There are provided bio-compatible means for delivery of at least one pharmaceutically
active agent to a patient in need of same, comprising a bio-compatible, bio-degradable anionic or cationic carrier and at least one pharmaceutically
active agent wherein the agent is cationic when the carrier is anionic and is anionic when the carrier is cationic. The delivery means further comprises at least one bio-compatible enclosing means for the carrier. This enclosing means may be bio-degradable or non bio-degradable and have a predetermined
permeation gradient for the passage therethrough of the at least one pharmaceutically
active agent. In an alternate embodiment the enclosing means may be biodegradable without a predetermined
permeation gradient for the passage therethrough of the at least one pharmaceutically active agent. In all embodiments the active agent is ionically linked to the carrier and the carrier / active
agent combination is enclosed in the enclosing means. There is also provided a method of administering at least one pharmaceutically active agent to the
tissue surface of a subject in need of same at a
rate dependent on the permeability and / or bio-degradability of the enclosing means of the delivery means which comprises contacting the
tissue surface with a bio-compatible delivery means as described above.