Rosuvastatin dropping pill and preparation method thereof

A technology of rosuvastatin and tingtin drop pills, which is applied in the field of rosuvastatin drop pills and its preparation, can solve the problems of slow onset of action, large dosage, heavy taste, etc., and achieve faster dissolution and absorption, and drug dispersion Uniform, easily absorbed effect

Inactive Publication Date: 2015-04-22
TIANJIN KANGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the existing rosuvastatin (rosuvastatin) drugs are tablets, which have the disadvantages of large dosage, heavy taste, difficult to swallow, slow onset of action, etc. Therefore, it is the need of current clinical treatment to seek new types of preparations for this type of drug At the same time, it has become an important issue of current research to find out a process suitable for new pharmaceutical forms

Method used

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preparation example Construction

[0019] The invention provides a rosuvastatin drop pill and a preparation method thereof. In the method, rosuvastatin is used as the main raw material, and polyethylene glycol and other substrates are added in a certain proportion, and prepared through specific processes and equipment. made. details as follows:

[0020] (1) Prescription: rosuvastatin + matrix

[0021] Base: Contains polyethylene glycol (1500, 2000, 4000, 6000, 8000, 10000, 20000), polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, One or more components of stearic acid, sodium stearate, glycerin gelatin, glyceryl monostearate, shellac, polyoxyethylene monostearate, polyether.

[0022] The weight ratio of rosuvastatin to matrix is ​​1:(1-60).

[0023] (2) Preparation process: the specific implementation steps are as follows:

[0024] The first step is to mix rosuvastatin with the matrix according to a certain ratio.

[0025] The second step is to use water bath, oil bath or oth...

Embodiment 1

[0039] Prescription: Rosuvastatin (rosuvastatin) 1g; PEG4000 5g;

[0040] PEG8000 25g; 1000 capsules in total.

[0041] Preparation method: After mixing rosuvastatin, PEG4000, and PEG8000 evenly, heat in a water bath to make it completely melted, pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the drip nozzle, and drop it into the In simethicone oil at -5°C, after molding, filter, separate, and wipe clean to obtain.

Embodiment 2

[0043] Prescription: Rosuvastatin (rosuvastatin) 2g; PEG1500 5g;

[0044] PEG6000 25g; 1000 capsules in total.

[0045] Preparation method: Mix rosuvastatin, PEG1500, and PEG6000 evenly, heat in a water bath to melt completely, pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the drip nozzle, and drop it into the In simethicone oil at -5°C, after molding, filter, separate, and wipe clean to obtain.

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Abstract

The invention discloses a rosuvastatin dropping pill serving as a drug for treating hyperlipidemia and a preparation method of the rosuvastatin dropping pill. The preparation method comprises the steps of with rosuvastatin as a raw material, adding a matrix according to a prescription, and uniformly mixing to obtain a mixed material; heating the mixed material to be molten, and uniformly stirring to obtain a mixture; placing the mixture into a special pill dropping machine; and dropping pills into a condensing agent at a proper speed to condense to form the rosuvastatin dropping pill. The rosuvastatin dropping pill is high in bioavailability, capable of rapidly releasing drugs, high in effect taking speed and drug stability and convenient to take; in addition, the consumption of auxiliary materials is reduced, the production process is simple, the preparation method is easy to operate, the weight difference is small, and the production cost is reduced; and no dust is generated, and labor protection can be favorably realized.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, specifically a rosuvastatin dropping pill and a preparation method thereof. Background technique [0002] Hyperlipidemia refers to abnormal fat metabolism or operation that makes one or more lipids in plasma higher than normal. Hyperlipidemia is a systemic disease, refers to blood cholesterol (TC) and or triglycerides (TG) too high or high-density lipoprotein cholesterol (HDL-C) too low, modern medicine is called dyslipidemia. The damage to the body of the disease is insidious, gradual, progressive and systemic. Its direct damage is to accelerate systemic atherosclerosis, because vital organs of the whole body rely on arterial blood supply and oxygen supply. Once the arteries are blocked by atherosclerotic plaques, serious consequences will result. Renal failure caused by arteriosclerosis is closely related to hyperlipidemia. A large number of research data show ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/22A61K9/28A61K31/505A61P3/06
Inventor 黄四周李明亮王琦
Owner TIANJIN KANGRUI PHARMA
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