46 results about "Ionophore" patented technology

Embodiments herein relate to an optical chemical sensor system that is wearable and includes a microneedle array. In one embodiment, the invention includes a chemical sensing device having a set of microneedles and sensor elements. The sensor element may include a first low refractive index gel layer, a second low refractive index gel layer, and a chromogenic ionophore sensing film disposed between the first low refractive index gel layer and the second low refractive index gel layer. In one embodiment, a retardation layer may be disposed between the sensor element and a set of microneedles. An optical emitter may be configured to emit light into the sensor element. An optical detector may be configured to receive light from the sensor element. Other embodiments are also included herein.

The invention discloses a covalent organic framework membrane material encapsulated with an ion carrier and a preparation method and application thereof. The covalent organic framework membrane material comprises a subject and an object, and the subject surrounds the object to encapsulate the object inside; the main body is a covalent organic framework membrane material which is obtained by carrying out condensation polymerization on an amino-functionalized monomer A and an aldehyde-group-functionalized monomer B and is shown as a formula (I) # imgabs0 #, the number x of amino groups of the monomer A is equal to the number y of aldehyde groups of the monomer B, and the sum of the functionality of the monomer A and the functionality of the monomer B is greater than or equal to 2. According to the invention, identification and separation of specific ions can be realized, and transmembrane transmission of the specific ions can be efficiently realized. The membrane preparation method is simple and stable, and the prepared membrane product can stably operate for a long time and maintain a constant separation ratio.

This invention discloses a low-leakage, high-stability magnetic sludge biochar adsorbent, its preparation method, and its application, comprising the following steps: S1: preparing a sludge biochar matrix from dewatered sludge; S2: mixing the sludge biochar matrix obtained in step S1 with nano-magnetic powder, and performing high-energy ball milling under an inert atmosphere to obtain a composite powder with a physically interlocked structure, thereby preparing the low-leakage, high-stability magnetic sludge biochar adsorbent. This invention provides a structurally stable, high-adsorption-performance, and environmentally friendly magnetic sludge biochar adsorbent that can effectively remove polyether ionocarrier antibiotics (such as maduramycin) from water, showing promising practical application prospects and environmental benefits.

The utility model relates to a device for determining the concentration of certain ions in a blood sample, comprising: a top layer of a membrane (1) capable of filtering out all components in the sample other than plasma; an intermediate layer of glass fibers (2) coated with an ion-selective complex comprising an ionophore (10), a cation exchanger (11) and a dye (12) for promoting the exchange between the certain ions (13) in the plasma and the dye (12); and a bottom layer comprising a millifluid channel (4) along which the dye can travel, where a distance (16) traveled by the dye is indicative of the concentration of the certain ions in the sample.

Disclosed herein are assays, methods, and devices for detecting a target ion via ionophore-based ion-selective sensing using Surface Enhanced Raman Spectroscopy (SERS). For example, disclosed herein are assays for detection of a target ion via SERS, the assays comprising: an ionophore, a nanostructured metal, an ion exchanger, and an indicator, wherein the ionophore comprises a binding portion configured to bind with the target ion, wherein the nanostructured metal is configured to enhance a Raman signal of at least a portion of the indicator, wherein the Raman signal changes when the target ion is bound to the ionophore. Also disclosed herein are methods, for example, comprising contacting any of the assays described herein with a liquid sample; subsequently collecting a surface enhanced Raman signal from the liquid sample and the assay; and processing the surface enhanced Raman signal to determine a property of the liquid sample.

