73 results about "Desorption ionization" patented technology

The invention discloses a method for rapidly detecting bacterial drug resistance by combining a bacterial metabolism fingerprint spectrum after short-time antibiotic stimulation with machine learning. Bacteria are incubated in a liquid culture medium containing antibiotics with break point concentration for a short time, the metabolic pathway of the bacteria can be changed, and then generation of downstream metabolites is affected. As the drug-resistant bacteria have a special drug-resistant mechanism, the change of the metabolic state of the drug-resistant bacteria is different from that of the sensitive bacteria. Analyzing the metabolite fingerprint spectrum of the bacteria after short-time stimulation of the antibiotics by adopting matrix-assisted laser desorption ionization time-of-flight mass spectrometry; after data acquisition, classified analysis is performed through machine learning, so that rapid detection of the antibiotic resistance of bacteria is realized. Compared with the prior art, the method has the advantages that bacterial drug resistance detection can be completed within 2 hours, high practicability and operability are achieved, and meanwhile the method has the advantages of being high in throughput and low in experiment cost.

The present invention relates to a method for quickly identifying white vaseline from different manufacturers based on silver salt-assisted laser desorption ionization-time of flight mass spectrometry, and belongs to the field of detection. Specifically comprising the following steps: S1, exploring and optimizing metal salt ion conditions, matrix conditions, and sampling methods, and using the optimized experimental conditions for sample preparation; S2, measuring the sample; S3, using eMSTAT Solution software for data analysis to achieve identification of white vaseline from different manufacturers. The method of the present invention replaces traditional organic matrices with silver salts, eliminates background interference, and improves the mass spectrometry signal-to-noise ratio; combines a direct smearing method to avoid complex solvent preparation and extraction, and is easy to operate; applies a mass spectrometer for mass spectrometry acquisition, has accurate molecular weight, reduces the detection time of each sample to 6 seconds, has high analytical throughput, and is low in cost, thereby achieving high-throughput, accurate, and rapid identification of large quantities of white vaseline from different sources.

The invention discloses a primer composition and application thereof. According to the invention, a group of primer compositions is obtained aiming at mycobacterium tuberculosis complex group identification and drug resistance related genes thereof. The primer composition can be combined with nucleic acid matrix-assisted laser desorption ionization time-of-flight mass spectrometry to detect a mycobacterium tuberculosis complex group, and can also detect the mutation conditions of 18 drug-resistant genes and 92 gene mutations related to drug resistance of 21 common first-line and second-line antituberculous drugs / types in the mycobacterium tuberculosis complex group. The medication is guided. Based on a MassARRAY technical platform, the primer composition has the advantages of good accuracy, high sensitivity, short required time and high efficiency when being used for detecting the mycobacterium tuberculosis complex group and the drug resistance thereof, is suitable for various sample types, can meet clinical detection requirements, is beneficial to clinical diagnosis and medication guidance of mycobacterium tuberculosis, and realizes precise treatment of pulmonary tuberculosis.

The application discloses application of 2-amino isophthalic acid (2-AIA) as a MALDI matrix in characterization of oligosaccharide additives in food. The skeleton structure of 2-AIA has a strong ultraviolet absorption group and a protonation site, which is beneficial to laser energy transmission and desorption ionization process of the measured object. Meanwhile, 2-AIA has multiple polar functional groups, which can effectively enhance the directional combination of the hydroxyl group of 2-AIA and oligosaccharide, and improve the anti-interference ability of impurities in a complex system. In addition, 2-AIA and a traditional organic matrix alpha-cyano-4-hydroxycinnamic acid (CHCA) are combined as a binary matrix (CHCA / 2-AIA), which can play a synergistic role of the double matrix, significantly improve the detection sensitivity of oligosaccharide. On the other hand, the combination of CHCA and 2-AIA with different pH values can significantly improve the uniformity of the co-crystallization, and improve the accuracy and reproducibility of quantitative detection.

The invention discloses a preparation method and application of a peptide specific quality nanoprobe. The nanoprobe is prepared by uniformly mixing mass tag molecules, functional polypeptide and a chloroauric acid solution and adding a sodium hydroxide solution through a simple one-pot method. The synthesized mass nanoprobe is specifically recognized and combined with target protein on cells or tissues through a peptide chain, and mass-to-charge ratio signals of mass tag molecules corresponding to different nanoprobes are detected through laser desorption ionization-time-of-flight mass spectrometry (LDI-TOFMS) ionization; the mass spectrum imaging analysis on the relative expression quantity of various proteins on different types of cancer cells and tumor tissue slices is realized. The probe has the characteristics of simple preparation, specific recognition, low background, high resolution and the like, and is easy to popularize to the detection of various proteins on the surfaces of other biological samples.

