A kind of zilpaterol compound veterinary drug composition and its preparation method and application

A composition and veterinary drug technology, applied in the direction of active ingredients of heterocyclic compounds, antibacterial drugs, pharmaceutical formulations, etc., can solve the problems of high cost of anti-CDV serum and monoclonal antibody treatment, complicated operation, and disease control, and achieve easy industrialization Simple application, simple operation, and long-lasting effect

Active Publication Date: 2021-03-05
JIANGSU LINGYUN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical manifestations of canine distemper virus are complex and diverse. At present, there is no specific drug for the treatment of canine distemper. Common medicines have a relatively high cure rate in the early stage of canine distemper, and are difficult to cure in the middle and late stages; anti-CDV serum and monotherapy Cloned antibody treatment is expensive, and it only has a certain effect on animals in the early stage of the disease, and the effect is still not good in the middle and late stages of the disease; immunological methods require special equipment and sample preparation, and the operation is complicated and costly
At present, there are also researches on the treatment of canine distemper by measures such as antibacterial and anti-inflammatory methods of traditional Chinese medicine, but due to the characteristics of canine distemper's sudden onset, Chinese medicine treatment can not control the disease quickly and in time in the early stage of the disease, so it is urgent to develop more diversified and more effective methods. Efficient Composition of Chinese and Western Medicines for Treating Canine Distemper

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  • A kind of zilpaterol compound veterinary drug composition and its preparation method and application
  • A kind of zilpaterol compound veterinary drug composition and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0038] 1. Prescription composition

[0039] Astragalus 1.5kg, Ephedra 1.5kg, Coptis 2kg, Shiwei 1.5kg, Bitter almond 1kg, Xanthium 0.5kg, Mint 0.5kg; Ribavirin 0.7kg, Zipaterol 0.45kg, Florfenicol 0.1 kg.

[0040] 2. Preparation method

[0041] Mint is extracted by steam distillation; astragalus, ephedra, berberine, Shiwei, bitter almonds, cocklebur seeds are crushed, passed through a 50-80 mesh sieve, added with ethanol for reflux extraction, and the extract is recovered from ethanol and concentrated to a relative density of Clear ointment I with a relative density of 1.05-1.15 at 60°C, set aside; mix the dregs extracted with alcohol and the volatile oil extracted from mint, add water to decoct, filter the extract, concentrate to 60°C with a relative density of 1.15-1.25 Clear cream II, set aside; mix clear cream I, clear cream II and peppermint volatile oil evenly to make a mixed clear cream; grind ribavirin, zilpaterol, and florfenicol into fine powder and mix with the pr...

Embodiment 2

[0045] 1. Prescription composition

[0046] Astragalus 2.5kg, Ephedra 2kg, Coptidis 1.5kg, Shiwei 1kg, Bitter almond 1.5kg, Xanthium 1.5kg, Mint 0.5kg; Ribavirin 0.5kg, Zipaterol 0.4kg, Florfenicol 0.3 kg.

[0047] 2. Preparation method

[0048] Mint adopts CO 2 Supercritical extraction method to extract volatile oil, extraction pressure 30MPa, temperature 55°C, CO2 Flow rate 25L / h, extraction 40min. ; Grind Astragalus, Ephedra, Coptidis, Shiwei, Bitter Almond, and Xanthium, pass through a 50-80 mesh sieve, add ethanol to reflux for extraction, recover ethanol from the extract, concentrate to a relative density of 1.05-1.15 at 60°C clear ointment I, set aside; mix the dregs extracted with alcohol and mint volatile oil, add water to decoct, filter the extract, and concentrate to clear ointment II with a relative density of 1.15-1.25 at 60°C, set aside; clear ointment II Paste I, Clear Paste II are uniformly mixed with peppermint volatile oil to obtain a mixed clear paste; R...

Embodiment 3

[0052] 1. Prescription composition

[0053] Astragalus 1kg, Ephedra 2.5kg, Coptidis 1kg, Shiwei 2kg, Bitter almond 0.5kg, Xanthium 1kg, Mint 1kg; Ribavirin 0.7kg, Zipaterol 0.3kg, Florfenicol 0.1kg.

[0054] 2. Preparation method

[0055] Mint adopts CO 2 Supercritical extraction method to extract volatile oil, extraction pressure 22MPa, temperature 40°C, CO 2 Flow rate 10L / h, extraction 90min. ; Grind Astragalus, Ephedra, Coptidis, Shiwei, Bitter Almond, and Xanthium, pass through a 50-80 mesh sieve, add ethanol to reflux for extraction, recover ethanol from the extract, concentrate to a relative density of 1.05-1.15 at 60°C clear ointment I, set aside; mix the dregs extracted with alcohol and mint volatile oil, add water to decoct, filter the extract, and concentrate to clear ointment II with a relative density of 1.15-1.25 at 60°C, set aside; clear ointment II Mix ointment I, ointment II and peppermint volatile oil evenly to prepare a mixed ointment; grind ribavirin, zi...

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PUM

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Abstract

The invention provides a zilpaterol compound veterinary drug composition, which comprises Chinese medicine ingredients and western medicine ingredients. The Chinese medicine ingredients include the following raw materials in parts by weight: 15-25 parts of Astragalus, 15-25 parts of Ephedra, and 10-25 parts of Coptidis 20 parts, Shi Wei 10-20 parts, bitter almond 5-15 parts, cocklebur 5-15 parts, peppermint 5-10 parts; Western medicine ingredients include the following raw materials: ribavirin 5-7 parts, zippat Luo 3-4.5 parts, Florfenicol 1-3 parts. The invention also provides a preparation method of the veterinary drug composition and its application in preventing and treating canine distemper and poultry leptospirosis. The composition provided by the invention is a compound preparation of Chinese and western medicines, which is compounded by selecting multi-flavored Chinese herbal medicines and western medicines. The compatibility of the various medicines is reasonable, and each medicine produces a strong synergistic effect after being composed, and can double the curative effect. It treats both symptoms and root causes, has definite curative effect, and has various dosage forms, which can be mixed feeding, mixed drinking, and injection. It is convenient to use, durable in efficacy, and high in bioavailability.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a zilpaterol compound veterinary medicine composition and a preparation method and application thereof. Background technique [0002] In recent years, due to economic development and improvement of people's living standards, pet breeding has gradually developed as a part of people's lives. With the increase of pets, many bacterial and viral infectious diseases are widely spread. [0003] Canine distemper (canine distemper, CD) is a highly contagious disease caused by canine distemper virus (canine distemper virus, CDV). It mainly occurs in canines, cats, mustelids and raccoons, and is highly contagious with a mortality rate of over 80%. [0004] Taking dogs as an example, canine distemper manifests as depression, loss of appetite, sneezing, diarrhea, and body temperature of 39-41°C in the early stage, elevated body temperature, cough, and purulent nasal discharge in the middl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61P31/14A61P31/04A61K31/7056A61K31/55A61K31/165
CPCA61K31/165A61K31/55A61K31/7056A61K36/12A61K36/17A61K36/28A61K36/481A61K36/534A61K36/718A61K36/736A61K2236/33A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 凌青云毕亚铃蒋忠良
Owner JIANGSU LINGYUN PHARMA
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