51 results about "Polymer nanoparticle" patented technology

The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.

The application provides a multifunctional nano particle for targeting abdominal aortic aneurysm and a preparation method and application thereof, and belongs to the field of nanobiomedicine, wherein polyphenol oxidation self-polymer nanoparticles are used as carriers, doxycycline is loaded, and a targeting ligand cRGD is modified on the surface of the nano carrier; the neovasculature in the media and adventitia of AAA sites helps accumulation of the nanoparticles in the abdominal aortic aneurysm, and the integrin αν3 beta receptor highly expressed on the surface of the diseased cell membrane can recognize the cRGD with high affinity, and then mediate the targeted endocytosis of the nanoparticles; after intravenous injection, the nanoparticles can be effectively enriched in the lesion site and achieve long-term retention, and can release DC in response to the high ROS level in the tumor microenvironment; the drug is rapidly released to take effect, and the non-specific toxic side effects are reduced; the free radical scavenging capacity of the nanoparticles can be synergized with the DC activity to treat AAA through multiple mechanisms such as anti-inflammatory, antioxidant, macrophage repolarization promotion, anti-apoptosis and calcification inhibition, and MMPs inhibition.

The present invention deals with the development of novel nanocomposite paints for biofouling removal coatings, which result from the mixing of two components, where the first component is an epoxy resin (component A) and the second component is a suitably modified polymerization agent (hardener). These hardeners are modified with hydrophobic nanoparticles based on functional dendritic polymers with symmetric or asymmetric architecture or based on functional inorganic nanoparticles (metal or metalloid nanoparticles or a mixture thereof). Both the polymeric nanoparticles and the inorganic nanoparticles were modified with suitable lipophilic groups. These nanocomposite paints addressed by the present invention exhibit organic microfilm control properties and can be effectively applied to objects immersed in seawater as biofouling removal coatings.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

The invention discloses polymer nanoparticles for colorectal cancer immunotherapy as well as a preparation method and application of the polymer nanoparticles. Small interfering RNAsiDhx9 is entrapped in the nanoparticles, a CD19 antibody is coupled to the surfaces of the nanoparticles, and immunotherapy of colorectal cancer is realized by specifically silencing Dhx9 on B cells. The nanoparticles provided by the invention not only can activate cytotoxic T (CD8 + T) cells, induce powerful anti-tumor immune response and remarkably inhibit the progress of colorectal cancer, but also can enhance the immune memory effect.

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

This invention belongs to the technical field of antibacterial and antioxidant materials, and discloses a high-antibacterial and antioxidant nanoparticle based on an iron-zinc bimetallic coordination polymer, its preparation, and application. Method: 1) Polyvinylpyrrolidone is dissolved in an ethanol solution, followed by the addition of an ethanol solution of an iron salt. The pH is adjusted to 8-9, the stirring speed is increased, and an ethanol solution of tannic acid is added dropwise. After the addition is complete, stirring continues to obtain an iron-based tannic acid metal phenolic network; 2) An ethanol solution of zinc chloride is added to the iron-based tannic acid metal phenolic network, and the reaction is stirred for 8-12 hours to obtain high-antibacterial and antioxidant nanoparticles based on an iron-zinc metal coordination polymer. The method of this invention is simple, and the nanoparticles of this invention have good antioxidant and antibacterial effects. The nanoparticles are used to prepare antibacterial and antioxidant materials, particularly for the preparation of drugs for treating corneal ulcers.

Disclosed are a composition for inducing immunity against an active ingredient and a method for preparing same, the composition comprising: a nucleic acid, a polypeptide, or a combination thereof as the active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the active ingredient is encapsulated in a nanoparticle structure formed by the amphiphilic block copolymer and the polylactate.

A hard coating film containing a polymer nanoparticle (A) and a matrix component (B), whereina Martens hardness HMA of the polymer nanoparticle (A) and a Martens hardness HMB of the matrix component (B) satisfy a relationship of HMB / HMA>1, anda Martens hardness HM of the hard coating film is 100 N / mm2 or more.

The invention belongs to the technical field of functional cosmetics, and particularly discloses a menthyl lactate and succinic acid eutectic cool-feeling acne removing agent and a preparation method thereof. The cool-feeling acne removing agent is prepared from the following components in percentage by weight: 1.0 to 3.5 percent of menthyl lactate-succinic acid eutectic, 8 to 15 percent of nano-liposome or polymer nanoparticle carrier, 0.2 to 0.6 percent of capryloyl salicylic acid, 0.3 to 0.8 percent of zinc lactobionate or zinc pyrrolidone carboxylate, 0.1 to 0.4 percent of asiaticoside, 0.5 to 1.2 percent of herba portulacae extract, 0.3 to 0.7 percent of panthenol, 0.1 to 0.3 percent of sodium hyaluronate and the balance of water. And the balance of deionized water, a polyol moisturizing system and a non-irritant anti-corrosion system. The invention also discloses a preparation method of the cool acne removing agent. The cool-feeling acne-removing agent disclosed by the invention can achieve a synergistic effect on cool feeling and an anti-acne effect, and the component stability and the skin infiltration capacity are improved.