A novel method for artificial photosynthesis utilizing a chemical system that operates by harnessing visible light and directly capturing carbon dioxide and water from the atmosphere. The system is based on self-organizing complexes comprising visible-light-sensitive chromophores, such as 2-phenyl indole and 2-phenyl benzoxazole, along with titanium tetrachloride, which autonomously perform continuous, complex chemical operations to produce long-chain (C2 to C17) oxygenated organic materials. The process employs earth-abundant metal coordination compounds, including titanium (Ti), zirconium (Zr), hafnium (Hf), and vanadium (V), in the solid state. These compounds form carbonated metal derivatives upon hydrolysis, which are subsequently reduced through proton transfer from water. The system initially generates C1 materials that oligomerize via a novel self-catalyzed mechanism intrinsic to the system's operation. Monitoring and characterization of the chemical transformations have been conducted using high-resolution MALDI-TOF (matrix-assisted laser desorption ionization-time of flight) mass spectrometry, supported by infrared (IR) spectroscopy and nuclear magnetic resonance (NMR) analysis. This innovation represents a sustainable and scalable approach for converting atmospheric CO2 into valuable organic materials.

The present invention belongs to the field of forensic genetics, specifically a forensic composite amplification kit for detecting 50 SNP sites on chromosome X based on MALDI-TOF MS platform. The main technical methods of the present invention are single base extension technology (SBE-PCR) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) technology, which uses X-SNP genetic markers to identify the gender and identity of individuals of unknown origin, and also has good effects in complex kinship identification. The kit includes 50 pairs of primer mixtures for composite amplification, and simultaneously amplifies 50 SNP sites on chromosome X, so that 50 X-SNPs can be detected at one time more conveniently, and the identity of unknown individuals can be identified.

The invention discloses an application of a benzophenone derivative as a bipolar matrix-assisted laser desorption ionization matrix in mass spectrometry detection. The benzophenone derivative matrix provided by the invention can effectively improve desorption ionization efficiency and reduce background interference, is compatible with a positive ion and negative ion bipolar detection mode, and solves the technical bottleneck of single polarity of a traditional matrix detection mode. The matrix has a wide-spectrum absorption characteristic in an ultraviolet region, can be adapted to laser wavelengths of various matrix-assisted laser desorption ionization mass spectrometers, and has a wide application prospect. Besides, when the matrix is used for lipid compound detection, lipid endogenous metabolite spectrum signals with high sensitivity and high coverage rate can be obtained in positive and negative ion modes, the matrix is expected to be widely used for metabonomics and clinical basic research, and key technical support is provided for high-sensitivity and bipolar imaging of small molecule compounds in complex biological samples.

The present application relates to atmospheric pressure ion manipulation technology, specifically, the present application discloses a thermal desorption ionization reaction device, specifically, a thermal desorption ionization reaction device, comprising a stainless steel metal desorption ionization cavity, the metal desorption ionization cavity is a hollow circular cylinder with an open upper end and a closed lower end, an insulating cover for sealing the open upper end is arranged on the open upper end, and a gas and ion outlet is arranged in the middle of the insulating cover; the counter electrode and the electrode with holes are connected to the high-voltage output end of the high-voltage power supply and the ground electrode (or negative electrode) respectively. The voltage applied to the counter electrode and the electrode with holes is alternating current or direct current, and the voltage amplitude is 2000V. The present application improves the consistency and stability of batch production of thermal desorption ionization modules based on integrated design, reduces power consumption and processing cost, and is beneficial to the industrialization of mass spectrometry or ion mobility spectrometry.

