166results about How to "Easy surface modification" patented technology

The invention discloses a magnetic gold nanoparticle composite material, and a preparation method and application thereof. The preparation method comprises the following steps: synthesizing ferroferric oxide magnetic microspheres, adding tetraethoxyl silicon to implement hydrolysis and polymerization on the magnetic microsphere surfaces, adding N-(2-aminoethyl)-3-aminopropyltrimethoxysilane to obtain surface-modified double-amino-group Fe3O4 / SiO2 magnetic microspheres, and compounding the surface-modified double-amino-group magnetic microspheres with gold nanoparticles. The chelation action of the double amino groups is utilized to adsorb the gold nanoparticles more firmly; and the material combines the surface selectivity of the gold nanoparticles and the superparamagnetism of the magnetic nanoparticles, can extract benzopyrene in water, and can implement quick and efficient separation.

The invention relates to a preparation method and an application of a magnetic fluorescent nanoparticle with a shell-core structure. Firstly, a silica magnetic microsphere with a shell-core structure is prepared by using one or more than one of nanoparticles of Fe3O4, gamma-Fe2O3, MeFe2O4 (Me=Co, Mn, Ni), metal Ni, Co, Fe, and alloy Fe-Co, Ni-Fe as the inner core, and coating a silica shell, and then a fluorescent material (a chelate of Eu3+, Sm3+, Dy3+, Tb3+ and the like) is absorbed on the silica shell. Then, a layer of silica is coated on the surface to improve the stability of the fluorescent magnetic microsphere, and to prevent agglomeration and fluorescent material leakage. A lot of rare earth fluorescent materials are wrapped in the shell layer, so the fluorescence intensity signal of a prepared sample is greatly increased. The nanoparticle has dual functions of enrichment and marking, and has wider application prospects in the biomedical field.

The invention provides super macroporous polymer microspheres and a preparation method thereof. The preparation method comprises the following steps of: firstly, preparing an oil-in-water in-water composite emulsion as a template for super macroporous microspheres through a two-step emulsion process; then, solidifying an oil phase by using a solvent removal method to form super macroporous microspheres provided with inner-outer through pore passages; and finally, after molding the microspheres, further crosslinking microsphere skeleton molecules to obtain microspheres with rigid resin structures. The microspheres prepared by the method have a through pore passage structure, the controllable particle size range is 0.1-300 microns, the controllable pore size range is 0.09-90 microns, and the controllable porosity range is 10-90%. Super macroporous structures are beneficial for biological macromolecules to penetrate through and enter the microspheres, the mass transfer by convection in the microspheres can be realized, and the rigid structure can tolerate higher pressure and higher flow velocity. The super macroporous polymer microspheres can be used as stationary phase fillers for chromatographic separation, immobilized carriers of enzymes, cell culture micro-carriers, tissue engineering micro scaffold materials, adsorbing materials and the like.

The invention discloses a method for preparing silicon dioxide-coated magnetic microspheres, which belongs to the technical field of nano-magnetic materials. In the method, the characteristic that nanoparticles are easily arranged on a two-phase solution interface is utilized to form oil-in-water emulsion or microemulsion which is stabilized by oil-soluble magnetic nanoparticles and the hydrolysis of tetraethyl orthosilicate is further produced on the surfaces of droplets, so that a silicon dioxide-coated layer is formed. The method has the advantages of no need of using any surfactant, simple reaction operation process and short reaction time; particle diameters of the coated magnetic microspheres are 50 to 400nm; and the magnetic content of the microspheres can be simply controlled at the same time when the particle diameters of the magnetic microspheres are controlled.

The invention relates to a method for preparing monodisperse hollow meso-porous silicon dioxide nanometer particles, belonging to the field of inorganic nanometer materials. According to the method, styrene, acrylamide, G570 and deionized water are added into a reactor and then heated to 60-80 DEG C, an initiator is added into the reaction system after the reaction system is blown by nitrogen gas, and polystyrene microspheres are obtained after reaction; the polystyrene microsphere solution and a cationic surfactant are added into a PBS buffer solution and then put into the reactor after ultrasonic dispersion, tetraethyl orthosilicate is added into the reactor, centrifugation is carried out after reaction, and the monodisperse hollow meso-porous silicon dioxide nanometer particles are obtained by drying and calcining of the precipitates. The method has the advantages of simplicity in operation, mild reaction conditions, low price of experimental materials, good economy and short reaction period, the meso-porous material prepared according to the method has uniform size, small density, large specific surface area, high drug loading and good biocompatibility, is easily subjected to surface modification, and does not have the problem of silicon source self-polycondensation; and based on the method, control on the inner diameter of the hollow meso-porous silicon dioxide nanometer microspheres is achieved.

