Traditional Chinese medicine composition for strengthening spleen and increasing height and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for tonifying spleen and increasing height and application. The traditional Chinese medicine composition comprises the following components: pseudo-ginseng, radix achyranthis bidentatae, radix ophiopogonis, medicated leaven, astragalus membranaceus, fingered citron, bighead atractylodes rhizome, radix pseudostellariae and rice-grain sprouts. The Chinese herbal medicines with the effects of invigorating the spleen, replenishing qi, harmonizing the stomach, promoting digestion, promoting blood circulation, dredging collaterals, tonifying the kidney and strengthening the bones are scientifically compounded, and the medicines are mutually assisted and compatible and have a synergistic effect, so that the prepared traditional Chinese medicine composition can fully regulate the nutrient absorption and substance conversion efficiency of a human digestive system; the traditional Chinese medicine composition can be used for promoting growth and development of human bones and other systems, achieves the purpose of treating short or slightly short stature, and is low in cost, simple and convenient to prepare and free of side effects on the human body.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a spleen-strengthening and height-increasing traditional Chinese medicine composition and application thereof. Background Art

[0002] Due to many factors such as genetics, disease and nutrition, the height of a child is more than 2 standard deviations (SDS) lower than the average height of the same age, gender and region, which is medically known as short stature. For children with medically known short stature, the current scientific research method is to supplement the growth hormone of the human pituitary gland or use genetic recombinant growth hormone for treatment, but its high cost, potential risk of side effects and inconvenience in application have limited its clinical application.

[0003] As for children whose height has not yet reached the standard for short stature, that is, children whose height is in the range of -1SD to -2SD, especially those whose height growth is delayed due to nutritional absorption disorders, modern medicine currently focuses on life guidance such as diet, exercise, and regular work and rest, and there is currently no specific treatment.

[0004] In view of this, there is an urgent need to improve the existing treatment methods for short stature, to solve the problems of high cost, potential side effects and inconvenient application in existing treatment methods, and to provide new ideas and methods to increase the treatment of short children. Summary of the invention

[0005] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art and provide a Chinese medicine composition for strengthening the spleen and increasing height and its application, so as to improve the spleen and stomach transportation and absorption function, increase growth rate and promote bone growth.

[0006] To achieve the above objectives, the technical solutions adopted by the present invention include:

[0007] In a first aspect, the present invention provides a Chinese medicine composition for strengthening the spleen and increasing height, the Chinese medicine composition comprising the following components: Panax notoginseng, Achyranthes bidentata, Ophiopogon japonicus, Ligusticum chuanxiong, Astragalus membranaceus, Citron, Atractylodes macrocephala, Pseudostellaria baicalensis and rice sprouts.

[0008] The therapeutic effects of each component in the Chinese medicine composition of the present invention are as follows:

[0009] Astragalus: As an important Qi-tonifying herb, Astragalus occupies a dominant position in this prescription, targeting the core pathogenesis of spleen deficiency, strengthening the Qi of the spleen and stomach, and serving as the main herb;

[0010] Atractylodes macrocephala and Radix Pseudostellariae: Atractylodes macrocephala strengthens the spleen and eliminates dampness, while Radix Pseudostellariae replenishes Qi and produces body fluid. The two complement each other and help Astragalus membranaceus strengthen the effect of strengthening the spleen and replenishing Qi, and are the assistant drugs.

[0011] Achyranthes bidentata, Ophiopogon japonicus, Citron, Rhizoma Cibotii, and Rice Sprouts: Achyranthes bidentata nourishes the liver and kidneys to benefit the spleen and stomach, Ophiopogon japonicus nourishes yin, produces body fluids and prevents dryness, Citron stalks regulates qi and harmonizes the stomach, Rhizoma Cibotii and Rice Sprouts help digestion, resolve accumulation, and aid digestion. These five herbs assist the principal and ministerial herbs from different angles, harmonize the medicinal properties, and improve concurrent symptoms, and are collectively referred to as adjuvants.

[0012] Panax notoginseng: This drug is paired with the above-mentioned drugs, which is not a commonly used drug pair in traditional medicine. Its function of promoting blood circulation and removing blood stasis can guide the drug power to penetrate deeply, promote the circulation of qi and blood, and indirectly assist the monarch, ministerial and adjuvant drugs to act on the spleen and stomach.

