Medicinal composition and preparation method thereof
A composition and drug technology, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, cardiovascular system diseases, etc., can solve the problems of difficult industrial production, high energy consumption of dry granulation, high equipment requirements, and overcome mutual constraints. , The effect of smooth granulation process and low equipment requirements
Inactive Publication Date: 2012-07-04
BEIJING D VENTUREPHARM TECH DEV
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Problems solved by technology
However, dry granulation has the disadvantages of high energy consumption, small adaptability, high requirements for equipment or the need to renovate workshops, and certain dust pollution, making industrial production difficult.
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Abstract
The invention discloses a medicinal composition. The medicinal composition consists of the following ingredients in percentage by weight: 1 to 5 percent of amlodipine and pharmaceutically acceptable salt thereof, 20 to 50 percent of valsartan, 1 to 10 percent of hydrochlorothiazide, 20 to 50 percent of filling agent, 8 to 24 percent of disintegrating agent, 0.01 to 0.06 percent of adhesive 1, 0.01 to 0.2 percent of adhesive 2, 0.3 to 2 percent of flow aid and 0.5 to 2.5 percent of lubricating agent. The medicinal composition has the advantages of simple preparation process, low equipment requirement, simplicity in operation and small dust pollution, guarantees the quality of medicines and contributes to industrialized production.
Description
technical field [0001] The invention relates to a pharmaceutical composition for treating hypertension and a preparation method thereof, in particular to a pharmaceutical composition containing amlodipine and a pharmaceutically acceptable salt thereof, valsartan and hydrochlorothiazide and a preparation method thereof. Background technique [0002] Hypertension is a common cardiovascular disease and can induce or aggravate other related diseases. At present, about 2 / 3 of hypertensive patients need to take two or more antihypertensive drugs to control blood pressure. Various clinical studies have shown that the use of drug combinations is one way to achieve desired therapeutic endpoints. The solid preparation of compound amlodipine valsartan hydrochlorothiazide is a safe and oral effective antihypertensive drug widely used in clinic. Amlodipine valsartan not only provides two powerful antihypertensive drugs, but also significantly reduces adverse reactions, and is convenie...
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61K31/4422A61K31/41A61K47/38A61K47/10A61P9/12
Inventor 黄雪吕青远
Owner BEIJING D VENTUREPHARM TECH DEV
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