A premix for improving urinary tract health in pets and its preparation method

Abstract

This invention belongs to the field of pet food processing and relates to a premix for improving the urinary tract health of pets. The premix contains the following components in parts by weight: 25-35 parts of Dioscorea opposita, 25-35 parts of Poria cocos, 15-25 parts of Taraxacum mongolicum, 15-25 parts of Centella asiatica, 15-25 parts of Plantago asiatica, 5-15 parts of Polygonatum sibiricum, 5-15 parts of Cornus officinalis, and 5-15 parts of Lycium barbarum. Adding this premix to the cat's diet reduces serum creatinine, blood urea nitrogen, and serum oxalate concentrations, affecting oxalate absorption and excretion, and preventing the formation of calcium oxalate stones. This premix can alleviate the nephrotoxicity of sodium oxalate in cats, improve renal physiological indicators, reduce the formation of calcium oxalate stones, and provide a basic guarantee for the treatment of chronic urinary system diseases. This premix can improve the urinary tract health of cats.

Description

Technical Field

[0001] This invention belongs to the field of pet food processing and relates to a premix for improving the urinary tract health of pets and its preparation method. Background Technology

[0002] Feline lower urinary tract syndrome is a syndrome of diseases of the posterior urinary tract in cats caused by a variety of factors. It does not represent a single disease symptom and may include one or all of the following diseases: urethritis, cystitis, urethral plug (soft plug, gravel plug or true stone) or obstructive urinary tract disease (partial or complete obstruction) caused by urethral stricture.

[0003] Common causes include cystitis, urethritis (functional stricture caused by inflammation and spasm), urethral plug, urolithiasis, and urethral anatomical abnormalities (stricture, compression of periurethral tissues), etc.

[0004] Clinically, it is characterized by difficulty urinating, painful dribbling of urine, straining, frequent urination, hematuria, and urethral obstruction.

[0005] When cystitis and urethritis occur, symptoms include frequent urination, difficulty urinating, dribbling urination, hematuria, and painful urination. When urethral obstruction occurs, symptoms include anuria, extreme bladder distension, licking of the external genitalia, abdominal pain, and even bladder rupture. When urinary tract infection occurs, the urine is cloudy white (pus). When acute urinary retention occurs, it can lead to acute renal failure or uremia, and there is a strong urea smell in the mouth.

[0006] In cases of urinary stones, the symptoms are related to the severity of urethral obstruction. With incomplete urethral obstruction, the cat experiences painful urination, with urine flowing out in dribbles or thin streams, intermittently, and only small amounts. Sometimes, there is blood in the urine, with a larger amount of blood initially. Complete urethral obstruction results in complete urinary retention, with the bladder extremely distended. The cat strains frequently but no urine is expelled, and palpation of the bladder reveals severe pain.

[0007] Western medicine typically sedates the affected cat and then uses atropine to reduce smooth muscle contraction, or injects hyaluronidase to reduce the surface tension of the embolus and promote its excretion. Urine is then drained via catheterization. If a catheter cannot be inserted, bladder puncture can be used to quickly drain urine. The bladder is flushed with 1% potassium permanganate solution to achieve antibacterial effects, and antibiotics are administered intravenously.

[0008] Western medicine often uses antibiotics to treat urinary tract infections in cats, but with the increasing problem of antibiotic overuse and resistance, finding safe alternative therapies has become particularly important.

[0009] Developing a safe premix that can significantly improve the urinary tract health of cats for use in pet food would be of great significance. Summary of the Invention

[0010] The purpose of this invention is to provide a premix for improving the urinary tract health of pets and its preparation method. The premix of this invention significantly improves the urinary tract health of cats and reduces the formation of calcium oxalate stones.

[0011] To achieve the above objectives, this application adopts the following technical solution:

[0012] In a first aspect, the present invention provides a premix for improving the urinary tract health of pets, the premix containing the following components in parts by weight: 25-35 parts of yam, 25-35 parts of poria cocos, 15-25 parts of dandelion, 15-25 parts of centella asiatica, 15-25 parts of plantain seed, 5-15 parts of polygonatum sibiricum, 5-15 parts of cornus officinalis, and 5-15 parts of wolfberry.

