29 results about "Ionophore" patented technology

Embodiments herein relate to an optical chemical sensor system that is wearable and includes a microneedle array. In one embodiment, the invention includes a chemical sensing device having a set of microneedles and sensor elements. The sensor element may include a first low refractive index gel layer, a second low refractive index gel layer, and a chromogenic ionophore sensing film disposed between the first low refractive index gel layer and the second low refractive index gel layer. In one embodiment, a retardation layer may be disposed between the sensor element and a set of microneedles. An optical emitter may be configured to emit light into the sensor element. An optical detector may be configured to receive light from the sensor element. Other embodiments are also included herein.

This invention discloses a low-leakage, high-stability magnetic sludge biochar adsorbent, its preparation method, and its application, comprising the following steps: S1: preparing a sludge biochar matrix from dewatered sludge; S2: mixing the sludge biochar matrix obtained in step S1 with nano-magnetic powder, and performing high-energy ball milling under an inert atmosphere to obtain a composite powder with a physically interlocked structure, thereby preparing the low-leakage, high-stability magnetic sludge biochar adsorbent. This invention provides a structurally stable, high-adsorption-performance, and environmentally friendly magnetic sludge biochar adsorbent that can effectively remove polyether ionocarrier antibiotics (such as maduramycin) from water, showing promising practical application prospects and environmental benefits.

Disclosed herein are assays, methods, and devices for detecting a target ion via ionophore-based ion-selective sensing using Surface Enhanced Raman Spectroscopy (SERS). For example, disclosed herein are assays for detection of a target ion via SERS, the assays comprising: an ionophore, a nanostructured metal, an ion exchanger, and an indicator, wherein the ionophore comprises a binding portion configured to bind with the target ion, wherein the nanostructured metal is configured to enhance a Raman signal of at least a portion of the indicator, wherein the Raman signal changes when the target ion is bound to the ionophore. Also disclosed herein are methods, for example, comprising contacting any of the assays described herein with a liquid sample; subsequently collecting a surface enhanced Raman signal from the liquid sample and the assay; and processing the surface enhanced Raman signal to determine a property of the liquid sample.

The present invention provides an antifouling lead ion selective electrode prepared using dendritic polypeptides, which belongs to the technical field of marine pollution detection. The present invention first electrodeposit polyaniline (PANI) nanowires on a glassy carbon substrate to form a GC / PANI substrate, then prepare MXene nanosheets and composite them with PANI to form GC / PANI-MXene, and then drop lead ion carrier Pb onto the GC / PANI-MXene. 2+ ‑ISM, and finally the electrode surface was modified with dendrimer peptides to obtain GC / PANI‑MXene / Pb 2+ -ISM / pep electrode. The electrode prepared by the present invention can inhibit the adhesion of nonspecific microorganisms and has excellent stability.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

The invention discloses a bionic hybrid nano regulator for enhancing cell copper death and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The invention designs a bionic nano-platform which simultaneously loads a lactic acid regulator cyclostilbene Su 3118 and a copper ion carrier disulfiram DSF, and the bionic nano-platform is combined with hybrid macrophages and tumor cell membranes to construct a nano-regulator SCTDM. The nano regulator can exert multiple functions, including tumor targeting, in-situ photothermal therapy, lactic acid regulation and enhanced copper death. The nano regulator provided by the invention is simple and convenient to manufacture, is combined with in-situ photothermal therapy and lactic acid regulation and is used for enhancing cell death immunotherapy of copper death so as to eliminate primary tumors and delay relapse, and a technical support is provided for regulating immunity by enhancing copper-induced cell death through metabolic reprogramming.

The present invention provides: a culture medium composition which contains an iron ionophore, and which is for promoting the production of viruses each carrying a target gene or for improving the proportion of viruses each carrying the target gene with respect to all of produced viruses in the culturing of mammalian cells having the target gene introduced therein and having virus production capability; and others.

The invention relates to the technical field of ion selective electrode materials, and particularly discloses a functional polymer film for a chloride ion selective electrode and a preparation method of the functional polymer film. The functional polymer film comprises a polymer skeleton and a covalently grafted nitrogen-containing basic functional group, the polymer skeleton is selected from polyvinyl chloride, carboxylated polyvinyl chloride and other polymers, and the nitrogen-containing basic functional group is a tertiary amine group or an arylamine group and is connected with the skeleton through an amido bond, an ester bond or a polymeric chain segment. Converting into a quaternary ammonium salt structure through a quaternization reagent; the preparation method comprises the following steps: firstly, carrying out catalytic grafting reaction on the functional monomer and the polymer skeleton in an organic solvent through an initiator, then carrying out spin coating or curtain coating to form a film, drying, activating and finally carrying out quaternization treatment. The composition can be used for constructing a long-acting chloride ion selective electrode, and has the advantages of zero dissolution of an ion carrier, high selectivity and strong mechanical stability; in addition, the preparation method provided by the invention can realize controllable distribution of sites.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

An example sensor includes a conductive electrode and an ion-selective membrane over the conductive electrode. The ion-selective membrane includes an ionophore that is selective for ionized magnesium (iMg) and at least two types of anionic lipophilic salts. The at least two types of anionic lipophilic salts may include one or more fluorinated borate salts and one or more chlorinated borate salts.

