Ointment with clindamycin and metronidazole and method for preparing the same

A technology of clindamycin and metronidazole, which is applied in the field of medicine, can solve the problems of poor heat resistance and cold resistance, difficult industrial production and clinical application, complex composition and the like, and achieves simple production process and novel drug composition. , Easy to use and carry

Inactive Publication Date: 2006-02-15
王卫阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] For the cream mentioned in USP5849776A, the composition of the prescription is very complicated, and most of the auxiliary materials are not domestic conventional cream bases, and the prepared cream product has the disadvantages of poor heat resistance and cold resistance, and is difficult to apply Industrial production and clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Prescription composition:

[0046] Clindamycin 10g

[0047] Metronidazole 8g

[0048] Stearic acid 100g

[0049] Liquid paraffin 80g

[0050] Glyceryl monostearate 70g

[0051] White Vaseline 90g

[0052] Glycerin 100g

[0053] Sodium Lauryl Sulfate 5g

[0054] Ethylparaben 1g

[0055] Ethanol 10ml

[0056] Distilled water up to 1000g

[0057] Preparation method: Take ethyl paraben, put it in a container, add ethanol to dissolve it, add water-soluble substrate glycerin, sodium lauryl sulfate and distilled water, stir in a water bath at 70-75°C to dissolve, and clindamycin , metronidazole, stir to dissolve, and mix evenly; put the oily base stearic acid, liquid paraffin, glyceryl monostearate, and white petrolatum in another container, melt and mix evenly in a water bath at 70-75°C ; Add the mixed oily base to the water-soluble base at the same temperature, stir in the same direction under the same temperature conditions, make it fully emulsified, mix evenly, and...

Embodiment 2

[0059] Prescription composition:

[0060] Clindamycin 10g

[0061] Metronidazole 8g

[0062] Cetyl Alcohol 120g

[0063] Liquid paraffin 60g

[0064] White Vaseline 150g

[0065] Glycerin 60g

[0066] Sodium Lauryl Sulfate 5g

[0067] Ethylparaben 1g

[0068] Distilled water up to 1000g

[0069] Preparation method: put the water-soluble base glycerin, sodium lauryl sulfate, ethylparaben and distilled water into a container, stir in a water bath at 70-75°C to dissolve, add clindamycin and metronidazole, stir to dissolve Dissolve and mix evenly; put cetyl alcohol, liquid paraffin, and white petrolatum into another container, melt and mix evenly in a water bath at 70-75°C; Stir in the same direction in the same temperature condition to make it fully emulsified, mix evenly, and cool naturally.

Embodiment 3

[0071] Prescription composition:

[0072] Clindamycin 10g

[0073] Metronidazole 8g

[0074] Glyceryl monostearate 120g

[0075] White Vaseline 90g

[0076] Liquid paraffin 90g

[0077] Span-60 30g

[0078] Glycerin 100g

[0079] Ethylparaben 1g

[0080] Tween-80 35g

[0081] Sodium Lauryl Sulfate 2.5g

[0082] Distilled water up to 1000g

[0083] Preparation method: Take the water-soluble substrate glycerin, ethylparaben, Tween-80, sodium lauryl sulfate and distilled water, put them in a container, stir in a water bath at 70-75°C to dissolve, and mix clindamycin and metronidazole Add azole, stir to dissolve, and mix evenly; put the oily base glyceryl monostearate, white petrolatum, liquid paraffin, and Span-60 in another container, dissolve and mix evenly in a water bath at 70-75°C; Add the mixed oily base into the water-soluble base at the same temperature, stir in the same direction under the same temperature conditions, make it fully emulsified, mix evenly, and c...

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PUM

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Abstract

Disclosed is an ointment using the salts or esters of clindamycinum and metronidazole as the active constituents, the constituents of the ointment include (by weight percent): clindamycinum or its medicinal salts or its esters 0.25-5%, metronidazole 0.2-4%, oleaginous base 10-40%, water soluble base 5-50%, and balancing water, wherein the oleaginous base is selected from stearinic acid, glyceryl monostearate, paraffin wax, fluid wax, Vaseline, lanoline, cetyl alcohol, stearyl alcohol, Span series, bee wax, animal or vegetable fat, the water soluble base is selected from glycerin, propylene glycol, sorbitol, polyethylene glycol series, Tween series, sodium dodecylsulfate, dimethyl sulfoxide, triethanolamine, and ethanol.

Description

Technical field: [0001] The invention belongs to the field of medicine, and relates to a clindamycin compound, a clindamycin-metronidazole ointment and a preparation method thereof. Background technique: [0002] Cuokangwang, which is currently clinically used, is a combined preparation of clindamycin hydrochloride and metronidazole, that is, clindamycin metronidazole liniment, which is used for acne, otitis media, sinusitis, folliculitis and other bacterial diseases. Treatment of skin infections. Clinical practice has proved that the combination of the two can effectively inhibit and kill Propionibacterium acnes, Pityrosporum and other sensitive bacteria, inhibit the growth of hair follicles, thereby reducing the production of lipase and preventing the hydrolysis of triacylglycerol into free fatty acids . [0003] There are also patents on the combination of clindamycin and metronidazole: USP5849776A discloses the combination of clindamycin and metronidazole, which is mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K9/06A61P17/10A61P17/00A61P31/04A61P31/10A61K31/4164
Inventor 王国勤周文艳
Owner 王卫阳
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