Preparation method for doxycycline modified release pellet and preparation

Abstract

The invention discloses a preparation method for a doxycycline modified release pellet and preparation. The method includes the steps of: preparing a doxycycline hydrochloride drug loaded pellet, then mixing the pellet with an appropriate amount of a coating material, applying a fluidized bed to perform coating by bottom spraying, and carrying out drying to obtain the doxycycline hydrochloride modified release pellet; mixing auxiliary materials evenly, and mixing an adhesive with the auxiliary materials uniformly according to a weight ratio of 0.01-1:1; and under a molten state of the adhesive, sticking the auxiliary materials to the surface of the coated pellet prepared form doxycycline by the adhesive so as to obtain a pellet particle; and subjecting the pellet particle to direct tabletting, or mixing the pellet particle with a buffer particle prepared by a conventional method according to a weight ratio of 1:9-9:1 and then conducting tabletting, thus obtaining a pellet tablet. The preparation method provided by the invention is free of layering phenomenon in the tabletting process, and the prepared pellet tablet has uniform quality and drug content. Thus, the method is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular, the invention relates to a preparation method of doxycycline modified-release pellet preparation. Background technique [0002] Doxycycline is a semi-synthetic tetracycline antibiotic with strong and long-acting characteristics. Both in vivo and in vitro tests have shown that it has good antibacterial effects on Gram-positive and negative bacteria. It is mainly used to treat sensitive Gram-positive bacteria. Upper respiratory tract infections, tonsillitis and senile chronic bronchitis caused by cocci and gram-negative bacilli are also used to treat cholera, typhus, scrub typhus, mycoplasma pneumonia, etc., and to prevent falciparum malaria and leptospirosis infections. It is highly sensitive to mycoplasma, chlamydia and rickettsia, and has inhibitory effect on a variety of periodontal bacteria. At the same time, it can also inhibit the activity of collagenase and directly promote...

AI Technical Summary

Problems solved by technology

[0003] Doxycycline hydrochloride is bitter in taste and has a strong irritating effect on the upper digestive tract. Since the original oral dosage form of doxycycline is ordinary tablets and capsules, it has a strong irritating effect on the gastrointestinal tract, so its clinical application is limited. Therefore, it is necessary to improve the dosage form and reduce irritation, but often followed by a decrease in bioavailability

The best absorption site of doxycycline is the stomach and upper small intestine, which belongs to active absorption, and enteric-coated capsules will undoubtedly reduce its bioavailability

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