Traditional Chinese medicine compound preparation for treating anxiety, depression and insomnia of young and middle-aged women and preparation method of traditional Chinese medicine compound preparation

Abstract

The embodiment of the invention discloses a traditional Chinese medicine compound preparation for treating anxiety, depression and insomnia of young and middle-aged women and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. Comprising the following raw materials: 15-25 parts of radix rehmanniae preparata, 10-15 parts of angelica sinensis, 13-17 parts of radix paeoniae alba, 13-17 parts of spina date seed, 10-15 parts of ligusticum wallichii, 10-15 parts of pawpaw, 10-15 parts of lily, 7-11 parts of platycladi seed, 7-11 parts of fructus aurantii, 7-11 parts of gardenia, 7-11 parts of perilla stem, 7-11 parts of poria cocos, 13-17 parts of oyster and 7-11 parts of liquorice. The traditional Chinese medicine compound preparation has the effects of enhancing memory and improving anxiety, depression and sleep quality, is reasonable in compatibility through research on all the raw materials, achieves a synergistic effect among all the raw materials, is convenient to use, good in taste, easy to absorb, free of toxic and side effects and addiction, is especially suitable for middle-aged and young female patients to take, and has a wide application prospect. The raw materials are wide in source, low in cost and high in safety.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women and a preparation method thereof. Background Art

[0002] In recent years, with the development and progress of society, people's pace of life has accelerated, work pressure has increased, and psychological problems have become increasingly serious and are showing a trend of younger people. The results of the mental health survey show that the number of people with varying degrees of mental disorders among young people aged 17 to 35 in my country accounts for 68.2% of all cases; among them, the incidence is mainly high among young and middle-aged women, especially the number of patients with depression has increased year by year. Among the common symptom diseases among young and middle-aged women, anxiety and mental illness are at the forefront. According to the World Health Organization, about 300 million people in the world suffer from various forms of depression. Among patients with depression, nearly half of the patients are between the ages of 15 and 29; and among all suicides, about two-thirds suffer from depression.

[0003] However, the understanding of "depression" in China is not common. Many people have a rejection attitude towards it, thinking that it is a morbid manifestation and are unwilling to mention it or seek help. However, in fact, as long as it is treated correctly, the negative effects caused by this disease can be effectively prevented and alleviated. There are also many studies on the treatment of depression. Among them, drug therapy is one of the most commonly used means. Antidepressants can relieve symptoms such as depression and physical discomfort, but these drugs often have certain side effects and addiction. Therefore, they cannot be used or abused for a long time, otherwise they will cause irreversible effects on the body. Moreover, these drugs usually take a long time to work, and patients need to take them persistently to achieve the desired goals. In addition, there are other non-drug auxiliary measures to help us cope with stress and negative emotional states in life. Various intervention methods including cognitive behavioral therapy (CBT) and biofeedback technology can effectively improve the patient's condition. These therapies can enhance the individual's ability to resist negative events by changing thinking patterns and improving self-efficacy, thereby reducing the possibility of suffering from psychological distress. In addition, some studies have shown that physical exercise can also significantly improve people's mental health and positive emotional experience.

[0004] To sum up, we can see that more and more researchers have begun to pay attention to people’s mental health levels. Therefore, how to find more scientific and effective treatment plans has become an urgent problem to be solved. Summary of the invention

[0005] To this end, the embodiment of the present invention provides a Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women and a preparation method thereof, so as to solve the problem in the prior art that antidepressants have certain side effects and addictiveness, which may cause irreversible effects on the body.

[0006] In order to achieve the above purpose, the embodiment of the present invention provides the following technical solutions:

[0007] According to a first aspect of an embodiment of the present invention, the present invention provides a method for preparing a Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women, the method comprising the following steps:

[0008] S1: Weigh the following raw materials in weight ratio: 15-25 parts of Rehmannia glutinosa, 10-15 parts of Angelica sinensis, 13-17 parts of White Peony Root, 13-17 parts of Ziziphus jujuba seeds, 10-15 parts of Ligusticum chuanxiong, 10-15 parts of Papaya, 10-15 parts of Lilium, 7-11 parts of Platycladus orientalis seeds, 7-11 parts of Citrus aurantium, 7-11 parts of Gardenia jasminoides, 7-11 parts of Perilla stems, 7-11 parts of Poria, 13-17 parts of Oyster, and 7-11 parts of Licorice;

