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Zilpaterol compound veterinary composition as well as preparation method and application thereof

A composition and veterinary drug technology, which is applied in the direction of heterocyclic compound active ingredients, antibacterial drugs, pharmaceutical formulations, etc., can solve the problems of high cost, poor effect and complicated operation of anti-CDV serum and monoclonal antibody treatment, and achieve easy Industrial application, various dosage forms, and simple operation

Active Publication Date: 2018-07-13
JIANGSU LINGYUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical manifestations of canine distemper virus are complex and diverse. At present, there is no specific drug for the treatment of canine distemper. Common medicines have a relatively high cure rate in the early stage of canine distemper, and are difficult to cure in the middle and late stages; anti-CDV serum and monotherapy Cloned antibody treatment is expensive, and it only has a certain effect on animals in the early stage of the disease, and the effect is still not good in the middle and late stages of the disease; immunological methods require special equipment and sample preparation, and the operation is complicated and costly
At present, there are also researches on the treatment of canine distemper by measures such as antibacterial and anti-inflammatory methods of traditional Chinese medicine, but due to the characteristics of canine distemper's sudden onset, Chinese medicine treatment can not control the disease quickly and in time in the early stage of the disease, so it is urgent to develop more diversified and more effective methods. Efficient Composition of Chinese and Western Medicines for Treating Canine Distemper

Method used

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  • Zilpaterol compound veterinary composition as well as preparation method and application thereof
  • Zilpaterol compound veterinary composition as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0038] 1. Prescription composition

[0039] Astragalus 1.5kg, Ephedra 1.5kg, Coptis 2kg, Shiwei 1.5kg, Bitter almond 1kg, Xanthium 0.5kg, Mint 0.5kg; Ribavirin 0.7kg, Zipaterol 0.45kg, Florfenicol 0.1 kg.

[0040] 2. Preparation method

[0041] Mint is extracted by steam distillation; astragalus, ephedra, berberine, Shiwei, bitter almonds, cocklebur seeds are crushed, passed through a 50-80 mesh sieve, added with ethanol for reflux extraction, and the extract is recovered from ethanol and concentrated to a relative density of Clear ointment I with a relative density of 1.05-1.15 at 60°C, set aside; mix the dregs extracted with alcohol and the volatile oil extracted from mint, add water to decoct, filter the extract, concentrate to 60°C with a relative density of 1.15-1.25 Clear cream II, set aside; mix clear cream I, clear cream II and peppermint volatile oil evenly to make a mixed clear cream; grind ribavirin, zilpaterol, and florfenicol into fine powder and mix with the pr...

Embodiment 2

[0045] 1. Prescription composition

[0046] Astragalus 2.5kg, Ephedra 2kg, Coptidis 1.5kg, Shiwei 1kg, Bitter almond 1.5kg, Xanthium 1.5kg, Mint 0.5kg; Ribavirin 0.5kg, Zipaterol 0.4kg, Florfenicol 0.3 kg.

[0047] 2. Preparation method

[0048] Mint adopts CO 2 Supercritical extraction method to extract volatile oil, extraction pressure 30MPa, temperature 55°C, CO2 Flow rate 25L / h, extraction 40min. ; Grind Astragalus, Ephedra, Coptidis, Shiwei, Bitter Almond, and Xanthium, pass through a 50-80 mesh sieve, add ethanol to reflux for extraction, recover ethanol from the extract, concentrate to a relative density of 1.05-1.15 at 60°C clear ointment I, set aside; mix the dregs extracted with alcohol and mint volatile oil, add water to decoct, filter the extract, and concentrate to clear ointment II with a relative density of 1.15-1.25 at 60°C, set aside; clear ointment II Paste I, Clear Paste II are uniformly mixed with peppermint volatile oil to obtain a mixed clear paste; R...

Embodiment 3

[0052] 1. Prescription composition

[0053] Astragalus 1kg, Ephedra 2.5kg, Coptidis 1kg, Shiwei 2kg, Bitter almond 0.5kg, Xanthium 1kg, Mint 1kg; Ribavirin 0.7kg, Zipaterol 0.3kg, Florfenicol 0.1kg.

[0054] 2. Preparation method

[0055] Mint adopts CO 2 Supercritical extraction method to extract volatile oil, extraction pressure 22MPa, temperature 40°C, CO 2 Flow rate 10L / h, extraction 90min. ; Grind Astragalus, Ephedra, Coptidis, Shiwei, Bitter Almond, and Xanthium, pass through a 50-80 mesh sieve, add ethanol to reflux for extraction, recover ethanol from the extract, concentrate to a relative density of 1.05-1.15 at 60°C clear ointment I, set aside; mix the dregs extracted with alcohol and mint volatile oil, add water to decoct, filter the extract, and concentrate to clear ointment II with a relative density of 1.15-1.25 at 60°C, set aside; clear ointment II Mix ointment I, ointment II and peppermint volatile oil evenly to prepare a mixed ointment; grind ribavirin, zi...

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Abstract

The invention provides a zilpaterol compound veterinary composition. The zilpaterol compound veterinary composition comprises traditional Chinese medicine components and Western medicine components, wherein the traditional Chinese medicine components comprise the following raw material medicines in parts by weight: 15 to 25 parts of astragalus membranaceus, 15 to 25 parts of ephedra, 10 to 20 parts of coptis chinensis, 10 to 20 parts of pyrrosia lingua, 5 to 15 parts of semen armeniacae amarae, 5 to 15 parts of cocklebur fruit and 5 to 10 parts of mint; and the Western medicine components comprise the following raw material medicines in parts by weight: 5 to 7 parts of ribavirin, 3 to 4.5 parts of a zilpaterol and 1 to 3 parts of florfenicol. The invention also provides a preparation method of the veterinary composition as well as application of the veterinary composition to prevention and treatment of canine distemper and poultry leptospirosis. The composition provided by the invention is a traditional Chinese medicine and Western medicine compound preparation and is prepared by selecting and compounding various traditional Chinese herbal medicines and Western medicines, various medicines are reasonable in compatibility, strong synergistic effect is generated after the medicines are composed, and the curative effect can be doubled. The zilpaterol compound veterinary composition can treat both symptoms and root causes, has obvious curative effect and various dosage forms, can perform mixed feeding, mixed drinking and injection, is convenient to use, and has durable medicineeffect and high bioavailability.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a zilpaterol compound veterinary medicine composition and a preparation method and application thereof. Background technique [0002] In recent years, due to economic development and improvement of people's living standards, pet breeding has gradually developed as a part of people's lives. With the increase of pets, many bacterial and viral infectious diseases are widely spread. [0003] Canine distemper (canine distemper, CD) is a highly contagious disease caused by canine distemper virus (canine distemper virus, CDV). It mainly occurs in canines, cats, mustelids and raccoons, and is highly contagious with a mortality rate of over 80%. [0004] Taking dogs as an example, canine distemper manifests as depression, loss of appetite, sneezing, diarrhea, and body temperature of 39-41°C in the early stage, elevated body temperature, cough, and purulent nasal discharge in the middl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P31/14A61P31/04A61K31/7056A61K31/55A61K31/165
CPCA61K31/165A61K31/55A61K31/7056A61K36/12A61K36/17A61K36/28A61K36/481A61K36/534A61K36/718A61K36/736A61K2236/33A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 凌青云毕亚铃蒋忠良
Owner JIANGSU LINGYUN PHARMA
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