The application relates to a gold nanoparticle array preparation method with strong stability and reusability, high cysteamine-stabilized gold nanoparticles are prepared first, the spacing between the gold nanoparticles is changed by utilizing the coulomb repulsion between the gold nanoparticles, then the gold nanoparticle solution is added dropwise to a glass surface modified by gamma-glycidoxypropyltrimethoxysilane to react, stable covalent bonds are formed, and gold nanoparticle arrays with uniform distribution on the glass surface can be obtained after the reaction. The preparation does not require high temperature, the experimental operation is simple and convenient, the gold nanoparticles are arranged in order and closely, have high detection sensitivity, have strong ultraviolet absorption capacity, good stability, reusability, salt resistance and low background interference, and can be reused. The gold nanoparticle array can realize detection analysis on high-salt-content samples in surface-assisted laser desorption ionization mass spectrometry and be used for rapid analysis of small molecule compounds in positive and negative ion dual modes.

The application discloses an ion source device for desorption of americium 241, and relates to the technical field of ion sources.The ion source device mainly comprises americium 241, a clamping device for the americium 241, an R-axis rotating platform and a sample stage.The americium 241 is installed on the clamping device for the americium 241, and the clamping device is installed on the R-axis rotating platform.A glass slide coated with a sample is installed on the sample stage, and the sample stage and the R-axis rotating platform are installed on two XYZ-axis displacement platforms, respectively, and the two XYZ-axis displacement platforms are adjusted to move in the X, Y and Z directions, respectively.The alpha particles generated by the americium 241 decay generate a series of plasmas in the air and are injected into the surface of the sample, so that the molecules on the surface of the sample are ionized and desorbed, and the ions enter a mass spectrometer through a sample inlet for detection.The relative positions of the americium 241, the sample stage and the sample inlet are adjusted, so that the mass spectrometer obtains the best ion signal, and the operation is safe and simple, and the common molecules can be rapidly detected.

The present application relates to the technical field of food microbial detection, and specifically to a method for identifying Daqu, comprising the following steps: (1) weighing a Daqu sample and filtering the Daqu sample to obtain a filtrate; (2) measuring the filtrate, adding magnetic beads to the filtrate, and incubating the filtrate to obtain an incubation solution; (3) removing the magnetic beads from the incubation solution and lysing the microorganisms on the magnetic beads to obtain a sample to be tested; (4) detecting the sample to be tested using matrix-assisted laser desorption ionization time-of-flight mass spectrometry; and identifying the type of Daqu based on characteristic peaks in the mass spectrum of the sample to be tested. The present application has the advantages of accurate detection results and high detection efficiency.

A post-ionization laser module (30) for docking an atmospheric-pressure MALDI ion source (10) comprises a pulsed post-ionization (PI) laser (32), a synchronisation device with a delay generator, for controlling a timing of laser pulses of the post-ionization laser with respect to desorption events in the MALDI ion source, and an optical system (46, 48, 50, 52) for directing the laser pulses on an optical path from the post-ionization laser into a desorption plume (26) of the MALDI ion source. In a further aspect, the invention relates to an AP-MALDI ion source (10), comprising a target holder (12) for mounting a sample target (16), a pulsed desorption laser (14) for irradiating the sample target and creating desorption events, and a post-ionization laser module (30).

The invention provides a mass spectrum imaging method for visually analyzing terpenoid and coumarin components in ferula asafetida stems, and belongs to the technical field of molecular imaging. The method comprises the following steps: embedding a to-be-detected sample of a ferula ferulaeoides stem, freezing and slicing the to-be-detected sample with the thickness of 30 microns, performing matrix-assisted laser desorption ionization mass spectrometry imaging on the obtained slice in a positive ion mode, and obtaining the spatial distribution information of terpenoids and coumarins in the to-be-detected tissue sample in situ according to the accurate mass-to-charge ratio of ions in an imaging picture. The slice under specific conditions has a relatively complete tissue structure, the established mass spectrum imaging method does not need complex sample pretreatment, basically does not change the spatial distribution information of active components in a sample to be detected, and can accurately position the spatial distribution information of a plurality of compounds at the same time; therefore, the visualization of the internal active ingredients of the ferula ferulaeoides stems is realized. The invention provides a new technical support for researching the anabolic pathway and physiological function of terpenoid and coumarin compounds in ferula plants in the future, and has important significance in improving the separation and extraction rate of active ingredients in ferula and the utilization rate of ferula stem tissues.

