Probiotics preparation for conditioning infant intestinal tract and preparation method thereof

A technology for probiotic preparations and infants, which is applied in the fields of probiotic drops and its preparation, and probiotic preparations for regulating the intestines of infants and young children, and can solve the problems of destroying the biological activity of probiotics, short shelf life of probiotics, and Reduce the number of bacteria and other problems, achieve the effect of restoring the function of the micro-ecological environment, increasing the blood supply of the intestine, and promoting the baby's development

Inactive Publication Date: 2019-07-23
彤博士健康产业河北有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. Newborns have been spoiled by their parents and elders since they were born. They lack regular sleep, especially at night and sleep more during the day. They are picky eaters and are most prone to constipation.
[0004] 2. Due to obvious changes in diet and living conditions, those who are not breastfeeding at the same time, their diet is mostly milk and sugar, and they do not pay attention to adding complementary foods that are beneficial to defecation. Constipation often occurs in infancy. In addition, in early childhood, If the main food is refined soft children's food on the market, the food (such as milk powder) contains a lot of casein and the palm oil often added in milk powder will combine with the calcium in the food to form a hard calcium soap, and the feces Containing a large amount of insoluble calcium soap in the urine will increase the stool, spoilage bacteria will multiply excessively, damage the intestinal mucosa, cause the intestinal wall to absorb water excessively, and the intestinal wall muscles will lose their contraction function, thus making constipation more serious
[0006] At present, most infants and young children are treated with probiotics for constipation and diarrhea. The commercially available probiotics are mainly tablets and powders. Tablet probiotics are poorly preserved and easy to store due to the high temperature and drying process required for tableted candies. Probiotics are very afraid of high temperature and water when exposed to moisture, so the number of viable bacteria in tableted probiotics is relatively small; and the ingredients of compressed candy include sweeteners, binders, disintegrating agents and other additives, so probiotics Tablets are mainly suitable for children over three years old and adults to eat as daily supplements of probiotics. They are not suitable for adjuvant treatment of probiotics for specific symptoms, especially for babies. It is not so convenient to eat
Powder probiotics are mostly freeze-dried powder preparations of probiotics, most of which are processed by low-temperature freeze-drying technology. During the process of probiotics being processed into powder, without the protection of freeze-drying technology, it is difficult for probiotics to survive. , In addition, in the process of taking it, the overheated water will reduce the number of viable bacteria and the intestinal arrival rate of probiotics. In addition, there are many supporting auxiliary materials in the powder probiotic ingredients, such as maltodextrin, milk powder, glucose and other additives. These excipients not only have low nutritional value, but some are not suitable for all babies, such as lactose intolerant babies
[0007] The existing tablet or powder probiotics have a short shelf life, and it is inconvenient for young infants and young children to eat them. Due to the unique living activity of probiotics, they are more susceptible to external water, air, high temperature, strong acid, and strong alkaline environments. impact, reducing its stability and the activity of probiotics, thereby reducing the health effects of probiotics on the human body. In addition, when probiotics in tablets or powders enter the human body, due to the strong acidity of gastric acid and bile, some probiotics may be destroyed The biological activity of the probiotics reduces the number of probiotics reaching the intestinal tract and weakens its ability to regulate the intestinal tract

Method used

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  • Probiotics preparation for conditioning infant intestinal tract and preparation method thereof
  • Probiotics preparation for conditioning infant intestinal tract and preparation method thereof
  • Probiotics preparation for conditioning infant intestinal tract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 A kind of probiotic preparation and its preparation method for conditioning the intestinal tract of infants and young children

[0041] This embodiment is a preparation method of a probiotic preparation for regulating the intestinal tract of infants, which is carried out in sequence according to the following steps:

[0042] (11) After cleaning the aseptic liquid preparation tank, remove the water, add 20kg of walnut oil to it {the ratio of linoleic acid to linolenic acid is (5-6): 1}, 0.002kg of isomaltooligosaccharide, and mix The liquid tank is cooled to below 10°C by low-temperature cooling water, and the liquid in the liquid distribution tank is recorded as A1;

[0043] (12), add 10kg lactobacillus probiotic powder and medium-chain triglyceride 0.01kg to A1 according to the speed of 40g / s, after stirring evenly, deaeration stirring under 0.01MPa negative pressure, deaeration stirring speed is 200rpm, to get whole oil anaerobic embedding suspension flo...