The present invention provides an antifouling lead ion selective electrode prepared using dendritic polypeptides, which belongs to the technical field of marine pollution detection. The present invention first electrodeposit polyaniline (PANI) nanowires on a glassy carbon substrate to form a GC / PANI substrate, then prepare MXene nanosheets and composite them with PANI to form GC / PANI-MXene, and then drop lead ion carrier Pb onto the GC / PANI-MXene. 2+ ‑ISM, and finally the electrode surface was modified with dendrimer peptides to obtain GC / PANI‑MXene / Pb 2+ -ISM / pep electrode. The electrode prepared by the present invention can inhibit the adhesion of nonspecific microorganisms and has excellent stability.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

The invention discloses a bionic hybrid nano regulator for enhancing cell copper death and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The invention designs a bionic nano-platform which simultaneously loads a lactic acid regulator cyclostilbene Su 3118 and a copper ion carrier disulfiram DSF, and the bionic nano-platform is combined with hybrid macrophages and tumor cell membranes to construct a nano-regulator SCTDM. The nano regulator can exert multiple functions, including tumor targeting, in-situ photothermal therapy, lactic acid regulation and enhanced copper death. The nano regulator provided by the invention is simple and convenient to manufacture, is combined with in-situ photothermal therapy and lactic acid regulation and is used for enhancing cell death immunotherapy of copper death so as to eliminate primary tumors and delay relapse, and a technical support is provided for regulating immunity by enhancing copper-induced cell death through metabolic reprogramming.

The present invention provides: a culture medium composition which contains an iron ionophore, and which is for promoting the production of viruses each carrying a target gene or for improving the proportion of viruses each carrying the target gene with respect to all of produced viruses in the culturing of mammalian cells having the target gene introduced therein and having virus production capability; and others.

The invention relates to the technical field of ion selective electrode materials, and particularly discloses a functional polymer film for a chloride ion selective electrode and a preparation method of the functional polymer film. The functional polymer film comprises a polymer skeleton and a covalently grafted nitrogen-containing basic functional group, the polymer skeleton is selected from polyvinyl chloride, carboxylated polyvinyl chloride and other polymers, and the nitrogen-containing basic functional group is a tertiary amine group or an arylamine group and is connected with the skeleton through an amido bond, an ester bond or a polymeric chain segment. Converting into a quaternary ammonium salt structure through a quaternization reagent; the preparation method comprises the following steps: firstly, carrying out catalytic grafting reaction on the functional monomer and the polymer skeleton in an organic solvent through an initiator, then carrying out spin coating or curtain coating to form a film, drying, activating and finally carrying out quaternization treatment. The composition can be used for constructing a long-acting chloride ion selective electrode, and has the advantages of zero dissolution of an ion carrier, high selectivity and strong mechanical stability; in addition, the preparation method provided by the invention can realize controllable distribution of sites.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

Polycation carrier particles obtained by polymerizing one or more multiacrylate monomers with one or more hydrophilic monomers to form a crosslink. The polycation carrier particles have a net positive charge. The multiacrylate monomer and the hydrophilic monomer(s) are as defined herein.

The present invention is directed to novel resistance modifying agents (RMAs) compounds configured to potentiate antibiotic compounds, such as polymyxin antibiotics, including colistin, directed to multi-drug resistance (MDR) gram-negative bacteria.

An example sensor includes a conductive electrode and an ion-selective membrane over the conductive electrode. The ion-selective membrane includes an ionophore that is selective for ionized magnesium (iMg) and at least two types of anionic lipophilic salts. The at least two types of anionic lipophilic salts may include one or more fluorinated borate salts and one or more chlorinated borate salts.

The application discloses a high-sensitivity ammonium ion electrochemical sensor and application thereof, and belongs to the technical field of electrochemical sensors.The electrochemical sensor comprises a full-solid-state ammonium ion selective electrode, the electrode comprises an electrically conductive base, a solid-state contact layer and an ammonium ion sensitive film arranged in sequence, the electrically conductive base is a silk screen printed carbon electrode with copper nanoparticles on the surface; the solid-state contact layer is composed of a polyaniline and reduced graphene oxide composite; and the composition of the ammonium ion sensitive film comprises polydopamine and an ammonium ion carrier.The characteristics of the above-mentioned modified materials expand the linear detection range of the sensor to ammonium ions, improve the sensitivity, and can sensitively detect 10 ‑7 ~ 10 ‑1 M ammonium ion concentrations, and have good application prospects in the fields of on-site rapid detection of low-concentration ammonium ions in environmental water, aquaculture water and seawater.