[0013] The present invention selects the above-mentioned Chinese herbal medicines with the effects of strengthening the spleen and replenishing qi, harmonizing the stomach and promoting digestion, promoting blood circulation and unblocking meridians, and nourishing the kidneys and strengthening bones for scientific compounding. The medicines complement each other and work synergistically to enhance the effectiveness, so that the prepared Chinese medicine composition can fully regulate the efficiency of nutrient absorption and material conversion of the human digestive system, thereby promoting the growth and development of human bones and other systems, and achieving the purpose of treating short stature (or being relatively short).

[0014] Preferably, the Chinese medicine composition comprises the following components in parts by weight: 3-5 parts of Panax notoginseng, 8-15 parts of Achyranthes bidentata, 8-10 parts of Ophiopogon japonicus, 5-10 parts of Ligusticum chuanxiong, 10-15 parts of Astragalus membranaceus, 8-10 parts of Citron, 10-15 parts of Atractylodes macrocephala, 5-10 parts of Pseudostellaria pseudoginseng and 10-15 parts of Rice sprouts.

[0015] Preferably, the Chinese medicine composition comprises the following components in parts by weight: 3 parts of Panax notoginseng, 10 parts of Achyranthes bidentata, 8 parts of Ophiopogon japonicus, 10 parts of Ligusticum chuanxiong, 10 parts of Astragalus membranaceus, 8 parts of Citron, 10 parts of Atractylodes macrocephala, 10 parts of Pseudostellaria pseudoginseng and 15 parts of rice sprouts.

[0016] After investigation, it was found that when the dosage of each component in the traditional Chinese medicine composition of the present invention is the above-mentioned optimal value, the various medicines complement each other and are well compatible, which has a good promoting effect on the growth and development of children, especially those with short stature or who are slightly short.

[0017] Preferably, the traditional Chinese medicine composition further includes at least one of the following components in parts by weight: 5-10 parts of licorice, 8-10 parts of raw cornus fruit, 8-10 parts of yam, 3-5 parts of angelica dahurica, 8-10 parts of Poria cocos, 10-12 parts of Polygonum multiflorum, 8-10 parts of Chinese yam, 3-5 parts of white peony root, 5-10 parts of Uncaria rhynchophylla, and 3-5 parts of ebony.

[0018] Traditional Chinese medicine believes that short stature children may have insufficient food intake, gastrointestinal dysfunction, insufficient nutrients absorbed to meet the needs of normal growth and development, or may be due to liver and kidney deficiency, heart and spleen deficiency, or qi and blood deficiency. Therefore, only by distinguishing and treating according to different causes can better treatment effects be achieved, and short stature can be effectively alleviated to a certain extent. Based on this, the present invention also selects different Chinese medicine ingredients to assist the above Chinese medicine formula for scientific compatibility, and distinguishes and treats according to different causes to achieve sufficient spleen-strengthening and height-increasing effects, as well as enhance other functions of the human body.

[0019] Licorice in the prescription: has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, alleviating the toxicity and potency of drugs, and harmonizing various drugs. Raw cornus fruit: has the effects of tonifying the liver and kidney, astringing the essence and qi, and consolidating collapse. Chinese yam: strengthens the spleen, tonifies the lungs, consolidates the kidneys, and benefits the essence; treats diarrhea due to spleen deficiency, chronic dysentery, cough due to consumptive labor, thirst, spermatorrhea, leucorrhea, and frequent urination. Angelica dahurica: has the effects of dispelling cold, dispelling wind and relieving pain, drying dampness and stopping leucorrhea, and reducing swelling and discharging pus. Poria: has the effects of treating spleen deficiency, poor appetite, phlegm and fluid, palpitations, palpitations, insomnia, etc. Polygonum multiflorum: nourishes blood and calms the mind, dispels wind and dredges the meridians; mainly treats symptoms such as insomnia, strain, hyperhidrosis, and body pain due to blood deficiency. White peony root: has the effects of nourishing blood and regulating menstruation, softening the liver and relieving pain, astringing yin and stopping sweating, and calming liver yang. Uncaria rhynchophylla: has the functions of calming, lowering blood pressure, clearing heat and calming the liver, and calming wind and calming shock. Black plum: It has the effects of astringing the lungs and relieving cough, astringing the intestines and relieving diarrhea, stopping bleeding, and promoting salivation.

[0020] Preferably, the traditional Chinese medicine composition further comprises the following components in parts by weight: 5-10 parts of licorice or 8-10 parts of raw cornus fruit.

[0021] Preferably, the traditional Chinese medicine composition further comprises the following components in parts by weight: 10 parts of licorice or 8 parts of raw cornus fruit.

