55 results about "Ionophore" patented technology

Embodiments herein relate to an optical chemical sensor system that is wearable and includes a microneedle array. In one embodiment, the invention includes a chemical sensing device having a set of microneedles and sensor elements. The sensor element may include a first low refractive index gel layer, a second low refractive index gel layer, and a chromogenic ionophore sensing film disposed between the first low refractive index gel layer and the second low refractive index gel layer. In one embodiment, a retardation layer may be disposed between the sensor element and a set of microneedles. An optical emitter may be configured to emit light into the sensor element. An optical detector may be configured to receive light from the sensor element. Other embodiments are also included herein.

The invention discloses a covalent organic framework membrane material encapsulated with an ion carrier and a preparation method and application thereof. The covalent organic framework membrane material comprises a subject and an object, and the subject surrounds the object to encapsulate the object inside; the main body is a covalent organic framework membrane material which is obtained by carrying out condensation polymerization on an amino-functionalized monomer A and an aldehyde-group-functionalized monomer B and is shown as a formula (I) # imgabs0 #, the number x of amino groups of the monomer A is equal to the number y of aldehyde groups of the monomer B, and the sum of the functionality of the monomer A and the functionality of the monomer B is greater than or equal to 2. According to the invention, identification and separation of specific ions can be realized, and transmembrane transmission of the specific ions can be efficiently realized. The membrane preparation method is simple and stable, and the prepared membrane product can stably operate for a long time and maintain a constant separation ratio.

The invention relates to the technical field of electrochemistry, in particular to a supramolecular ionic liquid gel electrolyte of a solid-state zinc-iodine battery for a high-voltage platform, which is characterized in that free water in hydrogel is replaced by supramolecular interaction between ionic liquid and polyvinyl alcohol molecules to construct a water-poor ionic liquid polymer network; zinc bromide is introduced to serve as an ion carrier in a polymer network through the HofMichael effect, and preparation of the high-voltage solid-state zinc-iodine battery is finally achieved through the chemical coupling effect of bromide ions and iodide ions; the solid electrolyte is prepared from an ionic liquid and a hydrogel solution, imidazole cations of the ionic liquid have a strong electron withdrawing effect, and anions of the ionic liquid are combined with zinc ions and bromide ions to form polyanions. And the ionic liquid is used for replacing water in the hydrogel, so that the ionic liquid gel electrolyte with good chemical stability, mechanical property and electrochemical property is prepared.

The invention provides the use of a formulation containing cyclodextrine, quercetin and zinc, at appropriate concentrations to mitigate infections by enveloped viruses like SARS-COV-2, influenza and HIV / AIDS, when administered via pulmonary and dermal route. While the different forms of cyclodextrin prevent the entry of coated virus into host cells by extracting and sequestering cholesterol molecules at the virus coat and at the host cell plasma membrane, the natural plant-based ionophore quercetin in the formulation, enables cellular entry of zinc, inhibiting viral replication by altering polymerase activity in the host cell. Hence cyclodextrine, and quercetin plus zinc, either in combination or in tandem order of administration, serves both as prophylactic and therapeutic.

This invention discloses a low-leakage, high-stability magnetic sludge biochar adsorbent, its preparation method, and its application, comprising the following steps: S1: preparing a sludge biochar matrix from dewatered sludge; S2: mixing the sludge biochar matrix obtained in step S1 with nano-magnetic powder, and performing high-energy ball milling under an inert atmosphere to obtain a composite powder with a physically interlocked structure, thereby preparing the low-leakage, high-stability magnetic sludge biochar adsorbent. This invention provides a structurally stable, high-adsorption-performance, and environmentally friendly magnetic sludge biochar adsorbent that can effectively remove polyether ionocarrier antibiotics (such as maduramycin) from water, showing promising practical application prospects and environmental benefits.

The utility model relates to a device for determining the concentration of certain ions in a blood sample, comprising: a top layer of a membrane (1) capable of filtering out all components in the sample other than plasma; an intermediate layer of glass fibers (2) coated with an ion-selective complex comprising an ionophore (10), a cation exchanger (11) and a dye (12) for promoting the exchange between the certain ions (13) in the plasma and the dye (12); and a bottom layer comprising a millifluid channel (4) along which the dye can travel, where a distance (16) traveled by the dye is indicative of the concentration of the certain ions in the sample.