The application discloses a method for screening metabolic biomarkers based on saliva metabolic fingerprint and application, and relates to the technical field of biological sample metabolic analysis. The method comprises the following steps: step 1, inorganic nanoparticles are used to enhance laser desorption ionization time-of-flight mass spectrometry technology, saliva samples of Parkinson's disease patients and healthy volunteers are subjected to metabolic detection, and saliva metabolic fingerprints are obtained; step 2, the saliva metabolic fingerprints obtained in step 1 are subjected to a machine learning algorithm, saliva samples are subjected to a variety of model training, a variety of models are evaluated through a cross-validation method, and a final prediction model is screened according to a verification result; step 3, saliva samples of Parkinson's disease patients and healthy volunteers are predicted according to the prediction model of step 2, a prediction result is obtained, and metabolic biomarkers in the saliva samples are screened according to the prediction result. The application has high screening efficiency, the result is accurate and reliable, and the screened metabolic biomarkers can be used for prediction of Parkinson's disease.

The invention belongs to the technical field of analysis and detection, and particularly relates to a preparation method and application of a matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometry plant sample, the preparation method of the plant sample created by the invention can separate leaf inner epidermis and mesophyll tissue, and the leaf inner epidermis and mesophyll tissue are utilized to research metabolites in leaves. After the inner epidermis and mesophyll of the leaf are separated, not only can organic acid, small molecular compounds and macromolecular substances in the leaf be detected, but also the change of the content of the organic acid can be revealed. According to the MALDI mass spectrometry technology, assimilation of NH4 < + > / NO3 <-> in leaf inner epidermis or mesophyll tissue can be monitored in an imaging mode, so that the metabolic process of nitrogen is visualized; in the nitrogen metabolism process, NH4 < + > is directly used for synthesizing amino acid, NO3 <-> is reduced into NO2 <->, and NO2 <-> is assimilated into amino acid and derivatives thereof. The preparation method provided by the invention has unique advantages, and is beneficial to deeply understanding the metabolic process and biological functions of plants.

The application discloses a nucleic acid mass spectrometry technology-based method for identifying common respiratory tract infection pathogens in children. The application provides a complete set of primers, including specific primer group 1 and specific primer group 2; the primer group 1 (i.e. the primer corresponding to well1) is composed of single-stranded DNA molecules shown in sequences 1-17 and single-stranded DNA molecules shown in sequences 24-40; the primer group 2 (i.e. the primer corresponding to well2) is composed of single-stranded DNA molecules shown in sequences 18-23 and single-stranded DNA molecules shown in sequences 41-46. The CCRP-MS of the application is a 23-pathogen determination method combining matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and multiple reverse transcription polymerase chain reaction (MRT-PCR), and can directly detect common respiratory tract pathogens in children.

This disclosure relates to apparatus and methods for sublimation and deposition of chemicals. In particular aspects, this disclosure relates to apparatus and methods for patterned sublimation and deposition of chemicals for use in matrix assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). In specific aspects, the apparatus comprises a vacuum chamber and a template comprising a planar surface containing the chemical to be sublimed, where the template is located within the vacuum chamber.

A computer-implemented method for detecting at least one analyte in a sample with a laser desorption mass spectrometer (220) is disclosed. The method comprises:a) at least one imaging step comprising imaging at least one reflective target (128) by using at least one imaging device (235), wherein the sample comprising the at least one analyte is applied to the reflective target (128);b) at least one sample recognition step comprising localizing at least one sample region on the reflective target (128); andc) at least one analyte detection step comprising detecting the at least one analyte in the sample using surface assisted laser desorption ionization mass spectrometry (SALDI-MS) with the laser desorption mass spectrometer (220), wherein laser irradiation is applied to the reflective target (128) by using at least one laser source (222) of the laser desorption mass spectrometer (220) such that at least one ion of the at least one analyte is generated which is detected by using at least one of a mass analyzing unit (224) or an ion-mobility spectrometry device of the laser desorption mass spectrometer (220), wherein the laser irradiation is steered on the localized sample region by using at least one control device (237).

The invention belongs to the field of environmental sample analysis and detection, and particularly relates to a target-oriented synthesized TCBPA molecularly imprinted polymer, a preparation method thereof and a tetrachlorobisphenol A. After glass fibers are cleaned, the surface of the glass fibers is bonded with the TCBPA molecularly imprinted polymer, and an enrichment probe is obtained; the method comprises the following steps: placing an enrichment probe in a to-be-detected sample solution, carrying out vortex adsorption for a set time, washing away a residual matrix on the surface of the enrichment probe after the adsorption is completed, then fixing the enrichment probe at a mass spectrum injection port, and keeping a set distance between the tip of the enrichment probe and the mass spectrum injection port; the charged desorption solution continuously flows onto the enrichment probe to wet the enrichment probe, stable spray is formed at the tip of the enrichment probe, the adsorbed tetrachlorobisphenol A is desorbed and ionized under the combined action of an electric field and the desorption solution, and the obtained ions directly enter a mass spectrometer to be detected. The MIP is directly fixed on the surface of the glass fiber to construct a functional coating capable of being used for continuous flow desorption ionization mass spectrometry detection, so that rapid enrichment and ionization of target molecules are realized.

