The invention provides a
calcium-containing micro-
precipitation liposome entrapped with a photothermal agent and a chemotherapeutic
drug as well as a preparation method and application of the
calcium-containing micro-
precipitation liposome, and belongs to the technical field of liposomes. The
calcium-containing micro-
precipitation liposome entrapped with the photothermal agent and the chemotherapeutic
drug comprises a calcium-containing micro-precipitation inner core and a
phospholipid bilayer shell entrapped outside the calcium-containing micro-precipitation inner core, the calcium-containing micro-precipitation core comprises the photothermal agent, the chemotherapeutic
drug,
bovine serum albumin and a calcium-containing precipitate; the
phospholipid bilayer shell comprises an inner-layer
phospholipid material, an outer-layer phospholipid material and
cholesterol. According to the calcium-containing micro-precipitation liposome entrapped with the photothermal agent and the chemotherapeutic drug, the half-life period of the photothermal agent is prolonged, the stability is improved, and the
treatment effect of the photothermal agent on
tumor cells is improved; the toxic and side effects of
chemotherapeutic drugs can be obviously reduced, and the
therapeutic effect on the
tumor cells is improved; the photothermal-chemical
combined treatment can be realized, the
side effect is small, and the positioning and treatment effects on the
tumor cells are excellent.