The invention discloses a magnetic resonance imaging nanometer drug carrier, and a nanometer drug loading system and a preparation method thereof. The magnetic resonance imaging nanometer drug carrieris a triblock polymer nanoparticle, wherein the triblock polymer is PLGA-PEI-PEG, and has active groups on the surface, and the active groups comprise amino, hydroxyl and carboxyl. According to the present invention, the drug carrier can efficiently load a nuclear magnetic resonance imaging drug and an antitumor drug to make the antitumor drug specifically reach the tumor lesion site, such that the nuclear magnetic resonance positioning of the superparamagnetic ferroferric oxide nanoparticle at the tumor region can be achieved while the high-selectivity and low-toxicity treatment effect can be achieved, and the disadvantages of poor selectivity, strong toxic-side effect, easy drug-resistance generation and the like of the traditional cytotoxic drugs can be overcome; and the preparation method is simple and is easy to perform, the prepared triblock polymer nanoparticle can be stably stored in the aqueous solution so as to be easily stored, and various functional groups exist on the surface of the particle, such that the prepared triblock polymer nanoparticle can be easily subjected to surface modification or surface functionalization.

The invention belongs to the technical field of medicine, and designs and synthesizes a series of disulfide bond-containing micromolecular prodrugs in which carbon chains in different lengths are linked (sulfur atoms in the disulfide bond are respectively located alpha, beta and gamma sites of an ester bond). PTX (Paclitaxel)-CIT (Citronellol) is used as a sample, and a synthesis method is simpleand easy. On the basis, a micromolecular prodrug self-assembly nano-drug delivery system is prepared. The preparation method is simple and convenient, the stability is high, and efficient encapsulation and delivery of drugs are realized. The invention discovers that the disulfide bond has redox dual sensitivity, can be fractured under the action of high-expression ROS (Reactive Oxygen Species) andGSH (Glutathione) of tumor cells, and PTX can be released; particularly, redox dual hypersensitivity is shown by PTX-CIT prodrugs (alpha-PTX-SS-CIT), which are located in the alpha site of a carbonylgroup, of the disulfide bond, the alpha-PTX-SS-CIT prodrugs can be quickly fractured to release the PTX and take effects, an anti-tumor effect of the PTX is remarkably improved, and a wide development prospect is obtained.

The invention relates to a method for removing mercury ions in water and a regeneration method of an adsorbent used in the same. An adsorbent is put in water to be treated to adsorb mercury ions in the water. The adsorbent is a palladium nanoparticle supported / iron oxide magnetic modified carbon nanotube composite material. The carbon nanotube composite material provided by the invention has nanostructure and large specific area; and after the carbon nanotube composite material is oxidized and activated, carboxyl group, hydroxyl group and other active functional groups are formed on the surface of the carbon nanotube composite material, thereby enhancing the hydrophilic property and the adsorptive capacity for positively charged metallic ions. The iron oxide is coated on the surface of the activated carbon nanotube composite material, and therefore, the activated carbon nanotube composite material has strong soft magnet property, and can easily implement solid-liquid separation of the adsorbent and the polluted water body under the action of an external magnetic field. The palladium modification strengthens the affinity of the composite material with mercury ions, and greatly enhances the adsorption capacity and selectivity of the original carbon nanotube composite material for mercury ions (the maximum adsorption capacity is 55.3mg / g).

The invention relates to a core-shell heterojunction structure nano-wire of Te / Bi or a Te / Bi2Te3 and a preparation method thereof. The nano-wire is characterized in that the preparation method applies liquid phase epitaxial method with glycol as solvent, PVP as an organic additive and a Te nano-wire as an in-situ template to synthesize the Te / Bi and the Te / Bi2Te3 core-shell heterojunction structure nano-wires; the nano-wire grows along the direction of and lt;001andgt;, and takes simple substance Te single crystal nano-wire with a hexagonal structure as core material, and has single crystal coating material formed by the extension of simple substance Bi with a hexagonal structure and alloy Bi2Te3; the extension relation between the simple substance and the alloy is as follows: Te(100) crystal plane is parallel to Bi(100) crystal plane or Bi2Te3 (100) crystal plane, and Te and lt;001 and gt; direction axis is parallel to Bi and lt;001and gt; direction axis or Bi2Te3 and lt;001and gt; direction axis. The heterojunction structure nano-wire of the invention can improve the thermoelectric properties of materials and quicken the application of thermoelectric materials.

