14 results about "Charged species" patented technology

Membranes and related systems and methods for separation of components in liquids are generally described. The membrane may include particles in a polymer matrix (e.g., a polyamide layer). The particles may include metal-organic framework particles comprising functional groups (e.g., from post-synthetic modification) that can, in some instances, improve the rejection and / or selectivity of the membrane. For example, the metal-organic framework may comprise functional groups bound to hydrophobic groups (e.g., alkyl chains) that assist with suspension stability in nonpolar solvents during membrane fabrication. As another example, the metal-organic framework may comprise functional groups bound to crosslinking agents that facilitate in situ crosslinking of the particles with the polymer matrix, thereby reducing voids in the membrane and / or leaching. In some instances, the membrane is a thin-film nanocomposite membrane (e.g., for separating components like charged species and / or neutral species) formed via, for example, interfacial polymerization in the presence of the particles.

Devices to detect analytes (e.g., charged species such as ions) in samples are provided as are methods for their use. The devices comprise a tube or container comprising a water-immiscible sensing oil phase comprising at least one sensing chemical that binds the at least one analyte. The tube further receives an aqueous sample. Upon mixing of the two immiscible phases, the analyte partitions into the oil phase and binds to the sensing chemical, delectably changing the optical properties of the sensing chemical (or of an associated reporter molecule). Detection of the changes permits quantification of the amount or concentration of analyte in the sample without optical interference from the sample. The devices are suitable for home use and other decentralized settings.

High-throughput microfluidic devices comprising one or more fluidic microchannels each with at least one flow-through 3D structure comprising a 3D electrode, or alternatively a 3D permselective structure, and optional secondary bead bed(s) are disclosed. Such devices can be used for counter-flow focusing of charged species via ion concentration polarization and in situ quantification of electrokinetically enriched charged species from an ionically conductive solution by both optical and electrical detection.

Polypeptide nanopores synthetically functionalized with positively charged species, and methods of making and using the same, are provided herein. In some examples, a polypeptide nanopore includes a first side, a second side, a channel extending through the first and second sides, and a mutated amino acid residue. The mutated amino acid residue may be synthetically functionalized with a positively charged species that inhibits translocation of cations through the channel.

The invention discloses an in-source cracking controllable pulse direct-current arc induced nano-liter electrospray ionization source and mass spectrum combined system and a detection method. The system comprises a mass spectrum, a quartz capillary tube, a metal coil, a positive wire, a negative wire and a direct-current arc generator. The high charge density characteristic of pulse direct-current arc plasma and the solution polarization effect induced by a metal coil are combined to construct a dual-drive ionization system. Under low voltage, molecular ion integrity is maintained; under high voltage, the characteristic fragment ion strength is obviously enhanced, the compound structure information can be obtained without depending on tandem mass spectrometry, and the problems of time consumption and sample consumption of nanoliter electrospray ionization source analysis are effectively solved. The pulse direct-current arc provides high-density positive and negative charges, the metal coil strengthens directional migration of charged species to the tip of the capillary tube through potential difference, and ionization stability and efficiency are remarkably improved.

This method comprises the following steps:a) providing a stack successively comprising:a substrate;a first electrode;a first dielectric layer, having a first electrical strength;a second metal electrode;a second dielectric layer, having a second dielectric strength that is strictly less than the first dielectric strength;a third electrode;the first dielectric layer and the second electrode having a first interface, the second dielectric layer and the second electrode having a second interface;b) etching the stack by bombardment with electrically charged species, so as to define resistive memory cells;the bombardment of step b) being adapted so that electrically charged species accumulate at the first and second interfaces of each resistive memory cell, so as to generate an electric field that is strictly less than the first electrical strength and is strictly greater than the second dielectric strength.

A system for electrically detecting a biomarker, the system comprising: a sample unit comprising: a sample chamber configured to contain a fluid sample; a reference electrode in fluid communication with the sample chamber; a detection zone in fluid communication with the sample chamber and configured to capture a biomarker; a signal zone in fluid communication with the detection zone; and a working electrode configured such that its surface potential changes in the presence of charged species (e.g., protons) generated by a reaction (e.g., between an enzyme and a radical substrate) occurring in the signal zone; and a measuring unit comprising a field-effect transistor in electrical communication with the reference electrode and the working electrode, the measuring unit configured to measure a change in surface potential of the working electrode due to generated charged species.

An additive manufacturing method for fabricating 3D nanostructures, comprising: generating charged species, and controlling a first fluid field to transport the charged species; controlling a second fluid field and a first electric field to transport and screen the charged species, thereby generating charged screened particles for printing; configuring a second electric field to directionally migrate the charged screened particles, enabling them to move to preset printing sites; moving the printing sites in multiple directions to realize 3D printing, the second electric field is generated by three parallel plates connected to external electric potentials, the plates comprise a conductive upper plate connected to V1, a patterned layer connected to V2, and a substrate connected to V3; the upper plate and the patterned layer generate the first electric field, and the patterned layer is located between the upper plate and the substrate, with distances h1 and h2 respectively.

High-throughput microfluidic devices comprising one or more fluidic microchannels each with at least one flow-through 3D structure comprising a 3D electrode, or alternatively a 3D permselective structure, and optional secondary bead bed(s) are disclosed. Such devices can be used for counter-flow focusing of charged species via ion concentration polarization and in situ quantification of electrokinetically enriched charged species from an ionically conductive solution by both optical and electrical detection.

A method for processing a substrate is provided. The method includes disposing a substrate in a processing region of a process chamber and flowing a silicon containing precursor gas into the processing region. The method also includes exposing the precursor gas to only plasma radicals and non-charged species generated from an inert gas plasma to deposit a low-k film on the substrate, wherein the low-k film comprises preserved bonds of one or more silicon containing functional groups from the one or more silicon containing precursors of the precursor gas.

The present disclosure provides relates to sensors for determining a property of a target analyte in a sample, devices for manipulating a charged species in a sample and systems and methods for determining a property of a target analyte in a sample. These comprise an electric field generator comprising a first electrode element; a second electrode element spaced apart from the first electrode element to define a region therebetween; and a plurality of structures provided within the region, wherein the each of the plurality of structures is configured to concentrate an applied electric field to form corresponding high electric field regions within the region.

The present invention relates to a drug delivery device, a method for transporting charged species, a method for manufacturing a drug delivery device, and a method for generating charged fluids. The drug delivery device is configured to deliver a drug to a drug delivery site in body tissue, the drug delivery device includes a cavity configured to continuously receive charged fluids, the drug delivery device is configured to receive charged particles comprising the drug in a space adjacent to the cavity, and to drive the charged particles from the space to the drug delivery site driven by the action of an electric field generated by the charged fluid in the cavity.

A method for processing a substrate is provided. The method includes disposing a substrate in a processing region of a process chamber and flowing a silicon containing precursor gas into the processing region. The method also includes exposing the precursor gas to only plasma radicals and non-charged species generated from an inert gas plasma to deposit a low-k film on the substrate, wherein the low-k film comprises preserved bonds of one or more silicon containing functional groups from the one or more silicon containing precursors of the precursor gas.

The present invention relates to a drug delivery device, a method to transport a charged species, a method to manufacture a drug delivery device, and a method to generate a charged fluid. A drug delivery device is configured to deliver a drug to a drug delivery site in a bodily tissue, the drug delivery device comprising a cavity configured to continuously receive a charged fluid, wherein the drug delivery device is configured to receive a charged particle comprising a drug in a space adjacent to the cavity and drive the charged particle from the space to the drug delivery site, the charged particle being driven by the action of an electric field generated by the charged fluid in the cavity.