15 results about "Chlorothiazide" patented technology

The invention discloses a telmisartan and hydrochlorothiazide compound tablet which is characterized in that the telmisartan and hydrochlorothiazide compound tablet comprises a double-layer tablet A and a double-layer tablet B, and the layer A is prepared from telmisartan lipidosome, a diluent and a lubricant; and the layer B is prepared from hydrochlorothiazide, a diluent, a disintegrating agent, a lubricant and an antioxidant. The telmisartan liposome comprises lipid and telmisartan, the dosage ratio of the lipid to the telmisartan is (0.5-2.3): 1, the lipid comprises phospholipid and cholesterol, and in the lipid, the content of the cholesterol accounts for 20%-60% of the total amount of the lipid. The telmisartan liposome comprises lipid, telmisartan and a PH buffer solution, and the PH of the PH buffer solution is 5-7. According to the telmisartan and hydrochlorothiazide compound tablet prepared by the invention, the telmisartan dissolution is good, and the tablet is safe and stable.

The invention relates to novel application of chlorothiazide, in particular to a bacterial cell membrane bionic nano-drug loaded with an ROS responsive chlorothiazide prodrug and application of the bacterial cell membrane bionic nano-drug. The invention relates to novel application of chlorothiazide and bionic nano-drugs in preparation of drugs for treating inflammatory bowel diseases. The inventor finds for the first time that the Chl active compound can directly drive phenotype reversal of macrophages from M1 to M2 and synchronously repair intestinal mucosal barriers, and breaks the pathogenic closed loop of barrier destruction-inflammation aggravation; however, the colon targeting property is poor, the water solubility is low, and the whole body exposure is limited. Therefore, according to the application, Chl is transformed into an ROS responsive prodrug (CH NPs), and the ROS responsive prodrug (CH NPs) is coated with a cell membrane of an escherichia coli Nissle1917 strain, so that the bionic nanoparticles (CHM NPs) are constructed. The system not only retains the ROS responsiveness of CH NPs, but also obviously improves the targeting ability and residence time of the nanoparticles in a colon area by virtue of the biological characteristics of the bacterial membrane.

The present application relates to the technical field of hyperuricemia modeling, and particularly relates to a method for inducing and constructing a cynomolgus monkey hyperuricemia model and application thereof, comprising the following steps: S1: selecting male cynomolgus monkeys as model animals; S2: administering an inducing agent to the experimental animals, wherein the inducing agent is composed of hydrochlorothiazide, potassium oxonate and adenine. The inducing agent is added to ordinary monkey feed for normal feeding of the experimental animals, the intake dose of hydrochlorothiazide is 0.1 g / kg / day, the intake dose of potassium oxonate is 0.2 g / kg / day, the intake dose of adenine is 0.1 g / kg / day, and 10% fructose water is used to replace ordinary drinking water at the same time. The present application can induce a stable hyperuricemia state in the cynomolgus monkey body by means of dietary induction, combined use of hydrochlorothiazide, potassium oxonate and adenine, compared with a traditional model induced by a single intraperitoneal injection of a drug, the present application better simulates the pathogenic cause of human hyperuricemia, and is easier to operate.

The invention relates to the technical field of irbesartan and hydrochlorothiazide capsules, in particular to an irbesartan and hydrochlorothiazide capsule as well as a preparation method and application thereof. The irbesartan capsule is prepared from 150 parts of irbesartan, a sorbitol functionalized beta-cyclodextrin hydrochlorothiazide inclusion compound containing 12.5 parts of hydrochlorothiazide effective components, 38.5 parts of lactose, 27 parts of microcrystalline cellulose 101, 12 parts of croscarmellose sodium, 5 parts of hydroxypropyl methylcellulose, 2.5 parts of silicon dioxide and 2.5 parts of magnesium stearate. Natural beta-cyclodextrin is subjected to hydrophilic function modification, diethylene glycol anhydride serves as a connecting agent, sorbitol serves as a hydrophilic function raw material, sorbitol functionalized beta-cyclodextrin is prepared through an esterification reaction, hydrochlorothiazide is included through the sorbitol functionalized beta-cyclodextrin, and the sorbitol functionalized beta-cyclodextrin hydrochlorothiazide inclusion compound is formed. The water solubility and the stability of hydrochlorothiazide are obviously improved.

The invention discloses a three-compound composition of olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide and a preparation method of the three-compound composition. The three-compound preparation comprises three active ingredients of olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide, the auxiliary materials comprise pregelatinized starch, silicified microcrystalline cellulose, cross-linked carboxymethyl cellulose, polylactic acid spray-dried powder, tocopherol and the like; an olmesartan medoxomil, amlodipine and hydrochlorothiazide tablet obtained after coating operation of the olmesartan medoxomil, amlodipine and hydrochlorothiazide three-compound composition is stable in dissolution, consistent with an original product, very smooth in surface, free of dents and more stable in quality.