[0009] S2: Wash all the raw materials and set aside, add 10-12 times the weight of water to the raw materials for the first decoction, and filter to obtain the first decoction liquid; add 8-10 times the weight of water to the raw materials for the second decoction, and filter to obtain the second decoction liquid;

[0010] S3: combining the first decoction liquid and the second decoction liquid obtained in step S2, adding 6-10 times volume of ethanol, reflux extraction at 70-90° C. for 30-60 min, extracting 1-3 times, filtering to obtain a filtrate and concentrating to obtain an alcohol-extracted concentrated solution;

[0011] S4: adding sucrose to the alcohol-extracted concentrated solution obtained in step S3, drying, crushing and granulating, to obtain the Chinese herbal compound preparation for treating anxiety, depression and insomnia in young and middle-aged women.

[0012] Furthermore, in step S2, the first decoction is performed at 80-100°C for 1-2 hours; the second decoction is performed at 80-100°C for 0.5-1 hour.

[0013] Furthermore, in step S3, the concentration of ethanol is 60-80%.

[0014] Further, in step S3, the filtrate is concentrated to a relative density of 1.13-1.15.

[0015] Furthermore, in step S3, the concentration conditions are vacuum negative pressure 0.06-0.07Mpa, 60-80°C.

[0016] Furthermore, in step S4, the drying condition is 60-80° C. for 3-4 hours.

[0017] According to a second aspect of an embodiment of the present invention, the present invention provides a Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women, which is prepared by the above method and includes the following raw materials by weight: 20 parts of cooked rehmannia, 12 parts of angelica, 15 parts of white peony root, 15 parts of spiny jujube seed, 12 parts of chuanxiong, 12 parts of papaya, 12 parts of lily, 9 parts of cypress seed, 9 parts of bitter orange, 9 parts of gardenia, 9 parts of perilla stem, 9 parts of poria, 15 parts of oyster, and 9 parts of licorice.

[0018] Furthermore, the dosage form of the Chinese medicine compound preparation is granules.

[0019] The embodiments of the present invention have the following advantages:

[0020] The Chinese medicine compound preparation of the present invention has the effects of enhancing memory, improving anxiety, depression and sleep quality. Through the research on various raw materials, the compatibility is reasonable, the raw materials play a synergistic role, and it is easy to use, has a good taste, is easy to absorb, has no toxic side effects and is non-addictive. It is especially suitable for young and middle-aged female patients to take, and the raw material source is wide, the cost is low, and the safety is high. DETAILED DESCRIPTION

[0021] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] Example 1

[0023] The present embodiment discloses a Chinese medicinal compound preparation for treating anxiety, depression and insomnia in young and middle-aged women. The raw materials are: 20 parts of cooked rehmannia, 12 parts of angelica, 15 parts of white peony root, 15 parts of spiny jujube seed, 12 parts of chuanxiong, 12 parts of papaya, 12 parts of lily, 9 parts of cypress seed, 9 parts of bitter orange, 9 parts of gardenia, 9 parts of perilla stem, 9 parts of poria, 15 parts of oyster and 9 parts of liquorice.

[0024] The preparation method comprises the following steps:

[0025] S1: Weigh the raw materials according to the weight ratio of the formula;

[0026] S2: Wash all the raw materials and set aside, add 10 times the weight of water to the raw materials for the first decoction, decoct at 100°C for 1 hour, and filter to obtain the first decoction liquid; add 8 times the weight of water to the raw materials for the second decoction, decoct at 80°C for 1 hour, and filter to obtain the second decoction liquid;

[0027] S3: combining the first decoction liquid and the second decoction liquid obtained in step S2, adding 8 times the volume of 75% concentration ethanol, refluxing extraction at 80° C. for 45 min, extracting 3 times, filtering to obtain a filtrate, and concentrating to a relative density of 1.14 under vacuum negative pressure of 0.07 MPa and 80° C. to obtain an alcohol-extracted concentrated solution;

[0028] S4: adding sucrose to the alcohol-extracted concentrated solution obtained in step S3, drying at 80° C. for 3 h, crushing and granulating, and obtaining a Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women.

[0029] Example 2

[0030] The present embodiment discloses a Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women, wherein the raw materials are: 15 parts of Rehmannia glutinosa, 10 parts of Angelica sinensis, 13 parts of White Peony Root, 13 parts of Ziziphus jujuba seeds, 10 parts of Chuanxiong, 10 parts of Papaya, 10 parts of Lilium, 7 parts of Platycladus orientalis seeds, 7 parts of Citrus aurantium, 7 parts of Gardenia jasminoides, 7 parts of Perilla stems, 7 parts of Poria, 13 parts of Oyster, and 7 parts of Licorice.