The application discloses a high-sensitivity ammonium ion electrochemical sensor and application thereof, and belongs to the technical field of electrochemical sensors.The electrochemical sensor comprises a full-solid-state ammonium ion selective electrode, the electrode comprises an electrically conductive base, a solid-state contact layer and an ammonium ion sensitive film arranged in sequence, the electrically conductive base is a silk screen printed carbon electrode with copper nanoparticles on the surface; the solid-state contact layer is composed of a polyaniline and reduced graphene oxide composite; and the composition of the ammonium ion sensitive film comprises polydopamine and an ammonium ion carrier.The characteristics of the above-mentioned modified materials expand the linear detection range of the sensor to ammonium ions, improve the sensitivity, and can sensitively detect 10 ‑7 ~ 10 ‑1 M ammonium ion concentrations, and have good application prospects in the fields of on-site rapid detection of low-concentration ammonium ions in environmental water, aquaculture water and seawater.

Described herein are gloves having antimicrobial properties, as well as compositions (e.g., coagulant formulations) and methods for producing such gloves. In some embodiments, the gloves comprise an ionophore-ion functional group complex (e.g., Ca2+- carboxylate complex) at the outer surface, which imparts antimicrobial properties to the gloves.

Synthetic ionophores for the active carry and transport of free ions across biological membranes in vivo, comprising coordination complexes of molecules with polarized hexa-aqua and / or tetra-aqua systems of free ionic metals and ionic salts as the ionophores, useful in transporting pharmaceutical, nutrient, and personal healthcare compounds. Also described are methods of their administration, methods of their synthesis and manufacture, and the ionophore products of such synthesis and manufacturing methods.

This invention discloses a biomimetic nanofluidic sensing membrane, its preparation method, and its applications. The biomimetic nanofluidic sensing membrane comprises a top supporting lipid bilayer membrane and a bottom anodic aluminum oxide membrane with a macroporous structure. A portion of the supporting lipid bilayer membrane corresponds to and communicates with some macropores in the anodic aluminum oxide membrane. An ion carrier is embedded in the supporting lipid bilayer membrane, and its surface is modified with cholesterol-modified aptamers and polyethylene glycol. This invention utilizes the lateral fluidity of the supporting lipid bilayer to achieve multivalent and efficient capture of aptamers. The natural antifouling properties of phospholipids and the steric hindrance of polyethylene glycol synergistically suppress non-specific adsorption, and the detection signal is amplified by the ion current rectification effect induced by the asymmetric structure. The detection limit for TNF-α is as low as 0.219 pM, and with machine learning, it can accurately distinguish six proteins. The preparation method is simple, and the detection sensitivity and specificity are high, showing broad application prospects in early disease diagnosis and high-throughput protein analysis.

This disclosure provides a method for lithium extraction from brine by electrochemical adsorption and its application. The method includes: placing an electrode containing a low-lithium lithium ion carrier as the cathode electrode in the middle of the brine; adding a lithium ion adsorbent to the brine to enrich the lithium ions in the brine; centrifugally stirring the brine and energizing the electrode to obtain an electrode containing a lithium-rich lithium ion carrier. This disclosure utilizes a lithium ion adsorbent to enrich lithium ions in the brine pool, cleverly employing external force to move the lithium ion adsorbent material, transporting the lithium ion adsorbent to the vicinity of the electrode to form a lithium-rich region. This significantly shortens the distance from the lithium ions to the electrode, thereby improving lithium extraction efficiency and greatly saving extraction time.

Synthetic ionophores for the active carry and transport of free ions across biological membranes in vivo, comprising coordination complexes of molecules with polarized hexa-aqua and / or tetra-aqua syst

Described a coagulant formulation for use in the preparation of a material that is formed by dipping, wherein the formulation includes a lipophilic and / or amphiphilic polymeric ionophore:ion complex wherein the polymeric ionophore is a hydrophilic and / or amphiphilic polymer and wherein the polymeric ionophore:ion complex imparts antimicrobial and / or antiviral properties to the material.

The present invention relates to the use of neocuproine, elesclomol, disulfiram and / or dithiocarbamate for use in treatment of cancer, optionally in combination with MAPK-pathway inhibitors in cancers carrying mutations that are recognized as MAPK-pathway activating mutations.

Disclosed herein are assays, methods, and devices for detecting a target ion via ionophore-based ion-selective sensing using Surface Enhanced Raman Spectroscopy (SERS). For example, disclosed herein are assays for detection of a target ion via SERS, the assays comprising: an ionophore, a nanostructured metal, an ion exchanger, and an indicator, wherein the ionophore comprises a binding portion configured to bind with the target ion, wherein the nanostructured metal is configured to enhance a Raman signal of at least a portion of the indicator, wherein the Raman signal changes when the target ion is bound to the ionophore. Also disclosed herein are methods, for example, comprising contacting any of the assays described herein with a liquid sample; subsequently collecting a surface enhanced Raman signal from the liquid sample and the assay; and processing the surface enhanced Raman signal to determine a property of the liquid sample.

