Hemostasis starch and preparation method thereof

A technology of starch and modified starch, applied in the fields of medical science, absorbent pads, surgery, etc., can solve the problems of low water absorption of modified starch and unstable preparation, and achieve the effect of improving water absorption performance, stable preparation and benefiting industrial production.

Active Publication Date: 2013-08-28
江苏德威兰医疗器械股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] An object of the present invention is to provide a new hemostatic starch, which has good water absorption, safety, and stable performance, and overcomes the shortcomings of low water absorption and unstable preparations of modified starch in the prior art.

Method used

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  • Hemostasis starch and preparation method thereof
  • Hemostasis starch and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Hydroxypropyl distarch phosphate is subjected to etherification, cross-linking, and esterification with chemical reagents such as propylene oxide and phosphoric acid to make new modified starch, and then the modified starch slurry is placed under X-ray irradiation. Irradiated for 12 minutes, the X-ray intensity was 0.8KeV, suction filtered, washed with alcohol, and dried to obtain hemostatic starch 1.

Embodiment 2

[0038] Put the hydroxypropyl distarch phosphate slurry under X-ray irradiation for 12 minutes, the X-ray intensity is 1.5KeV, filter with suction, wash with alcohol, dry, and then etherify and exchange with chemical reagents such as propylene oxide and phosphoric acid. The new modified starch was produced after multiple denaturations of linkage and esterification, filtered by suction, washed with alcohol, and dried to obtain hemostatic starch 2.

Embodiment 3

[0040] The hydroxyethyl starch is subjected to etherification, cross-linking, and esterification with chemical reagents such as propylene oxide and phosphoric acid to make a new modified starch, and then the modified starch slurry is placed under X-ray irradiation for 8 minutes. The X-ray intensity was 0.8KeV, washed with alcohol and dried to obtain hemostatic starch 3.

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Abstract

The present invention relates to hemostasis starch and applications thereof, wherein modified starch in the existing technology is subjected to denaturation again, and then is subjected to a ray irradiation treatment to finally prepare the hemostasis starch. The hemostasis starch has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for a wound surface having blood.

Description

technical field [0001] The invention relates to a hemostatic starch and a preparation method thereof, in particular to a biocompatible hemostatic starch which can be directly used on bloody wounds and a preparation method thereof. Background technique [0002] Bleeding is the most likely phenomenon in accidents and medical treatment. A large amount of bleeding will endanger human life. Therefore, it is necessary to stop bleeding in time for bleeding wounds. [0003] With the development of medicine, there are many kinds of hemostatic materials. In terms of biocompatibility, commonly used biocompatible hemostatic materials include: absorbable gelatin starch, collagen starch and other gelatin hemostatic materials; oxidized cellulose, oxidized regeneration Cellulose hemostatic materials; chitosan / chitin, starch polysaccharides and other natural biopolysaccharide hemostatic materials, etc. [0004] The content of the present invention relates to the hemostatic material of starc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B31/16C08B31/00C08J3/28A61L15/28A61L31/04
Inventor 刘泊志
Owner 江苏德威兰医疗器械股份有限公司
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