Method for preparing amoxicillin floating tablets and use thereof
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A technology of amoxicillin gastric and gastric floating tablets, applied in the preparation of amoxicillin gastric floating tablets, a new dosage form of amoxicillin, achieving the effect of high quality, simple method and good stability
Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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Longer et al. used bioadhesion to combine chlorothiazide and albumin to make drug-containing albumin particles, which were mixed with polycarbomer (PCP, 3:7) particles and loaded into capsules. The in vivo dissolution showed that the capsules could be released continuously. Drug 8h, but release more than 60% within 2h
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Embodiment 1
[0018] Embodiment 1: specification 1000 pieces
[0019] prescription:
[0020] Amoxicillin 250g
[0021] Hydroxypropyl Methyl Cellulose 150g
[0022] Cetyl Alcohol 200g
[0023] Sodium bicarbonate 50g
[0024] Macrogol 4000 50g
[0025] Micronized silica gel 3g
[0026] Preparation method:
[0027] Mix the prescribed amount of amoxicillin, hydroxypropyl methylcellulose, cetyl alcohol, sodium bicarbonate, and polyethylene glycol evenly, then mix evenly through an 80-mesh sieve, add micropowder silica gel, mix the raw and auxiliary materials evenly, and directly press film, finished product inspection, packaging.
Embodiment 2
[0028] Embodiment 2: specification 10000 pieces
[0029] prescription:
[0030] Amoxicillin 2500g
[0031] Hydroxypropyl Methyl Cellulose 1500g
[0032] Cetyl Alcohol 2000g
[0033] Sodium bicarbonate 500g
[0034] Macrogol 4000 500g
[0035] Micronized silica gel 30g
[0036] Preparation method:
[0037] Mix the prescribed amount of amoxicillin, hydroxypropyl methylcellulose, cetyl alcohol, sodium bicarbonate, and polyethylene glycol evenly, then mix evenly through an 80-mesh sieve, add micropowder silica gel, mix the raw and auxiliary materials evenly, and directly press film, finished product inspection, packaging.
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Abstract
The invention belongs to the novel technical field of medicaments, and relates to a novel dosage form of amoxicillin used for treating: 1, upper respiratory tract infections, such as tympanitis, nasosinusitis, pharyngitis and tonsillitis resulted from streptococcus hemolyticus, streptococcus pneumoniae, staphylococcus or haemophilus influenzae; 2, genitourinary tract infections resulted from escherichia coli,proteus mirabilis or enterococcus faecalis; 3, skin and soft tissue infection resulted from streptococcus hemolyticus, staphylococcus bacteria or escherichia coli; 4, lower respiratory tract infections, such as acute bronchitis and pneumonia, resulted from streptococcus hemolyticus, streptococcus pneumoniae, staphylococcus bacteria or haemophilus influenzae; 5, acute simple gonorrhea; and 6, typhoid, typhoid bacteria-carrier, leptospirosis and the like. The novel dosage form is characterized in that the stomach floating tablet is hydrated into gel on the surface to expand the volume thereof after contacting with the gastric juice at the body temperature because of a plurality of hydrophilic macromolecular materials contained. Meanwhile, the weight of the tablet is less than the buoyant force of the gastric juice to float the tablet on the gastric juice and prolong the retention time in the stomach.
Description
technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of amoxicillin, which is used for 1. otitis media, sinusitis, pharyngitis, tonsillitis, etc. Respiratory infection. 2. Urinary tract infection caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis. 3. Skin and soft tissue infection caused by hemolytic streptococcus, staphylococcus or Escherichia coli. 4. Acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic Streptococcus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae. 5. Acute simple gonorrhea. 6. This product can still be used in pharmaceutical preparations and preparation methods for treating typhoid fever, typhoid carriers and leptospirosis, etc., specifically a preparation method and application of amoxicillin gastric floating tablets. Background technique [0002] Amoxicillin is a broad-spectrum semi-synthetic penicillin an...
Claims
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Application Information
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