Use of porous metal oxide microspheres as light stabilizers for shaped artificial polymer articles, wherein the porous metal oxide microspheres are prepared by a process comprising forming a liquid dispersion of polymer nanoparticles and a metal oxide; forming liquid droplets from the dispersion; drying the droplets to provide polymer template microspheres comprising polymer nanospheres; and removing the polymer nanospheres from the template microspheres to provide the porous metal oxide microspheres.

The invention discloses temperature-sensitive fluorescent coating ink based on triplet state-triplet state annihilation up-conversion as well as a preparation method and application of the temperature-sensitive fluorescent coating ink. The ink is composed of a polymer substrate material, silicone rubber polymer nanoparticles loaded with triplet state-triplet state annihilation up-conversion fluorescent dye and a solvent, a temperature-sensitive fluorescent coating is formed on the surface of an electronic component through a dispensing method, a spin coating method, a blade coating method or a spraying method, and a uniform fluorescent film is prepared; exciting the fluorescent film by using laser; a photoluminescence signal is collected through a confocal light path, and spectrum analysis is carried out through a monochromator; the method comprises the following steps: performing micro-area scanning on a fluorescent film on the surface of a measured object by controlling a displacement table or a galvanometer, and capturing spectral information of each pixel point; and according to a pre-calibrated temperature-spectrum relation curve, reconstructing a micro-scale two-dimensional or three-dimensional temperature distribution diagram of the chip in a working state. According to the invention, non-contact and high-resolution real-time temperature imaging of a chip working state microcell is realized, and a key technology is provided for temperature anomaly detection, thermal management optimization and failure analysis of a miniature electronic component.

The present application relates to liposome polymer nanoparticle mixed preparation technical field, disclose a kind of liposome polymer nanosphere preparation system and method based on lavall nozzle collision injection technology.The system includes jet mixer;Jet mixer includes collision mixing unit and at least two lavall nozzles;Collision mixing unit has mixing chamber in it, at least one liquid outlet channel and at least two liquid inlet channels are formed in collision mixing unit;Liquid inlet channel and liquid outlet channel are communicated with mixing chamber;Multiple lavall nozzles are correspondingly arranged in liquid inlet channel.Lavall nozzle can accelerate fluid to supersonic state to form high kinetic energy jet, high-speed jet is sprayed from different jet ports, and collision occurs in mixing chamber, increase the contact area of fluid, improve shear force and turbulent effect, improve the mixing uniformity of fluid, solve the problem of uneven particle size when liposome polymer nanoparticles are prepared by microfluidic system in prior art.

The invention discloses a design method and application of a non-conjugated polymer photosensitizer with a flexible structure, belongs to the technical field of biological medicines, and particularly relates to the non-conjugated polymer photosensitizer with the flexible structure for enhancing the tumor photoimmunotherapy performance of targeted lysosome. The non-conjugated polymer photosensitizer is composed of a lipophilic electron donor, a hydrophilic electron acceptor and a flexible alkyl chain; according to the non-conjugated polymer photosensitizer, photosensitizers with different properties are constructed by changing the lengths of different flexible chains; the non-conjugated polymer photosensitizer is flexible cationic polymer nanoparticles prepared from a flexible cationic polymer.

The disclosure relates to block copolymer nanoparticles for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides that encode polypeptides.

The invention discloses a polypeptide modified cationic polymer nanoparticle as well as a preparation method and application thereof, and relates to the technical field of genetic engineering medicine and vaccine manufacturing, the polypeptide modified cationic polymer nanoparticle comprises a cationic polymer nanoparticle PBAE-536 and plasmid DNA which is in electrostatic binding and tight winding with the PBAE-536; the cell-penetrating peptide HIV-TAT is indirectly coupled to the surface of the PBAE-536, the auxiliary peptide HA2-TAT is mixed with the PBAE-536, and the oligopeptide is coupled with a carrier of the PBAE-536 and contains a microtubule related sequence MTAS and a nuclear localization signal NLS; the polypeptide modified cationic polymer nanoparticles have low cytotoxicity, and can enter cells through endocytosis after being incubated with T lymphocytes from peripheral blood for 30 minutes, so that rapid and efficient gene delivery is realized.

