The invention relates to a preparation method of a hollow
silicon-star
gold core / shell nano material for wrapping adriamycin. The preparation method comprises the following steps of dissolving an HMSs (Hollow
Mesoporous Silica Sphere), ultrasonically dispersing the dissolved HMSs, adding MPTMS (Mercaptopropyltrimethoxysilane) into the dispersed HMSs, introducing
nitrogen into an obtained first mixture, refluxing the obtained first mixture in an
oil bath, so as to obtain HMSs-SH (Hollow
Mesoporous Silica Sphere-Sulfhydryl), afterwards, dissolving the HMSs-SH in water, adding an Au NPs (Aurum Nanoparticles) solution into an obtained second mixture, agitating the obtained second mixture, so as to obtain an HMSs / Au seed, dissolving the HMSs / Au seed in water, ultrasonically dispersing an obtained third mixture, adding a
chloroauric acid solution into the dispersed third mixture, agitating an obtained fourth mixture, adding a
silver nitrate solution and an
ascorbic acid solution into the agitated fourth mixture, continuously agitating an obtained fifth mixture, so as to obtain an HMSs / Au NSs (Normal
Saline Solution), dispersing the HMSs / Au NSs in water, adding an HS-PEG-RGD (Hassium-
Polyethylene Glycol-
Arginine-
Glycine-
Aspartic Acid)
aqueous solution into an obtained sixth mixture, agitating an obtained seventh mixture, so as to obtain an HMSs / Au-PEG-RGD NSs, afterwards, dispersing the HMSs / Au-PEG-RGD NSs into
ultrapure water, adding a DOX*HCL
aqueous solution into an obtained eighth solution, agitating an obtained ninth mixture in a light-shielding manner, so that the hollow
silicon-star
gold core / shell nano material for wrapping the adriamycin is obtained. The nano material provided by the invention owns a specific targeting effect and excellent
biocompatibility on a U87MG
cell, has a synergistic enhancement effect on chemical therapy and
photothermal therapy, and is wide in application prospect.