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Blood pressure lowering dripping pills with chryanthemum flower and pearl and its preparation process

A technology of dropping pills and nacre powder, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., which can solve the problems that are not conducive to improving the ability of patients to seek medical treatment, the bioavailability of the first-pass effect of the liver and intestines, and the physical hazards of staff and other issues, to achieve the effect of improving bioavailability, drug safety, and low labor intensity

Inactive Publication Date: 2005-11-23
广西宝瑞坦广明制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0032] The preparation method of Zhenju Jiangya Dropping Pills of the present invention will be further described with several groups of specific examples.

[0033] [Group 1: Trials with a single substrate]

[0034] 1. Raw materials: According to [Preparation Method 1], the mixture dry powder containing 5 kinds of drugs such as wild chrysanthemum paste powder, nacre powder, clonidine hydrochloride, hydrochlorothiazide, and rutin was prepared for use;

[0035] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0036] 3. Proportion: take g or kg as the unit, by weight parts, drug mixture: matrix = 1:1~1:9;

[0037] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain Zhenju Jiangya Dropping Pills of different specifications...

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PUM

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Abstract

Disclosed is a dripping pill for treating hypertension. The objective of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, easy administration, low price, and causing no pollution during production. The drop pill is prepared from powdered wild chrysanthemum flower, pearl powder, clonidine hydrochloride, hydrochlorothiazidum, globularicitrin as raw material, and medicinal carrying agent as the base material.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has antihypertensive effect and is used for the treatment of hypertension, especially relates to the preparation of 5 kinds of medicines such as wild chrysanthemum paste powder, nacre powder, clonidine hydrochloride, hydrochlorothiazide and rutin as raw materials A pharmaceutical composition oral preparation. Background technique [0002] According to the ministerial drug standard WS 3 -Zhenju Jiangya tablet prepared by the preparation method given in B-3925-98 is a kind of oral tablet with antihypertensive effect for the treatment of hypertension. and common medicines used at home to treat the above conditions. [0003] The following is the drug standard WS 3 -Formulation and process and brief description given in B-3925-98: [0004] Prescription: Wild chrysanthemum cream powder 100g, nacre powder 100g, clonidine hydrochloride 30mg, hydrochlorothiazide 5g, rutin 20g [0005] Pre...

Claims

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Application Information

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IPC IPC(8): A61K35/618
Inventor 梁宁省曲韵智
Owner 广西宝瑞坦广明制药有限公司
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