[0022] Preferably, the Chinese medicine composition is prepared by a decoction method, specifically: adding water to the medicinal materials and soaking them for 15-25 minutes, the amount of water added is 8-12 times the total weight of the medicinal materials, and then decocting them twice, each time for 0.5-1.5 hours, combining the extracts, filtering, and obtaining the Chinese medicine composition.

[0023] Preferably, the dosage form of the traditional Chinese medicine composition includes one of aqueous solution, ointment, pill, tablet and granule.

[0024] In a second aspect, the present invention provides the use of the Chinese medicine composition in the preparation of medicines or health products for strengthening the spleen and increasing height.

[0025] In a third aspect, the present invention provides a Chinese medicine preparation for strengthening the spleen and increasing height, the Chinese medicine preparation comprising the Chinese medicine composition and a medically acceptable carrier.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] (1) The present invention selects Chinese herbal medicines with the effects of strengthening the spleen and replenishing qi, harmonizing the stomach and promoting digestion, promoting blood circulation and unblocking meridians, and nourishing the kidneys and strengthening bones for scientific compounding. The various medicines complement each other and work synergistically to enhance the efficacy, so that the prepared Chinese medicine composition can fully regulate the efficiency of nutrient absorption and material conversion of the human digestive system, thereby promoting the growth and development of the human skeleton and other systems, thereby achieving the purpose of treating short stature (or short stature).

[0028] (2) Compared with the prior art, the Chinese medicine composition of the present invention has low cost, simple preparation, and no side effects on the human body. In addition, it can also improve human memory, prevent and treat osteoporosis, promote blood circulation, promote muscle growth, eliminate fatigue and other functions. DETAILED DESCRIPTION

[0029] To better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. It should be understood by those skilled in the art that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0030] In order to verify the efficacy of the Chinese medicine composition of the present invention in treating short stature or partial short stature in children, the inventor retrospectively analyzed the examples of the Chinese medicine composition of the present invention used in outpatient clinics in the past three years. It should be noted that the Chinese medicine compositions selected for the case review of the present invention are all the formulas and methods of administration of the examples of the present invention.

[0031] (1) Diagnostic criteria

[0032] The physical growth evaluation criteria in Practical Pediatrics (8th edition) (Table 1) and the relevant diagnostic criteria in the Chinese Expert Consensus on Diagnosis and Treatment of Idiopathic Short Stature in Children were included: 1. The height, weight and stature proportion of the children were within the normal range at birth; 2. The height evaluation grade was at the lower middle or lower level; or the height SDS decreased (>1SD / year); or the growth rate was <7.0cm / y in children <2 years old, <5.5cm / y in children 2-<4 years old, <5.0cm / y in children 4-<6 years old, and <4.0cm / y in children 6 years old to prepubertal children.

[0033] Table 1 Physical fitness evaluation classification method

[0034] grade Deviation method Percentile method superior >X+2SD >P97 Upper middle X+(1~2)SD P75~P97 middle X±1SD P25~P75 Middle and lower X-(1~2)SD P3~P25 Down X<-2SD <P3

[0035] (2) Inclusion criteria

[0036] 1. Age 2-11 years old (prepubertal); 2. Meet the above diagnostic criteria.

[0037] (3) Exclusion criteria

[0038] 1. Those who have received growth hormone or thyroid hormone treatment; 2. Those with dwarfism caused by genetic or organic diseases; 3. Those who are allergic to the trial drugs; 4. Those with severe heart, liver and kidney dysfunction; 5. Those with infectious diseases such as tuberculosis; 6. Those with incomplete data.

[0039] (4) Efficacy results

[0040] Referring to the "Chinese Expert Consensus on Diagnosis and Treatment of Idiopathic Short Stature in Children", the treatment efficacy standards for children with short stature or short stature are as follows:

[0041] Marked effect: defined as an increase in height SDS after treatment, and a height growth rate of >8cm / y for children aged 2-6 (including 6 years old), and ≥7.0cm / y for children aged 6-prepubertal;

[0042] Effective: defined as an increase in height SDS after treatment, and a height growth rate of >7.0 cm / y for children aged 2-6 (including 6 years old), and ≥6.0 cm / y and <7.0 cm / y for children aged 6-prepubertal;

[0043] Ineffectiveness: defined as no increase in height SDS after treatment, or height growth velocity <7.0cm / y in children aged 2-6 years (including 6 years) and <6.0cm / y in children aged 6 years to prepubertal children.

[0044] Height growth velocity GV (cm / year) = (height after intervention - height before treatment) / number of months*12.