Described herein are gloves having antimicrobial properties, as well as compositions (e.g., coagulant formulations) and methods for producing such gloves. In some embodiments, the gloves comprise an ionophore-ion functional group complex (e.g., Ca2+- carboxylate complex) at the outer surface, which imparts antimicrobial properties to the gloves.

Synthetic ionophores for the active carry and transport of free ions across biological membranes in vivo, comprising coordination complexes of molecules with polarized hexa-aqua and / or tetra-aqua systems of free ionic metals and ionic salts as the ionophores, useful in transporting pharmaceutical, nutrient, and personal healthcare compounds. Also described are methods of their administration, methods of their synthesis and manufacture, and the ionophore products of such synthesis and manufacturing methods.

This invention discloses a biomimetic nanofluidic sensing membrane, its preparation method, and its applications. The biomimetic nanofluidic sensing membrane comprises a top supporting lipid bilayer membrane and a bottom anodic aluminum oxide membrane with a macroporous structure. A portion of the supporting lipid bilayer membrane corresponds to and communicates with some macropores in the anodic aluminum oxide membrane. An ion carrier is embedded in the supporting lipid bilayer membrane, and its surface is modified with cholesterol-modified aptamers and polyethylene glycol. This invention utilizes the lateral fluidity of the supporting lipid bilayer to achieve multivalent and efficient capture of aptamers. The natural antifouling properties of phospholipids and the steric hindrance of polyethylene glycol synergistically suppress non-specific adsorption, and the detection signal is amplified by the ion current rectification effect induced by the asymmetric structure. The detection limit for TNF-α is as low as 0.219 pM, and with machine learning, it can accurately distinguish six proteins. The preparation method is simple, and the detection sensitivity and specificity are high, showing broad application prospects in early disease diagnosis and high-throughput protein analysis.

This disclosure provides a method for lithium extraction from brine by electrochemical adsorption and its application. The method includes: placing an electrode containing a low-lithium lithium ion carrier as the cathode electrode in the middle of the brine; adding a lithium ion adsorbent to the brine to enrich the lithium ions in the brine; centrifugally stirring the brine and energizing the electrode to obtain an electrode containing a lithium-rich lithium ion carrier. This disclosure utilizes a lithium ion adsorbent to enrich lithium ions in the brine pool, cleverly employing external force to move the lithium ion adsorbent material, transporting the lithium ion adsorbent to the vicinity of the electrode to form a lithium-rich region. This significantly shortens the distance from the lithium ions to the electrode, thereby improving lithium extraction efficiency and greatly saving extraction time.

Synthetic ionophores for the active carry and transport of free ions across biological membranes in vivo, comprising coordination complexes of molecules with polarized hexa-aqua and / or tetra-aqua syst

Described a coagulant formulation for use in the preparation of a material that is formed by dipping, wherein the formulation includes a lipophilic and / or amphiphilic polymeric ionophore:ion complex wherein the polymeric ionophore is a hydrophilic and / or amphiphilic polymer and wherein the polymeric ionophore:ion complex imparts antimicrobial and / or antiviral properties to the material.

Compounds, compositions and their use in the treatment of a human copper deficiency or proliferative disease or condition, for instance the proliferative disease or disorder may have intracellular copper levels sensitivity. Also described in the use of a copper ionophore for the treatment of an SF3B1-mutated cancer. The compounds disclosed are of Formula (I), wherein A, R1 to R4, X1 to X3 and are as defined herein:

The present invention relates to the use of neocuproine, elesclomol, disulfiram and / or dithiocarbamate for use in treatment of cancer, optionally in combination with MAPK-pathway inhibitors in cancers carrying mutations that are recognized as MAPK-pathway activating mutations.

