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Pseudoephedrine hydrochloride dripping pill

A technique for pseudoephedrine hydrochloride and alkali dropping pills, which is applied in the directions of pill delivery, respiratory diseases, organic active ingredients, etc., can solve the problems such as data reports of pseudoephedrine hydrochloride dropping pills that have not yet been found, and achieves avoidance of liver and intestine first-pass effect, simple equipment, and side effects. small effect

Inactive Publication Date: 2005-05-18
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, no reports about pseudoephedrine hydrochloride dripping pills have been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0034] Below in conjunction with two groups of specific embodiment tests, the preparation process and test results of the pseudoephedrine hydrochloride dripping pills involved in the present invention are further described.

[0035] Example Test 1 Prescription Experiment of Pseudoephedrine Hydrochloride and Different Substrates

[0036] Experimental Design: In order to observe the impact of pseudoephedrine hydrochloride and different matrix prescriptions on the pseudoephedrine hydrochloride dripping pills involved in the present invention, polyethylene glycol 2000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 8000 , polyethylene glycol 10000 , stearic acid, sodium stearate, glycerin gelatin, polyoxyl 40 stearate, shellac, polyoxyethylene monostearate, polyether, sodium carboxymethyl starch, sodium lauryl sulfate, etc. Any one of the pharmaceutical excipients is used as a base, and pseudoephedrine hydrochloride and the above bases are formulate...

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PUM

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Abstract

The present invention discloses medicine composition for remitting nose congestion caused by cold, allergic rhinitis, rhinitis and nasosinusitis, and is especially orally taken medicine composition dripping pill with pseudoephedrine hydrochloride as active component. The present invention aims at providing pseudoephedrine hydrochloride dripping pill with great medicine carrying amount, fast medicine release, quick acting, high bioavailability, less toxic side effect, convenient use and low cost. Pseudoephedrine hydrochloride as active medicine component is mixed with medicine carrier as matrix, and the mixture is heated until obtaining medicine composition molten liquid and / or emulsion and / or suspension, which is dropped into condensating agent in dripping pill machine to contracting form.

Description

technical field [0001] The invention relates to a pharmaceutical composition for alleviating nasal congestion symptoms caused by colds, allergic rhinitis, rhinitis and sinusitis, in particular to an oral preparation of the pharmaceutical composition with pseudoephedrine hydrochloride as an active ingredient. Background technique [0002] Ephedrine belongs to alkaloids, is a sympathomimetic drug, clinical indications bronchial asthma, colds, allergic reactions, nasal congestion, edema and hypotension and other diseases. However, excessive application of ephedrine can easily cause toxic side effects on the heart and central nervous system, and even cause death. Pseudoephedrine has few side effects and is relatively safe. Ephedra is mainly produced in China, India, Pakistan and Egypt. my country has used ephedra to treat hay fever (hay fever) and asthma for more than 5,000 years. The (-)-E crystal was isolated from Ephedra in 1887 and has been used as a folk medicine for mor...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/137A61P11/02A61P37/08
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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