[0045] Example 1

[0046] The present embodiment provides a Chinese medicine composition for strengthening the spleen and increasing height, comprising the following components in parts by weight: 3 parts of Panax notoginseng, 10 parts of Achyranthes bidentata, 8 parts of Ophiopogon japonicus, 10 parts of Aconitum carmichaelii, 10 parts of Astragalus membranaceus, 8 parts of Citron, 10 parts of Atractylodes macrocephala, 10 parts of Pseudostellaria pseudoginseng, 15 parts of Rice sprouts, and 10 parts of Licorice.

[0047] The Chinese medicine composition is prepared by a decoction method, specifically: adding water to the medicinal materials and soaking them for 20 minutes, the amount of water added is 10 times the total weight of the medicinal materials, then decocting them twice, each time for 1 hour, combining the extracts, filtering, and preparing the Chinese medicine composition; taking, 1 dose per day, divided into 2 doses.

[0048] Specific examples:

[0049] 1. Cao*, a 6-year-old boy, was 104 cm (-2.66SD) tall and weighed 15.5 kg (-2.36SD) before taking the Chinese medicine composition. He was a short child. After taking the decoction for 3 months, his height was measured again and was 105.8 cm (-2.48SD) tall and weighed 15.8 kg.

[0050] The height growth rate GV = 8.64cm / year, significantly effective;

[0051] The standard deviation of height is △HtSDS=+0.18.

[0052] 2. Wang*, boy, 7 years old, was 120.9 cm (-1.2SD) tall and weighed 20.4 kg (-1.56SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 8 months, his height was measured again to be 124.2 cm (-1SD) and his weight was 21.65 kg (-1.43SD);

[0053] The height growth rate GV = 7.92cm / year, significant effect;

[0054] The standard deviation value difference △HtSDS=0.2.

[0055] 3. Lu*, a 5-year-old girl, had a height of 98.9 cm (-2.23 SD) and a weight of 15.2 kg (-1.26 SD) before taking the Chinese medicine composition. She was a short child. After taking the decoction for 3 and a half months, her height was measured again to be 101.4 cm (-1.98 SD) and her weight was 15.25 kg (-1.47 SD);

[0056] The height growth rate GV = 8.57 cm / year, significantly effective;

[0057] The standard deviation of height is △HtSDS=+0.25.

[0058] Example 2

[0059] The present embodiment provides a Chinese medicine composition for strengthening the spleen and increasing height, comprising the following components in parts by weight: 3 parts of Panax notoginseng, 10 parts of Achyranthes bidentata, 8 parts of Ophiopogon japonicus, 10 parts of Aconitum carmichaelii, 10 parts of Astragalus membranaceus, 8 parts of Citron, 10 parts of Atractylodes macrocephala, 10 parts of Pseudostellaria pseudoginseng, 15 parts of Rice sprouts, and 8 parts of Raw Cornus officinalis.

[0060] The Chinese medicine composition is prepared by a decoction method, specifically: adding water to the medicinal materials and soaking them for 20 minutes, the amount of water added is 10 times the total weight of the medicinal materials, then decocting them twice, each time for 1 hour, combining the extracts, filtering, and preparing the Chinese medicine composition; taking, 1 dose per day, divided into 2 doses.

[0061] Specific examples:

[0062] 1. Li*, a 5-year-old girl, had a height of 102.4 cm (-2.71 SD) and a weight of 13.6 kg (-3 SD) before taking the Chinese medicine composition. She was a short child. After taking the decoction for 2 and a half months, her height was measured again to be 104.6 cm (-2.49 SD) and her weight was 13.65 kg (<3 SD);

[0063] The height growth rate GV = 10.56cm / year, significant effect;

[0064] The standard deviation of height is △HtSDS=+0.22.

[0065] 2. Xie*, a 9-year-old boy, was 127.4 cm (-1.4SD) tall and weighed 24.4 kg (-1.3SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 2 months, his height was measured again and was 129.3 cm (-1.19SD) tall and weighed 23.75 kg (-1.54SD).

[0066] The height growth rate GV = 11.4 cm / year, which was significantly effective;

[0067] The standard deviation of height is △HtSDS=+0.21.

[0068] 3. Cai*, a 6-year-old girl, had a height of 112 cm (-2.06 SD) and a weight of 18.3 kg (-1.53 ​​SD) before taking the Chinese medicine composition. She was a short child. After taking the decoction for 2 and a half months, her height was measured again to be 114 cm (-1.84 SD) and her weight was 19.45 kg (-1.19 SD);

[0069] The height growth rate GV = 9.6 cm / year, significantly effective;

[0070] The standard deviation of height is △HtSDS=+0.22.

