100 results about "Polymer nanoparticle" patented technology

The disclosure relates to block copolymer nanoparticles for therapeutic delivery of nucleic acids, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering miRNAs.

The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.

The invention discloses a multi-technology combined medication analysis platform of an oligonucleotide drug, which relates to the technical field of drug analysis and is technically characterized by comprising an oligonucleotide drug delivery technology module, a liposome, a polymer nanoparticle or an exosome is selected as a delivery carrier, the surface of the delivery carrier is modified with hydrophilic polyethylene glycol or a targeting ligand, and the oligonucleotide drug delivery technology module is connected with the oligonucleotide drug delivery module. The performance of the material is represented by dynamic light scattering and a transmission electron microscope; the multi-technology platform analysis module integrates RT-qPCR, LC-FL, LC-MS / MS and LC-HRMS technologies, is respectively used for target gene expression quantification, drug distribution tracking, drug principal component quantification and metabolite structure analysis, establishes a cross validation rule, and requires a correlation coefficient R2gt of an LC-MS / MS quantitative result and RT-qPCR expression data; 0.95%, 0.95%; the pharmacokinetic evaluation module constructs a PBPK model to predict human pharmacokinetic parameters, and draws a drug metabolism network diagram in combination with an LC-HRMS metabolite identification result; by integrating various advanced analysis technologies, the problems of low sensitivity, poor specificity and difficult metabolite analysis in the prior art are solved.

The disclosure relates to block copolymer nanoparticles for therapeutic delivery of nucleotides, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering miRNAs.

The application provides a multifunctional nano particle for targeting abdominal aortic aneurysm and a preparation method and application thereof, and belongs to the field of nanobiomedicine, wherein polyphenol oxidation self-polymer nanoparticles are used as carriers, doxycycline is loaded, and a targeting ligand cRGD is modified on the surface of the nano carrier; the neovasculature in the media and adventitia of AAA sites helps accumulation of the nanoparticles in the abdominal aortic aneurysm, and the integrin αν3 beta receptor highly expressed on the surface of the diseased cell membrane can recognize the cRGD with high affinity, and then mediate the targeted endocytosis of the nanoparticles; after intravenous injection, the nanoparticles can be effectively enriched in the lesion site and achieve long-term retention, and can release DC in response to the high ROS level in the tumor microenvironment; the drug is rapidly released to take effect, and the non-specific toxic side effects are reduced; the free radical scavenging capacity of the nanoparticles can be synergized with the DC activity to treat AAA through multiple mechanisms such as anti-inflammatory, antioxidant, macrophage repolarization promotion, anti-apoptosis and calcification inhibition, and MMPs inhibition.

The present invention deals with the development of novel nanocomposite paints for biofouling removal coatings, which result from the mixing of two components, where the first component is an epoxy resin (component A) and the second component is a suitably modified polymerization agent (hardener). These hardeners are modified with hydrophobic nanoparticles based on functional dendritic polymers with symmetric or asymmetric architecture or based on functional inorganic nanoparticles (metal or metalloid nanoparticles or a mixture thereof). Both the polymeric nanoparticles and the inorganic nanoparticles were modified with suitable lipophilic groups. These nanocomposite paints addressed by the present invention exhibit organic microfilm control properties and can be effectively applied to objects immersed in seawater as biofouling removal coatings.

The present application relates to the field of high polymer material and medical engineering, and particularly relates to a high polymer nanoparticle with bone targeting, neutralizing acidic environment and antioxidant properties and a preparation method thereof. The preparation raw material of the high polymer nanoparticle comprises a zoledronic acid modified polycaprolactone-polypeptide copolymer, and a chemical structural formula of the copolymer is shown as follows: The high polymer nanoparticle prepared by using the zoledronic acid modified polycaprolactone-polypeptide copolymer as the raw material has the bone targeting, excellent antioxidant property and the ability of neutralizing acidic environment. The high polymer nanoparticle can exert the significant therapeutic effect (antioxidant, neutralizing acidic environment) of osteoporosis only by relying on the inherent activity of the material itself, so that a series of toxicity problems possibly caused by traditional drugs are fundamentally and greatly reduced, and a new scheme is provided for the treatment of osteoporosis.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

