35 results about "Leptospirosis" patented technology

This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira Bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona. The vaccines of the present invention include a Bordetella bronchiseptica p68 antigen.

The present invention relates to a gene chip for detecting several infections lideases and its application. It can be used for detecting, typing and strain-identifying 7 main infections diseases of epidemic hemorrhagic fever, tsutsugamushi disease, leptospirosis, schistosomiasis, malaria, cholera and hemorrhagic enteritis due to 0157:H7. Said invention can select specific gene probe and PCR primer respectively from S gene of epidemic hemorrhagic fever virus, 56KD protein gene of oriental rickettsia, 23 SRNA gene of leptospirosis, 5D antigen gene of schistosomiasis, SSrRNA gene of malarial parasite, 0157 antigen gene of colibacillus 0157:H7, H7 antigen gene and toxic gene and outer membrane OWP protein gene of cholera vibrio and toxic gene.

This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention relates to vaccines and methods for protecting dogs against disease caused by Leptospira bratislava. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona.

The invention relates to a trivalent gene recombination vaccine for preventing leptospirosis and a preparation method thereof and aims to effectively prevent infection of leptospira interrogans of different sero-groups with low manufacturing cost. The technical scheme is that: the trivalent gene recombination vaccine for preventing the infection of leptospira interrogans of different sero-groups consists of a lipL32 / 1 gene, a lipL21 gene and an ompL1 / 2 gene cloned from a leptospira icterohemorrhagiae genome; a fusion gene lipL32 / 1-lipL21-ompL1 / 2 prepared by a technique for gene engineering has a nucleotide sequence and an amino acid sequence shown in a sequence 5; and the lipL32 / 1 gene is connected with the lipL21 gene, and the lipL21 gene is connected with the ompL1 / 2 gene through two same flexible peptides shown in a sequence 4.

The invention discloses a traditional Chinese medicine composition used for treating dog leptospirosis, and a preparation method thereof. The traditional Chinese medicine composition used for treating the dog leptospirosis comprises, by weight, 1-2 parts of artemisiae scopariae herba, 1-3 parts of gypsum, 1-3 parts of unprocessed rehmannia root, 1-2 parts of rheum officinale, 1-2 parts of cape jasmine, 1-2 parts of fructus forsythia and 1-2 parts of akebia caulis. The above ingredients are used as raw material drugs. The preparation method is carried out according to the following steps of adding water with an amount of 8 times that of the raw material drugs, decocting for two times (2.0 hours for the first time, and 1.5 hours for the second time), mixing two decoction liquids, filtering, concentrating to a relative density of the solution being 1.24 (70-80 DEG C), adding powdered sugar in an amount of 50-70% based on a total amount of the raw material drugs, making into granules, drying at a temperature of 70 DEG C and straightening the granules. The traditional Chinese medicine composition combines all the drugs, co-playing the effect of benefiting bile and removing jaundice, and clearing heat and removing toxicity.

This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira Bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona. The vaccines of the present invention include a Bordetella bronchiseptica p68 antigen.

The invention discloses an application of vincoside lactam extracted from common camptotheca fruit in preparation of antibacterial or antiviral or anti-hyperthermia or anti-inflammatory or pain relieving drugs or in preparation of drugs for treating infectious diseases caused by sensitized bacteria and viruses or leptospirosis. The diseases caused by sensitized bacteria and viruses comprise: acute tonsillitis, faucitis, upper respiratory tract infections, bronchitis, otitis media pneumonia, conjunctivitis, hordeolum, periodontal abscess, burn wound infections, urinary tract infections, and infections caused during after-surgery prevention. The invention also discloses a vincoside-lactam preparation with the application.

