Preparation method for compound losartan potassium-hydrochlorothiazide pharmaceutical composition
A losartan potassium hydrochlorothiazide tablet and a technology for hydrochlorothiazide are applied in the field of preparation of losartan potassium hydrochlorothiazide tablets, and can solve the problems of affecting the dissolution and release rate of amlodipine, the effect is not very obvious, the volume ratio of auxiliary materials is increased, and the like, achieving The difference in loading is not obvious, the fluidity is good, and the effect of improving stability
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[0033] particle 1
[0034] Losartan Potassium 50g
[0035] Starch 150g
[0036] 10% starch slurry appropriate amount
[0037] particle 2
[0038] Hydrochlorothiazide 12.5g
[0039] Croscarmellose Sodium 10g
[0040] Lactose 150g
[0041] 5% povidone K30 solution appropriate amount
[0042] Magnesium Stearate 2g
[0043] Makes 1000 pieces
[0044] The preparation steps are as follows:
[0045] 1) Sieve the prescription amount of losartan potassium, mix it evenly with starch, use 10% starch slurry to make a soft material with suitable hardness, use a 20-mesh sieve to granulate, and dry at 60°C to make the water content less than 5 %,spare;
[0046] 2) Pulverize the prescription amount of hydrochlorothiazide to a qualified particle size, and set aside;
[0047] 3) Mix the prescribed amount of hydrochlorothiazide, croscarmellose sodium, and lactose evenly, use 5% povidone K30 solution to prepare a soft material with suitable hardness, use a 20-mesh sieve to granulate, a...
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