30 results about "Zilpaterol" patented technology

The present inventions relates to a method of increasing beef production in cattle with feed additives, comprising feeding cattle with feed, comprising an effective amount of an ionophore in combination with a macrolide antibiotic, and thereafter feeding cattle with feed, comprising zilpaterol and essentially no ionophore or macrolide antibiotic for the succeeding about 20 to 40 days.

The present invention relates to one pot process for the preparation of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid of Formula-I, which is a key intermediate and its use in the preparation of Zilpaterol, which comprises condensation of methyl-4-chloro butyrate with 1-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one in presence of a base and suitable solvent to give corresponding ester derivative, further hydrolyzation and acidification in presence of inorganic solvent to obtain Formula-I.

A zilpaterol monoclonal antibody hybridoma cell line and application thereof belong to the technical field of food safety immunoassay. Zilpaterol monoclonal antibody hybridoma cell line SMB1C2 has been deposited in the General Microbiology Center CGMCC of the Chinese Microbiological Culture Collection Management Committee, classified and named as a monoclonal cell strain, and the date of preservation is November 28, 2019, and the preservation number is CGMCC No. 19170. The complete antigen of zilpaterol was mixed and emulsified with the same amount of Freund's adjuvant, and BALB / c mice were immunized by multi-point subcutaneous injection on the back of the neck, and finally a monoclonal antibody hybridoma cell line was obtained. The monoclonal antibody secreted by this cell line has good specificity and detection sensitivity to zilpaterol (IC 50 The value is 0.5ng / mL), which can realize the detection of zilpaterol residues in milk, muscle tissue and urine, and provides raw materials for the immunological detection of zilpaterol residues in food, which has practical application value.

The invention discloses a method for utilizing CdTe quantum dots to measure zZilpaterol. The method comprises the steps that a CdTe-zZilpaterol antigen is prepared; an enzyme-labeledELISA plate coatedwith a zZilpaterol antibody is prepared; a Zzilpaterol standard solution and a CdTe-zZilpaterol antigen solution in the series concentrations are added into holes of the enzyme-labeledELISA plate, meanwhile, a blank control group is set, and incubation and washing are conducted; the fluorescence intensity F of each hole in the enzyme-labeledELISA plate and the fluorescence intensity fF0 of the blank control group are measured, the inhibition ratio I is calculated according to the formula that I=(F-F0) / (Fmax-F0), the inhibition ratio serves is treated as the vertical coordinate, the logarithmof the concentration of the zZilpaterol standard solution serves as the horizontal coordinateabscissa, and a standard curve is drawn; and a to-be-detected sample and the CdTe-zZilpaterol antigen solution are added into the enzyme-labeledELISA plate to be subjected to incubation and washing, the fluorescence intensity is measured, the standard curve is substituted in, and the concentration of zZilpaterol in the to-be-detected sample is obtained. Zilpaterol is measured by utilizing the CdTe quantum dots, the detection cost is low, the detection time is short, the sensitivity is high, and the specificity is good.

This invention relates to a process for the hydrogenation of a ketooxime to selectively form an aminoalcohol stereoisomer, and, in particular, to a process for the hydrogenation of 4,5-dihydro-imidazo[4,5,1-jk][1]benzazepin-2,6,7[1H]-trione-6-oxime or a salt thereof to selectively form a stereoisomer of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one or a salt thereof. This invention also relates to the use of the 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one hydrogenation product or a salt thereof to selectively make a stereoisomer of zilpaterol or a salt thereof, as well as the use of such a zilpaterol stereoisomer or salt in methods of treatment and medicaments for animals.

The invention provides a method for synthesizing zilpaterol hydrochloride. The method comprises the following steps: (1) hydrogenating a compound (h) under the action of a nickel-based catalyst to obtain 6-aminobenzimidazolidone azepine-7-one (compound k); (2) carrying out an alkylation reaction on the 6-aminobenzimidazolidinone azepine-7-one and 2-bromopropane to obtain 6-isopropylaminobenzimidazolidoneazepine-7-one (compound m); and (3) reducing the 6-isopropylaminobenzimidazolidinoneazepine-7-one to obtain zilpaterol. The method has the advantages of no high pressure conditions, low cost, simplicity in operation, and suitableness for industrial large-scale production.

The invention provides a zilpaterol compound veterinary drug composition, which comprises Chinese medicine ingredients and western medicine ingredients. The Chinese medicine ingredients include the following raw materials in parts by weight: 15-25 parts of Astragalus, 15-25 parts of Ephedra, and 10-25 parts of Coptidis 20 parts, Shi Wei 10-20 parts, bitter almond 5-15 parts, cocklebur 5-15 parts, peppermint 5-10 parts; Western medicine ingredients include the following raw materials: ribavirin 5-7 parts, zippat Luo 3-4.5 parts, Florfenicol 1-3 parts. The invention also provides a preparation method of the veterinary drug composition and its application in preventing and treating canine distemper and poultry leptospirosis. The composition provided by the invention is a compound preparation of Chinese and western medicines, which is compounded by selecting multi-flavored Chinese herbal medicines and western medicines. The compatibility of the various medicines is reasonable, and each medicine produces a strong synergistic effect after being composed, and can double the curative effect. It treats both symptoms and root causes, has definite curative effect, and has various dosage forms, which can be mixed feeding, mixed drinking, and injection. It is convenient to use, durable in efficacy, and high in bioavailability.