The invention relates to the technical field of mass spectrum detection, in particular to a metal heterogeneous material, a chip and application of the metal heterogeneous material and the chip in drug mass spectrum analysis. According to the metal heterogeneous material, tight combination of TiO2 and gold is achieved through lattice matching design, and a plasma resonance enhanced heterogeneous interface is constructed. The chip comprises a titanium dioxide nanorod array formed on the substrate, a gold array deposited on the surface of the semiconductor layer and formed by gold nanoparticles, and a surface modification layer. Through the heterostructure design of a semiconductor and gold nanoparticles and a surface modification technology, the laser desorption ionization efficiency and the specific adsorption capacity to drug small molecules are remarkably improved, high-flux, high-sensitivity and high-resolution detection of complex components of traditional drugs is achieved, the gold nanoparticles are applied to drug screening and quality control, and the application prospect is wide. And an efficient analysis tool is provided for traditional drug research.

Disclosed are methods for enhancing a Raman intensity of a sample by adding to the sample an aromatic compound having an absorbance ranging from about 250 nm to about 500 nm, and also, a solvent and a matrix-assisted laser desorption / ionization (MALDI) matrix. Workflows for a combined Raman-MALDI imaging instrument also are disclosed.

The invention relates to a device for generating ions from a sample material deposited on a substrate at least partially transparent to electromagnetic waves, comprising: - a support device having a holder for the substrate, - a desorption / ionization unit comprising a desorption device and an ionization device, the desorption device being arranged and designed to desorb the deposited sample material from a desorption site on the substrate using at least one energy burst, and the ionization device being arranged and designed to irradiate the desorbed sample material above the substrate using electromagnetic waves after at least one energy burst, wherein the electromagnetic waves pass through the substrate at a position corresponding to the desorption site before entering the desorbed sample material, and - an extraction device arranged and designed to extract ions from the desorbed sample material and transfer them to an analyzer. The invention also relates to a correspondingly arranged method.

This method for analyzing a morpholine ring-containing oligonucleotide is configured such that a morpholine ring-containing oligonucleotide contained in a sample is analyzed with a matrix-assisted laser desorption / ionization mass spectrometer using a mixed matrix containing 3-hydroxypicolinic acid (3-HPA) and 2',4',6'-trihydroxyacetophenone (THAP). This method uses a matrix suitable for the ionization of molecules of a morpholine ring-containing oligonucleotide by the MALDI method, and it is thus possible to more reliably measure the molecular weight of a morpholine ring-containing oligonucleotide in mass spectrometry using the MALDI method.

The invention discloses a method for detecting monosaccharide / oligosaccharide based on 6-aminoquinoxaline assisted laser desorption ionization mass spectrometry, and belongs to the technical field of monosaccharide and oligosaccharide detection methods. A mixed solution of a 6-aminoquinoxaline matrix solution and a to-be-detected sample is dripped on a target plate, and a matrix-assisted laser desorption ionization time-of-flight mass spectrometer is used for mass spectrometry detection for rapid analysis of monosaccharides and oligosaccharides in the sample. The 6-aminoquinoxaline not only can be used as a reactive matrix to efficiently derive monosaccharide and reducing sugar with the polymerization degree of 2-10, but also can remarkably promote the ionization efficiency of non-reducing sugar, and has the advantages of high sensitivity, high universality, low cost, low background interference, uniform crystallization with an analyte and the like; the problems that a traditional organic matrix is uneven in crystallization, and the signal-to-noise ratio of mono / oligosaccharide detection is low are solved. 6-aminoquinoxaline is taken as a matrix, so that high-efficiency detection of monosaccharide and oligosaccharide in a complex sample by an MALDI-MS (matrix-assisted laser desorption ionization-mass spectrometry) method can be realized, and the method has a good application prospect in the fields of medicine, food, medicines and the like.

