Preparation method for compound losartan potassium-hydrochlorothiazide pharmaceutical composition
A technology of losartan potassium hydrochlorothiazide tablets and hydrochlorothiazide, which is applied in the field of preparation of losartan potassium hydrochlorothiazide tablets, can solve the problems affecting the release rate of amlodipine dissolution, the effect is not very obvious, and increase the volume ratio of auxiliary materials, etc., to achieve There is no obvious difference in loading capacity, good fluidity, and the effect of improving stability
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[0033] particle 1
[0035] Starch 150g
[0036] 10% starch slurry appropriate amount
[0037] particle 2
[0038] Hydrochlorothiazide 12.5g
[0039] Croscarmellose Sodium 10g
[0040] Lactose 150g
[0041] 5% povidone K30 solution appropriate amount
[0043] Makes 1000 pieces
[0044] The preparation steps are as follows:
[0045] 1) Sieve the prescription amount of losartan potassium, mix it evenly with starch, use 10% starch slurry to make a soft material with suitable hardness, use a 20-mesh sieve to granulate, and dry at 60°C to make the water content less than 5 %,spare;
[0046] 2) Pulverize the prescription amount of hydrochlorothiazide to a qualified particle size, and set aside;
[0047] 3) Mix the prescribed amount of hydrochlorothiazide, croscarmellose sodium, and lactose evenly, use 5% povidone K30 solution to prepare a soft material with suitable hardness, use a 20-mesh sieve to granulate, a...
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