5results about How to "Achieving Combined Therapy" patented technology

The invention discloses a gambogic acid and cis-platinum co-loaded molybdenum disulfide nano delivery system. The system comprises the following components in parts by weight: 1-5 parts of molybdenum sulfide, 5-50 parts of manganese dioxide, 0.1-5 parts of gambogic acid, 1-50 parts of a cis-platinum prodrug Pt (IV) and 10-50 parts of polyethylene glycol. The invention also provides a preparation method of the nano conveying system. According to the MoS2-MnO2-PEG-Pt (IV) / GA nano-drug delivery system constructed by the invention, the sequential release of the drug is controlled through GSH and near-infrared light, the tumor hypoxia drug resistance is reversed in combination with the characteristics of the carrier, the synergistic treatment effect of GA and CDDP is maximized, and finally, the combined drug synergistic treatment and photo-thermal combined treatment of lung cancer are realized, so that the application prospect is wide. A new thought and a research strategy are provided for clinical treatment of lung cancer, and the application range of anti-cancer traditional Chinese medicines in tumor treatment is expanded.

The invention discloses pillararene WP5-PEG-DNS and a preparation method and application thereof.The preparation method comprises the steps that under the protection of inert gas, HATU serves as a condensing agent, diisopropylethylamine serves as alkali, DMF serves as a solvent, a compound 1, amino polyethylene glycol, HATU, diisopropylethylamine and DMF are subjected to an amidation reaction, and an intermediate WP5-PEG-NH2 is obtained; the method comprises the following steps: adding an intermediate WP5-PEG-NH2 and 2, 4-dinitrobenzene sulfonyl chloride into a single-neck round-bottom flask, and reacting at room temperature by taking diisopropylethylamine as alkali and CH2Cl2 as a solvent to obtain pillararene WP5-PEG-DNS; the pillararene WP5-PEG-DNS can be used for constructing a nano-drug carrier with excellent water solubility, a chemotherapy drug DOX can be further loaded, combined treatment of chemotherapy and SO2 gas is realized, and the tumor treatment effect is further improved.

The invention belongs to the technical field of gel preparations, and particularly relates to a chitosan photosensitive hydrogel, a drug-loaded photosensitive hydrogel and a preparation method and application of the chitosan photosensitive hydrogel and the drug-loaded photosensitive hydrogel. The invention provides a chitosan photosensitive hydrogel. The chitosan photosensitive hydrogel comprises a chitosan-photosensitizer cross-linked substance and water, the photosensitizer is a tetra-p-phenylamino porphyrin compound. According to the chitosan photosensitive hydrogel provided by the invention, chitosan is used as a hydrogel framework material, a tetra-p-phenylamino porphyrin compound is used as a photosensitizer, a novel photodynamic hydrogel network is constructed, and the obtained chitosan photosensitive hydrogel takes elasticity as a leading material, has relatively good temperature sensitivity and light sensitivity, and can be used for preparing a photodynamic hydrogel. The compound can be used as a chemotherapy drug carrier, realizes combined treatment of a photodynamic therapy and a chemotherapy, realizes an efficient combined anticancer effect, improves a curative effect, reduces toxicity, and provides a new idea for construction and application of a photodynamic-chemotherapy anticancer drug system.

This invention provides a nanoformulation capable of enhancing the immune response to in situ tumor vaccines. The nanoformulation comprises zoledronic acid, all-trans retinoic acid, and metal ions. Preferably, the metal ion is a lanthanide metal, such as Gd. 3+ Preferred, zoledronic acid: Gd 3+ The mass ratio of all-trans retinoic acid is 4:1:5. The nano-formulation consists of zoledronic acid and Gd... 3+ Zol / Gd-NPs nanocoagulation polymers were formed by mixing in water. All-trans retinoic acid was dissolved in anhydrous ethanol to prepare albumin-encapsulated nanoparticles (A-NPs), which were then mixed with the Zol / Gd-NPs nanocoagulation polymers and sonicated to obtain the final product. These nanoparticles, on the one hand, can utilize zoledronic acid to eliminate macrophages, thereby reversing the inhibition of intratumoral dendritic cells (DCs) by the tumor immunosuppressive microenvironment; on the other hand, all-trans retinoic acid can significantly increase the expression of MHC-I and tumor antigens in tumor cells, thus ensuring the activation of CD8. + T cells can effectively recognize and kill tumors, generating a systemic anti-tumor immune response.

The application belongs to the technical field of medicine, and particularly relates to a tumor cell membrane coated stibnite sulfur bond bridged dimer prodrug nanoassemblies and a preparation and application thereof. The nanoassemblies are co-assembled with small molecule immunoadjuvant and paclitaxel dimer prodrug to form a multifunctional small molecule as a nano core of the nanoassemblies, and the nano core is surface modified and wrapped with tumor cell membranes. The nano core can intelligently activate and release the chemotherapeutic drug paclitaxel and the immunoadjuvant at the tumor site, and realizes the combined treatment of chemotherapy and immunotherapy on the tumor. Then, the tumor cell membranes are used for surface engineering modification of the nano core, and the specific proteins on the tumor cell membranes prolong the in-vivo circulation time of the nano particles and improve the tumor targeting accumulation capacity. The tumor cell membrane coated multifunctional small molecule self-assembled nano particles aim to solve the technical problems of poor water solubility of traditional chemotherapeutic drugs, non-specific distribution, strong toxic side effects, limited treatment effect of single chemotherapy, easy induction of drug resistance and the like.