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Preparation method and application of hydroxysafflor yellow A

A technology of hydroxysafflower and yellow pigment, applied in the field of natural medicinal chemistry, can solve the problems of unfavorable utilization of safflower medicinal materials, loss of production process of hydroxysafflower yellow A, unsatisfactory yield of hydroxysafflower yellow A, etc. Achieve the effects of being beneficial to extraction and utilization, easy to store in a long-term and stable manner, and environmentally friendly process

Active Publication Date: 2012-10-03
ZHEJIANG YONGNING PHARMA
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AI Technical Summary

Problems solved by technology

However, the yield of hydroxysafflower yellow A in the prior art method for producing hydroxysafflower yellow A from safflower is still not ideal, which is not conducive to the full utilization of safflower medicinal materials, and causes the production of hydroxysafflower yellow A Lost in large quantities during the production process

Method used

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  • Preparation method and application of hydroxysafflor yellow A
  • Preparation method and application of hydroxysafflor yellow A
  • Preparation method and application of hydroxysafflor yellow A

Examples

Experimental program
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Embodiment 1

[0045] Weigh safflower, crush it, add purified water 10-13 times the weight of the medicinal material, extract at 40-60°C and 40KHZ ultrasonic frequency for 50 minutes, filter, cool the extract to room temperature, centrifuge with a centrifuge, and take the centrifuge for later use.

[0046]Slowly add the above-mentioned centrifugate to the HZ801 (macroporous adsorption resin HZ801 purchased from East China University of Science and Technology) macroporous adsorption resin column that has been treated and balanced. After loading the sample, it was eluted with normal temperature purified water at a flow rate of 20ml per minute. Collect the eluate rich in safflower yellow, and concentrate the eluate under reduced pressure at a temperature lower than 80°C to obtain a crude safflower yellow concentrate, calculated as safflower, per kilogram of safflower to obtain a crude safflower yellow Concentrate 100ml.

[0047] The safflower yellow crude product concentrated solution is put o...

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Abstract

The invention discloses a preparation method for extracting, separating and purifying hydroxysafflor yellow A from a Chinese medicinal material safflower at high yield and purity. The method comprises the following steps of: performing ultrasonic water extraction on the safflower medicinal material, separating by using HZ801 macroporous adsorption resin, performing LH-20 sephadex chromatographic separation, performing ultrafiltration, and performing freeze drying. The content of the prepared hydroxysafflor yellow A dry powder is 99.8 percent, and the yield of the hydroxysafflor yellow A is 62.7 percent.

Description

technical field [0001] The invention relates to a preparation method and application of hydroxysafflower yellow A, in particular to a preparation method for extracting hydroxysafflower yellow A from Chinese medicinal material safflower. It belongs to the field of natural medicinal chemistry. Background technique [0002] Safflower is the dried flower of Safflower safflower, which has the effect of promoting blood circulation and relieving pain. The active ingredients of safflower and blood circulation are mainly concentrated in water-soluble safflower yellow pigment. Safflower yellow is a mixture of three water-soluble components, namely hydroxysafflower yellow A, hydroxysafflower yellow B and hydroxysafflower yellow C. Among them, hydroxysafflower yellow A has the highest content and is the most effective water-soluble component of safflower pharmacological effects. [0003] In the prior art, there have been many reports on the pharmacological effects and clinical drug p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D309/10
Inventor 叶凤起卢敏林德君邵圣省刘晓波
Owner ZHEJIANG YONGNING PHARMA
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