20 results about "Kidney stones" patented technology

This invention belongs to the biomedical field and relates to the application of a compound in preventing the recurrence of calcium oxalate kidney stones. The application of the compound, or its pharmaceutically acceptable salts, esters, solvates, crystal forms, or prodrugs, in the preparation of reagents for preventing the recurrence of calcium oxalate kidney stones is described. The structure of the compound is as follows: [structure details missing]. The calcium oxalate kidney stones originate from Randall plaques. Extensive experimental evidence demonstrates that Benathin can enhance intercellular adhesion by repairing the adhesion protein network damaged by hydroxyapatite (HAP), thereby reversing epithelial damage, preventing epithelial cell detachment, and effectively protecting the renal papillary mucosal barrier, thus reducing the risk of stone formation and recurrence of calcium oxalate kidney stones.

The invention provides an analysis method for measuring negative ions in urine based on gas phase ion chromatography, and belongs to the technical field of urine analysis. One of the urine analysis methods based on gas phase ion chromatography can comprise the following steps: injecting a chelating ligand into an analyzer through a continuous sample injector electrospray to obtain a background signal; a to-be-detected urine sample is fed one by one through an online six-way valve automatic sampler, a chelating ligand solution and the urine sample can be fully mixed through an online mixer, electrospray ionization is realized, the mixture enters an analyzer, an ion chromatograph records a sample signal, and a background is deducted to obtain a urine analysis result; wherein the ionization technology is an electrospray ion source. According to the method disclosed by the invention, separation of various ions on the gas phase ion chromatography can be realized; the kit can also be used for qualitatively and quantitatively detecting trace inflammatory factors, trace proteins and other proteins in urine, and can be applied to prevention and treatment of kidney stone.

Provided herein are devices, systems and methods for treating kidney stones. In particular, provided herein are devices for improving the safety and efficiency of percutaneous nephrolithotomy.

The application discloses a metabolic marker, a screening method and application related to gout combined with uric acid nephrolithiasis, and belongs to the technical field of biology. The application analyzes the significant differences of metabolic small molecules in the serum of asymptomatic hyperuricemia and gout combined with uric acid nephrolithiasis patients through a metabolomics method, screens metabolic markers that can be used for predicting gout combined with uric acid nephrolithiasis, and further verifies the sensitivity, specificity and accuracy of the metabolic markers. These findings not only provide markers for early diagnosis and precise treatment of gout combined with uric acid nephrolithiasis, but also provide important basis for understanding the clinical heterogeneity of hyperuricemia and the evolution mechanism thereof.

The application discloses a kidney stone filtering collector, which comprises a urine pool, a stone collecting table, a urine collecting table and a water storage tank, the urine pool is arranged in a toilet style, the bottom of the urine pool is fixedly connected with the stone collecting table as an integrated structure, the inside of the urine pool is composed of a urine cavity, a separation cavity, a stone discharging channel and a urine discharging channel, the separation cavity is arranged below the urine cavity and is communicated with the urine cavity, the bottom of the separation cavity is communicated with the urine discharging channel, the end of the urine discharging channel is communicated with the urine collecting table through a connecting pipeline, and a movable cavity wall which can rotate is arranged in the separation cavity and is used for communicating with the stone discharging channel. The urine of a patient can be automatically filtered and separated, and the patient can directly obtain a stone sample and a urine sample after urinating, so that the application is very convenient and clean and sanitary.

The present application relates to a kind of bubble drinks for high uric acid population, production method, equipment, belong to functional food processing technical field.It includes the following weight parts of component: acid-eliminating composition extract: 6 to 9 parts by crude drug amount;Alkalization acid-eliminating regulator: 0.9 to 1.5 parts;Natural sweet and functional agent: 0.5 to 6 parts;And the balance of water;Acid-eliminating composition extract is prepared from chicory, tuckahoe and gardenia;Alkalization acid-eliminating regulator is composed of food-grade sodium bicarbonate and citric acid, both are reacted in water to generate sodium citrate buffer pair, and the mass ratio of citric acid and sodium bicarbonate is 1:(1.2-2.0), and the final pH of the bubble drink is 6.2-6.8.Utilize the sodium citrate buffer generated by alkalization acid-eliminating regulator reaction, fundamentally resolve uric acid crystallization, prevent uric acid kidney stone.Combined with acid-eliminating composition extract, physiological level of synthesis inhibition and excretion promotion and physicochemical level of urine alkalization and solubility promotion are realized.

An embodiment in accordance with the present invention provides a method for accurate and objective quantification of stone fragment size. The method includes intraoperative measurement of objects during URS. The method analyzes URS procedures for ureteral and renal stones during basket extraction of fragments. An instrument is passed through an instrument channel of the ureteroscope and advanced until it is adjacent to the stone fragment to be measured. The measurement of stone fragment size is based on the known distance of a tip of the instrument in the ureteroscope's visual field.