Disclosed herein are assays, methods, and devices for detecting a target ion via ionophore-based ion-selective sensing using Surface Enhanced Raman Spectroscopy (SERS). For example, disclosed herein are assays for detection of a target ion via SERS, the assays comprising: an ionophore, a nanostructured metal, an ion exchanger, and an indicator, wherein the ionophore comprises a binding portion configured to bind with the target ion, wherein the nanostructured metal is configured to enhance a Raman signal of at least a portion of the indicator, wherein the Raman signal changes when the target ion is bound to the ionophore. Also disclosed herein are methods, for example, comprising contacting any of the assays described herein with a liquid sample; subsequently collecting a surface enhanced Raman signal from the liquid sample and the assay; and processing the surface enhanced Raman signal to determine a property of the liquid sample.

The present invention discloses an intelligent responsive copper-death nanomedicine, its preparation and anti-tumor application. The intelligent responsive copper-death nanomedicine is obtained by loading a copper ion carrier in an intelligent responsive nanocarrier. The intelligent responsive nanocarrier uses copper nanoparticles as the core, and its outer layer is wrapped with a shell of organic mesoporous silica containing X-ray responsive double bonds, and the shell is modified with an acid-responsive polymer. The intelligent responsive nanocarrier has multiple responsive stimulation effects, which can change the charge carried by the drug-carrying system and increase the amount of drug administered into the cell; and has a drug delivery system with good targeting and spatiotemporal controlled release, which can reduce the toxic and side effects of drug molecules on other normal tissues and achieve precise treatment of tumors. The intelligent responsive copper-death nanomedicine can combine the metabolic therapy controlled by copper death with immunotherapy, which will effectively improve tumor resistance, reduce the side effects of radiotherapy on the whole body, and improve the survival rate of patients.

This application belongs to the technical field of ion-selective electrodes, and specifically relates to a preparation method of a chloride ion-selective polymer membrane. The chloride ion-selective polymer membrane includes a chloride ion carrier, a high molecular polymer, a plasticizer, and an ion localizer. The ratio of the chloride ion carrier, the high molecular polymer, the plasticizer, and the ion localizer is 1-8:100-150:200-300:0.1-2. The chloride ion carrier is 4,5-dimethyl-3,6-dioctyloxy-o-phenylene-bis(mercuric trifluoroacetate), the high molecular polymer is polyvinyl chloride, the plasticizer is di-n-octyl sebacate, and the ion localizer is dodecylammonium chloride. When preparing, the ion localizer dodecylammonium chloride is added, so that the prepared chloride ion-selective polymer membrane is not interfered by other anions when detecting chloride ions.

The present invention is directed to novel resistance modifying agents (RMAs) compounds configured to potentiate antibiotic compounds, such as polymyxin antibiotics, including colistin, directed to multi-drug resistance (MDR) gram-negative bacteria.

The present invention relates to a selective membrane for separating desalinated water and a selected mineral salt from seawater or another high-salinity solution, wherein the selective membrane comprises a polysulfone layer and a salt separation layer, and wherein the salt separation layer comprises a polyamide layer comprising one or more ionophore. The invention also relates to a seawater reverse osmosis (SWRO) system comprising the selective membrane; as well as a system and method for recovering a selected mineral salt from seawater using the SWRO system. The invention further provides a method of making the selective membrane.

An ion-selective optical sensor for detecting potassium (K +) ions and a method of manufacturing an ion-selective sensor comprising the steps of: treating a surface of the sensor with (3-aminopropyl) triethoxysilane (APTES) and then with glutaraldehyde (GA); coating the APTES-GA surface with a crown ether ionophore to produce a functionalized layer; wherein when the functionalized layer is in contact with a target ion in the sample, a complex is formed between the crown ether and the target ion, thus changing the material index of the functionalized layer, the change corresponding to the concentration of the target ion in the sample.