[0031] The preparation method comprises the following steps:

[0032] S1: Weigh the raw materials according to the weight ratio of the formula;

[0033] S2: Wash all the raw materials and set aside, add 12 times the weight of water to the raw materials for the first decoction, decoct at 80°C for 2h, and filter to obtain the first decoction liquid; add 8 times the weight of water to the raw materials for the second decoction, decoct at 100°C for 0.5h, and filter to obtain the second decoction liquid;

[0034] S3: combining the first decoction liquid and the second decoction liquid obtained in step S2, adding 8 times the volume of 65% ethanol, refluxing and extracting at 80° C. for 45 min, extracting 3 times, filtering to obtain a filtrate, and concentrating to a relative density of 1.13 under vacuum negative pressure of 0.07 MPa and 80° C. to obtain an alcohol-extracted concentrated solution;

[0035] S4: adding sucrose to the alcohol-extracted concentrated solution obtained in step S3, drying at 60° C. for 4 h, crushing and granulating, and obtaining a Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women.

[0036] Example 3

[0037] The present embodiment discloses a Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women, wherein the raw materials are: 25 parts of Rehmannia glutinosa, 15 parts of Angelica sinensis, 17 parts of White Peony Root, 17 parts of Ziziphus jujuba seeds, 15 parts of Chuanxiong, 15 parts of Papaya, 15 parts of Lilium, 11 parts of Platycladus orientalis seeds, 11 parts of Citrus aurantium, 11 parts of Gardenia jasminoides, 11 parts of Perilla stems, 11 parts of Poria cocos, 17 parts of Oyster, and 11 parts of Licorice.

[0038] The preparation method comprises the following steps:

[0039] S1: Weigh the raw materials according to the weight ratio of the formula;

[0040] S2: Wash all the raw materials and set aside, add 11 times the weight of water to the raw materials, perform the first decoction, decoct at 100° C. for 1 hour, and filter to obtain the first decoction liquid; add 10 times the weight of water to the raw materials, perform the second decoction, decoct at 80° C. for 1 hour, and filter to obtain the second decoction liquid;

[0041] S3: combining the first decoction liquid and the second decoction liquid obtained in step S2, adding 8 times the volume of 75% concentration ethanol, refluxing extraction at 70° C. for 60 min, extracting 3 times, filtering to obtain a filtrate, and concentrating to a relative density of 1.15 under vacuum negative pressure of 0.07 MPa and 80° C. to obtain an alcohol-extracted concentrated solution;

[0042] S4: adding sucrose to the alcohol-extracted concentrated solution obtained in step S3, drying at 70° C. for 3 h, crushing and granulating, and obtaining a Chinese medicine compound preparation for treating anxiety, depression and insomnia in young and middle-aged women.

[0043] Test Example 1

[0044] 1. Experimental background: 62 young and middle-aged female patients with anxiety and insomnia due to liver blood deficiency were selected and randomly divided into the Chinese medicine compound preparation group of Example 1 and the control group with 31 cases in each group by random number table method. The age of the patients in the group was 28 to 51 years old, with an average age of (35.8±5.7) years old; the body mass index (BMI) was 17.3 to 32.1 kg·m -2 The average BMI was (22.1±2.2) kg·m -2 The course of disease ranged from 3 to 27 months, with an average course of (12.3±2.4) months. There was no significant difference in general data between the two groups (P<0.05), and the two groups were comparable.

[0045] 2. Experimental methods

[0046] Observation group: The Chinese medicine compound preparation prepared in Example 1, 1 dose (150 g) per day, taken warm in the morning and evening, for 4 weeks;

[0047] Control group: oral zopiclone tablets (Guangdong Huarun Shunfeng Pharmaceutical Co., Ltd., national medicine standard H10980247, 7.5 mg / tablet, 3.75 mg.d -1 ), taken once before going to bed every night, without any other treatment during the treatment, for a total of 4 weeks.

[0048] Clinical effect observation index: All patients were evaluated for sleep quality using the PSQI scale, and the PSQI scores of the two groups of patients before and after treatment were recorded. Considering that the observation group discontinued any hypnotic drugs during treatment, and the control group only took zopiclone tablets orally, the hypnotic drug items were not evaluated in both groups. The remaining 17 items were divided into 6 dimensions: sleep time, sleep efficiency, sleep quality, sleep time, sleep disorders, and daytime function. Each dimension was scored 0 to 3 points, and the total PSQI score was the cumulative score of each dimension, ranging from 0 to 18 points. The lower the score, the better the sleep quality.