Embodiment 2-5

[0047] Example 2-5 Probiotic preparation for regulating the intestinal tract of infants and young children and its preparation method

[0048] The following examples are respectively a probiotic preparation for regulating the intestinal tract of infants and its preparation method. The preparation steps are similar to those in Example 1, except that the corresponding technical parameters in the preparation process are different, as follows.

[0049]

[0050]

[0051] The preparations prepared in the above examples are made into drops, each drop is 0.2-0.25ml.

[0052] The products prepared in the above examples have stable performance, uniform composition, long-term and stable storage time, light taste, natural safety, high survival rate of probiotics, simple preparation method, easy control of the process, low-temperature ingredients and deoxygenation under negative pressure to make the probiotic package Buried in the carrier, it ensures that the activity of the probioti...

Embodiment 6

[0053] Example 6 Environment simulation experiment of probiotic preparations for regulating the intestinal tract of infants and young children

[0054] This embodiment simulates the colonization of the drops prepared by the present invention in the gastrointestinal tract, constipation and diarrhea, at room temperature, and in the feces of healthy subjects, and fully evaluates the preservation status of the number of viable bacteria in the entire shelf life of the test product And the human body colonization situation, the drop provided by embodiment 1 has been carried out following experiment.

[0055] (1) Stress resistance experiment

[0056] 1. Experiments in gastrointestinal environment

[0057] The drops prepared in Example 1 are used to simulate the death of bacterial strains in the gastric environment. The specific steps are as follows. Take 4 Erlenmeyer flasks in the laboratory, respectively put them into and mark the simulated artificial gastric juice with a pH value ...

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Abstract

The invention discloses a probiotics preparation for conditioning infant intestinal tracts. The preparation is prepared by the following steps: taking walnut oil or plant blend oil taking walnut oil as a main component as a carrier, adds probiotics and other blend components into the carrier, performing blending at low temperature, and carries out negative-pressure deoxygenation to enable the probiotics to be embedded in the carrier so as to obtain drops. The method is simple, the process is easy to control, and the drops are stable in performance, do not solidify at low temperature, and are uniform in components. The viable bacteria in the probiotic drops are always in a dormant state, and the drops are stable after long-time preservation, light in taste, and natural and safe. After the drops are taken, the drops can withstand the acid and alkali environment in a human body, the survival rate of probiotics is high, the probiotics are rapidly planted and propagated in the intestinal tract of the human body, and the balance of microecology is adjusted, so that various intestinal tract problems are safely, effectively and efficiently solved. The method is suitable for preparing the probiotic preparation, and the preparation is further used for conditioning symptoms such as constipation and diarrhea in intestinal tracts of infants under the age of 3 years.

Description

technical field [0001] The invention belongs to the field of food, and relates to a probiotic drop and a preparation method thereof, in particular to a probiotic preparation for regulating the intestinal tract of infants and a preparation method thereof. Background technique [0002] Constipation and diarrhea in children are common diseases, most of which are caused by functional disorders (imbalance of intestinal flora). The proportion has also become an upward trend, and the main reasons for the frequent occurrence are as follows: [0003] 1. Newborns have been spoiled by their parents and elders since they were born. They lack regular sleep, especially those who do not sleep at night and sleep more during the day. They are picky eaters and are most likely to suffer from constipation. [0004] 2. Due to obvious changes in diet and living conditions, those who are not breastfeeding at the same time, their diet is mostly milk and sugar, and they do not pay attention to addi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23D9/007A23D9/04A23L33/135A23L33/115A23L33/21
CPCA23D9/007A23D9/04A23L33/135A23L33/115A23L33/21A23V2002/00A23V2400/113A23V2400/143A23V2400/173A23V2400/175A23V2400/515A23V2400/519A23V2400/531A23V2200/3202A23V2200/3204A23V2250/1944A23V2250/194A23V2250/18A23V2250/712A23V2250/1628A23V2250/28A23V2250/5062A23V2250/55A23V2250/1868A23V2250/1872A23V2250/1874
Inventor 韩军涛卓林双徐永刚张涛王涛刘博
Owner 彤博士健康产业河北有限公司
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