Disclosed herein are assays, methods, and devices for detecting a target ion via ionophore-based ion-selective sensing using Surface Enhanced Raman Spectroscopy (SERS). For example, disclosed herein are assays for detection of a target ion via SERS, the assays comprising: an ionophore, a nanostructured metal, an ion exchanger, and an indicator, wherein the ionophore comprises a binding portion configured to bind with the target ion, wherein the nanostructured metal is configured to enhance a Raman signal of at least a portion of the indicator, wherein the Raman signal changes when the target ion is bound to the ionophore. Also disclosed herein are methods, for example, comprising contacting any of the assays described herein with a liquid sample; subsequently collecting a surface enhanced Raman signal from the liquid sample and the assay; and processing the surface enhanced Raman signal to determine a property of the liquid sample.

The present invention provides an antifouling lead ion selective electrode prepared using dendritic polypeptides, which belongs to the technical field of marine pollution detection. The present invention first electrodeposit polyaniline (PANI) nanowires on a glassy carbon substrate to form a GC / PANI substrate, then prepare MXene nanosheets and composite them with PANI to form GC / PANI-MXene, and then drop lead ion carrier Pb onto the GC / PANI-MXene. 2+ ‑ISM, and finally the electrode surface was modified with dendrimer peptides to obtain GC / PANI‑MXene / Pb 2+ -ISM / pep electrode. The electrode prepared by the present invention can inhibit the adhesion of nonspecific microorganisms and has excellent stability.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

APPARATUS FOR TESTING A BLOOD SAMPLE FOR THE CONCENTRATION OF CERTAIN IONS THEREIN 5 The invention relates to an apparatus for testing a blood sample for the concentration of certain ions therein, comprising: a top layer of membrane (1) capable of filtering out all constituents of the sample except plasma; a middle layer of glass fibre (2) coated with an ion-selective complex which includes an ionophore (10), a cation exchanger (11) and a dye (12), for facilitating an interchange between 10 said certain ions (13) in the plasma and the dye (12); and a bottom layer which includes a milli-fluidic channel (4) along which the dye can travel, wherein the distance (16) travelled by the dye indicates the concentration of said certain ions in the sample. 15

The invention discloses a bionic hybrid nano regulator for enhancing cell copper death and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The invention designs a bionic nano-platform which simultaneously loads a lactic acid regulator cyclostilbene Su 3118 and a copper ion carrier disulfiram DSF, and the bionic nano-platform is combined with hybrid macrophages and tumor cell membranes to construct a nano-regulator SCTDM. The nano regulator can exert multiple functions, including tumor targeting, in-situ photothermal therapy, lactic acid regulation and enhanced copper death. The nano regulator provided by the invention is simple and convenient to manufacture, is combined with in-situ photothermal therapy and lactic acid regulation and is used for enhancing cell death immunotherapy of copper death so as to eliminate primary tumors and delay relapse, and a technical support is provided for regulating immunity by enhancing copper-induced cell death through metabolic reprogramming.

The present invention provides: a culture medium composition which contains an iron ionophore, and which is for promoting the production of viruses each carrying a target gene or for improving the proportion of viruses each carrying the target gene with respect to all of produced viruses in the culturing of mammalian cells having the target gene introduced therein and having virus production capability; and others.

The invention relates to the technical field of ion selective electrode materials, and particularly discloses a functional polymer film for a chloride ion selective electrode and a preparation method of the functional polymer film. The functional polymer film comprises a polymer skeleton and a covalently grafted nitrogen-containing basic functional group, the polymer skeleton is selected from polyvinyl chloride, carboxylated polyvinyl chloride and other polymers, and the nitrogen-containing basic functional group is a tertiary amine group or an arylamine group and is connected with the skeleton through an amido bond, an ester bond or a polymeric chain segment. Converting into a quaternary ammonium salt structure through a quaternization reagent; the preparation method comprises the following steps: firstly, carrying out catalytic grafting reaction on the functional monomer and the polymer skeleton in an organic solvent through an initiator, then carrying out spin coating or curtain coating to form a film, drying, activating and finally carrying out quaternization treatment. The composition can be used for constructing a long-acting chloride ion selective electrode, and has the advantages of zero dissolution of an ion carrier, high selectivity and strong mechanical stability; in addition, the preparation method provided by the invention can realize controllable distribution of sites.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

Polycation carrier particles obtained by polymerizing one or more multiacrylate monomers with one or more hydrophilic monomers to form a crosslink. The polycation carrier particles have a net positive charge. The multiacrylate monomer and the hydrophilic monomer(s) are as defined herein.