The invention belongs to the novel technical field of medicaments, and relates to a novel dosage form of amoxicillin used for treating: 1, upper respiratory tract infections, such as tympanitis, nasosinusitis, pharyngitis and tonsillitis resulted from streptococcus hemolyticus, streptococcus pneumoniae, staphylococcus or haemophilus influenzae; 2, genitourinary tract infections resulted from escherichia coli,proteus mirabilis or enterococcus faecalis; 3, skin and soft tissue infection resulted from streptococcus hemolyticus, staphylococcus bacteria or escherichia coli; 4, lower respiratory tract infections, such as acute bronchitis and pneumonia, resulted from streptococcus hemolyticus, streptococcus pneumoniae, staphylococcus bacteria or haemophilus influenzae; 5, acute simple gonorrhea; and 6, typhoid, typhoid bacteria-carrier, leptospirosis and the like. The novel dosage form is characterized in that the stomach floating tablet is hydrated into gel on the surface to expand the volume thereof after contacting with the gastric juice at the body temperature because of a plurality of hydrophilic macromolecular materials contained. Meanwhile, the weight of the tablet is less than the buoyant force of the gastric juice to float the tablet on the gastric juice and prolong the retention time in the stomach.

A process for the culture of Leptospires in a protein-free culture medium and without any fatty acid source in the culture medium, wherein a fatty acid source is fed continuously or intermittently.

This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention relates to vaccines and methods for protecting dogs against disease caused by Leptospira bratislava. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona.

In alternative embodiments, provided are pharmaceutical compositions and methods for treatment, amelioration and prevention of infection-associated blood vessel diseases, and also for the treatment, amelioration and prevention of non-vessel diseases affected by infective agents which can be treated by these compositions. In alternative embodiments, one common pathogen targeted by compositions and methods as provided herein is Chlamydia and Chlamydophila species, including pneumoniae, trachomatis and psittaci species which infect humans, including Chlamydophila penumoniae which also infects humans. In alternative embodiments, pathogens targeted and infections (diseases) treated ameliorated, or prevented by compositions and methods as provided herein include Mycoplasma, Listeria, Leptospirosis, Q fever or Coxiella burnetii infection, Lyme disease or Lyme borreliosis or any Borrelia infection, and Bartonella or of the family Bartonellaceae, including cat scratch disease.

Wind dispelling and cold expelling semen trichosanthis oil is prepared from the following raw materials in parts by weight: 250-260 parts of semen trichosanthis, 30-40 parts of flaxseed, 70-80 parts of zanthoxylum armatum, 50-60 parts of coconut shells, 90-120 parts of artemisia capillaries, 70-90 parts of fructus gardenia, 20-30 parts of rhubarb, and the like. During the preparation process, the zanthoxylum armatum with the efficacies of dispelling wind and expelling cold is added; the artemisia capillaries can clear heat, remove dampness, and eliminate jaundice; the fructus gardenia clears heat to decrease internal heat, conduces the circulation of triple energizers, and guides damp-heat to be discharged from urine; the rhubarb purges heat, removes blood stasis, facilitates feces excretion, and guides stagnant heat to be discharged from feces; dampness removal and heat elimination cooperate to facilitate urination and defecation, eliminate pathogens from front and back, remove damp-heat, and eliminate stagnant heat, so that jaundice spontaneously subsides; the semen trichosanthis oil can clear heat, expel damp, and is suitable for being taken by people suffering from jaundice due to damp-heat containing rheumatic ostealgia, acute icteric hepatitis, hepatitis B, cholecystolithiasis, cholecystitis, leptospirosis, ileotyphus, pneumonia, hemolytic jaundice caused by favism, and the like.

The invention relates to the technical field of medical biology, in particular to a leptospira interrogans DNA (Deoxyribose Nucleic Acid) vaccine as well as a construction method and application thereof. The leptospira interrogans can rapidly invade the inside of human and various animals to cause infection via the skin or the mucous membranes, and result in leptospirosis with the main symptoms of fever, jaundice and bleeding after humans are infected, the leptospirosis is the common zoonosis with wide world distribution and seriously threat the health of the humans and the production of animal husbandry, and China is one of the main countries with the epidemic leptospirosis. The invention provides the leptospira interrogans DNA vaccine, which comprises a eukaryon expression vector and leptospira interrogans LB018 genes, wherein the nucleotide sequence of the LB018 genes is shown as SEQ ID NO: 1. The leptospira interrogans DNA vaccine can effectively induce the immune response reaction of a piggy, which shows that the leptospira interrogans DNA vaccine has a certain immune protection action on the leptospira interrogans of the animals, and the leptospira interrogans DNA vaccine has the advantages of simple production technology, low cost and stable physical and chemical properties, and is convenient for storage and transportation.

