High-content toltrazuril soluble powder, as well as preparation method and application thereof

A technology of soluble powder and toltrazuril, which is applied in powder delivery, drug combination, anti-infective drugs, etc., can solve the problems of poor water solubility of toltrazuril preparations, limited therapeutic effect and application, prone to precipitation and discoloration, etc. To achieve the effect of improving bioavailability, increasing drug content, and fast dissolution speed

Inactive Publication Date: 2013-06-12
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims to solve the problems of poor water solubility, low bioavailability, poor stability, easy precipitation and discoloration of the toltrazuril preparation prepared by the existing preparation method, which greatly limits its therapeutic effect and application, and provides A kind of high-content toltrazuril soluble powder and its preparation method and application

Method used

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  • High-content toltrazuril soluble powder, as well as preparation method and application thereof
  • High-content toltrazuril soluble powder, as well as preparation method and application thereof
  • High-content toltrazuril soluble powder, as well as preparation method and application thereof

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specific Embodiment approach 1

[0028] Specific embodiment one: present embodiment is a kind of high-content toltrazuril soluble powder, and it is made up of 1 part to 60 parts of toltrazuril, 5 parts to 40 parts of alkaline pH regulator, It is prepared by 4-40 parts of co-solvent and 1-89 parts of soluble filler.

[0029] This embodiment has the following advantages: 1. A kind of high-content toltrazuril soluble powder of this embodiment has added solubilizing adjuvant in toltrazuril, has greatly improved the toltrazuril preparation. The high drug content improves the bioavailability; two, a high-content toltrazuril soluble powder of the present embodiment has a fast dissolution rate and stable preparation, and there is no agglomeration and discoloration phenomenon at room temperature for three years; three, The high-content toltrazuril soluble powder of this embodiment can be directly added to the drinking water of animals for administration, and can also be used as a raw material and mixed with auxiliary ...

specific Embodiment approach 2

[0030] Specific embodiment two: the difference between this embodiment and specific embodiment one is that: the alkaline pH regulator is an alkaline inorganic salt; wherein, the alkaline inorganic salt is sodium hydroxide, potassium hydroxide, One or a mixture of sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium bicarbonate, sodium carbonate and potassium carbonate. Others are the same as in the first embodiment.

[0031] Each component in the mixture described in this embodiment is in any ratio.

specific Embodiment approach 3

[0032] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the co-solvent is polyethylene glycol polymer compound, polyvinylpyrrolidone polymer compound, polyvinyl alcohol polymer compound , sodium benzoate, sodium salicylate, p-aminobenzoic acid, urea and acetamide, or a mixture of several of them. Others are the same as in the first or second embodiment.

[0033] Each component in the mixture described in this embodiment is in any ratio.

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Abstract

The invention provides a high-content toltrazuril soluble powder, as well as a preparation method and application of the high-content toltrazuril soluble powder, relates to the field of the soluble powders, preparation methods and application of the soluble powders, and aims at solving the problems of the existing preparation method that the toltrazuril preparation is low in water solubility, low in bioavailability, poor in stability, and easy to generate precipitate and discolor so that the treatment effects and application of the toltrazuril preparation are greatly limited. The high-content toltrazuril soluble powder is prepared from toltrazuril, an alkaline pH (Potential of Hydrogen) regulator, a cosolvent and a soluble filler in parts by weight. The preparation method comprises the following steps of: 1, weighing; 2, mixing and preparing solution; and 3 preparing the powder by the spray drying process. The application is the application of the high-content toltrazuril soluble powder serving as the raw material in tablet preparations, granular preparations and freeze-dried powder preparations. The preparation method is simple in preparation process; the prepared powder contains the toltrazuril up to 60% and is quick to dissolve; and the preparations can be placed for three years at the room temperature without packing and discoloring. The high-content toltrazuril soluble powder is applicable to the field of veterinary drug preparations.

Description

technical field [0001] The present invention relates to the field of soluble powder and its preparation method and application. Background technique [0002] Chicken coccidiosis is very harmful to the poultry industry, and it is very common. Wherever chickens are raised, there is coccidiosis. Coccidiosis generally breaks out in spring or summer, while intensive chicken farms can occur all year round, with an incidence rate of 50% to 70%. Chicken coccidiosis mainly threatens chicken flocks within 3 months of age, with the highest morbidity and mortality in 15 to 50-day-old chickens. At present, drugs are the main means to prevent and treat coccidiosis in chickens, and there are many drugs used clinically. Because the life cycle of coccidia is very complicated, drug resistance is easy to appear. Most of the old drugs currently used in clinical practice have developed drug resistance, which affects the efficacy of drugs. There is an urgent need for new, broad-spectrum and hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/53A61P33/02
Inventor 龚显峰李强赵学玲刘丽娟孙少平
Owner HEILONGJIANG UNIV
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