[0071] Example 3

[0072] The present embodiment provides a Chinese medicine composition for strengthening the spleen and increasing height, comprising the following components in parts by weight: 5 parts of Panax notoginseng, 10 parts of Achyranthes bidentata, 8 parts of Ophiopogon japonicus, 10 parts of Aconitum carmichaelii, 10 parts of Astragalus membranaceus, 8 parts of Citron, 10 parts of Atractylodes macrocephala, 10 parts of Pseudostellaria pseudoginseng, and 15 parts of Rice sprouts.

[0073] The Chinese medicine composition is prepared by a decoction method, specifically: adding water to the medicinal materials and soaking them for 20 minutes, the amount of water added is 10 times the total weight of the medicinal materials, then decocting them twice, each time for 1 hour, combining the extracts, filtering, and preparing the Chinese medicine composition; taking, 1 dose per day, divided into 2 doses.

[0074] Specific examples:

[0075] 1. Zheng*, a 3-year-old girl, was 88 cm (-2.4 SD) tall and weighed 13 kg (-1 SD) before taking the Chinese medicine composition. She was a short child. After taking the decoction for 5 months, her height was measured again and was 91.5 cm (-2.28 SD) tall and weighed 12 kg (-2.4 SD).

[0076] The height growth rate GV = 8.4 cm / year, which was significantly effective;

[0077] The standard deviation of height is △HtSDS=+0.12.

[0078] 2. Liang*, a 9-year-old boy, was 131.1 cm (-1.14 SD) tall and weighed 25.7 kg (-1.37 SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 6 months, his height was measured again to be 134.9 cm (-1.01 SD) and his weight was 27.15 kg (-1.3 SD).

[0079] The height growth rate GV = 7.6 cm / year, which was significantly effective;

[0080] The standard deviation of height is △HtSDS=+0.13.

[0081] Example 4

[0082] The present embodiment provides a Chinese medicine composition for strengthening the spleen and increasing height, comprising the following components in parts by weight: 3 parts of Panax notoginseng, 8 parts of Achyranthes bidentata, 10 parts of Ophiopogon japonicus, 10 parts of Liushenqu, 10 parts of Astragalus, 8 parts of Citron, 15 parts of Atractylodes macrocephala, 10 parts of Pseudostellaria pseudoginseng, 10 parts of Rice sprouts, 10 parts of Polygonum multiflorum, and 5 parts of White Peony Root.

[0083] The Chinese medicine composition is prepared by a decoction method, specifically: adding water to the medicinal materials and soaking them for 20 minutes, the amount of water added is 10 times the total weight of the medicinal materials, then decocting them twice, each time for 1 hour, combining the extracts, filtering, and preparing the Chinese medicine composition; taking, 1 dose per day, divided into 2 doses.

[0084] Specific examples:

[0085] 1. Dong*, a 3-year-old boy, was 88.8 cm (-2.92 SD) tall and weighed 11.1 kg (-2.66 SD) before taking the Chinese medicine composition. He was a short child. After taking the decoction for 3 and a half months, his height was measured again and was 91 cm (-2.84 SD) tall and weighed 12 kg (-2.64 SD).

[0086] The converted height growth rate GV = 7.54cm / year, effective;

[0087] The standard deviation is △HtSDS=+0.08.

[0088] 2. Ye*, a 5-year-old girl, had a height of 100.4 cm (-2.7 SD) and a weight of 15.2 kg (-1.8 SD) before taking the Chinese medicine composition. She was a short child. After taking the decoction for 2 and a half months, her height was measured again to be 102.3 cm (-2.6 SD) and her weight was 15.2 kg (-1.93 SD);

[0089] The height growth rate GV = 9.12cm / year, significant effect;

[0090] The standard deviation is △HtSDS=+0.1.

[0091] Example 5

[0092] The present embodiment provides a Chinese medicine composition for strengthening the spleen and increasing height, comprising the following components in parts by weight: 5 parts of Panax notoginseng, 15 parts of Achyranthes bidentata, 8 parts of Ophiopogon japonicus, 10 parts of Aconitum carmichaelii, 10 parts of Astragalus membranaceus, 10 parts of Citron, 10 parts of Atractylodes macrocephala, 10 parts of Pseudostellaria pseudoginseng, 15 parts of rice sprouts, 10 parts of Licorice root, 10 parts of Polygonum multiflorum, and 10 parts of Chinese yam.

