament for treating and/or preventing psychoneuroimmunology chronic inflammatory diseases caused by microglia-mediated neurotoxic effects. The tanshinone I provided by the invention has the novel functions of remarkably suppressing microglia cell-activated and induced cell death, suppressing the generation and expression of inflammatory mediators, i.e., NO and TNF alpha of microglia cells, and remarkably lowering the cell toxicity of activated microglia cells on neurons, the tanshinone I can be applied to prevention and treatment of brain immune inflammation-related diseases such as Alzheimer's disease, Parkinson's disease, and the like. The formula I is shown in the specifications.

The present invention belongs to the technical field of food additives and provides a method for extracting a natural food antioxidant from areca catechu leaves. The method is as follows: the areca catechu leaves are washed, the washed areca catechu leaves are dried, the dried areca catechu leaves are crushed, then the crushed areca catechu leaves are mixed with acid substances, alcohol substancesand water, the mixture is added into an extraction tank for ultrasonic-assisted extraction to obtain an extract, then the extract is concentrated, and the concentrated extract is infrared-ray dried to obtain the natural food antioxidant. Compared with the traditional method, the extraction method is short in time and high in extraction rate. The obtained polyphenolic compounds are all derived from natural ingredients, good in antioxidant performance, good in medical performance, and free of toxic and side effects. Besides, the raw materials in the whole extraction method are easily available,the processes are simple, the costs are relatively low, pollution is small, and the method has certain development and application value and can be popularized and applied.

The invention provides a remote control intelligent trolley system based on a bluetooth technology. The system comprises an intelligent trolley, a remote controller or/and a mobile terminal, when theremote controller and the intelligent trolley establish communication based on the bluetooth technology, the remote controller can carry out remote control on the intelligent trolley through keys or voice, and when the mobile terminal establishes communication with the intelligent trolley based on the bluetooth technology, the mobile terminal can carry out remote control on the intelligent trolleyby simulating and generating the keys of the remote controller and the control function realized by the keys, or carry out remote control on the intelligent trolley by simulating and generating the voice of the remote controller and the control function realized by the voice. According to the system, during implementation, under the condition that the cost is not increased, a flexible operation mode of a user is provided, and different requirements can be met.

The invention discloses a purification method of beta-glucuronidase. The method comprises the steps of taking adult snails, cutting off shells, taking down soft parts, cutting off body walls in a culture dish, pulling out digestive glands, and putting digestive glands into a culture dish; puncturing the digestive glands by using a needle head, collecting the flowing viscous liquid and the digestive glands respectively, centrifuging under a certain condition to remove precipitates, combining supernate, and filtering by using a filter membrane to obtain a crude extract containing beta-glucuronidase; enabling the crude extract to pass through a DEAE ion exchange column for linear gradient elution, firstly determining the enzyme activity of the obtained eluents, then combining the eluents withrelatively high enzyme activity to obtain a beta-glucuronidase purified product; adding a preservative and an antioxidant; and performing low-temperature preservation. According to the invention, thepurification method is simple and feasible; the active material (snail) is rich in source, low in price, easy to obtain and short in period; and the purified beta-glucuronidase is high in activity, good in stability and high in recovery rate, can completely meet the requirements of an in-vitro diagnostic kit, and has relatively high development and application values.