The disclosure relates to block copolymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods thereof. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides.

The invention relates to the technical field of coatings, in particular to an anti-corrosion coating material and a preparation method thereof.The anti-corrosion coating material comprises a base material, nano-composite anti-corrosion particles, compound anti-corrosion filler, a dispersing agent, a cross-linking accelerant, a coalescing agent, a defoaming agent, an environment-friendly solvent and an ultraviolet light absorber; the base material is an interpenetrating network polymer of two kinds of epoxy resin, the nanoparticles are pretreated by a coupling agent and coated by phytic acid, and the assistants are compounded or prepared according to a specific mode. The weather resistance and flexibility are improved by the base material, the dispersity and the corrosion resistance are improved by the nanoparticles, the uniformity and the mechanical property of the coating are optimized by the compound additive, the environment-friendly solvent and the ultraviolet light absorber meet the environment-friendly requirement and prolong the outdoor service life, and the process is easy to industrialize.

Porous metal oxide microspheres are prepared by a method comprising forming a liquid solution or dispersion of polydisperse polymer nanoparticles and metal oxide; forming liquid microdroplets from the solution or dispersion; drying the liquid microdroplets to provide polymer template microspheres comprising polymer nanospheres and metal oxide; and removing the polymer nanospheres from the template microspheres to provide porous metal oxide microspheres. The porous microspheres exhibit saturated colors and are suitable as colorants for various end uses.

The invention provides application of an LRG1 inhibitor or a miR-145-5p nano-complex in preparation of a medicine for preventing and / or treating prostatitis, and belongs to the technical field of biological medicine manufacturing. The invention discloses application of an LRG1 inhibitor in preparation of a medicine for preventing and / or treating prostatitis. In order to further improve the stability and the delivery efficiency of the miR-145-5p in vivo when the miR-145-5p is used as an LRG1 inhibitor, the invention provides a miR-145-5p nano-composite which is a polymer nano-particle loaded with the miR-145-5p. According to the invention, through targeted down-regulation of LRG1 and regulation and control of a TGF-beta / Smad signal channel, polarization of macrophages from M1 to M2 is remodeled, and oxidative stress of prostate tissues is synchronously relieved, so that mandatory treatment of prostatitis is realized.

This invention discloses a polyphenylene sulfide (PPS) composite masterbatch, a hollow fiber membrane, and a method for preparing the same. The PPS composite masterbatch comprises, by mass percentage: 64%–95% PPS resin, 4%–35% polymer, 0.1%–0.5% nanoparticles, and 0.2%–1.5% dispersant. The PPS resin includes linear high molecular weight PPS and hyperbranched PPS, and the polymer is a polymer different from PPS. The mass ratio of linear high molecular weight PPS to hyperbranched PPS is 85%–99%:15%–1%. The composite masterbatch of this invention incorporates a suitable proportion of hyperbranched PPS. Using this composite masterbatch to prepare hollow fiber membranes avoids the long-term, high-temperature dissolution process, saving time and improving production efficiency. Simultaneously, it can improve the mechanical properties of the hollow fiber membrane, thus enabling the efficient preparation of high-quality PPS hollow fiber membranes.

The invention discloses an insulation and heat conduction enhanced PC material and a preparation method thereof, and belongs to the technical field of high polymer materials. The insulating heat-conducting reinforced PC material is prepared from the following raw materials in parts by mass: 33 to 57 parts of PC resin, 10 to 15 parts of glass fiber, 25 to 40 parts of heat-conducting filler and 0.5 to 1 part of modified interface solubilizer, the modified interface solubilizer is mixed shell type polymer nanoparticles, a shell layer monomer comprises butyl acrylate and MAH-g-PE, and a core layer monomer is styrene. By adding the modified interface solubilizer, the interface adhesion is obviously enhanced, and the mechanical property is obviously improved; the core function of the modified interface solubilizer is to reduce the interfacial tension between the PC matrix and the glass fiber, form stable interface bonding through chemical and physical actions, and improve the impact resistance.

The present invention relates to a thyroid hormone delivery system comprising lipid or polymeric nanoparticles, preferably a targeting agent comprising the TRCP6 receptor. The delivery system can be used for treating diabetic cardiomyopathy or diabetic nephropathy.