To enable a user to easily prepare a highly uniform crystal in which a sample and a matrix are mixed in the preparation of the sample in mass spectrometry by a MALDI (matrix-assisted laser desorption ionization) method.SOLUTION: A sample preparation method in mass spectrometry by a MALDI method includes a step S12 of preparing a mixed solution of a liquid containing a compound to be subjected to mass spectrometry and a matrix liquid on a sample plate, and a step S10 and a S14 of adjusting the temperature of the sample plate to a temperature within a preparation range. The temperature in the preparation range is 30-60 °C.SELECTED DRAWING: Figure 4

A computer-implemented method for detecting at least one analyte in a sample with a laser desorption mass spectrometer (220) is disclosed. The method includes: a) at least one imaging step, including imaging at least one reflective target (128) to which a sample containing at least one analyte is applied, using at least one imaging device (235); b) at least one sample recognition step, including locating at least one sample area on the reflective target (128); and c) at least one analyte detection step, including detecting at least one analyte in the sample using surface-assisted laser desorption / ionization mass spectrometry (SALDI-MS) in a laser desorption mass spectrometer (220), wherein laser radiation is applied to the reflective target (128) using at least one laser source (222) of the laser desorption mass spectrometer (220), and the laser radiation is directed to the located sample area using at least one control device (237), such that at least one ion of the at least one analyte is generated, and the ion is detected using at least one of a mass analysis unit (224) of the laser desorption mass spectrometer (220) or an ion mobility spectrometer.

The invention relates to the technical field of clinical blood concentration monitoring and control, and discloses a method for rapidly, accurately and quantitatively detecting the blood concentration of antibiotics, which comprises the following steps: collecting a blood sample containing to-be-detected antibiotics through standard clinical operation (such as venipuncture); the method comprises the following steps: performing protein precipitation treatment on a biological sample containing one or more antibiotics to be detected, and extracting supernate; taking the supernate, applying the supernate to the surface of a solid sample injection carrier, and carrying out drying treatment; placing the solid sample introduction carrier carrying the dry sample between a direct normal pressure ion source and a sample introduction port of a mass spectrometer, and carrying out desorption, ionization and mass spectrometry to obtain mass spectrometry data; and based on the mass spectrum data, calculating to obtain the blood concentration of the to-be-detected antibiotic in the biological sample. By means of the plasma in-situ ion source-mass spectrometry, the accuracy of the mass spectrometry is achieved, rapid and accurate quantitative detection of the plasma concentration can be achieved, and a patient can be treated in time.

The present disclosure provides a kit and its application, the kit comprising two sets of amplification primer groups, single base extension primers and processing reagents; the amplification primer groups are used for amplifying Mycobacterium tuberculosis flora identification sites and anti-tuberculosis drug pharmacogenetic polymorphism sites; each pair of primers corresponds to the upstream and downstream regions of a SNP site; the processing reagents include PCR reaction mixture, PCR enzyme mixture, SAP reaction mixture, SAP enzyme mixture, extension reaction mixture and extension enzyme mixture. By designing specific amplification primer groups and single base extension primers, the system and reagents are optimized, and the sensitivity is high. The kit combined with matrix-assisted laser desorption ionization time-of-flight mass spectrometry can complete the detection of all sites, and the detection cost is low and the efficiency is high.

The present invention relates to the field of nanomaterial application technology, and more specifically, to the application of mass spectrometry analysis of water-soluble melanin nanoparticles modified with bifunctional groups. The water-soluble melanin nanoparticles modified with bifunctional groups are MNP-PEG, with a particle size of 4nm to 5nm, uniform particle size, good monodispersity in water, strong ultraviolet absorption ability at 355nm, and an absorbance value of 0.35 to 0.56. In addition, the synthesis process is simple, the preparation cost is low, it is safe, non-toxic, and biodegradable. As a new matrix for matrix-assisted laser desorption ionization time-of-flight mass spectrometry, it can perform efficient mass spectrometry analysis. When detecting tetrabromobisphenol A series molecules, it has the advantages of low background interference peaks, high ion intensity, high sensitivity, etc., and MNP-PEG can also be used for mass spectrometry analysis of small molecules of environmental pollutants in food, which has potential significance for evaluating related health problems caused by the intake of tetrabromobisphenol A and its various derivatives through food.