The invention discloses a method for detecting related substances of telmisartan and hydrochlorothiazide double-layer tablets. According to the detection method disclosed by the invention, octyl silane bonded silica gel is used as a filling agent or a chromatographic column with equivalent efficiency, and an impurity trapping column is added; carrying out gradient elution by taking an ammonium dihydrogen phosphate solution as a mobile phase A and acetonitrile-methanol in a volume ratio of 1: 1 as a mobile phase B; dual wavelength detection is adopted, and the detection wavelengths are 268 nm to 272 nm and 296 nm to 300 nm. The detection method provided by the invention can realize effective separation and quantitative calculation of related substances of two active components (telmisartan and hydrochlorothiazide) in a telmisartan bulk drug, a hydrochlorothiazide bulk drug and a telmisartan and hydrochlorothiazide double-layer tablet, and has the characteristics of good sensitivity, specificity, accuracy, durability and the like; and meanwhile, the working efficiency is greatly simplified.

The invention discloses a method for determining the content of formaldehyde in a hydrochlorothiazide bulk drug, which comprises the following steps: precisely weighing a formaldehyde solution, adding acetonitrile, an acetonitrile solution of 2, 4-dinitrophenylhydrazine and a phosphoric acid solution, and diluting to prepare a reference substance solution; the method comprises the following steps: precisely weighing a hydrochlorothiazide bulk drug, adding acetonitrile, an acetonitrile solution of 2, 4-dinitrophenylhydrazine and a phosphoric acid solution, and diluting to prepare a test solution; the method comprises the following steps: precisely measuring an acetonitrile solution of 2, 4-dinitrophenylhydrazine, a phosphoric acid solution and 1ml of acetonitrile, and diluting with acetonitrile to prepare a blank solution; analyzing by adopting high performance liquid chromatography, precisely measuring the blank solution, the test solution and the reference substance solution, respectively injecting into a liquid chromatograph, recording chromatograms, and calculating by peak area according to an external standard method to obtain the content of formaldehyde in the hydrochlorothiazide bulk drug. The method has the remarkable effects that the method has the characteristics of simple process, low use cost, good precision, high accuracy and the like, and the content of formaldehyde in the hydrochlorothiazide bulk drug can be rapidly measured.

The invention provides a losartan potassium and hydrochlorothiazide pharmaceutical composition and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the composition is a tablet, and comprises the following components by weight: 15%-25% of losartan potassium, 5%-10% of hydrochlorothiazide, 10%-30% of a hydrophilic polymer carrier, 0.1%-5% of a pH regulator, 40%-60% of a filler, 3%-15% of a disintegrating agent, 0.5%-2% of a lubricant, and 1%-5% of an adhesive. The preparation method is divided into two methods, one method is a dry granulation process, material pretreatment is firstly carried out, and then tabletting is carried out after primary granulation, premixing, secondary granulation and total mixing; and the other method is a direct mixing process, the particle size of the solid dispersion is controlled after the materials are pretreated, and premixing, total mixing and direct tabletting are performed. According to the invention, the bioavailability of hydrochlorothiazide can be effectively improved, the drug can be rapidly dissolved out to take effect, the long-term stability of the preparation is obviously improved, the process reproducibility is good, and the preparation is suitable for industrial production.

The invention belongs to the field of medicaments, and provides candesartan cilexetil, 5-8 mg of hydrochlorothiazide, 7-10 mg of PEG (polyethylene glycol) 8000, 60-90 mg of lactose monohydrate, 3-8 mg of HPMC (hydroxypropyl methyl cellulose), 0.1-1 mg of magnesium stearate and 3-8 mg of disintegrating agent per 110 mg of the candesartan cilexetil, the hydrochlorothiazide, the PEG 8000, the lactose monohydrate, the HPMC, the magnesium stearate and the disintegrating agent. By selecting a proper disintegrating agent combination, the candesthia tablet disclosed by the invention effectively improves the dissolution performance in artificial gastric juice, and a basis is provided for further improvement of the drug effect.

