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Composition containing clerodendranthus spicatus aqueous extract

A technology of composition and tea, applied in the direction of drug combination, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of unsatisfactory treatment effect of kidney stones, loss of beneficial ingredients of kidney tea, etc., to achieve enhanced stone-dissolving effect, Enhance the effect of melting stone

Inactive Publication Date: 2010-04-14
芜湖梁氏新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patents "Extraction method of kidney tea" (publication number CN 1723923A), "method of extracting compounds from kidney tea leaves and stems" (patent number ZL 200510127325.7) and "kidney tea anti-urinary calculus extract and its preparation method "(Publication No. CN 101066292A) discloses the process of extracting kidney tea with water, alcohol mentioning ethyl acetate to extract, Chinese patent "a kind of kidney tea extract and its preparation method and use" (publication number CN 101143160A), but the above-mentioned The kidney tea extract prepared by the process does not take into account the characteristics of kidney tea itself, and directly extracts it with water, methanol, and ethyl acetate, resulting in the loss of many beneficial components in kidney tea, and the therapeutic effect on kidney stones is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0022] 1. Cleaning and drying process: take the kidney tea raw material, remove the sundries, wash with water, and dry in the sun.

[0023] 2. Crushing process: crush the sun-dried kidney tea into 40-80 mesh particles.

[0024] 3. Pretreatment process: add water and cellulosic mold to the crushed kidney tea granules, react at 30-35°C for 5 hours, then raise the temperature to 50-60°C, react for 2 hours, cool to room temperature, filter, that is Yes; the weight ratio of kidney tea and water is 1:4, and the weight / volume (kg / L) ratio of kidney tea and compound cellulase is 1:0.02.

[0025] The compound cellulosic mold is a mixture of Trichoderma sp CGMCC 3.3068 and Trichoderma koningii CGMCC 3.2774, and the volume ratio of the expansion medium is 1:0.5.

[0026] 4. The post-treatment process is: extract the filtrate 3 times with ether, combine the ether extracts, and evaporate to dryness at 50° C. to obtain a brown extract. The volume ratio of the filtrate to ether is 1: 0.5, a...

Embodiment 2

[0029] Except that the composition in each capsule is composed of kidney tea water extract equivalent to 1 gram of the original drug and 5 mg of hydrochlorothiazide, and the composition accounts for 60% of the total weight of the capsule, the rest is the same as in Example 1.

Embodiment 3

[0031] The preparation of kidney-removing tea water extract is:

[0032] 1. Cleaning and drying process: take the kidney tea raw material, remove the sundries, wash with water, and dry in the sun.

[0033] 2. Crushing process: crush the sun-dried kidney tea into 100-200 mesh particles.

[0034] 3. Pretreatment process: add water and cellulosic mold to the crushed kidney tea granules, react at 35-40°C for 2 hours, then raise the temperature to 50-60°C, react for 2 hours, cool to room temperature, filter, that is Yes; the weight ratio of kidney tea and water is 1:10, and the weight / volume (kg / L) ratio of kidney tea and compound cellulase is 1:0.1.

[0035] The compound cellulosic mold is a mixture of Trichoderma sp CGMCC 3.3068 and Trichoderma koningii CGMCC 3.2774, and the volume ratio of the expansion medium is 1:0.8.

[0036] 4. The post-treatment process is: extract the filtrate 3 times with ether, combine the ether extracts, and evaporate to dryness at 50° C. to obtain a ...

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Abstract

The invention discloses a composition containing a clerodendranthus spicatus aqueous extract, which comprises the clerodendranthus spicatus aqueous extract and hydrochlorothiazide, wherein the weight ratio of the clerodendranthus spicatus aqueous extract and the hydrochlorothiazide which have the weight being equivalent to 1 gram of primary medicine is 1:0.005-0.01. Compared with the prior art, the invention has the advantages that the water-soluble beneficial components packaged in cellulose can be sufficiently extracted by using composite cellulase to dissolve the cellulose in clerodendranthus spicatus stalks in the extracting process of the clerodendranthus spicatus aqueous extract and simultaneously the litholytic and diuretic functions of the clerodendranthus spicatus aqueous extract are enhanced by using the hydrochlorothiazide.

Description

technical field [0001] The invention belongs to the combination of Chinese and Western medicines, in particular to the combination of water extract of kidney tea and hydrochlorothiazide. Background technique [0002] Kidney tea is a plant of the genus Clerodendranthus of the Labiatae family, also known as cat's whiskers. There are about 5 species in the world, and there is only one in my country, which is Kidney tea [C.Spi-catus (Thunb).C.Y.Wu], mainly produced in Guangxi and Guangdong , Yunnan, Fujian, Taiwan and other places. Folks believe that the whole plant has diuretic, antibacterial, anti-inflammatory, stone-dissolving, and stone-dispelling effects. It is often used for acute and chronic nephritis, cystitis, urinary tract stones, pharyngitis, and rheumatoid arthritis. At present, 14 flavonoids have been isolated from the aerial part of kidney tea, 12 of which are flavonoid aglycones and 2 of which are flavonoid glycosides; 8 phenolic acids, namely caffeic acid, the di...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P13/04A61P13/12A61K31/549
Inventor 梁有泉
Owner 芜湖梁氏新材料有限公司
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