The present invention is directed to novel resistance modifying agents (RMAs) compounds configured to potentiate antibiotic compounds, such as polymyxin antibiotics, including colistin, directed to multi-drug resistance (MDR) gram-negative bacteria.

Provided herein are devices and methods for continuously measuring the concentration of a target analyte in an in vivo biological fluid. In some examples, the device includes an indwelling sensor and sensor electronics. The sensor may include a substrate, a first electrode disposed on the substrate, an ionophore disposed on the substrate and configured to selectively transport a target ion to or within the first electrode, and a second electrode disposed on the substrate. The sensor electronics are configured to generate a signal corresponding to an electromotive force based at least in part on a potential difference generated between the first electrode and the second electrode in response to the ionophore transporting the target ion to the first electrode.

An example sensor includes a conductive electrode and an ion-selective membrane over the conductive electrode. The ion-selective membrane includes an ionophore that is selective for ionized magnesium (iMg) and at least two types of anionic lipophilic salts. The at least two types of anionic lipophilic salts may include one or more fluorinated borate salts and one or more chlorinated borate salts.

The invention relates to a pyrido [1, 2-a] pyrimidine mesoion derivative containing a sulfoxide structure as well as a preparation method and application of the pyrido [1, 2-a] pyrimidine mesoion derivative. The compound disclosed by the invention has a structure as shown in a formula (I), has excellent insecticidal activity on Frankliniella occidentalis, Sogatella furcifera, aphid, Spodoptera frugiperda, Plutella xylostella, Chilo suppressalis, Prodenia litura, armyworm and the like, and can be used for drugs or medicaments for preventing and treating pests such as Frankliniella occidentalis, Sogatella furcifera, aphid, Spodoptera frugiperda, Plutella xylostella, Chilo suppressalis, Prodenia litura, armyworm and the like. The structure and the preparation process are simple, and the production cost is low. (I)

A functionalized metal / carbon nanotube-based electrified nanoporous membrane with a cooperative nitrite-enriching component to achieve energy-efficient ammonia production from low-concentration nitrate. The use of flow-through electrofiltration reduces energy consumption and treatment time. Integrating an ionophore as a cooperative component into the conductive filtration membrane enriches nitrite within the catalyst microenvironment, enabling conversion of unreacted NO2- to NH3 to enhance overall selectivity without directly modifying the catalytic active sites.

Disclosed is the use of copper ionophores for overcoming or inhibiting the development of resistance of a gram-positive bacterium to an antibiotic. More particularly, this disclosure relates to the use of a thiosemicarbazone, elesclomol or nitroxoline or a pharmaceutically acceptable salt or solvate thereof for conferring antibiotic sensitivity to a resistant gram-positive bacterium, inhibiting the development of resistance of a gram-positive bacterium to an antibiotic, increasing the susceptibility of a gram-positive bacterium to an antibiotic and / or treating or inhibiting the development of a gram-positive bacterial infection in a subject. Also provided is the use of a thiosemicarbazone, elesclomol or nitroxoline or a pharmaceutically acceptable salt or solvate thereof as an antibiotic adjuvant or potentiator.

A pharmaceutical or dietary composition containing zinc combined with at least one zinc ionophore, magnesium, vitamin B6, and vitamin D, and usable for blocking the production of polypeptides by ribosomes. According to the invention, this composition can be used to block viral replication, bacterial multiplication, and / or cancer cells.

The invention belongs to the technical field of plant deodorization distillate treatment, and provides an iron-tannin foam adsorbent for deodorization distillate purification and a preparation method and application thereof.The preparation method comprises the following steps that waxberry tannin is dissolved in water, then a cross-linking agent and a cross-linking catalyst are added for primary stirring, then a nonionic surfactant is added, and the mixture is stirred to be uniform; the rotating speed is increased for secondary stirring, full foaming is performed until the volume is stable, then curing is performed, and tannin foam is obtained; the tannin foam and the iron ion solution are mixed and stirred, and the iron-tannin foam adsorbent is obtained. Porous tannin foam rich in phenolic hydroxyl groups is adopted as an iron ion carrier, FeCl3. 6H2O is selected as a precursor of iron ions, the iron ions are uniformly anchored to a tannin foam framework through a chelation reaction, and the composite material with the tannin foam loaded with the iron ions is successfully prepared. The preparation method is simple and easy to implement, the uniform dispersion of iron ions is effectively ensured, and a relatively high removal effect on tebuconazole in the DD oil is achieved.

The invention relates to a pyrido [1, 2-a] pyrimidine mesoion derivative containing a diaryl sulfide structure as well as a preparation method and application of the pyrido [1, 2-a] pyrimidine mesoion derivative. The compound disclosed by the invention has a structure shown as a formula (I), has excellent insecticidal activity on spodoptera frugiperda, chilo suppressalis, plutella xylostella, ostrinia nubilalis and the like, and can be used for preparing drugs or medicaments for preventing and treating pests such as spodoptera frugiperda, chilo suppressalis, plutella xylostella, ostrinia nubilalis and the like. The structure and the preparation process are simple, and the production cost is low. (I)