12results about How to "Fast dissolution rate" patented technology

The invention discloses an ionic liquid modified polyimide nanofiber film and an air purification filter screen based on the ionic liquid modified polyimide nanofiber film, and belongs to the technical field of film filtering materials. The preparation method comprises the following steps: firstly, selecting a diamine monomer and a dianhydride monomer to carry out low-temperature polycondensation reaction, and then carrying out solvent replacement and freeze drying to obtain polyamide acid powder; dissolving the powder to obtain a polyamide acid spinning solution, preparing an ionic liquid / polyamide acid spinning solution on the basis, and carrying out electrostatic spinning to obtain an ionic liquid / polyamide acid nanofiber membrane; and finally, carrying out high-temperature thermal imidization treatment to prepare the ionic liquid / polyimide nanofiber membrane. The method is simple and efficient, the problems of low resistance, high pressure drop and the like of a traditional nanofiber film in air filtration are solved, development and application of the nanofiber film in the field of air filtration are further widened, and the nanofiber film has important scientific significance and application value in the fields of high-temperature filtration, gas adsorption and the like.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an indobufen pharmaceutical composition, a tablet and a preparation method. According to the embodiment of the invention, indobufen, ground lactose and an internally added lubricant are co-crushed, the D90 particle size of the co-crushed material is controlled to be 10-40 [mu] m, then spray-dried lactose, microcrystalline cellulose and an internally added disintegrating agent are added for dry granulation, and finally an externally added disintegrating agent and an externally added lubricant are added for tabletting to prepare the indobufen tablet. Through the process, the prepared material is good in compressibility, the problems of sticking, tablet cracking, low hardness and the like in the tabletting process of indobufen are solved, meanwhile, the dissolution level of the prepared indobufen tablet in an acid medium is remarkably improved, the clinical effect of the product can be better exerted, and therefore replacement of an original product can be achieved; and the preparation is simple in production process, easy to realize large-scale industrial production, and relatively high in popularization and application value.

The invention discloses a benidipine hydrochloride tablet. The benidipine hydrochloride tablet is a preparation formed by coating a tablet core with a coating solution, the tablet core is formed by mixing and pressing material particles with the following particle sizes in proportion: gt; 0.8%-8% of 20 meshes, 5%-20% of 20-40 meshes, 9%-21% of 40-60 meshes, 15%-48% of 60-80 meshes and 20%-51% of 80-100 meshes; 3-21% of 100 mesh; the material particles comprise the following raw and auxiliary materials in parts by weight: 2-5 parts of benidipine hydrochloride, 76-99 parts of a diluent, 1-2 parts of an adhesive and 0.5-1.5 parts of a lubricant. According to the invention, a specific process of stirring, cutting and atomizing is adopted, so that the raw and auxiliary materials in the tablet are uniformly mixed, material particles with specific granularity are easily prepared for tabletting, the preparation process is simple, and the obtained tablet has the advantages of low content of related substances, stable property, quick dissolution and quick effect, and has practical popularization and application values.

The invention discloses a method for producing polyacrylamide by a kneading machine. The method comprises the following steps: (1) forming a mixed solution A from acrylamide, 2-acrylamido-2-methyl propane sodium sulfonate, polyethylene glycol diacrylamide, a chain transfer auxiliary agent and water; (2) forming a cationic monomer solution from a cationic monomer, a cosolvent and water; (3) forming a mixed solution B from a part of the mixed solution A and a part of the cation mixed solution; (4) forming a mixed solution C from a redox initiator, an azo initiator and water; (5) putting the residual mixed solution A into a polymerization reaction kettle, introducing nitrogen to remove oxygen, regulating the temperature, adding the mixed solution C, stirring to react, cooling, adding the cationic monomer solution and the mixed solution C, stirring to react, cooling, adding the mixed solution B and the mixed solution C, stirring to react, heating, preserving heat and standing to obtain colloid; and (6) transferring the colloid into a kneading machine, vacuumizing and kneading. The produced polyacrylamide is high in molecular weight and concentrated in distribution, and has good dissolution and flocculation performance.

The utility model is suitable for the technical field of mineralized water purification, and discloses a filter element, a filter cartridge and a mineral spring water purifier. The filter element comprises a carbon fiber filter body, the carbon fiber filter body comprises at least two mineralized carbon fiber filter layers which are sequentially attached, and the at least two mineralized carbon fiber filter layers are provided with the same or different mineralizer layers. And the mineralized carbon fiber filter body is formed by winding. The filter cartridge comprises a cartridge shell and the filter element, and the filter element is arranged in the cartridge shell. The mineral spring water purifier comprises the filter element or the filter cartridge. The filter element comprises a carbon fiber filter body, the carbon fiber filter body comprises at least two mineralized carbon fiber filter layers which are sequentially attached, and the at least two mineralized carbon fiber filter layers are provided with different mineralizers, so that different use requirements are met, and the water body contains mineral components beneficial to human health; and high-end requirements of users on drinking water beneficial to health can be met.