The present invention is directed to novel resistance modifying agents (RMAs) compounds configured to potentiate antibiotic compounds, such as polymyxin antibiotics, including colistin, directed to multi-drug resistance (MDR) gram-negative bacteria.

An example sensor includes a conductive electrode and an ion-selective membrane over the conductive electrode. The ion-selective membrane includes an ionophore that is selective for ionized magnesium (iMg) and at least two types of anionic lipophilic salts. The at least two types of anionic lipophilic salts may include one or more fluorinated borate salts and one or more chlorinated borate salts.

The application discloses a high-sensitivity ammonium ion electrochemical sensor and application thereof, and belongs to the technical field of electrochemical sensors.The electrochemical sensor comprises a full-solid-state ammonium ion selective electrode, the electrode comprises an electrically conductive base, a solid-state contact layer and an ammonium ion sensitive film arranged in sequence, the electrically conductive base is a silk screen printed carbon electrode with copper nanoparticles on the surface; the solid-state contact layer is composed of a polyaniline and reduced graphene oxide composite; and the composition of the ammonium ion sensitive film comprises polydopamine and an ammonium ion carrier.The characteristics of the above-mentioned modified materials expand the linear detection range of the sensor to ammonium ions, improve the sensitivity, and can sensitively detect 10 ‑7 ~ 10 ‑1 M ammonium ion concentrations, and have good application prospects in the fields of on-site rapid detection of low-concentration ammonium ions in environmental water, aquaculture water and seawater.

Described herein are gloves having antimicrobial properties, as well as compositions (e.g., coagulant formulations) and methods for producing such gloves. In some embodiments, the gloves comprise an ionophore-ion functional group complex (e.g., Ca2+- carboxylate complex) at the outer surface, which imparts antimicrobial properties to the gloves.

The invention discloses an ion selective membrane, a sodium ion sensor and a preparation method of the ion selective membrane. The ion selective membrane comprises the following components in percentage by mass: 90-95% of a high-molecular polymer, 0.5-1.5% of an ion exchanger and 4.5-8.5% of an ion carrier, the high-molecular polymer contains lipophilic plasticizing groups, and the glass transition temperature of the high-molecular polymer is less than or equal to 0 DEG C. The sodion sensor comprises a sodion working electrode and a reference electrode, the sodion working electrode is sequentially coated with Ag / AgCl slurry, carbon slurry and an ion selective membrane, the Ag / AgCl slurry is coated on an Au substrate of the PCB, and the ion selective membrane is the ion selective membrane. The ion selective membrane and the sodium ion sensor do not depend on plasticizers, and the sensitivity stability of the sensor in long-term use is improved.

Synthetic ionophores for the active carry and transport of free ions across biological membranes in vivo, comprising coordination complexes of molecules with polarized hexa-aqua and / or tetra-aqua systems of free ionic metals and ionic salts as the ionophores, useful in transporting pharmaceutical, nutrient, and personal healthcare compounds. Also described are methods of their administration, methods of their synthesis and manufacture, and the ionophore products of such synthesis and manufacturing methods.

This invention discloses a biomimetic nanofluidic sensing membrane, its preparation method, and its applications. The biomimetic nanofluidic sensing membrane comprises a top supporting lipid bilayer membrane and a bottom anodic aluminum oxide membrane with a macroporous structure. A portion of the supporting lipid bilayer membrane corresponds to and communicates with some macropores in the anodic aluminum oxide membrane. An ion carrier is embedded in the supporting lipid bilayer membrane, and its surface is modified with cholesterol-modified aptamers and polyethylene glycol. This invention utilizes the lateral fluidity of the supporting lipid bilayer to achieve multivalent and efficient capture of aptamers. The natural antifouling properties of phospholipids and the steric hindrance of polyethylene glycol synergistically suppress non-specific adsorption, and the detection signal is amplified by the ion current rectification effect induced by the asymmetric structure. The detection limit for TNF-α is as low as 0.219 pM, and with machine learning, it can accurately distinguish six proteins. The preparation method is simple, and the detection sensitivity and specificity are high, showing broad application prospects in early disease diagnosis and high-throughput protein analysis.

