A UP5 of mariner channel protein of yellow dragon moth and application of the UP5

By using the Margaritiferous tubule protein UP5 of the yellow-spotted moth to bind with calcium ions, the growth of calcium oxalate crystals is inhibited, thus solving the problem of calcium oxalate stone formation and providing a new treatment and prevention method.

CN119798399BActive Publication Date: 2025-12-12SOUTHWEST UNIV
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Patent Information

Application Number
CN202510009160.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-01-03
Publication Date
2025-12-12
Estimated Expiration
2045-01-03

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively inhibit the formation of calcium oxalate crystals, making it difficult to resolve the problems of calcium oxalate stones and urinary tract stones.

Method used

By utilizing the high affinity of the Margaritiferous tubule protein UP5 of the yellow-spotted moth to bind with calcium ions, the growth and morphology of calcium oxalate crystals can be inhibited. Calcium ion adsorbents and pharmaceutical forms can then be prepared for the prevention or treatment of calcium oxalate stones.

Benefits of technology

It effectively inhibits the formation of calcium oxalate crystals, providing a new strategy for treating calcium oxalate stones, with significant preventive and therapeutic effects.

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Abstract

The application discloses a protein UP5 of the Malpighian tubule of Euproctis pseudoconspersa and application thereof, the protein can be combined with calcium ions, and has a significant ability of inhibiting formation of calcium oxalate crystals, and can be used for preventing and treating calcium oxalate stones which are the most common kidney stones, so that a new strategy for treating kidney stones is expected to be provided, and the protein UP5 of the Malpighian tubule of Euproctis pseudoconspersa provides a new drug use.
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