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Drug balloon

A balloon and drug technology, applied in the field of medical devices, can solve the problems of insufficient smooth muscle cell inhibition, decreased lumen patency rate, drug toxicity, etc., to achieve the goal of inhibiting excessive proliferation of smooth muscle cells, improving patency rate, and high drug content Effect

Pending Publication Date: 2018-08-10
上海脉全医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of this, the object of the present invention is to provide a drug balloon for treating in-stent restenosis. If the drug content is too low, the inhibitory effect on smooth muscle cells will be insufficient, and the long-term lumen patency rate will decrease; if the drug content is too high, the total amount of drugs in the body will cause toxic reactions.

Method used

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Examples

Experimental program
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Effect test

Embodiment ( 1

[0035] Please refer to Figures 1(a), 2(a) and image 3 . Figure 1(a) is a schematic structural view of a drug balloon 1 in Example 1 of the present invention; Figure 2(a) is a schematic structural view of a drug coating 11; image 3 It is a structural schematic diagram of the cross section of the drug balloon 1 . In this implementation, the drug balloon 1 includes a balloon 10 and a drug coating 11 .

[0036]Wherein, the drug coating 11 is located on the surface of the balloon and includes a drug 113 and an excipient 114 . The drug coating 11 includes a proximal coating 110, a middle coating 111 and a distal coating 112, and the proximal coating 110, the middle coating 111 and the distal coating 112 are sequentially arranged and connected, distributed on the balloon 10 The outer surface. The drug loading density in the proximal coating 110 is greater than that in the middle coating 111 , and the drug loading density in the distal coating 112 is greater than that in the middl...

Embodiment ( 2

[0047] Please refer to Figures 1(b), 2(b) and image 3 . Figure 1(b) is a schematic structural view of the drug balloon 1 in Example 2 of the present invention; Figure 2(b) is a schematic structural view of the drug coating 11; image 3 It is a structural schematic diagram of the cross section of the drug balloon 1 . In this embodiment, the drug balloon 1 includes a balloon 10 and a drug coating 11 .

[0048] Wherein, the drug coating 11 is located on the surface of the balloon, including a proximal coating 110, a middle coating 111 and a distal coating 112, and the proximal coating 110, the middle coating 111 and the distal coating 112 are sequentially arranged and connected . Drug coating 11 includes drug 113 and excipient 114 . The drug loading density in the proximal coating 110 is greater than that in the middle coating 111 , and the drug loading density in the distal coating 112 is equal to the drug loading density in the middle coating 111 . In other embodiments, the...

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Abstract

The invention discloses a drug balloon. The drug balloon comprises a balloon body and a drug coating located on the surface of the balloon body, wherein the drug coating comprises a drug and an excipient; the drug coating comprises a near-end coating, a middle-section coating and a far-end coating, the drug-loading density of one of the near-end coating and the far-end coating is larger than the drug-loading density of the middle-section coating, and the drug-loading density of the other one of the near-end coating and the far-end coating is not smaller than the drug-loading density of the middle-section coating. When stent restenosis lesions are treated, the drug balloon is selected to be pressurized according to lesion characteristics, the drug balloon has a supporting function, part ofthe coating with a large drug-loading density is close to severe stenosis lesions at the near end or the far end, the drug content is selectively increased, and the stenosis rate of severe lesion areais reduced; meanwhile, the total drug content of the whole lesions is reduced, and the drug toxicity and adverse reactions of the body are reduced.

Description

technical field [0001] The invention relates to the technical field of medical devices, and more specifically relates to a drug balloon for treating restenosis in a stent. Background technique [0002] Cardiovascular and cerebrovascular diseases have become the number one cause of death in the world. At present, there are three main treatment methods for ischemic heart disease: basic treatment with drugs, surgical treatment with coronary artery bypass grafting, and interventional treatment for relieving coronary stenosis by placing coronary stents. The above-mentioned several treatment methods have achieved obvious effects in the treatment of coronary artery stenosis, but each still has some significant problems. [0003] Among them, coronary stent implantation is to deliver the stent system to the target area through puncture and intervention, and the balloon expands to release the stent, open the narrowed and diseased blood vessel, restore the blood supply, and treat isch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/958A61M25/10A61L29/08A61L29/16
CPCA61L29/085A61L29/16A61M25/10A61F2/958A61L2300/606A61L2300/416A61M2025/105
Inventor 祁勇翔罗雷霍勇聂芳芳唐乃杰缪永生
Owner 上海脉全医疗器械有限公司
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