The invention provides a zilpaterol compound veterinary composition. The zilpaterol compound veterinary composition comprises traditional Chinese medicine components and Western medicine components, wherein the traditional Chinese medicine components comprise the following raw material medicines in parts by weight: 15 to 25 parts of astragalus membranaceus, 15 to 25 parts of ephedra, 10 to 20 parts of coptis chinensis, 10 to 20 parts of pyrrosia lingua, 5 to 15 parts of semen armeniacae amarae, 5 to 15 parts of cocklebur fruit and 5 to 10 parts of mint; and the Western medicine components comprise the following raw material medicines in parts by weight: 5 to 7 parts of ribavirin, 3 to 4.5 parts of a zilpaterol and 1 to 3 parts of florfenicol. The invention also provides a preparation method of the veterinary composition as well as application of the veterinary composition to prevention and treatment of canine distemper and poultry leptospirosis. The composition provided by the invention is a traditional Chinese medicine and Western medicine compound preparation and is prepared by selecting and compounding various traditional Chinese herbal medicines and Western medicines, various medicines are reasonable in compatibility, strong synergistic effect is generated after the medicines are composed, and the curative effect can be doubled. The zilpaterol compound veterinary composition can treat both symptoms and root causes, has obvious curative effect and various dosage forms, can perform mixed feeding, mixed drinking and injection, is convenient to use, and has durable medicineeffect and high bioavailability.

Artemisiae capillaris herba wind expelling and cold removing sesame oil is prepared from, by weight, 300-320 parts of black sesame, 40-50 parts of flaxseeds, 80-90 parts of rattan pepper, 50-60 parts of coconut shells, 130-160 parts of artemisiae capillaris herba, 80-100 parts of fructus gardeniae, 40-50 parts of rheum officinale and the like. In the preparation process, the rattan pepper is added, and the effects of expelling wind and removing cold are achieved; the artemisiae capillaris herba can clear heat, promote diuresis and remove jaundice; the fructus gardenia clears heat, decreases internal heat, promotes sanjiao and guides damp and heat out through urine; the rheum officinale purges heat, removes blood stasis, promotes excrement and guides stagnant heat out through excrement; damp promoting and heat releasing are compatible, urine and excrement are promoted, respective removing is achieved through urine and excrement, dampness and heat are removed, stagnant heat goes downwards, jaundice fades, heat and dampness can be removed, and the sesame oil is suitable for people with rheumatism and ostalgia, acute icteric hepatitis, hepatitis B, gall-stone, cholecystitis, leptospirosis, jejunotyphoid, pneumonia and hemolytic jaundice caused by favism and people with jaundice with damp-heat pathogen.

The invention belongs to the technical field of drag hook tools and particularly relates to a hook body of an industrial drag hook. The hook body of the industrial drag hook comprises an upper hook body and a lower hook body, the upper hook body is in flush connection with the upper end of the lower hook body, and the area of the upper end face of the upper hook body is twice of that of the upper end face of the lower hook body. The upper hook body comprises a straight rod, a curved rod and an oblique rod, and the straight rod is twice longer than the oblique rod. The lower hook body comprises a front hook, a middle rod and a tail rod, the front hook is arranged at the bottom of the oblique rod, the middle rod is an arc rod, and the tail rod gradually shrinks from one end, close to the middle rod, of the tail rod to the upper end of the lower hook body. The hook body of the industrial drag hook has the advantages that when the hook body is used, objects can be hooked more easily, loss of the hook body can be reduced, and service life of the hook body is prolonged.

The invention discloses a leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus triple inactivated vaccine. The leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus triple inactivated vaccine is prepared by inactivating leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus epidemic strains separated in China and then adding an adjuvant. The invention relates to a method for isolated culture, identification and inactivation of pathogens, a production process, vaccine preservation and an immunization method. The canine triple inactivated vaccine is used for preventing leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus diseases, high antibodies can be generated after immunizing dogs, and the triple inactivated vaccine has a good protective effect on virulent attack. Leptospira is a human and animal infectious disease, dogs are human companion animals, and pet dogs are in close contact with human beings, so that the triple inactivated vaccine has good social benefits and important public health significance.