The invention discloses a kidney stone positioning method and system based on deep learning, and relates to the technical field of image processing. The method comprises the following steps: receiving a gray-scale image of B ultrasound in a target kidney region as a target image; taking the target image as input of a target recognition model to obtain a recognition result of the target image; the identification result is the size and the position of the stone; mapping to the size and position of the calculus in the target kidney region according to the identification result; according to the method, the accuracy of detecting the shape of the kidney stone and positioning the kidney stone is improved through the target recognition model, the calculation cost is reduced, then the detection frequency in an operation is reduced, and reliable technical support is provided for the intelligent extracorporeal lithotripter.

The invention relates to the technical field of gravel sampling, and discloses a gravel sampling device for examination in urine of a lithiasis patient, the gravel sampling device comprises a frame body, a support column is fixed at the bottom in the frame body, a water storage tank is fixed above the support column, a funnel is fixed above the water storage tank, and a drain pipe is fixed at the bottom of the water storage tank. The drainage pipe penetrates through the frame body, and the penetrating part is fixedly connected; according to the equipment for sampling the broken stones in the urine of the calculus patient during examination, through matched use of a pedal, a connecting plate, a torsional spring, a connecting rod, a cover plate, a rotating plate, a short plate, a central column and a connecting column, the cover plate is opened by treading the pedal, compressing the torsional spring, moving the connecting rod upwards and rotating the rotating plate around the connecting column, and after the pedal is not treaded any more, the broken stones are sampled under the gravity action of the torsional spring and the cover plate; the cover plate is closed, the cover is opened when a sample needs to be poured and closed when not needed, the clean environment in the funnel is effectively protected, and impurities in the funnel are prevented from entering the funnel to affect the purity of the sample.

This invention discloses a gut microbial biomarker, product, and its application related to kidney stones, belonging to the field of biomedicine. The microbial biomarker includes one or more of *Bacteroides fecalis*, *Streptococcus salivarius*, *Bifidobacterium bifidum*, and *Roseidobacterium myxoma*. This invention provides a kit including detection reagents for detecting the relative abundance of the aforementioned microbial biomarkers. This invention also provides a product for diagnosing kidney stones, a predictive system for assessing the risk of kidney stones in a test subject, and a computer program product related to kidney stones. The product provided by this invention has good feasibility and accuracy, can effectively assess the risk of kidney stones, and provides a new tool for clinical diagnosis.

The application discloses a protein UP5 of the Malpighian tubule of Euproctis pseudoconspersa and application thereof, the protein can be combined with calcium ions, and has a significant ability of inhibiting formation of calcium oxalate crystals, and can be used for preventing and treating calcium oxalate stones which are the most common kidney stones, so that a new strategy for treating kidney stones is expected to be provided, and the protein UP5 of the Malpighian tubule of Euproctis pseudoconspersa provides a new drug use.

The invention belongs to the field of feed additives, and particularly relates to a feeding traditional Chinese medicine extract for improving the disease resistance of pets and a preparation method thereof. The feed traditional Chinese medicine extract for improving the disease resistance of pets comprises the following raw material components in parts by mass: 5-10 parts of a traditional Chinese medicine extracting solution, 1-3 parts of a chitosan carrier, 1-5 parts of a mixed diluent, 0.5-2 parts of an antioxidant and 0.5-5 parts of an auxiliary material. By optimizing a traditional Chinese medicine formula and an extraction process, the feed traditional Chinese medicine extract prepared by taking the soluble starch as an auxiliary material and combining the chitosan carrier and the mixed diluent can well improve the immunity of pets, and has the effects of protecting eyes, resisting inflammation, preventing kidney stones and the like.

The subject of the application is a method of preparing a dietary supplement from the dried above-ground parts of the chanca piedra plant (Phyllanthus niruri) supporting the treatment of kidney stones and gout, and a dietary supplement from the dried above-ground parts of the chanca piedra plant (Phyllanthus niruri) supporting the treatment of kidney stones and gout. A method of preparing a dietary supplement from the dried above-ground parts of the Chanca piedra plant (Phyllanthus niruri) supporting the treatment of kidney stones and gout, comprising the process of brewing and freeze-drying the cooled infusion, characterized in that the dried above-ground parts of the Chanca piedra plant (Phyllanthus niruri) are boiled with a solvent until boiling, and then the temperature is reduced and the infusion is created at a temperature between 60 - 70°C for a period of 1 to 6 hours, then the product is left to cool down to a temperature close to room temperature,The infusion is then separated from the pulp. Subsequently, the separate infusion is frozen to a minimum temperature of approximately -18°C, preferably between -15°C and -20°C. Then, under reduced pressure close to vacuum, the infusion is freeze-dried at a temperature of approximately 60°C until the moisture content reaches below 4%. The product is then ground and encapsulated. The application also covers a dietary supplement made from the dried aerial parts of the Chanca piedra plant (Phyllanthus niruri) supporting the treatment of kidney stones and gout. It is characterized by a freeze-dried infusion made from the dried aerial parts of the Chanca piedra plant (Phyllanthus niruri) with a moisture content of at most 4%.

