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A method of enhancing performance in broiler chickens

A broiler chicken, performance technology, applied in the fields of application, metabolic diseases, animal feed, etc., can solve the problems of feed intake and feed conversion rate, weight gain, etc.

Pending Publication Date: 2015-01-14
INTERVET INT BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results showed that daily body weight gain, feed intake and feed conversion ratio were not significantly affected by administration of racopamine to broiler chicks
[0014] Towhidi et al. (The 3rd International Conference on Sustainable Agriculture for Developing Countries, 26-29 July 2011, pg 210) disclosed that zilpaterol supplementation of Japanese quail diets resulted in improved feed conversion but no weight gain, ultimately Significant differences in body weight, feed intake and carcass, thigh, breast, liver and carcass weights

Method used

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  • A method of enhancing performance in broiler chickens
  • A method of enhancing performance in broiler chickens
  • A method of enhancing performance in broiler chickens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Broiler chicks were fed zilpaterol daily at 1 ppm from 8 days to 56 days of age. Relatively small performance responses were observed with zilpaterol. In this study, no significant performance gains were reported, namely average daily gain (ADG) of 1.3-2.6% and feed efficiency (FE) of 0.6%-1.9%. However, when Zipateroda was fed daily at 1 ppm for 7 weeks, carcass was significantly (P<0.01) 2% higher compared to the control.

Embodiment 2

[0085] Broiler chickens were fed zilpaterol hydrochloride in a 42-day groundspheric study to evaluate the performance response of zilpaterol compared to a non-medicated control group. Six zilpaterol treatment groups consisted of three concentration levels (1, 3 and 5 ppm) and two feeding durations (7 and 14 days) and were administered in the feed and a non-medicated control group. A total of 1,680 broiler chicks were divided by sex into 56 pens, 30 birds / pen and 4 pens / sex / group (240 birds / group). 7-day zilpaterol treatment started at age 35 days and continued until age 42 days. The 14-day zilpaterol treatment started at age 28 days and continued until age 42 days. There were no significant differences in mean pre-treatment body weight between all groups (6 zilpaterol-treated and control groups).

[0086] After treatment, there were no statistically significant 2-factor or 3-factor interactions of sex with treatment duration and concentration; therefore, pooled results on se...

Embodiment 3

[0120] Zipaterol hydrochloride was fed to broiler chickens in the 42-day ground circle study as described above in Example 2, except for the following. There were zilpaterol treatment groups at seven concentration levels (0, 1, 3, 5, 7, 9, 11 and 13 ppm) and three feeding durations (7, 14 or 21 days). Zipaterol was administered in the feed, except for a control group that did not contain the drug. Zipaterol-treated groups started feeding at 21, 28 or 35 days of age. On day 21, feeding zilpaterol occurred for 21 or 14 days. On day 28, feeding with zilpaterol occurred for 14 or 7 days. Finally, on day 35, feeding zilpaterol begins for 7 days or longer if desired for larger birds to target sell-off weight. Within each feeding group, there were seven subgroups, one for each concentration level. For each group / subgroup, body weight and other performance characteristics were measured at the end of the feeding period as specified.

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Abstract

A method of enhancing the performance of chicken comprising administering zilpaterol to the chicken wherein the concentration of zilpaterol is from about 1 ppm to about 13 ppm and is administered every day for a period of about 7 to about 21 days.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application Serial No. 61 / 648,793, filed May 18, 2012, the contents of which are hereby incorporated by reference in their entirety. Background of the invention [0003] Zipaterol is a known adrenergic beta-2 agonist that corresponds structurally to formula (I): [0004] (I). [0005] The IUPAC name for zilpaterol is 4,5,6,7-tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk]-[1]benzazepine Cycloheptatrien-2(1H)-one. The Chemical Abstracts name for zilpaterol is 4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methyl-ethyl)amino]-imidazo[4,5,1-jk] [1] Benzazepine-2(1H)-one. [0006] Zipaterol hydrochloride by Merck Animal Health, under the trademark ZILMAX ? down sale. Approved in the United States for increasing rate of weight gain, improving feed efficiency, and increasing carcass leanness in cattle fed in confinement that are slaughtered during the last 20 to 40 day...

Claims

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Application Information

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IPC IPC(8): A23K1/00A23K1/16A23K1/18
CPCA23K1/1826A23K1/1628A61K31/55A23K20/137A23K50/75A61P3/00A23K20/00A23K20/111
Inventor J.A.罗格斯
Owner INTERVET INT BV
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