The invention discloses a preparation method for a metal sulfide and a composite metal sulfide nano crystal material, which is suitable for the preparation of the nano crystal materials of cadmium sulfide, cuprous sulfide, zinc sulfide, lead sulfide, bismuth sulfide, and zinc-cadmium sulfide. The method is characterized in that water or organic solvent used in the existing hydrothermal or solvent thermal synthetic methods is replaced with melt composite alkali metal hydroxide which is synthesized through a chemical reaction under the normal atmosphere and a temperature between 100 and 300 DEG C. The raw materials used are soluble inorganic metal salts and sulfide or sulfide compounds, thereby having less controllable parameters and simple art, and being able to amplify manufacturing during the process of synthesis. Metal sulfide crystal produced has the advantages of good crystal, clean surface and even size, and is suitable for the research on the intrinsic properties and the maximum play of the functions of the nano crystal materials. The metal sulfide and the composite metal nano crystal materials have properties of a semiconductor, LED and optoelectronic, thereby being suitable for biomarker and preparation of a nano electronic apparatus, an LED apparatus and an optoelectronic apparatus.

The invention relates to a preparing method and a detecting method of a liquid grid type grapheme field-effect tube based on polyimide (PI). The methods are characterized in that an aluminum layer is deposited on a silicon substrate to be used as a sacrificial layer, PI photoresist is coated on the aluminum layer in a spin mode to be used as a substrate of a flexible field-effect tube, a commercialized grapheme / polymethyl methacrylate thin film is transferred to a titanium / gold electrode which is deposited on the PI substrate in advance to form good ohmic contact, AZ 4620 photoresist is used as a mask layer for grapheme patterning, grapheme is etched through oxygen plasma, and an insulating layer is manufactured on the surface of the patterned grapheme through the PI photoresist to form a liquid grid type structure. The field-effect tube is in the liquid grid type structure, so that machining steps can be reduced, further surface decoration on the surface of the grapheme is convenient, and accordingly specific detection on various biological signals is achieved.

The invention relates to a nanometer biology enzyme electrode which is formed by the tree-sharp macromolecular packaging mental nanometer and enzyme self-assembling. The nanometer particle is packaged inside the tree-sharp macromolecular to keep better activity; the electrode surface forms multi-foil layer with better scattering character and nanometer mental particle which can abridge the respond time and improve the sensing ability of the enzyme sensor. It can make super sensitive nanometer biology enzyme electrode by choosing different enzyme oxide needed by different applied.

The invention relates to a process for producing formaldehyde-removing solid wood flooring. The process comprises the following steps of: processing a surface board, processing a core board, processing a base board, glue pressing and compounding, fine processing, coating the surface, and forming the finished product. The process has the advantages of strong natural visual sensation, comfortable foot sensation, good material quality, easy processing, cyclic utilization, good geothermy adaptability, strong stability, more simple and convenient construction and installation, excellent environmental performance, great increase of comprehensive utilization ratio of timbers and special effects on adsorbing and degrading free formaldehyde in indoor air.

The invention discloses a branched gold-platinum dual-metal nanoparticle as well as a preparation method and application thereof. The gold-platinum dual-metal nanoparticle has photo-thermal / radio-sensitization combined treatment performance and structurally contains gold-platinum nanoparticles and polyethylene glycol, wherein the gold-platinum nanoparticles are used for photo-thermal / radio-sensitization combined treatment, and polyethylene glycol is used for the surface modification of a thioctic acid terminal of a hydrophilic polymer. The gold-platinum dual-metal nanoparticle can be applied to the photo-thermal / radio-sensitization combined treatment and has the advantages of simplicity in preparation, low cost and remarkable treatment effect.

