Method for preparing monodisperse hollow meso-porous silicon dioxide nanometer particles

A mesoporous silica and nanoparticle technology, applied in the direction of silica, silicon oxide, nanotechnology, etc., can solve the problem of uneven particle size of hollow mesoporous silica, uncontrollable cavity pore size, and limit the next application and other issues, to achieve the effect of good biocompatibility, low density and low price

Inactive Publication Date: 2014-05-21
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor monodispersity of the template block copolymer aggregates, the obtained hollow mesoporous silica particle size is not uniform, and the cavity pore size is uncontrollable, which limits its further application.
Xu Xinhua et al. (Monodisperse Mesoporous Silica Hollow Nano Microspheres and Preparation Method, Chinese Patent, Publication No. CN101857234A) used ethyl orthosilicate, n-octylamine, Tween, inorganic sodium salt or potassium salt under the action of ultrasonic waves Mesoporous silica hollow nanospheres were prepared, the preparation time is short but the nanoparticle size can only be below 200nm, which limits the application of materials in catalysis and other fields

Method used

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  • Method for preparing monodisperse hollow meso-porous silicon dioxide nanometer particles
  • Method for preparing monodisperse hollow meso-porous silicon dioxide nanometer particles
  • Method for preparing monodisperse hollow meso-porous silicon dioxide nanometer particles

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Experimental program
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Effect test

Embodiment 1

[0026] The polystyrene microspheres were prepared as follows:

[0027] (1) Add 15ml styrene, 1ml acrylamide, 0.01ml G570, 500ml deionized water into the reaction vessel, stir under nitrogen protection and heat up to 70°C;

[0028] (2) After nitrogen purging for 30 min, 0.2 g of initiator was added to the reaction system, and under nitrogen protection, stirring was continued for 24 h to obtain polymer microspheres.

[0029] The preparation of hollow mesoporous silica composite microspheres is as follows:

[0030] (1) Add 1ml of polymer microsphere solution and 0.06g of cationic surfactant into 50ml of PBS buffer solution, and disperse evenly by ultrasonication for 30min;

[0031] (2) Add the mixed solution in step (1) into the reaction vessel, add 0.1ml tetraethyl orthosilicate dropwise, and stir for 5 hours at 70°C;

[0032] (3) After the reaction, centrifuge, dry the precipitate at 50°C for 1.5h, and then calcinate at 550°C for 6h to obtain hollow mesoporous silicon nanopar...

Embodiment 2

[0035] The polystyrene microspheres were prepared as follows:

[0036] (1) Add 25ml styrene, 1.5ml acrylamide, 0.015ml G570, 600ml deionized water into the reaction vessel, stir under nitrogen protection and heat up to 65°C;

[0037] (2) Add 0.5 g of initiator to the reaction system after nitrogen purging for 30 min, and continue to stir and react for 24 h under nitrogen protection to obtain polymer microspheres.

[0038] The preparation of hollow mesoporous silica composite microspheres is as follows:

[0039] (1) Add 1.5ml of polymer microsphere solution and 0.08g of cationic surfactant into 60ml of PBS buffer solution, and disperse evenly by ultrasonication for 30min;

[0040] (2) Add the mixed solution in step (1) into the reaction vessel, add 0.1ml tetraethyl orthosilicate dropwise, and stir for 5 hours at 70°C;

[0041] (3) After the reaction, centrifuge, dry the precipitate at 50°C for 1.5h, and then calcinate at 550°C for 6h to obtain hollow mesoporous silicon nanopa...

Embodiment 3

[0044] The preparation of polystyrene microspheres is with embodiment 1:

[0045] The preparation of hollow mesoporous silica composite microspheres is as follows:

[0046](1) Add 2ml of polymer microsphere solution and 0.05g of cationic surfactant into 50ml of PBS buffer solution, and disperse evenly by ultrasonication for 30min;

[0047] (2) Add the mixed solution in step (1) into the reaction vessel, add 0.2ml tetraethyl orthosilicate dropwise, and stir for 5 hours at 70°C;

[0048] (3) After the reaction, centrifuge, dry the precipitate at 50°C for 1.5h, and then calcinate at 550°C for 6h to obtain hollow mesoporous silicon nanoparticles.

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Abstract

The invention relates to a method for preparing monodisperse hollow meso-porous silicon dioxide nanometer particles, belonging to the field of inorganic nanometer materials. According to the method, styrene, acrylamide, G570 and deionized water are added into a reactor and then heated to 60-80 DEG C, an initiator is added into the reaction system after the reaction system is blown by nitrogen gas, and polystyrene microspheres are obtained after reaction; the polystyrene microsphere solution and a cationic surfactant are added into a PBS buffer solution and then put into the reactor after ultrasonic dispersion, tetraethyl orthosilicate is added into the reactor, centrifugation is carried out after reaction, and the monodisperse hollow meso-porous silicon dioxide nanometer particles are obtained by drying and calcining of the precipitates. The method has the advantages of simplicity in operation, mild reaction conditions, low price of experimental materials, good economy and short reaction period, the meso-porous material prepared according to the method has uniform size, small density, large specific surface area, high drug loading and good biocompatibility, is easily subjected to surface modification, and does not have the problem of silicon source self-polycondensation; and based on the method, control on the inner diameter of the hollow meso-porous silicon dioxide nanometer microspheres is achieved.

Description

technical field [0001] The invention belongs to the field of inorganic nanometer materials, in particular to a method for preparing hollow mesoporous silicon dioxide nanoparticles. Background technique [0002] Since Kresge et al first reported an ordered mesoporous silica material named MCM-41 in Nature in 1992, the research on mesoporous silica has rapidly become an international hotspot. The emergence of ordered mesoporous silica is a leap in the history of molecular sieves and porous materials. Due to its large specific surface area, high thermal stability and regular pore structure, mesoporous silica materials have shown broad application prospects in catalytic adsorption, separation and purification, biomaterials, nanomaterials, environment, energy and other fields. [0003] In recent years, with the rapid development of nanotechnology, nanoparticles with novel topological structures have aroused great interest, especially hollow mesoporous silica microspheres, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18B82Y30/00B82Y40/00
Inventor 戴李宗毛杰袁丛辉谢泓辉罗伟昂叶华立余世荣陈国荣李聪刘新瑜何凯斌
Owner XIAMEN UNIV
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