The invention provides an irbesartan solid dispersion and a preparation method of a preparation thereof, and belongs to the technical field of pharmaceutical preparations, the irbesartan solid dispersion is prepared from 10-30% by weight of irbesartan, 60-90% by weight of copovidone and 5-15% by weight of a plasticizer by adopting a twin-screw hot melt extrusion process, and the irbesartan solid dispersion is prepared from the preparation method of the irbesartan solid dispersion and the preparation of the irbesartan solid dispersion. And mixing the solid dispersion with a filling agent, a disintegrating agent and a lubricating agent which are conventional in pharmaceutics to prepare irbesartan unilateral tablets, or additionally adding hydrochlorothiazide and mixing to prepare irbesartan compound tablets. According to the irbesartan tablet and the preparation method thereof, irbesartan is prepared into the solid dispersion and then prepared into the tablet, so that the electrostatic agglomeration of irbesartan is improved to improve the mixing uniformity of the preparation, the dissolution performance of irbesartan is remarkably improved, and the bioavailability of the medicine is improved; therefore, the problems of insufficient subsequent mixing uniformity caused by electrostatic agglomeration in irbesartan preparation preparation and poor dissolution performance and low bioavailability caused by low solubility are effectively solved.

The application discloses an antihypertensive compound preparation, which comprises 4.0% benazepril hydrochloride, 5.0% hydrochlorothiazide, 78-82% diluent, 6-11% disintegrant, 2-3% lubricant and coating material in percentage by weight. The diluent is selected from one or more of lactose and microcrystalline cellulose, the ratio of the amount of lactose to the amount of microcrystalline cellulose is (10-13):(1-2), the disintegrant is crospovidone, the lubricant is hydrogenated castor oil, and the particle size of benazepril hydrochloride and hydrochlorothiazide is D90<70 mu m. The benazepril hydrochloride and hydrochlorothiazide tablet provided by the application has good stability and dissolution performance.

The application discloses a triple combination of olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide and a preparation method thereof. The triple combination preparation comprises three active ingredients of olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide, and further comprises pre-gelatinized starch, silicified microcrystalline cellulose, cross-linked carboxymethyl cellulose, polylactic acid spray-dried powder and tocopherol as auxiliary materials. The triple combination of olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide is coated to obtain olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide tablets, which have the same dissolution stability as the original research product, a very smooth surface, no indentation and more stable quality.

The invention provides a method for catalytically synthesizing a 3, 4-dihydrobenzothiadiazine medicine by using rare earth. According to the method, trifluoromethanesulfonic acid rare earth salt is taken as a catalyst, 4-amino-6-chlorobenzene-1, 3-disulfonamide, 4-amino-6-trifluoromethylbenzene-1, 3-disulfonamide and corresponding aldehyde are taken as raw materials, and seven 3, 4-difluorobenzene-1, 3-disulfonamide compounds are simply and conveniently prepared through one-step reaction. The compound is prepared from 2, 4-dihydrobenzothiadiazine medicines: cyclothiazide, buthiazide, cyclopenthiazide, hydrochlorothiazide, bendrofluthiazide, penfluthiazide and ethyl thiazide. The medicine has the effects of inducing diuresis, reducing blood pressure, resisting anxiety, resisting depression, treating edema and the like clinically. The synthesis method provided by the invention has the advantages of mild reaction conditions, simple operation, simple steps and high synthesis efficiency, has industrial application prospects, and plays a positive role in the fields of medicines, fine chemical engineering and the like.

This invention discloses a method for purifying hydrochlorothiazide, comprising dissolving crude hydrochlorothiazide in a mixture containing acid and solvent under heating conditions; then neutralizing with alkali under cooling conditions; and finally obtaining purified hydrochlorothiazide by cooling, crystallization, and filtration. The method provided by this invention further improves both the quality and purification yield of the hydrochlorothiazide product.

The invention discloses a valsartan and hydrochlorothiazide solid dispersion tablet with high bioavailability as well as a preparation method and application of the valsartan and hydrochlorothiazide solid dispersion tablet, raw materials of the tablet comprise valsartan, hydrochlorothiazide and a solid dispersion carrier, and the core of the tablet is that the solid dispersion carrier is a compound of hydroxypropyl methylcellulose acetate succinate and ethyl cellulose, the cosolvent, the surfactant and the cyclodextrin are cooperatively used. Through carrier compounding and auxiliary material synergism, the dissolution rate and the bioavailability are remarkably improved, and the long-term stability is reliably guaranteed. Compared with a conventional preparation, the tablet provided by the invention has the advantages that the 45-min dissolution rate is improved by 30% or more, the bioavailability is improved by 60% or more, the impurity level is not changed within 6 months of an acceleration test, and the technical problem that dissolution and stability of a single carrier system are difficult to consider at the same time is solved. In addition, the preparation process is suitable for large-scale industrial production and has extremely high industrial conversion value.