The invention relates to an open framework fluorine-based solid-state electrolyte material and a preparation method of the open framework fluorine-based solid-state electrolyte material. A chemical formula of the electrolyte material is as follows: AxMyFx+3y, wherein x is more than 0 and less than or equal to 6, y is more than 0 and less than or equal to 3, A is Na and / or Li and M is Al and / or Ga. The open framework fluorine-based solid-state electrolyte material AxMyFx+3y provided by the invention is lithium-enriched or sodium-enriched phase aluminum-based or gallium-based fluoride; the invention provides application of a novel open framework structural prototype to fluoride solid-state electrolyte for the first time; meanwhile, lithium enriching or sodium enriching is realized; the concentration of transferable alkali metal ions is increased so that the intrinsic ionic conductivity is easy to improve; the electrical conductivity of a bulk phase and a particle boundary can be improved through means of nanocrystallization, disordering, surface modification and the like.

The invention belongs to the field of new auxiliary materials and new dosage forms of medicine preparations and relates to a chemotherapeutic drug-photosensitizer co-assembled nanoparticles and construction thereof. A chemotherapeutic drug is an anthracycline chemotherapeutic drug selected from mitoxantrone, doxorubicin or epirubicin; a photosensitizer is a porphyrin photosensitizer selected fromchlorine e6, hematoporphyrin monomethyl ether or a chlorophyll derivative, wherein the molar ratio of the chemotherapeutic drug to the photosensitizer is 3:1-1:3. A certain quantity of the chemotherapeutic drug and the photosensitizer or a mixture of the chemotherapeutic drug, the photosensitizer and PEG is dissolved in a proper quantity of organic solvent, and the solution is slowly dropwise added to water while stirring to form uniform nanoparticles spontaneously. The preparation process is simple, enlarged production is easy, particle size is small and uniform, and the nanoparticles can beenriched at tumor parts through a reinforced permeation retention effect; the nanoparticles have ultrahigh drug loading capacity and can reduce related toxicity of auxiliary materials; and surface modification is easy, and the circulation time of the nanoparticles in blood can be prolonged by PEG modification.

The invention discloses a fluorescent large-grain-size dendrimer and a preparation method thereof. Specifically, a carbon quantum dot containing carboxyl is used as a fluorescent core and a third-generation PAMAM (Polyamidoamine) dendrimer with an end part containing amino is assembled on the surface of the carbon quantum dot through condensation reaction. The prepared fluorescent large-grain-diameter dendrimer has a macromolecular fluorescent effect and a relatively great grain diameter; various properties of the fluorescent large-grain-diameter dendrimer are better than that of the third-generation dendrimer. A preparation process of the method is relatively simple and easy to operate, low in cost, good in repeatability and safe and environmentally friendly; a product has a good fluorescent property and can be used for various fields including medicine carrying, fluorescent imaging, gene transfection and the like.

The invention relates to a non-toxic, environment-friendly and smellless decorative material for removing formaldehyde, which is mainly suitable for being used as a finishing material on walls, ceilings, cylindrical surfaces and the like inside buildings. 3-15g of nano TiO2 / infusorial earth composite catalysts are added in the decorative material per square meter, and the nano TiO2 / infusorial earth composite catalysts are formaldehyde removing agents. The decorative material of the invention can improve the indoor artistic environment to provide beautiful enjoyment for people, has various functions such as heat insulation, dampproofness, fire protection, sound absorption, sound insulation, and the like, and has the unique effects for absorbing and degrading free formaldehyde in the indoor air.

The manufacturing method of a kind of high density printing floor absorbing formaldehyde comprises the following procedurals: molding high density floor -> sanding light -> covering grounding -> printing texture -> thermal pressure -> UV primer floating -> UV surface painting -> formaldehyde absorbing UV wearable surface painting -> finished product. Adding formaldehyde absorbing agent is a key for the technique. If the formaldehyde absorbing agent is too little, then the effect of absorbing formaldehyde is worse, and if the formaldehyde absorbing agent is too much, the index of the surface paint is affected. This kind of composite light-catalysis material gives good photo-catalysis properties and has good stability and good performance of repeating use in the condition of UV light, sun's rays, and the daylight lamp. In the sun's rays, the discolored ratio and the COD wiping ratio of the Rhodamine-B solution can reach to more than 95 percent in 2 hours; the decomposition ratio of phenol can reach 99.18 percent; the decomposition ratio of COD can be 95.59 percent; in the daylight lamp, the formaldehyde decomposition ratio is more than 80 percent in 24 hours. The formaldehyde content reaches GB 1 8883-2002 standard in the Room Air Quality Standard of the Country, that is the generally said E1 environment-protection standard, and it fits to generalize.

