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Double-active emulsifier

An emulsifier and dual-active technology, applied in the field of dual-active emulsifiers, can solve problems such as difficult absorption, unsatisfactory drug availability, and low solubility, and achieve the effects of promoting dissolution and absorption, improving drug stability, and simple preparation

Inactive Publication Date: 2018-11-16
CHANGZHOU ZHONGKE XINGLONG WIRE & CABLE
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The existing emulsifiers used to improve the oral stability of curcumin have very low solubility in water, are not easily absorbed by the gastrointestinal tract, and cannot meet the availability of the drug

Method used

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Examples

Experimental program
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Embodiment Construction

[0008] A dual-active emulsifier, consisting of the following components by mass: 70-130 parts of polyoxyethylene nonylphenol ether, 1-8 parts of curcumin, 28-50 parts of polyethylene glycol, and 8 parts of ethyl oleate ~25 parts, micronized silica gel 45~80 parts, mannitol 15~32 parts.

[0009] A dual-active emulsifier, consisting of the following components by mass: 80-120 parts of polyoxyethylene nonylphenol ether, 2-5 parts of curcumin, 35-45 parts of polyethylene glycol, and 10 parts of ethyl oleate ~20 parts, micronized silica gel 50~70 parts, mannitol 18~23 parts.

[0010] A dual-active emulsifier, consisting of the following components by mass: 100 parts of polyoxyethylene nonylphenol ether, 3 parts of curcumin, 40 parts of polyethylene glycol, 15 parts of ethyl oleate, and 60 parts of micronized silica gel , 20 parts of mannitol.

[0011] The above description is only illustrative, rather than restrictive, to the present invention. Those skilled in the art understand...

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Abstract

The invention relates to the technical field of emulsifiers, especially to a bi-active emulsifier. The bi-active emulsifier is composed of the following ingredients (by weight): 70-130 parts of polyoxyethylene nonylalkylphenol ether, 1-8 parts of curcumin, 28-50 parts of polyethylene glycol, 8-25 parts of ethyl oleate, 45-80 parts of aerosol, and 15-32 parts of mannitol. The preparation process issimple. By stirring, oscillation, ultrasonic treatment, vortex and other modes for uniformly mixing the above ingredients, dissolution and absorption of the medicines can be better promoted, and drugstability is enhanced.

Description

technical field [0001] The invention relates to the technical field of emulsifiers, in particular to a double-active emulsifier. Background technique [0002] Emulsifier is a substance that can improve the surface tension between the various constituent phases in the emulsion to form a uniform and stable dispersion system or emulsion. Emulsifier is a surface active substance with both hydrophilic and lipophilic groups in the molecule. It gathers on the oil / water interface, which can reduce the interfacial tension and reduce the energy required to form the emulsion, thereby increasing the energy of the emulsion. The emulsifier refers to the surfactant that can stabilize the emulsion. Therefore, in After adding an emulsifier to the oil-water system, water and oil can mix with each other to form a completely dispersed emulsion. The emulsifier can not only improve the stability of the emulsion, but also determine the type of the emulsion. The existing emulsifiers used to improv...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/10A61K47/14A61K47/26A61K47/04A61K31/12
CPCA61K9/107A61K31/12A61K47/02A61K47/10A61K47/14A61K47/26
Inventor 臧顺良
Owner CHANGZHOU ZHONGKE XINGLONG WIRE & CABLE
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