Wind dispelling and cold expelling semen trichosanthis oil is prepared from the following raw materials in parts by weight: 250-260 parts of semen trichosanthis, 30-40 parts of flaxseed, 70-80 parts of zanthoxylum armatum, 50-60 parts of coconut shells, 90-120 parts of artemisia capillaries, 70-90 parts of fructus gardenia, 20-30 parts of rhubarb, and the like. During the preparation process, the zanthoxylum armatum with the efficacies of dispelling wind and expelling cold is added; the artemisia capillaries can clear heat, remove dampness, and eliminate jaundice; the fructus gardenia clears heat to decrease internal heat, conduces the circulation of triple energizers, and guides damp-heat to be discharged from urine; the rhubarb purges heat, removes blood stasis, facilitates feces excretion, and guides stagnant heat to be discharged from feces; dampness removal and heat elimination cooperate to facilitate urination and defecation, eliminate pathogens from front and back, remove damp-heat, and eliminate stagnant heat, so that jaundice spontaneously subsides; the semen trichosanthis oil can clear heat, expel damp, and is suitable for being taken by people suffering from jaundice due to damp-heat containing rheumatic ostealgia, acute icteric hepatitis, hepatitis B, cholecystolithiasis, cholecystitis, leptospirosis, ileotyphus, pneumonia, hemolytic jaundice caused by favism, and the like.