[0093] The Chinese medicine composition is prepared by a decoction method, specifically: adding water to the medicinal materials and soaking them for 20 minutes, the amount of water added is 10 times the total weight of the medicinal materials, then decocting them twice, each time for 1 hour, combining the extracts, filtering, and preparing the Chinese medicine composition; taking, 1 dose per day, divided into 2 doses.

[0094] Specific examples:

[0095] 1. Xie*, a 9-year-old boy, was 126.4 cm (-1.36 SD) tall and weighed 21.9 kg (-1.82 SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 5 and a half months, his height was measured again to be 129.5 cm (-1.16 SD) and his weight was 21.95 kg (-1.99 SD);

[0096] The converted height growth rate GV = 6.76cm / year, effective;

[0097] The standard deviation of height is △HtSDS=+0.2.

[0098] Example 6

[0099] The present embodiment provides a Chinese medicine composition for strengthening the spleen and increasing height, comprising the following components in parts by weight: 3 parts of Panax notoginseng, 10 parts of Achyranthes bidentata, 8 parts of Ophiopogon japonicus, 5 parts of Ligusticum chuanxiong, 15 parts of Astragalus membranaceus, 8 parts of Citron, 10 parts of Atractylodes macrocephala, 10 parts of Pseudostellaria pseudoginseng, 15 parts of Rice sprouts, and 5 parts of Uncaria rhynchophylla.

[0100] The Chinese medicine composition is prepared by a decoction method, specifically: adding water to the medicinal materials and soaking them for 20 minutes, the amount of water added is 10 times the total weight of the medicinal materials, then decocting them twice, each time for 1 hour, combining the extracts, filtering, and preparing the Chinese medicine composition; taking, 1 dose per day, divided into 2 doses.

[0101] Specific examples:

[0102] 1. Feng*, a 4-year-old boy, was 102.5 cm (-1.9 SD) tall and weighed 15.9 kg (-1.4 SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 2 months, his height was measured again and was 104 cm (-1.84 SD) tall and weighed 16.45 kg (-1.32 SD).

[0103] The height growth rate GV = 9cm / year, significant effect;

[0104] The standard deviation of height is △HtSDS=+0.06.

[0105] Example 7

[0106] The present embodiment provides a Chinese medicine composition for strengthening the spleen and increasing height, comprising the following components in parts by weight: 5 parts of Panax notoginseng, 10 parts of Achyranthes bidentata, 10 parts of Ophiopogon japonicus, 10 parts of Liushenqu, 15 parts of Astragalus membranaceus, 10 parts of Citron, 10 parts of Atractylodes macrocephala, 5 parts of Pseudostellaria pseudoginseng, 15 parts of rice sprouts, 10 parts of Licorice, 10 parts of Dioscorea opposita, and 5 parts of Ebony plum.

[0107] The Chinese medicine composition is prepared by a decoction method, specifically: adding water to the medicinal materials and soaking them for 20 minutes, the amount of water added is 10 times the total weight of the medicinal materials, then decocting them twice, each time for 1 hour, combining the extracts, filtering, and preparing the Chinese medicine composition; taking, 1 dose per day, divided into 2 doses.

[0108] Specific examples:

[0109] 1. Song*, boy, 8 years old, was 123.8cm (-1.3SD) tall and weighed 22kg (-1.4SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 3 months, his height was measured again and was 125.5cm (-1.14SD) tall and weighed 23.3kg.

[0110] The converted height growth rate GV = 6.8cm / year, effective;

[0111] The standard deviation of height is △HtSDS=0.16.

[0112] Comparative Example 1

[0113] This comparative example provides a Chinese medicine composition for strengthening the spleen and increasing height, which is different from the Chinese medicine composition described in Example 1 in that no astragalus and atractylodes components are added, and the remaining components, contents and administration methods are the same.

[0114] Specific examples:

[0115] 1. Liu*, boy, 11 years old, was 135.3cm (-1.16SD) tall and weighed 36.6kg (0.13SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 4 months, his height was measured again to be 136.8cm (-1.17SD) and his weight was 37.85kg (0.1SD);

[0116] The converted height growth rate GV = 4.5cm / year, invalid;

[0117] The standard deviation of height is △HtSDS=-0.01.

[0118] 2. Mo*, girl, 8 years old, before taking the Chinese medicine composition, her height was 117 cm (-1.54 SD) and her weight was 21.5 kg (-0.7 SD), belonging to a relatively short child. After taking the decoction for 10 and a half months, her height was measured again to be 122.4 cm (-1.3 SD) and her weight was 22.6 kg (-0.86 SD);

[0119] The converted height growth rate GV = 6.17cm / year, just reached the effective level;

[0120] The standard deviation of height is △HtSDS=+0.24.