The invention discloses a photovoltaic module gypsum accumulated dust cleaning agent and a use method thereof. The cleaning agent is composed of 10-40% by mass of a complexing agent, 5-10% by mass of a cleaning auxiliary agent, 0.5-2% by mass of a penetrant and demineralized water. And the complexing agent is used for complexing calcium ions in gypsum. The cleaning aid is used for increasing the reaction rate and promoting dissolution of gypsum. And the penetrating agent can accelerate the complexing agent and the cleaning auxiliary agent to penetrate into the gypsum and the gypsum-glass bonding surface, so that the dissolution reaction is accelerated. The cleaning agent can quickly dissolve gypsum, does not need to be soaked or washed for a long time, is easy to biodegrade, is easy to treat waste liquid, and is environment-friendly.

The application discloses a kind of stable indometacin tablets and its preparation process, belong to pharmaceutical preparation technical field.The tablet is composed of indometacin, hydroxypropyl beta-cyclodextrin, soybean phospholipid, composite stabilizer, binder and lubricant, and the composite stabilizer is compounded by succinylated c14-c18 alkyl sulfonate sodium, N-ethyl-L-glutamine and maltodextrin according to specific mass ratio.Preparation process includes liposome inclusion compound preparation, mixing granulation, drying whole particle, total mixing and tabletting.The application realizes the preparation of high drug loading design, and the composite stabilizer forms a multilayer coating protection system with hydroxypropyl beta-cyclodextrin and soybean phospholipid, which synergistically improves the dissolution performance and stability of the preparation, makes the dissolution rate of the preparation fast, and the content of the main component decreases little during long-term storage, solves the problems of low drug loading, poor stability and dissolution of existing indometacin tablets.

The invention belongs to the technical field of medicines, particularly discloses a masitinib oral cavity soluble film dosage form composition, and also discloses an oral cavity soluble film dosage form prepared from the composition and a preparation method of the dosage form. The masitinib oral soluble film dosage form composition provided by the invention comprises an active component and an auxiliary material, the active component comprises at least one of masitinib or pharmaceutically acceptable salt, prodrug, metabolite, solvate, crystal and deuterated substance thereof, and the auxiliary material comprises a film forming material. The masitinib oral soluble film provided by the invention has the characteristics of fast disintegration and good taste, and improves the compliance of medication of patients.

The invention belongs to the technical field of photoresist materials, and particularly relates to a photoresist composition as well as a preparation method and application thereof. The photoresist composition comprises a polymer, a photosensitizer, a first organic solvent and an optional auxiliary agent, the polymer is obtained by condensation polymerization of a first polymerization component and a second polymerization component, the first polymerization component and the second polymerization component have a structure shown in a formula (1), and the second polymerization component is an aldehyde compound. The key point of the invention lies in that the specific polymer is introduced and compounded with the photosensitizer and the organic solvent to obtain the photoresist composition, and the photoresist composition not only has good thermal stability and optical performance, but also has higher dissolution rate and better dissolution effect in a developing solution, reduces the residue of the photoresist after development, and improves the yield of the photoresist. Therefore, the resolution of the photoetching pattern is improved. # imgabs0 #

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a baloxvir dipivoxil pharmaceutical composition, a baloxvir dipivoxil tablet and a preparation method. According to the invention, the baloxvir dipivoxil is fully mixed with the spray-dried lactose and the colloidal silicon dioxide, so that the agglomeration behavior of the API is reduced, the dispersion surface area of the API is increased, and the dissolution rate of the product is improved; according to the preparation method, the prepared baloxvir dipivoxil tablet has excellent dissolution performance and is in a stable state all the time during an accelerated test, the problem that the dissolution rate of the baloxvir dipivoxil tablet is remarkably reduced in the accelerated test process is solved, the stability of the product is remarkably improved, the clinical effect of the product is better played, and the preparation method is suitable for industrial production. Therefore, the replacement of an original product can be realized; and the preparation is simple in production process, easy to realize large-scale industrial production, and relatively high in popularization and application value.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a cefpodoxime proxetil pharmaceutical composition, a dry suspension and a preparation method. According to the invention, SWELSTARTM PD-1 is taken as a disintegrating agent, the mass ratio of anhydrous citric acid to sodium glutamate is controlled in a specific proportion range, and a dry method-coating combined process is adopted, so that the stability of the prepared head poxime ester dry suspension is remarkably improved, and the application prospect is wide. The content of impurities A, C + B-II, H-I + H-II and total impurities is obviously slower than that of commercially available products and contrast under the condition of high-temperature storage, and meanwhile, the dissolution level of the prepared head poxime ester dry suspension in media with the pH value of 4.0, water and pH value of 6.8 is also improved, so that the clinical effect of the product is more favorably exerted, and the application prospect of the head poxime ester dry suspension is broad. Therefore, original products can be replaced, and the method has high popularization and application value.

The invention discloses an external instant film containing rucotinib as well as a preparation method and application of the external instant film, the external instant film comprises the following raw materials: rucotinib phosphate or pharmaceutically acceptable salt thereof and a film-forming agent in a weight part ratio of 1: (5-20), and the film-forming agent is polyethylene oxide or polyvinyl alcohol. The external instant film disclosed by the invention has the advantages of high drug loading capacity, high dissolution rate, high drug accumulative release amount and high permeation rate, is good in adhesion degree with skin, is not easy to contaminate clothes, and is better in compliance compared with cream or other external dosage forms.