The application discloses a kind of copper barrier layer chemical mechanical polishing fluid for BEOL, belong to the field of semiconductor manufacturing technology.The polishing fluid includes abrasive particles, chelating agent, corrosion inhibitor, oxidizing agent, pH regulator and water.The abrasive particles are P (MMA-EDMA-HEMA) tri-block copolymer nanoparticles, particle size is 60~150 nm, content is 0.5~5wt%;The corrosion inhibitor is triazole small molecule compound, content is 0.005~0.5wt%.The present application replaces traditional inorganic hard abrasive particles with soft elastomeric polymer nanoparticles, provides gentle mechanical force, cooperates with triazole corrosion inhibitor to form a dense passivation film on the copper surface, while maintaining the removal rate of Ta / TaN barrier layer and dielectric material to meet the process requirements, can effectively inhibit the static corrosion of copper, significantly reduce the total amount of scratch, depression and other polishing defects, make wafer surface planarization effect more optimal.

The invention discloses polymer nanoparticles for colorectal cancer immunotherapy as well as a preparation method and application of the polymer nanoparticles. Small interfering RNAsiDhx9 is entrapped in the nanoparticles, a CD19 antibody is coupled to the surfaces of the nanoparticles, and immunotherapy of colorectal cancer is realized by specifically silencing Dhx9 on B cells. The nanoparticles provided by the invention not only can activate cytotoxic T (CD8 + T) cells, induce powerful anti-tumor immune response and remarkably inhibit the progress of colorectal cancer, but also can enhance the immune memory effect.

This invention relates to tannic acid-terephthaloboric acid polymer nanospheres, their preparation, and applications. The preparation process involves adding tannic acid, terephthaloboric acid, and a surfactant to DMF, followed by heating under static conditions to obtain the target product, tannic acid-terephthaloboric acid polymer nanospheres. The tannic acid-terephthaloboric acid polymer nanospheres provided by this invention can be directly synthesized via a hydrothermal method, with sizes adjustable from tens to micrometers. The abundant phenolic hydroxyl groups and borate ester functional groups within the microspheres endow the material with superior reactive oxygen species scavenging ability and responsive drug release capacity, making it suitable for inflammation clearance and drug delivery targeting inflammatory environments.

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

The application discloses a one-step preparation method of fluorescent single-chain polymer nanoparticles, and particularly relates to the field of high polymer chemistry. The method comprises the following steps: dissolving polyethylene glycol methyl ether methacrylate, cyanostilbene methacrylate monomer and an initiator in a ninth solvent to obtain a reaction solution; performing a polymerization reaction on the reaction solution under a nitrogen environment to obtain poly((Z)-2-(2-(2-(2-(4-(2-cyano-2-(3,4,5-tri(dodecyloxy)phenyl)vinyl)hydroxyethoxy)ethoxy)ethoxy)ethoxy)methyl acrylate-polyethylene glycol methyl ether methacrylate); dissolving the product in water to obtain a copolymer solution; irradiating the copolymer solution under a UV lamp; and performing freeze-drying separation to obtain fluorescent single-chain polymer nanoparticles. The one-step preparation of the fluorescent polymer single-chain nanoparticles is realized.

This invention belongs to the technical field of antibacterial and antioxidant materials, and discloses a high-antibacterial and antioxidant nanoparticle based on an iron-zinc bimetallic coordination polymer, its preparation, and application. Method: 1) Polyvinylpyrrolidone is dissolved in an ethanol solution, followed by the addition of an ethanol solution of an iron salt. The pH is adjusted to 8-9, the stirring speed is increased, and an ethanol solution of tannic acid is added dropwise. After the addition is complete, stirring continues to obtain an iron-based tannic acid metal phenolic network; 2) An ethanol solution of zinc chloride is added to the iron-based tannic acid metal phenolic network, and the reaction is stirred for 8-12 hours to obtain high-antibacterial and antioxidant nanoparticles based on an iron-zinc metal coordination polymer. The method of this invention is simple, and the nanoparticles of this invention have good antioxidant and antibacterial effects. The nanoparticles are used to prepare antibacterial and antioxidant materials, particularly for the preparation of drugs for treating corneal ulcers.