In alternative embodiments, provided are pharmaceutical compositions and methods for treatment, amelioration and prevention of infection-associated blood vessel diseases, and also for the treatment, amelioration and prevention of non-vessel diseases affected by infective agents which can be treated by these compositions. In alternative embodiments, one common pathogen targeted by compositions andmethods as provided herein is Chlamydia and Chlamydophila species, including pneumoniae, trachomatis and psittaci species which infect humans, including Chlamydophila pneumoniae which also infects humans. In alternative embodiments, pathogens targeted and infections (diseases) treated, ameliorated, or prevented by compositions and methods as provided herein include Mycoplasma, Listeria, Leptospirosis, Q fever or Coxiella burnetii infection, Lyme disease or Lyme borreliosis or any Borrelia infection, and Bartonella or of the family Bartonellaceae, including cat scratch disease. The compositionscomprise at least three different antibiotic agents selected with compositions comprising a rifamycin (such as rifabutin), a macrolide (such as clarithromycin or azithromycin), and a tetracycline (such as doxycycline) or a nitrofuran (such as furazolidone) being preferred.

The invention relates to feed preventing leptospirosis in pigs. The feed is characterized by being prepared from, by weight, 450-480 parts of corn, 120-140 parts of whole-fat rice bran, 120-150 parts of soybean meal, 50-70 parts of fish meal, 120-140 parts of rice oily bran, 10-20 parts of zeolite powder, 5-10 parts of betaine, 5-10 parts of garlic powder, 3-6 parts of alocasia cucullata, 10-15 parts of isatis root, 10-15 parts of pogonatherum crinitum, 8-12 parts of cichorium intybus, 5-8 parts of canton love-pea vine, 5-8 parts of common bletilla rubber, 8-12 parts of dried tangerine peel and 5-8 parts of largeleaf gentian root. The feed can prevent the leptospirosis in pigs, can boost immunity and can promote growth and development.

The invention relates to fodder capable of preventing swine leptospirosis. The fodder is characterized by being prepared from the following raw materials in parts by weight: 450 to 480 parts of corn, 120 to 140 parts of tofukasu, 120 to 150 parts of soya bean meal, 50 to 70 parts of tapioca flour, 120 to 140 parts of rice bran, 10 to 20 parts of zeolite powder, 5 to 10 parts of glycine betaine, 5 to 10 parts of garlic powder, 3 to 6 parts of alocasia cucullate, 10 to 15 parts of radix isatidis, 10 to 15 parts of pogonatherum crinitum, 8 to 12 parts of herba cichorii, 5 to 8 parts of herba abri, 5 to 8 parts of rhizoma bletillae, 8 to 12 parts of tangerine peel and 5 to 8 parts of radix gentianae macrophyllae. The fodder provided by the invention is capable of well preventing the swine leptospirosis, boosting immunity and promoting growth and development.

The invention relates to a fixed-point feeding device on water. The device includes a fishing rod connecting line, a feeding barrel, a balance line fixedly connected to the mouth of the feeding barrel, a wire hook and a turning line. The wire hook includes a ring body and a hook body fixedly connected. One end of the connecting line of the fishing rod is fixedly connected to the ring body, the two ends of the turning line are fixedly connected to the ring body and the bottom of the feeding barrel respectively, and the two ends of the balance line are fixedly connected to two mutually symmetrical positions at the mouth of the feeding barrel, and the two ends of the balance line The middle part is set on the hook body. Compared with the prior art, the above-water fixed-point feeding device of the present invention has a relatively simple structure, is convenient and practical, and is suitable for large-scale popularization and application.

The invention relates to a feed capable of preventing swine leptospirosis. The feed capable of preventing the swine leptospirosis is prepared from the following raw materials in parts by weight: 450-480 parts of corns, 120-140 parts of broken rice, 120-150 parts of soybean meal, 50-70 parts of germ meal, 120-140 parts of cassava powder, 10-20 parts of zeolite powder, 5-10 parts of bone meal, 5-10 parts of garlic powder, 3-6 parts of hoodshaped alocasia rhizome, 10-15 parts of radix isatidis, 10-15 parts of rough melic herb, 8-12 parts of chicory, 5-8 parts of herba abri, 5-8 parts of rhizoma bletillae, 8-12 parts of dried orange peel, and 5-8 parts of large-leaved gentian. The feed is capable of relatively well preventing the swine leptospirosis; moreover, the feed is beneficial for enhancing immunity, as well as promoting growth and development.