[0121] 3. Mo*, boy, 6 years old, was 101 cm (-3SD) tall and weighed 14.7 kg (-2.69SD) before taking the Chinese medicine composition, belonging to a short child. After taking the decoction for 4 and a half months, the height was measured again to be 102.9 cm (-3SD) and the weight was 14.35 kg (-2.83SD);

[0122] The converted height growth rate GV = 5.7cm / year, invalid;

[0123] The standard deviation of height is △HtSDS=0.

[0124] Comparative Example 2

[0125] This comparative example provides a Chinese medicine composition for strengthening the spleen and increasing height, which differs from the Chinese medicine composition described in Example 1 in that Liushenqu and bergamot components are not added, and the remaining components, contents and methods of administration are the same.

[0126] Specific examples:

[0127] 1. Wu*, girl, 11 years old, before taking the Chinese medicine composition, her height was 128.6cm (-2.3SD), and her weight was 22.7kg (-2.4SD), belonging to a short child. After taking the decoction for 6 months, her height was measured again, 131.7cm (-2.34SD), and her weight was 22.35kg (-2.83SD);

[0128] The converted height growth rate GV = 5.8cm / year, invalid;

[0129] The standard deviation of height is △HtSDS=-0.04.

[0130] 2. He*, a 9-year-old boy, was 129 cm (-0.81SD) tall and weighed 23 kg (-1.48SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 4 months, his height was measured again to be 130 cm (-0.93SD) and his weight was 24.6 kg.

[0131] The converted height growth rate GV = 4cm / year is invalid;

[0132] The standard deviation of height is △HtSDS=-0.12.

[0133] 3. Chen*, girl, 5 years old, before taking the Chinese medicine composition, her height was 99.5cm (-2.83SD), and her weight was 13.2kg (-2.96SD), which was a short child. After taking the decoction for 5 and a half doses, her height was measured again, and her weight was 102cm (-2.81SD), and her weight was 13.15kg (<-3SD);

[0134] The converted height growth rate GV = 5.45cm / year, invalid;

[0135] The standard deviation of height is △HtSDS=+0.02.

[0136] 4. Liang*, boy, 6 years old, was 110cm (-1.7SD) tall and 19kg (-0.9SD) in weight before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 4 and a half months, his height was measured again and he was 112cm (-1.63SD) tall and 17.8kg (-1.48SD) in weight.

[0137] The converted height growth rate GV = 5.33cm / year, invalid;

[0138] The standard deviation of height is △HtSDS=+0.07.

[0139] Comparative Example 3

[0140] This comparative example provides a Chinese medicine composition for strengthening the spleen and increasing height, which differs from the Chinese medicine composition described in Example 1 in that no Pseudostellariae Radix, Citron and Panax Notoginseng components are added, and the remaining components, contents and methods of administration are the same.

[0141] Specific examples:

[0142] 1. Xie*, boy, 10 years old, before taking the Chinese medicine composition, his height was 132cm (-1.6SD), and his weight was 27.7kg (-1.2SD), belonging to a relatively short child. After taking the decoction for 6 and a half months, his height was measured again, 135cm (-1.51SD), and his weight was 29.6kg (-1.21SD);

[0143] The converted height growth rate GV = 5.53cm / year, invalid;

[0144] The standard deviation of height is △HtSDS=+0.09.

[0145] 2. Feng*, a 5-year-old boy, was 102.5 cm (-1.9 SD) tall and weighed 15.9 kg (-1.4 SD) before taking the Chinese medicine composition. He was a relatively short child. After taking the decoction for 2 months, his height was measured again and was 103.4 cm (-1.98 SD) tall and weighed 16.45 kg (-1.32 SD).

[0146] The converted height growth rate GV = 5.4cm / year, invalid;

[0147] The standard deviation of height is △HtSDS=-0.08.

[0148] 3. Huang*, boy, 11 years old, before taking the Chinese medicine composition, his height was 141.1 cm (-1.5SD), and his weight was 25.2 kg (-2.7SD), belonging to a relatively short child. After taking the decoction for 4 months, his height was measured again, 143.1 cm (-1.56SD), and his weight was 26.05 kg (-2.68SD);

[0149] The height growth rate GV = 6cm / year, just reached the effective level;

[0150] The standard deviation of height is △HtSDS=-0.06.