The present invention relates to nucleic acid fragment-encapsulated polymer nanoparticles and a method of preparing the same. The polymer may be a mucoadhesive polymer and specifically chitosan, and the nucleic acid fragment may be polydeoxyribonucleotide (PDRN). The nucleic acid fragment-encapsulated polymer nanoparticles may be used as an eye drop. Since the nucleic acid fragment-encapsulated polymer nanoparticles is capable of adhering to the mucus in the eyes, nucleic acid fragments inside the nanoparticles can be slowly released into the ocular mucous membrane. In addition, since nucleic acid fragment-encapsulated polymer nanoparticles can exhibit high efficiency in the eyes even with a small dose of drug, patient convenience can be increased or costs can be reduced.

Disclosed are a composition for inducing immunity against an active ingredient and a method for preparing same, the composition comprising: a nucleic acid, a polypeptide, or a combination thereof as the active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the active ingredient is encapsulated in a nanoparticle structure formed by the amphiphilic block copolymer and the polylactate.

The invention discloses square polymer nanoparticles based on hydrogen-bond interaction as well as a preparation method and application of the square polymer nanoparticles. The square polymer nanoparticles are formed by self-assembly of a guanosine-polyethylene glycol polymer in water through hydrogen bond interaction, wherein the guanosine-polyethylene glycol polymer is obtained by copolymerization of a guanosine-double bond monomer and a polyethylene glycol monomer through a reversible addition-fragmentation chain transfer reaction. The square polymer nanoparticles have the capacity of fixing potassium ions, can destroy the steady state of intracellular potassium ions and influence the cell activity when being delivered into tumor cells, and have potential application prospects in preparation of tumor treatment drugs.

The present invention discloses a psoralen mannosylated chitosan polymer nanoparticle and its preparation method and application. The psoralen is composed of psoralen, poly(lactic-co-glycolic acid) copolymer, mannosylated chitosan and polyvinyl alcohol, wherein the mass ratio of psoralen, poly(lactic-co-glycolic acid) copolymer, mannosylated chitosan and polyvinyl alcohol is 2-10:10-30:16.5-38.5:1-9. The psoralen mannosylated chitosan polymer nanoparticle is composed of free psoralen drug and mannosylated chitosan polymer carrier. Compared with traditional psoralen, the psoralen has a more stable structure and better physicochemical properties, and has higher bioavailability and tumor targeting. It can be used as a regulator of tumor-associated macrophages and cytokines, and can also inhibit the growth of MDA-MB-231 breast cancer cells and can be used to prepare a drug for treating triple-negative breast cancer.

The invention relates to the technical field of liposome polymer nano-particle mixing preparation, and discloses a liposome polymer nano-microsphere preparation system and method based on a Laval nozzle collision spraying technology. The system comprises a jet mixer; the jet mixer comprises a collision mixing unit and at least two Laval nozzles; the collision mixing unit is internally provided with a mixing cavity, and at least one liquid outlet flow channel and at least two liquid inlet flow channels are formed in the collision mixing unit; the liquid inlet runner and the liquid outlet runner are communicated with the mixing cavity; the multiple Laval nozzles are arranged in the liquid inlet flow channels in a one-to-one correspondence mode. The Laval nozzle can accelerate fluid to a supersonic speed state to form high-kinetic-energy jet flow, and the high-kinetic-energy jet flow is sprayed out from different jet flow openings and collides with one another in the mixing cavity, so that the contact area of the fluid is increased, the shearing force and the turbulence effect are improved, and the mixing uniformity of the fluid is improved; the problem that in the prior art, when a micro-fluidic system is adopted for preparing liposome polymer nanoparticles, the particle size is not uniform is solved.

The invention discloses a preparation method and application of small-size homopolymer nanoparticles, and relates to the technical field of polymer materials.The preparation method comprises the following steps that S1, rigid hydrophobic groups with the strong pi-pi stacking effect are introduced into a polymerization initiation / chain transfer system, a good solvent is added, hydrophilic monomer polymerization is initiated, the polymerization concentration is 20%-100%, and a hydrophilic monomer is obtained; the terminal of the amphiphilic homopolymer is a rigid hydrophobic group, the molecular weight of the amphiphilic homopolymer is 1000-100000g / mol, and the molecular weight distribution is 1.0-20.0; and S2, preparing the homopolymer into an aqueous solution with the concentration of 0.05-80%, and carrying out ultrasonic treatment to obtain the small-size polymer nanoparticles, thereby solving the problems that the small-size polymer nanoparticles are complex in preparation system, difficult to prepare and unfavorable for industrial production.

The application discloses a kind of three-dimensional nanofiber composite aerogel and its preparation method and application, it is related to nanofiber composite aerogel material technical field, the first nanofiber is prepared by electrospinning technology in the present application, then electrospinning nanofiber, cellulose nanocrystal, chemical crosslinking agent end-capped isocyanate and water are mixed homogeneously, and stable dispersion liquid is prepared, then sequentially freeze-drying and heat crosslinking treatment are carried out, finally, the surface of above-mentioned product is loaded with polymer nanoparticles, and three-dimensional nanofiber composite aerogel with porous three-dimensional network structure, good mechanical stability and excellent adsorption performance is obtained.The present application solves the technical problems of poor mechanical stability and low adsorption capacity of existing nanofiber aerogel adsorption material.The preparation method of three-dimensional nanofiber composite aerogel described in the present application is simple, and the operability is strong, and anion and cation dye can be simultaneously and efficiently adsorbed and separated.

The present invention relates to hybrid-shell polymer nanoparticles with high interfacial activity, as well as their preparation method and application. The preparation method specifically comprises the following steps: first, separately polymerizing two or more diblock copolymers, adding a crosslinking agent to a common good solvent for the two or more diblock copolymers, and inducing micellization of the block copolymers by covalently crosslinking nucleating segments to prepare hybrid-shell polymer nanoparticles with high interfacial activity. The hybrid-shell particles have a stable structure, a preparation efficiency approaching 100%, and can be prepared on a large scale at high concentrations. The preparation process is simple and the preparation method has a certain degree of universality, making it applicable to the construction of various functional hybrid-shell particles. The obtained hybrid-shell particles exhibit high interfacial activity comparable to Janus particles, can effectively reduce interfacial tension, and are suitable for emulsion stabilization and solubilization of polymer blend systems.

A hard coating film containing a polymer nanoparticle (A) and a matrix component (B), whereina Martens hardness HMA of the polymer nanoparticle (A) and a Martens hardness HMB of the matrix component (B) satisfy a relationship of HMB / HMA>1, anda Martens hardness HM of the hard coating film is 100 N / mm2 or more.

The invention belongs to the technical field of functional cosmetics, and particularly discloses a menthyl lactate and succinic acid eutectic cool-feeling acne removing agent and a preparation method thereof. The cool-feeling acne removing agent is prepared from the following components in percentage by weight: 1.0 to 3.5 percent of menthyl lactate-succinic acid eutectic, 8 to 15 percent of nano-liposome or polymer nanoparticle carrier, 0.2 to 0.6 percent of capryloyl salicylic acid, 0.3 to 0.8 percent of zinc lactobionate or zinc pyrrolidone carboxylate, 0.1 to 0.4 percent of asiaticoside, 0.5 to 1.2 percent of herba portulacae extract, 0.3 to 0.7 percent of panthenol, 0.1 to 0.3 percent of sodium hyaluronate and the balance of water. And the balance of deionized water, a polyol moisturizing system and a non-irritant anti-corrosion system. The invention also discloses a preparation method of the cool acne removing agent. The cool-feeling acne-removing agent disclosed by the invention can achieve a synergistic effect on cool feeling and an anti-acne effect, and the component stability and the skin infiltration capacity are improved.

The application belongs to the technical field of high-molecular anti-tumor drug delivery carriers, and particularly relates to an oxygen-deficient bioreduction responsive amphiphilic block polymer anti-tumor drug carrier and a preparation method and application thereof. The oxygen-deficient responsive block copolymer (POC7A-PCL) with a hydrophobic segment of PCL and a hydrophilic segment of POC7A is constructed through ring-opening polymerization and atom transfer radical polymerization. The polymer is used to load an anti-tumor drug doxorubicin to construct a responsive polymer nanoparticle, which shows stronger anti-tumor capacity. Therefore, the POC7A-PCL can be applied to the preparation of anti-tumor drugs as a drug carrier.

The invention discloses a gas molecule inlaid deformable polymer composite nano-particle for targeting microthrombus and a preparation method and application thereof, the composite nano-particle takes an amphiphilic block deformable copolymer PEG-PASp-Cx with a hydrophilic outer layer and a hydrophobic core as a skeleton, and the hydrophobic core encapsulates gas molecules through physical adsorption to obtain the gas molecule inlaid deformable polymer composite nano-particle; due to the existence of the gas molecules, the ultrasonic scattering characteristic of the nanoparticles is improved, meanwhile, the particle shear force sensitivity and the ultrasonic scattering characteristic of the polymer nanoparticles are improved, the thrombus adhesion effect is achieved, the high acoustic impedance difference between microthrombus and surrounding tissues is achieved, high-resolution development of the microthrombus is achieved, and the microthrombus can be developed through a contrast enhanced ultrasonic CEUS technology. The local enrichment process of the nanoparticles in thrombus can be tracked in real time, and the method has extremely high application value in the field of development detection of microthrombus diseases.

The application belongs to the field of medicine, and particularly relates to a modified polymer nanoparticle loaded with JPH203, a preparation method and application thereof. The preparation method is as follows: JPH203, polylactic acid-glycolic acid copolymer and polylactic acid-glycolic acid copolymer-maleimide are dissolved in an organic solvent to obtain a blending liquid; the blending liquid is added into a emulsifier solution and then sequentially subjected to ultrasonic emulsification, rotary evaporation, room temperature stirring to obtain a polymer nanoparticle solution loaded with JPH203; the polymer nanoparticle solution loaded with JPH203 is subjected to centrifugation, and the supernatant is discarded to obtain a precipitate; the precipitate is purified, redissolved, mixed with thiolated hyaluronic acid and subjected to a reaction, and the modified polymer nanoparticle loaded with JPH203 is obtained. The application synthesizes a nano JPH203 delivery system based on PLGA polymer through a microemulsion method, and then performs surface targeting modification of hyaluronic acid (HA), so that the targeting delivery of small molecule JPH203 is realized, and the serious toxic side effects caused by drug systemic exposure are reduced.

Use of porous metal oxide microspheres as light stabilizers for shaped artificial polymer articles, wherein the porous metal oxide microspheres are prepared by a process comprising forming a liquid dispersion of polymer nanoparticles and a metal oxide; forming liquid droplets from the dispersion; drying the droplets to provide polymer template microspheres comprising polymer nanospheres; and removing the polymer nanospheres from the template microspheres to provide the porous metal oxide microspheres.

Generally, a polymer nanomaterial encapsulation system useful in the production of polymer encapsulated nanoparticles comprised of a hydrophobic nanoparticle encapsulated in the hydrophobic region of the polymer with the external hydrophilic region of the polymer ensuring water-solubility and affording a functional group which can be utilized for the production of nanoparticle conjugates. Specifically, particular embodiments include a polymer nanoparticle structure including one or more of: a quantum dot and / or a superparamagnetic iron oxide nanoparticle and / or an upconverting nanoparticle, encapsulated in polystyrene-b-polyethylene glycol amine for the production of antibody conjugates useful in the capture of cellular targets.

The invention discloses temperature-sensitive fluorescent coating ink based on triplet state-triplet state annihilation up-conversion as well as a preparation method and application of the temperature-sensitive fluorescent coating ink. The ink is composed of a polymer substrate material, silicone rubber polymer nanoparticles loaded with triplet state-triplet state annihilation up-conversion fluorescent dye and a solvent, a temperature-sensitive fluorescent coating is formed on the surface of an electronic component through a dispensing method, a spin coating method, a blade coating method or a spraying method, and a uniform fluorescent film is prepared; exciting the fluorescent film by using laser; a photoluminescence signal is collected through a confocal light path, and spectrum analysis is carried out through a monochromator; the method comprises the following steps: performing micro-area scanning on a fluorescent film on the surface of a measured object by controlling a displacement table or a galvanometer, and capturing spectral information of each pixel point; and according to a pre-calibrated temperature-spectrum relation curve, reconstructing a micro-scale two-dimensional or three-dimensional temperature distribution diagram of the chip in a working state. According to the invention, non-contact and high-resolution real-time temperature imaging of a chip working state microcell is realized, and a key technology is provided for temperature anomaly detection, thermal management optimization and failure analysis of a miniature electronic component.