A process for the culture of Leptospires in a protein-free culture medium and without any fatty acid source in the culture medium, wherein a fatty acid source is fed continuously or intermittently.

The invention discloses a medicine for treating leptospirosis and a preparation method of the medicine. The medicine is mainly prepared from flos lonicerae, herbs of canscora lucidissima, roots of hupeh euphorbia, dried moss, herbs of laminated sanicle, stems of champion bauhinia, rhizoma bolbostemmae, glabrousleaf pittosporum seeds, thymifoious euphorbia herbs, Chinese eupatorium roots, herbs ofhydrocharis dubia, all-grass of nakedcaule groundsel, herba plantaginis, bark of axillary choerospondias, bark of common bombax, rhizoma arisaematis, herbs of oriental dodartia, herba stachytarpheta jamaicensis, twigs and leaves of pilular adina, Chinese brake herbs, goosegrass herbs, roots of cryptolepis buchananii, herba pholidotae chinensis, cluster mallow roots, herba dracocephali heterophylli, devil's rush herbs, herba lysionoti pauciflori, herba urenae lobatae, herbs of salvia cavaleriei, tubers of indigofera tinctoria, herba polygoni perfoliati, remote lemongrass herbs, field sowthistleherb, Chinese honeylocust fruits, fructus citri sarcodactylis, elaeagnus angustifolia leaves, roots of herba elephantopi and roots of delavay ampelopsis in a certain weight ratio. The medicine has the functions of clearing away heat and toxic materials, promoting diuresis, promoting blood circulation and removing blood stasis, takes effect quickly when used for treating leptospirosis and is goodin curative effect.

The invention relates to fodder capable of preventing swine leptospirosis. The fodder is characterized by being prepared from the following raw materials in parts by weight: 450 to 480 parts of extruded corn, 120 to 140 parts of wheat middling, 120 to 150 parts of soya bean meal, 50 to 70 parts of sorghum, 120 to 140 parts of bran, 10 to 20 parts of zeolite powder, 5 to 10 parts of bone meal, 5 to 10 parts of garlic powder, 3 to 6 parts of rhizoma alocasiae cucullate, 10 to 15 parts of radix isatidis, 10 to 15 parts of pogonatherum crinitum, 8 to 12 parts of herba cichorii, 5 to 8 parts of herba abri, 5 to 8 parts of rhizoma bletillae, 8 to 12 parts of tangerine peel and 5 to 8 parts of radix gentianae macrophyllae. The fodder provided by the invention is capable of well preventing the swine leptospirosis, boosting immunity and promoting growth and development.

The invention discloses a medicine for preventing and treating rabies. The medicine comprises rhizoma cibotii, black bamboo rhizomes, water lamp cores, native copper and the like. The traditional Chinese medicine composition is prepared from pure natural Chinese herbal medicines and is free of toxic and side effects and low in cost. Based on the guidance of traditional Chinese medicine theories, dialectical treatment is adopted, all the raw materials are reasonably matched and have a synergistic effect, and the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, killing insects and the like and has effective prevention and treatment effects on rabies. In addition, the traditional Chinese medicine composition can also be used for preventing and treating leptospirosis, and is high in medicinal value.

The invention relates to a composition for preventing swine leptospirosis. The composition is prepared from the following raw materials in parts by weight: 3-6 parts of hoodshaped alocasia rhizome, 10-15 parts of radix isatidis, 10-15 parts of rough melic herb, 8-12 parts of herba cichorii, 5-8 parts of herba abri, 5-8 parts of rhizoma bletillae, 8-12 parts of pericarpium citri reticulatae and 5-8 parts of radix gentianae macrophyllae. The composition has a relatively good effect of preventing the swine leptospirosis, and can improve immunity and facilitate growth and development.