The invention discloses a surface modification sulfydryl magnetic nanometer material as well as a preparation method and application of the surface modification sulfydryl magnetic nanometer material and belongs to the technical field of inorganic materials and analysis. The magnetic nanometer material is obtained by firstly adopting coprecipitation to synthesize the magnetic nanometer material and adopting gamma-sulfydryl propyl trimethoxy silane and tetraethoxysilane to carry out surface chemical modification. The material is used as an adsorbent, the specific surface is great, quadrivalent selenium can be selectively adsorbed, and hexavalent selenium is not adsorbed. The material has good application fields in the selenium form analysis field.

The invention relates to a non-toxic environmental-friendly odorless coating for removing formaldehyde in indoor air, which is a mat coat material mainly applicable to inner wall surfaces, ceilings, pillar surfaces, and the like of buildings. The coating is characterized by adding 6-9g of nano TiO2 / white carbon black composite material into each square meter of interior wall coating, and the nano TiO2 / white carbon black composite material is a formaldehyde removing agent. The coating can be used for eliminating and reducing formaldehyde harm, fixing and absorbing formaldehyde in the interior wall coating and absorbing formaldehyde in air at the same time.

The invention belongs to the technical field of oxidized graphene, and particularly relates to a method for preparing small oxidized graphene from cryptocrystalline graphite.The method mainly solves the problems of existing oxidized graphene preparing methods that purity is low, toxicity is high, technology is complicated and cost is high.According to the method, purified cryptocrystalline graphite, concentrated acid and strong oxidant are evenly mixed for reaction in an airtight environment at the temperature of 80-120 DEG C, a reaction mixture is slowly poured into an excessive amount of deionized water, uniform stirring is conducted, then an aqueous hydrogen peroxide solution with the mass concentration of 25% is added till turbid liquid becomes brown or luminous yellow, acid pickling and washing are conducted till pH value becomes 6-7, and then centrifugal separation is conducted to generate the small oxidized graphene.The ratio of the mass of purified cryptocrystalline graphite to the volume of concentrated acid is 1 : (20-80), and the mass ratio of purified cryptocrystalline graphite to purified cryptocrystalline graphite is 1 : (3-10).

The invention relates to a palladium-based dopamine-coated magnetic carbon nano-tube catalyst and application thereof. A preparation method comprises the following steps: (1) oxidizing carbon nano-tubes to obtain carboxylic carbon nano-tubes; (2) dissolving a nickel salt in a mixed solution of ethyl alcohol and water, adding the carboxylic carbon nano-tubes, performing ultrasonic treatment, drying and roasting to obtain nickel-filled carboxylic carbon nano-tubes; (3) dispersing the nickel-filled carboxylic carbon nano-tubes in Tris buffering liquid, adding dopamine, stirring, and performing centrifugal drying to obtain poly-dopamine-coated magnetic carbon nano-tubes; and (4) dispersing the poly-dopamine-coated magnetic carbon nano-tubes in an aqueous solution of a palladium salt, performing ultrasonic treatment, heating, stirring, evaporating, drying, and reducing to obtain the palladium-based dopamine-coated magnetic carbon nano-tube catalyst. The palladium-based dopamine-coated magnetic carbon nano-tube catalyst has excellent magnetic separating performance and can be effectively separated from a liquid phase after the completion of a reaction; and the recycling rate of the catalyst is effectively improved.

The invention discloses a sensing chip for detecting mercury ions. The sensing chip comprises a metal substrate (1) modified by a 11-sulfydryl hendecanoic acid membrane layer (16), wherein one corner of a gold layer of the metal substrate (1) is connected with a metal wire conductor (2) wrapped by a plastic insulation layer (3), and the connection part is wrapped and sealed by using expoxy resin glue (4); and the metal substrate (1) is formed by gradually sputtering and depositing a SiO2 membrane layer (12), a metal titanium membrane layer (13), a copper-tin alloy membrane layer (14) and a gold membrane layer (15) on a polished silicon nitride substrate (11), the gold membrane layer (15) is subjected to chemical cleaning treatment, and then a modification 11-sulfydryl hendecanoic acid membrane layer (16) is assembled on the surface of the gold membrane layer (15), thus the sensing chip for detecting the mercury ions is manufactured. The sensing chip is simple in manufacturing, low in cost and convenient to use and can be used for rapidly detecting trace amounts of mercury ions in environments.

