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A kind of preparation method of valsartan hydrochlorothiazide capsule

A technology for hydrochlorothiazide and hydrochlorothiazide, which is applied in the field of preparation of valsartan hydrochlorothiazide capsules, can solve the problems of complex preparation process, high equipment requirements, large dust and the like, and achieves the effects of simple process and low preparation cost

Active Publication Date: 2020-07-10
CHONGQING CONQUER PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dry granulation has the disadvantages of large dust, easy stickiness during pressing, uneven particle size and high particle hardness.
In order to solve the above problems, the patent 201410535086.8 uses micronization treatment of valsartan and hydrochlorothiazide to control its particle size to be less than 50 microns, so as to improve the dissolution rate of hydrochlorothiazide in water and improve its utilization, but micronization is the same It is easy to cause a large amount of dust, and the preparation process is complex and requires high equipment. Large-scale production will waste a lot of manpower and material resources

Method used

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  • A kind of preparation method of valsartan hydrochlorothiazide capsule
  • A kind of preparation method of valsartan hydrochlorothiazide capsule

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Experimental program
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Effect test

Embodiment 1

[0024] Embodiment 1 (500,000 grains):

[0025] A preparation method of valsartan hydrochlorothiazide capsules, comprising the following steps:

[0026] S1. Weigh valsartan, hydrochlorothiazide, disintegrant, cosolvent, filler, lubricant, and binder according to the proportion, wherein the disintegrator is sodium carboxymethyl starch, and the filler is microcrystalline Cellulose and cornstarch, described solubilizer is sodium lauryl sulfate, described lubricant is magnesium stearate, described binding agent is povidone K30;

[0027] S2, preparing a binder solution, adding the binder weighed in proportion to purified water to prepare a binder solution with a weight ratio of 5-10%, stirring evenly for later use;

[0028] S3. Mix and pulverize valsartan, 50% disintegrant, and filler through an 80-mesh sieve to obtain a mixed material, mix and pulverize hydrochlorothiazide and a cosolvent through an 80-mesh sieve to obtain hydrochlorothiazide powder;

[0029] S4. Add the mixed ma...

Embodiment 2

[0036] Embodiment 2 (500,000 grains)

[0037] A preparation method of valsartan hydrochlorothiazide capsules, comprising the following steps:

[0038] S1. Weigh valsartan, hydrochlorothiazide, disintegrant, cosolvent, filler, lubricant, and binder according to the proportion, wherein the disintegrator is sodium carboxymethyl starch, and the filler is microcrystalline Cellulose and cornstarch, described solubilizer is polyethylene glycol 6000, described lubricant is magnesium stearate, described binding agent is povidone K30;

[0039] S2, preparing a binder solution, adding the binder weighed in proportion to purified water to prepare a binder solution with a weight ratio of 5-10%, stirring evenly for later use;

[0040] S3. Mix and pulverize valsartan, 50% disintegrant, and filler through an 80-mesh sieve to obtain a mixed material, mix and pulverize hydrochlorothiazide and a cosolvent through an 80-mesh sieve to obtain hydrochlorothiazide powder;

[0041] S4. Add the mixed ...

Embodiment 3

[0048] Embodiment 3 (500,000 grains)

[0049] A preparation method of valsartan hydrochlorothiazide capsules, comprising the following steps:

[0050] S1. Weigh valsartan, hydrochlorothiazide, disintegrant, cosolvent, filler, lubricant, and binder according to the proportion, wherein the disintegrator is sodium carboxymethyl starch, and the filler is microcrystalline Cellulose and cornstarch, described solubilizer are meglumine, described lubricant is magnesium stearate, described binding agent is povidone K30;

[0051] S2, preparing a binder solution, adding the binder weighed in proportion to purified water to prepare a binder solution with a weight ratio of 5-10%, stirring evenly for later use;

[0052] S3. Mix and pulverize valsartan, 50% disintegrant, and filler through an 80-mesh sieve to obtain a mixed material, mix and pulverize hydrochlorothiazide and a cosolvent through an 80-mesh sieve to obtain hydrochlorothiazide powder;

[0053] S4. Add the mixed material obtai...

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Abstract

The invention relates to a valsartan hydrochlorothiazide capsule preparation method which includes the steps: mixing, crushing and screening valsartan, disintegrating agents and filling agents to obtain valsartan mixed materials, and adding the valsartan mixed materials into a binding agent to prepare into main medicine particles; mixing, dispersing and screening hydrochlorothiazide and cosolvents to obtain hydrochlorothiazide powder, mixing the hydrochlorothiazide powder and the main medicine particles to prepare into capsule fillers, and enabling the dissolution rate of the hydrochlorothiazide to be larger than 90%. The preparation method is simple in process, low in preparation cost and applicable to various types of preparation devices.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a method for preparing valsartan-hydrochlorothiazide capsules. Background technique [0002] Valsartan hydrochlorothiazide is a drug used to treat mild-moderate essential hypertension whose blood pressure is not adequately controlled by a single drug. Among them, valsartan is a non-peptide, orally effective angiotensin II (AT) receptor antagonist. It is highly selective for type I receptors (AT1) and can be competitively antagonized without any agonistic effect. It can also inhibit the release of aldosterol from adrenal cells mediated by AT1 receptors, but valsartan has no inhibitory effect on the release caused by potassium, which also shows that valsartan has a selective effect on AT1 receptors. In vivo tests on various types of hypertensive animal models have shown that valsartan has a good antihypertensive effect and has no significant effect on cardiac systolic f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/549A61K31/41A61K9/48A61P9/12
CPCA61K9/4866A61K31/41A61K31/549A61K2300/00
Inventor 何伟陈用芳杨绪凤冉诗念叶兆敏
Owner CHONGQING CONQUER PHARML
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