Traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions and preparations and quality control method thereof

A heat-clearing and detoxifying, extracting technology, applied in the field of medicine, can solve the problems of slow effect, large dosage, and influence on curative effect

Inactive Publication Date: 2013-05-01
朱柏丞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of the tablet is simple, the dosage is large, and the effect is slow; and the main active ingredients of Radix Radix are extracted by the traditional process, and the loss is relatively large, which affects the exertion of the curative effect.
Oral liquid also has the problem that the extraction process of Radix isatidis affects the curative effect, and baicalin is extracted from Scutellaria baicalensis in the process. Modern research shows that the active ingredients of Scutellaria baicalensis for clearing away heat, detoxification, antibacterial and anti-inflammatory effects are the total flavonoids, not a single component. At present, it has been found that Scutellaria baicalensis has 41 kinds of flavonoids, including baicalin, baicalein, wogonin, wogonin, baicalein, etc.
Therefore, the preparation process and curative effect of the above-mentioned preparations still need to be further improved.

Method used

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  • Traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions and preparations and quality control method thereof
  • Traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions and preparations and quality control method thereof
  • Traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions and preparations and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] ①Heat-clearing and detoxifying, anti-bacterial and anti-inflammatory traditional Chinese medicine extract

[0105] (1) After boiling 451g of dandelion and 112g of kudiding with 4-20 times of water, add 169g of Scutellaria baicalensis, decoct for 1-3 times, each time for 10-120min, combine the decoction, filter, take the filtrate and concentrate it into an extract I (relative density 1.01~1.20, measured at 50~70°C);

[0106] (2) Add ethanol to the extract I prepared in step (1) until the alcohol content is 30%-90%, let it stand for 6h-9h, filter, take the filtrate to recover ethanol, and obtain extract II (relative density 1.01 ~1.20, measured at 50~70℃);

[0107] (3) Add 4-20 times 30%-90% ethanol solution of Radix Radix 169g to reflux and extract 1-3 times, each time for 10-120 minutes, combine the extracts, filter, take the filtrate to recover ethanol, and obtain extract III (relatively Density 1.01~1.20, measured at 50~70℃);

[0108] (4) Combine the extract II pre...

Embodiment 2

[0176] ①Heat-clearing and detoxifying, anti-bacterial and anti-inflammatory traditional Chinese medicine extract

[0177] (1) After boiling 507g of dandelion and 85g of kudiding with 4 to 20 times of water, add 169g of Scutellaria baicalensis, decoct for 1 to 3 times, each time for 10 to 120 minutes, combine the decoction, filter, take the filtrate and concentrate it into an extract I (relative density 1.01~1.20, measured at 50~70°C);

[0178] (2) Add ethanol to the extract I prepared in step (1) until the alcohol content is 30%-90%, let it stand for 6h-9h, filter, take the filtrate to recover ethanol, and obtain extract II (relative density 1.01 ~1.20, measured at 50~70℃);

[0179] (3) Add 4-20 times of 30%-90% ethanol solution to 507g Radix Radix Radix and reflux extract 1-3 times, each time for 10-120min, combine the extracts, filter, take the filtrate to recover ethanol, and obtain extract III (relatively Density 1.01~1.20, measured at 50~70℃);

[0180] (4) Combine the ...

Embodiment 3

[0248] ①Heat-clearing and detoxifying, anti-bacterial and anti-inflammatory traditional Chinese medicine extract

[0249] (1) Boil 280g dandelion and 110g Kudiding with 4-20 times of water, then add 169g Scutellaria baicalensis, decoct 1-3 times, 10-120min each time, combine the decoction, filter, take the filtrate and concentrate it into an extract I (relative density 1.01~1.20, measured at 50~70°C);

[0250] (2) Add ethanol to the extract I prepared in step (1) until the alcohol content is 30%-90%, let it stand for 6h-9h, filter, take the filtrate to recover ethanol, and obtain extract II (relative density 1.01 ~1.20, measured at 50~70℃);

[0251] (3) Add 4-20 times 30%-90% ethanol solution of Radix Radix 140g to reflux and extract 1-3 times, each time for 10-120 minutes, combine the extracts, filter, take the filtrate to recover ethanol, and obtain extract III (relatively Density 1.01~1.20, measured at 50~70℃);

[0252] (4) Combine the extract II prepared in step (2) and...

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Abstract

The invention aims to provide a traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions. The traditional Chinese medicine extract with the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions is prepared by extracting the following medicine raw materials of radix scutellariae, dandelion, herba corydalis bungeanae and isatis root through a scientific and reasonable process method, wherein the mass ratio of radix scutellariae to dandelion to herba corydalis bungeanae to isatis root is (1-3): (3-5):(0.5-2):(1-3). The traditional Chinese medicine extract with the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions has the advantages the impurity ingredients in the medicine materials are maximumly removed, the effective ingredients are fully remained, and the heat-clearing, detoxifying, antibacterial and anti-inflammatory effects are realized. The invention also discloses four preparations containing the traditional Chinese medicine extract with the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions, i.e. syrup, mixture, buccal tablet and dripping pill. The four preparations have the advantages that the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions are realized, the preparations can be clinically used for preventing and controlling diseases, such as furuncle, pharyngitis, parotitis, lymphadenitis and tonsillitis, the content of effective ingredients is high, the dosage is small, the preparations are stable, and the therapeutic effect is good. The invention also provides a quality control method of the preparations containing the traditional Chinese medicine extract with the heat-clearing, detoxifying, antibacterial and anti-inflammatory functions.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory effects and oral preparations (syrup, mixture) that can be used clinically for the prevention and treatment of boils, pharyngitis, parotitis, lymphadenitis, tonsillitis and other diseases. , buccal tablets, dropping pills) and their quality control methods. Background technique [0002] The medicinal composition of the application research of the present invention is the four traditional Chinese medicinal materials of scutellaria baicalensis, dandelion, kudiding and isatidis root. Tablets and oral liquids made from the above four Chinese herbal medicines are used for boils, pharyngitis, parotitis, lymphadenitis, tonsillitis and other diseases. In the composition of medicines, Scutellaria baicalensis is the monarch drug, which tastes bitter and cold, and has the effects ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P17/00A61P11/04A61P31/14A61P31/04G01N30/88
Inventor 朱柏丞
Owner 朱柏丞
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