A preparation method of damp-proof, breathable and super-hydrophobic activated carbon comprises the steps as follows: an activated carbon sample is placed in a drying oven to be dried for 6-24 h for later use after moisture is fully removed; the pretreated activated carbon and a low-surface-energy substance are added to a vacuum drying oven in the mass ratio being (100-500):1, vacuum pumping is performed, the temperature is adjusted to 60-180 DEG C, and the mixture is kept for 2-24 h; or the pretreated activated carbon is soaked in a solution containing the low-surface-energy substance, the solution is placed in a drying oven at 60-120 DEG C and kept for 2-10 h; the activated carbon subjected to surface modification is taken out, placed in a drying oven at 80-150 DEG C and kept for 0.5-4 h, and the damp-proof, breathable and super-hydrophobic activated carbon can be obtained. The method is simple in process, easy to operate, low in equipment requirement, low in cost and suitable for mass preparation, and a new idea is provided for improving the damp-proof capacity, improving the adsorption performance and prolonging the service life of the activated carbon.

The invention relates to the field of biological medicines, and particularly provides an antitumor drug carrier and an application method thereof. The antitumor drug carrier is a phycobiliprotein nano particle. On the basis of the difference between normal cells and tumor cells, the phycobiliprotein nano particle without toxicity and immunogenicity is adopted as the antitumor drug carrier; the tumor-targeting capability is given; meanwhile, antitumor drugs are efficiently loaded; the antitumor drugs specifically reach the tumor lesion part; the treatment effects of high selectivity and low toxicity are realized; and the defects that a traditional cytotoxic drug is poor in selectivity and relatively high in toxic and side effect, and the drug resistance is easily generated are overcome. The preparation method provided by the invention is simple and feasible; and the prepared product can be stably stored in a water solution and is beneficial to storage.

The nano ternary composite glycyrrhizin particle of the present invention results in raised orally taken absorption rate and bioavailability of glycyrrhizin. The present invention prepares nano ternary composite glycyrrhizin particle through ion gelifying process of sodium tripolyphosphate, sodium carboxymethyl cellulose as anion polymer and chitosan or quaternized N-(2-hydroxy) propyl-3-trimethyl ammonium chloride, and the mutual action between glycyrrhizin and chitosan. Nano particles of different sizes may be obtained via controlling the molecular weight of chitosan and the concentration and ratio of the components. The nano particle is positively charged and thus favorable to surface modification. The method of the present invention is simple, feasible, repeatable and practical.

The invention discloses a water phase dispersing method for lyophobic organic dying nanoparticles. The method comprises the following steps of: (1) preparing lyophobic organic fluorescent dying molecules into precursor nanoparticles with a solvent exchange method, (2) preparing an amphipathic surfactant into 1mg / mL amphipathic surfactant aqueous solution; and (3) adding 300 muL of 1 mg / mL amphipathic surfactant aqueous solution into a suspension of the precursor nanoparticles, performing ultrasonic dispersion for 5 minutes, and standing for 6 hours to obtain water phase-dispersed lyophobic organic dying nanoparticles. In the method, surface modification of the lyophobic organic dying nanoparticles is realized by controlling the type and concentration of the amphipathic surfactant. The preparation method is easy and practicable, and can be widely applied in the fields of biology, medicine, chemistry and the like; and an experimental basis is provided for the preparation of other water phase-dispersed lyophobic organic small molecular fluorescent nanoparticles.

A functional lanthanide fluorescence nanoparticle (LFNP) is prepared from the strong-fluorescent RE matches as luminous center through chemically wrapping by silica gel. Its advantages are long fluorescence lift, big stoke shift, narrow emitting peak and strong specific signal. It can be used as the fluorescent marker for biological detection.

The invention relates to an application of prussian blue nanoparticles in preparation of drugs for preventing, delaying or treating nervous system degenerative diseases. Researches find that the prussian blue nanoparticles have remarkable effects in the aspects of preventing, delaying or treating nervous system degenerative diseases. Cell level test results show that the prussian blue nanoparticles can reduce the ROS level in nerve cells stimulated by hydrogen peroxide and increase the proportion of living cells in the nerve cells stimulated by hydrogen peroxide; and animal level test resultsshow that the prussian blue nanoparticles can significantly reduce the expression level of oxidative stress markers in hippocampus of nervous system degenerative disease model mice, significantly improve the learning and memory ability of nervous system degenerative disease model mice, and improve dyskinesia. The preparation process of the prussian blue nanoparticles is simple, the macro production is easy, the reaction condition is mild, and the surface modification is easy.