The invention relates to the technical field of analysis and detection, in particular to a method for detecting the concentration of organic matters in urine. The detection method comprises the following steps: mixing a urine sample with sulfuric acid for primary acidification, mixing the acidified supernatant with a mixed solution of aniline and dimethyl sulfoxide, then adding hydrochloric acid for secondary acidification, and adding an aqueous solution of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride for derivatization after acidification; and mixing the derived supernate with a sample diluent, centrifuging, and detecting by adopting a liquid chromatography-tandem mass spectrometry method. The detection method is simple and high in accuracy, creatinine, citric acid, oxalic acid and cystine in human urine can be detected at the same time, the requirements of related laws and regulations for linearity, repeatability, matrix effect, accuracy and the like of creatinine, citric acid, oxalic acid and cystine can be met, and the method has important reference significance for kidney stone evaluation.

The invention relates to a traditional Chinese medicine composition for treating kidney stone and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition for treating kidney stone is prepared from the following raw materials: poria cocos, cinnamon, bighead atractylodes rhizome, endothelium corneum gigeriae galli, lysimachia christinae hance, spora lygodii, radix curcumae and talc. According to the traditional Chinese medicine composition for treating the kidney stone and the preparation method and application thereof, the traditional Chinese medicine composition can tonify and strengthen the kidney and remove the stone, is high in safety, free of toxic and side effects, good in curative effect on the kidney stone, low in cost, economical and practical, easy to accept by patients, not prone to relapse after the kidney stone is removed, capable of treating both symptoms and root causes and free of toxic and side effects. The curative effect on kidney stone is obvious.

This invention belongs to the field of risk prediction technology, specifically relating to a biomarker, model, and application for predicting the recurrence of calcium oxalate kidney stones. It constructs a risk prediction model for short-term, multiple recurrences of calcium oxalate kidney stones using five core variables: butyric acid, isobutyric acid, isovaleric acid, and triglycerides in the blood, and phenylacetic acid in the intestine. The predictive model of this invention has high efficacy and can serve as a risk prediction indicator for the frequency of stone recurrence.

The present application provides a method for preparing stable calcium oxalate crystals with different particle sizes. The calcium oxalate crystals prepared by the method of the present application are regular in shape and stable in properties, and can be used to simulate different stages of kidney stone formation, and can be used to explore the mechanism of kidney stone formation and development and preventive measures.

This invention provides a method, system, and medium for assessing the fragility of kidney stones based on CT images, belonging to the field of CT image processing technology. The method includes: acquiring CT images with stone border labels and a training set of the maximum fragment volume after ESWL (Extract, Scale, and Lie); extracting stone morphology, texture, and heterogeneity features from the CT images to construct an original multimodal feature vector; constructing a multimodal grouped autoencoder, with the first layer being a group discovery layer; setting a group weight matrix; using mean squared error as the reconstruction loss; and introducing an L2,1 norm sparse regularization term during training to obtain the weight matrix; filtering features based on the absolute value threshold of the weights in each row of the matrix to construct feature groups; calculating group weights based on the variance of each feature group in the training set; for each sample, taking the mean of features within the group, and weighting and fusing them with group weights to obtain a fused feature vector; and finally training a multilayer perceptron regression model using the fused features as input to obtain a fragility assessment model. This method integrates multiple types of features and automatically mines associated feature groups, solving the problem of low accuracy in assessing kidney stone fragility caused by a single reference factor.

This invention relates to the field of pharmaceutical technology, and in particular to a ferric gallate nanonetwork, its preparation method, and its applications. The preparation method includes the steps of: preparing a PVP aqueous solution, stirring vigorously at room temperature, and then adding Fe dropwise. 3+ A saline solution was added dropwise; after incubation, the gallic acid aqueous solution was added to the above mixture, stirred, and dialyzed to obtain the gallic acid nanonetwork. This preparation method can synthesize ultra-small gallic acid iron nanonetworks with a particle size of less than 10 nm, which have good crystallization regulation and antioxidant functions, and can be used to prepare drugs for treating kidney stones.

An oral composition comprising synergistic combination of Punica granatum fruit extract and Terminalia chebula fruit extract in admixture with suitable carriers and excipients is disclosed. The composition is useful for the prevention and treatment of kidney stones.