[0049] 3. Experimental results: The comparison of PSQI scores between the two groups of patients (x±s) is shown in Table 1 below.

[0050] Table 1

[0051]

[0052] Note: Compared with the observation group before treatment, △ P<0.05; compared with the control group after treatment, #P<0.05.

[0053] The PSQI scale of the two groups of patients was compared, and there was no significant difference in the scores of each dimension before treatment (all P < 0.05), which was comparable. Comparison before and after treatment, after treatment with the Chinese medicine compound preparation group, the observation group had a decrease in sleep time, sleep efficiency, sleep quality, sleep time, sleep disorders, daytime function scores and total scores compared with before treatment (P < 0.05), and the control group had a decrease in sleep time, sleep time, sleep efficiency scores and total scores (P < 0.05). After the two groups were treated, the Chinese medicine group had less sleep time, sleep quality, sleep disorders, daytime function scores and total scores than the control group (P < 0.05). Therefore, it can be concluded that the Chinese medicine compound preparation obtained in Example 1 of the present invention has excellent efficacy in improving sleep quality.

[0054] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A method for preparing a Chinese medicinal compound preparation for treating anxiety, depression and insomnia in young and middle-aged women, characterized in that: The method comprises the following steps: S1: Weigh the following raw materials in weight ratio: 15-25 parts of Rehmannia glutinosa, 10-15 parts of Angelica sinensis, 13-17 parts of White Peony Root, 13-17 parts of Ziziphus jujuba seeds, 10-15 parts of Ligusticum chuanxiong, 10-15 parts of Papaya, 10-15 parts of Lilium, 7-11 parts of Platycladus orientalis seeds, 7-11 parts of Citrus aurantium, 7-11 parts of Gardenia jasminoides, 7-11 parts of Perilla stems, 7-11 parts of Poria, 13-17 parts of Oyster, and 7-11 parts of Licorice; S2: Wash all the raw materials and set aside, add 10-12 times the weight of water to the raw materials for the first decoction, and filter to obtain the first decoction liquid; add 8-10 times the weight of water to the raw materials for the second decoction, and filter to obtain the second decoction liquid; S3: combining the first decoction liquid and the second decoction liquid obtained in step S2, adding 6-10 times volume of ethanol, reflux extraction at 70-90° C. for 30-60 min, extracting 1-3 times, filtering to obtain a filtrate and concentrating to obtain an alcohol-extracted concentrated solution; S4: adding sucrose to the alcohol-extracted concentrated solution obtained in step S3, drying, crushing and granulating, to obtain the Chinese herbal compound preparation for treating anxiety, depression and insomnia in young and middle-aged women.

2. The method for preparing the Chinese medicinal compound preparation according to claim 1, characterized in that: In step S2, the first decoction is performed at 80-100°C for 1-2 hours; the second decoction is performed at 80-100°C for 0.5-1 hour.

3. The method for preparing the Chinese medicinal compound preparation according to claim 1, characterized in that: In step S3, the concentration of ethanol is 60-80%.

4. The method for preparing the Chinese medicinal compound preparation according to claim 1, characterized in that: In step S3, the filtrate is concentrated to a relative density of 1.13-1.

15.

5. The method for preparing the Chinese medicinal compound preparation according to claim 1, characterized in that: In step S3, the concentration conditions are vacuum negative pressure 0.06-0.07Mpa, 60-80°C.

6. The method for preparing the Chinese medicinal compound preparation according to claim 1, characterized in that: In step S4, the drying condition is 60-80° C. for 3-4 hours.

7. A Chinese medicinal compound preparation for treating anxiety, depression and insomnia in young and middle-aged women, characterized in that: The Chinese medicine compound preparation is prepared by the method according to any one of claims 1 to 6, and comprises the following raw materials by weight: 20 parts of cooked rehmannia, 12 parts of angelica, 15 parts of white peony root, 15 parts of spiny jujube seeds, 12 parts of chuanxiong, 12 parts of papaya, 12 parts of lily, 9 parts of cypress seeds, 9 parts of fructus aurantii, 9 parts of gardenia, 9 parts of perilla stems, 9 parts of poria, 15 parts of oysters, and 9 parts of liquorice.

8. The Chinese medicinal compound preparation according to claim 7, characterized in that: The dosage form of the Chinese medicine compound preparation is granules.

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