This disclosure provides a method for lithium extraction from brine by electrochemical adsorption and its application. The method includes: placing an electrode containing a low-lithium lithium ion carrier as the cathode electrode in the middle of the brine; adding a lithium ion adsorbent to the brine to enrich the lithium ions in the brine; centrifugally stirring the brine and energizing the electrode to obtain an electrode containing a lithium-rich lithium ion carrier. This disclosure utilizes a lithium ion adsorbent to enrich lithium ions in the brine pool, cleverly employing external force to move the lithium ion adsorbent material, transporting the lithium ion adsorbent to the vicinity of the electrode to form a lithium-rich region. This significantly shortens the distance from the lithium ions to the electrode, thereby improving lithium extraction efficiency and greatly saving extraction time.

Provided herein are devices and methods for measuring the concentration of a target analyte in a biological fluid in vivo. In some examples, an apparatus includes an indwelling sensor and sensor electronics. The sensor can include a substrate; the first electrode is arranged on the substrate; an ion carrier disposed on the substrate to selectively transport a target ion to the first electrode or to selectively transport the target ion within the first electrode; and a second electrode disposed on the substrate. The sensor electronics are configured to generate a signal corresponding to an electromotive force based at least in part on a potential difference generated between the first electrode and the second electrode in response to the ionophore transporting the target ion to the first electrode.

The invention belongs to the field of polymer membrane ion selective electrode sensitive membranes, and particularly relates to a bifunctional polymer membrane and application thereof in preparation of a potentiometric sensor. The bifunctional polymer membrane comprises the following components in parts by weight: 0.05-10 parts of an ion exchanger and 10-90 parts of a sensitive membrane matrix of a grafted ion carrier, wherein the sensitive membrane matrix of the grafted ion carrier is a fluorine-containing methacrylate polymer of the grafted ion carrier. According to the method disclosed by the invention, a novel fluorine-based sensing membrane ion selective electrode is constructed, so that the problem of biological fouling when a sensitive membrane of a traditional polymer membrane ion selective electrode is applied to a biological fluid is avoided, and meanwhile, the problems of electrode performance reduction and toxicity to a to-be-detected object caused by reagent seepage of the traditional sensitive membrane are eliminated; and the stability, the service life and the biocompatibility of the electrode are effectively improved. The method is of great significance in application of a potentiometric sensor of a polymer sensitive film substrate in biomedical equipment.

Synthetic ionophores for the active carry and transport of free ions across biological membranes in vivo, comprising coordination complexes of molecules with polarized hexa-aqua and / or tetra-aqua syst

Described a coagulant formulation for use in the preparation of a material that is formed by dipping, wherein the formulation includes a lipophilic and / or amphiphilic polymeric ionophore:ion complex wherein the polymeric ionophore is a hydrophilic and / or amphiphilic polymer and wherein the polymeric ionophore:ion complex imparts antimicrobial and / or antiviral properties to the material.

Compounds, compositions and their use in the treatment of a human copper deficiency or proliferative disease or condition, for instance the proliferative disease or disorder may have intracellular copper levels sensitivity. Also described in the use of a copper ionophore for the treatment of an SF3B1-mutated cancer. The compounds disclosed are of Formula (I), wherein A, R1 to R4, X1 to X3 and are as defined herein:

Polynucleotide sequencing using ionophores is provided herein. In some examples, a sequencing method includes inhibiting current flow across a barrier; contacting a polymerase with a first polynucleotide, a second polynucleotide, and a fluid comprising a first nucleotide coupled to a first ionophore; while the polymerase adds the first nucleotide to the second polynucleotide based on a sequence of the first polynucleotide, providing a first current flow across the barrier using the first ionophore; and identifying the first nucleotide using an electrical characteristic of the first ionophore.