The invention discloses a light-operated biological hybrid micro-robot drug-loaded delivery carrier and preparation and application thereof, and the light-operated biological hybrid micro-robot drug-loaded delivery carrier is composed of polymer nanoparticles carrying anti-fibrosis drugs and flexible living microorganisms, wherein 0.1-1 mg of the anti-fibrosis drug can be loaded on each flexible living microorganism with the order of magnitude of 1 * 10 < 5 >-1 * 10 < 6 >; the anti-fibrosis drug in the polymer nanoparticles loaded with the anti-fibrosis drug is nintedanib, the polymer is a polylactic acid-glycolic acid copolymer, and the mass ratio of the polylactic acid-glycolic acid copolymer to the nintedanib is (10: 1)-(20: 1). The ratio of lactide to glycolide in the polylactic acid-glycolic acid copolymer is 30: 70-50: 50, and the molecular weight of the polylactic acid-glycolic acid copolymer is 38000-54000. According to the photo-biological hybrid micro-robot, flexible living microalgae and a micro-robot drug delivery system are combined to achieve light-operated accurate regulation and control, light-operated permeation enhancement is achieved, drug retention time is prolonged, and good biocompatibility and safety are achieved.

The invention belongs to the technical field of medical materials, and discloses metal coordination polymer-based nanoparticles as well as preparation and application thereof. The preparation method comprises the following steps: 1) mixing polyvinylpyrrolidone and ferric salt in a solvent, adjusting the pH value to 8-9, dropwise adding an ethanol solution of curcumin, and continuously stirring after dropwise adding to obtain iron-based curcumin; (2) tannic acid and iron-based curcumin are subjected to a reaction, and tannic acid coordinated iron-based curcumin is obtained; and 3) in a reaction medium, carrying out a reaction on polylysine and tannic acid coordinated iron-based curcumin to obtain the metal coordination polymer nanoparticles. The method disclosed by the invention is simple, and the components of the nanoparticles are all natural materials, so that the nanoparticles have good biocompatibility, can be retained in biological tissues to play a role and do not cause other injuries. The nano particles disclosed by the invention have relatively good antioxidant, antibacterial and anti-inflammatory effects. The nanoparticles are used for preparing drugs for treating bacterial keratitis or wound infection.

A hard coating film containing a polymer nanoparticle (A) and a matrix component (B), whereina Martens hardness HMA of the polymer nanoparticle (A) and a Martens hardness HMB of the matrix component (B) satisfy a relationship of HMB / HMA>1, anda Martens hardness HM of the hard coating film is 100 N / mm2 or more.

The present invention relates to the field of nanoparticles, conjugates thereof, and their use in methods of treating or preventing vascular inflammation. The present invention also relates to methods of delivering an agent to a region of a patient's blood vessel, comprising: a) conjugating an agent to a nanoparticle to produce a conjugate; and b) delivering the conjugate to a region of a blood vessel.

The application discloses a kind of synthesis method of spherical polymer nanoparticles, it is related to vaccine technical field, and the method comprises the following steps: polyvinylpyrrolidone is dissolved in mixed solvent, then glyoxal, ascorbic acid and ethylenediamine are added in turn respectively, after stirring for a certain time, the color of solution obviously changes from yellowish to wine red.The solution containing prepolymer is transferred into reaction kettle, the reaction kettle is put into oven to react, the previous prepolymer will further crosslink and polymerize, form nonlinear network polymer skeleton, through repeated centrifugation and ethanol washing, finally drying can obtain the target spherical nanoparticle material.The application uses ascorbic acid as raw material, ethylenediamine as initiator and connecting agent, glyoxal as crosslinking agent, successfully synthesizes a kind of brand-new polymer nanoparticle, simultaneously realizes efficient antigen delivery and specific activation B cell, and is a kind of brand-new ideal vaccine adjuvant with promising application.

The application discloses a kind of gas response intelligent super double water-oil repellent separation membrane materials and its preparation method and application, preparation method includes first by silica nanoparticle template method preparation hydrophilic π-conjugated polymer nanoparticles;Then by spraying or layer-by-layer self-assembly method, negative polyacrylic acid polyelectrolyte with positive hydrophilic π-conjugated polymer nanoparticles are deposited on the substrate of reticular structure or porous structure, obtain porous nanostructure coating;Finally, perfluoroalkanoic acid is modified, the obtained gas response intelligent super double water-oil repellent separation membrane material can realize intelligent conversion between super double water-oil repellent from oil adhesion under gas stimulation response, gas response is rapid, anti-oil pollution, self-cleaning ability is strong, realizes fast oil-water separation, solves the separation failure problem caused by the insufficient self-cleaning ability of existing special wetting oil-water separation membrane material, easy to be contaminated by viscous oil.

The disclosure relates to block copolymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods thereof. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides.