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178results about How to "Formulation stability" patented technology

Long-acting slow release preparation for treating keratomycosis as well as preparation method and application thereof

The invention relates to a preparation for treating treating keratomycosis, and particularly relates to a long-acting slow release preparation for treating keratomycosis as well as a preparation method and application thereof. The substrate of the long-acting slow release preparation is formed through electrostatic bonding of a graphene material and a drug-carried chitosan material, drugs are carried on the sheet structure of the graphene material, the structure is stable, and the loading rate is high. The preparation provided by the invention has excellent bacteriostatic activity on fungus and bacterium, and is excellent in cytocompatibility, toughness, and tensile strength. The preparation can be simply and conveniently applied onto cornea, and has no toxic effects on normal tissue while achieving excellent bacteriostatic activity. The long-acting slow release preparation is taken as a dosage form in ophthalmology, can be adhered onto a cornea of a patient for long-acting slow release, so as to achieve effective drug concentration, and the preparation has the advantages that the preparation is simple and convenient, the drug-carried material self is excellent in bacteriostatic activity and mechanical property, stimulation and toxic or side effects on orbital tissue can be avoided, and the use is convenient.
Owner:SOUTH CHINA AGRI UNIV

Traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions and preparations and quality control method thereof

The invention aims to provide a traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions. The traditional Chinese medicine extract with the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions is prepared by extracting the following medicine raw materials of radix scutellariae, dandelion, herba corydalis bungeanae and isatis root through a scientific and reasonable process method, wherein the mass ratio of radix scutellariae to dandelion to herba corydalis bungeanae to isatis root is (1-3): (3-5):(0.5-2):(1-3). The traditional Chinese medicine extract with the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions has the advantages the impurity ingredients in the medicine materials are maximumly removed, the effective ingredients are fully remained, and the heat-clearing, detoxifying, antibacterial and anti-inflammatory effects are realized. The invention also discloses four preparations containing the traditional Chinese medicine extract with the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions, i.e. syrup, mixture, buccal tablet and dripping pill. The four preparations have the advantages that the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions are realized, the preparations can be clinically used for preventing and controlling diseases, such as furuncle, pharyngitis, parotitis, lymphadenitis and tonsillitis, the content of effective ingredients is high, the dosage is small, the preparations are stable, and the therapeutic effect is good. The invention also provides a quality control method of the preparations containing the traditional Chinese medicine extract with the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions.
Owner:朱柏丞

High-content toltrazuril soluble powder, as well as preparation method and application thereof

The invention provides a high-content toltrazuril soluble powder, as well as a preparation method and application of the high-content toltrazuril soluble powder, relates to the field of the soluble powders, preparation methods and application of the soluble powders, and aims at solving the problems of the existing preparation method that the toltrazuril preparation is low in water solubility, low in bioavailability, poor in stability, and easy to generate precipitate and discolor so that the treatment effects and application of the toltrazuril preparation are greatly limited. The high-content toltrazuril soluble powder is prepared from toltrazuril, an alkaline pH (Potential of Hydrogen) regulator, a cosolvent and a soluble filler in parts by weight. The preparation method comprises the following steps of: 1, weighing; 2, mixing and preparing solution; and 3 preparing the powder by the spray drying process. The application is the application of the high-content toltrazuril soluble powder serving as the raw material in tablet preparations, granular preparations and freeze-dried powder preparations. The preparation method is simple in preparation process; the prepared powder contains the toltrazuril up to 60% and is quick to dissolve; and the preparations can be placed for three years at the room temperature without packing and discoloring. The high-content toltrazuril soluble powder is applicable to the field of veterinary drug preparations.
Owner:HEILONGJIANG UNIV

Probiotics preparation for conditioning infant intestinal tract and preparation method thereof

The invention discloses a probiotics preparation for conditioning infant intestinal tracts. The preparation is prepared by the following steps: taking walnut oil or plant blend oil taking walnut oil as a main component as a carrier, adds probiotics and other blend components into the carrier, performing blending at low temperature, and carries out negative-pressure deoxygenation to enable the probiotics to be embedded in the carrier so as to obtain drops. The method is simple, the process is easy to control, and the drops are stable in performance, do not solidify at low temperature, and are uniform in components. The viable bacteria in the probiotic drops are always in a dormant state, and the drops are stable after long-time preservation, light in taste, and natural and safe. After the drops are taken, the drops can withstand the acid and alkali environment in a human body, the survival rate of probiotics is high, the probiotics are rapidly planted and propagated in the intestinal tract of the human body, and the balance of microecology is adjusted, so that various intestinal tract problems are safely, effectively and efficiently solved. The method is suitable for preparing the probiotic preparation, and the preparation is further used for conditioning symptoms such as constipation and diarrhea in intestinal tracts of infants under the age of 3 years.
Owner:彤博士健康产业河北有限公司
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