[0151] 4. Chen*, girl, 8 years old, was 115.4cm (-2.63SD) tall and weighed 17kg (-2.89SD) before taking the Chinese medicine composition. She was a relatively short child. After taking the decoction for 2 and a half months, her height was measured again and was 115.8cm (-2.7SD) tall and weighed 17.6kg (-2.73SD).

[0152] The converted height growth rate GV = 2.4cm / year, invalid;

[0153] The standard deviation of height is △HtSDS=-0.07.

[0154] It can be seen from the results of the embodiments and comparative examples that the present invention selects 9 kinds of Chinese herbal medicines with the effects of strengthening the spleen and replenishing qi, harmonizing the stomach and promoting digestion, promoting blood circulation and unblocking meridians, and tonifying the kidney and strengthening bones, including Panax notoginseng, Achyranthes bidentata, Ophiopogon japonicus, Rhizoma Cibotii, Astragalus membranaceus, Citron, Atractylodes macrocephala, Radix Pseudostellariae and Rice sprouts for scientific compounding. The medicines complement and complement each other and synergize to enhance the effect, so that the prepared Chinese medicine composition can fully regulate the efficiency of nutrient absorption and material conversion of the human digestive system, thereby promoting the growth and development of human bones and other systems, and achieving the purpose of treating short stature (or short stature). When one or several of the specified Chinese medicine ingredients in the Chinese medicine composition are missing, the spleen-strengthening and height-increasing effects of the Chinese medicine composition will be significantly affected, thereby failing to effectively treat the symptoms of short stature.

[0155] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A Chinese medicine composition for strengthening the spleen and increasing height, characterized in that: The traditional Chinese medicine composition comprises the following components: Panax notoginseng, Achyranthes bidentata, Radix Ophiopogonis, Radix Astragali ... Citron, Atractylodes macrocephala, Radix Pseudostellariae and rice sprouts.

2. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition comprises the following components in parts by weight: 3-5 parts of Panax notoginseng, 8-15 parts of Achyranthes bidentata, 8-10 parts of Radix Ophiopogonis, 5-10 parts of Rhizoma Cibotii, 10-15 parts of Radix Astragali, 8-10 parts of Citron, 10-15 parts of Atractylodes macrocephala, 5-10 parts of Radix Pseudostellariae and 10-15 parts of Rice sprouts.

3. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition comprises the following components in parts by weight: 3 parts of Panax notoginseng, 10 parts of Achyranthes bidentata, 8 parts of Radix Ophiopogonis, 10 parts of Rhizoma Cibotii, 10 parts of Radix Astragali, 8 parts of Citron, 10 parts of Atractylodes macrocephala, 10 parts of Radix Pseudostellariae and 15 parts of Rice sprouts.

4. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The traditional Chinese medicine composition also includes at least one of the following components in parts by weight: 5-10 parts of licorice, 8-10 parts of raw cornus fruit, 8-10 parts of yam, 3-5 parts of angelica dahurica, 8-10 parts of Poria cocos, 10-12 parts of Polygonum multiflorum, 8-10 parts of Chinese yam, 3-5 parts of white peony root, 5-10 parts of Uncaria rhynchophylla, and 3-5 parts of black plum.

5. The Chinese medicine composition according to claim 4, characterized in that: The traditional Chinese medicine composition further comprises the following components in parts by weight: 5-10 parts of liquorice or 8-10 parts of raw cornus fruit.

6. The Chinese medicine composition according to claim 5, characterized in that: The traditional Chinese medicine composition further comprises the following components in parts by weight: 10 parts of liquorice or 8 parts of raw cornus fruit.

7. The Chinese medicine composition according to any one of claims 1 to 6, characterized in that: The Chinese medicine composition is prepared by a decoction method, specifically, adding water to the medicinal materials and soaking them for 15-25 minutes, wherein the amount of water added is 8-12 times the total weight of the medicinal materials, and then decocting them twice, each time for 0.5-1.5 hours, combining the extracts, filtering, and obtaining the Chinese medicine composition.

8. The Chinese medicine composition according to any one of claims 1 to 6, characterized in that: The dosage form of the Chinese medicine composition includes one of aqueous solution, ointment, pill, tablet and granule.

9. Use of the Chinese medicine composition according to any one of claims 1 to 6 in the preparation of medicines or health products for strengthening the spleen and increasing height.

10. A Chinese medicine preparation for strengthening the spleen and increasing height, characterized in that: The traditional Chinese medicine preparation comprises the traditional Chinese medicine composition according to any one of claims 1 to 6 and a medically acceptable carrier.