[0013] In one embodiment of the present invention, the premix contains the following components in parts by weight: 30 parts of yam, 30 parts of poria cocos, 20 parts of dandelion, 20 parts of centella asiatica, 20 parts of plantain seed, 10 parts of polygonatum sibiricum, 10 parts of cornus officinalis, and 10 parts of wolfberry.

[0014] In one embodiment of the present invention, the premix contains the following components in parts by weight: 25 parts of yam, 35 parts of poria cocos, 25 parts of dandelion, 25 parts of centella asiatica, 15 parts of plantain seed, 15 parts of polygonatum rhizome, 5 parts of cornus officinalis, and 15 parts of wolfberry.

[0015] In one embodiment of the present invention, the premix contains the following components in parts by weight: 35 parts of yam, 25 parts of poria cocos, 15 parts of dandelion, 15 parts of centella asiatica, 25 parts of plantain seed, 5 parts of polygonatum sibiricum, 15 parts of cornus officinalis, and 5 parts of wolfberry.

[0016] Secondly, the present invention provides a method for preparing the above-mentioned premix, wherein the preparation method is as follows: the prescribed amounts of Chinese herbal medicines, such as yam, poria cocos, dandelion, plantain seed, centella asiatica, polygonatum sibiricum, cornus officinalis, and wolfberry, are premixed, pulverized, and sieved to obtain a premix for improving the urinary tract health of pets.

[0017] Thirdly, the present invention provides the application of the above-mentioned premix for improving the urinary tract health of pets in the preparation of pet food.

[0018] Furthermore, the pet is a cat or a dog.

[0019] Furthermore, the premix of the present invention for improving the urinary tract health of pets reduces the formation of calcium oxalate stones.

[0020] The dosage of the premixed feed used in this invention to improve the urinary tract health of pets is 0.5%-1.5% of the base diet.

[0021] Furthermore, the amount of the premix used to improve the urinary tract health of pets is 0.8% of the base diet.

[0022] This invention's premix contains the following components: yam, poria cocos, dandelion, plantain seed, centella asiatica, polygonatum sibiricum, cornus officinalis, and wolfberry. Cornus officinalis tonifies kidney yang and warms and nourishes the liver and kidneys; polygonatum sibiricum tonifies spleen and kidney qi and strengthens the spleen and kidneys; wolfberry nourishes liver blood and tonifies the liver and kidneys; and yam tonifies spleen yin and strengthens kidney essence. The four herbs work together to tonify the internal organs, strengthen the foundation and cultivate vitality, enhance the functions of the spleen, kidneys, and liver, and restore the dynamics of fluid metabolism. Plantain seed drains kidney turbidity and promotes urination; centella asiatica clears liver turbidity and detoxifies, and removes spleen dampness; dandelion drains liver fire and clears heat and detoxifies; and poria cocos drains spleen dampness, strengthens the spleen, and eliminates dampness. The four herbs work together to clear damp heat, stones, and inflammation while balancing the tonifying effects, preventing the body from being overly nourished. The formula combines tonification and purgation, strengthening the foundation and cultivating vitality, treating both the root cause and symptoms, and nourishing both innate and acquired constitutions.

[0023] The beneficial effects achieved by this invention are as follows:

[0024] Adding the premix of this invention to the diet reduces the concentrations of serum creatinine, blood urea nitrogen, and serum oxalate in cats, affecting the absorption and excretion of oxalate and preventing the formation of calcium oxalate stones. This premix can alleviate the nephrotoxicity of sodium oxalate in cats, improve renal physiological indicators, reduce the formation of calcium oxalate stones, and provide a basic guarantee for the treatment of chronic urinary tract diseases. This premix can improve the urinary tract health of pets. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in this invention or the prior art, the accompanying drawings used in the specific embodiments will be briefly described below.

[0026] Figure 1 Comparison of serum oxalate concentrations among groups, compared with group C. & P < 0.05 && P < 0.01; compared with group M, * P < 0.05 ** P < 0.01; compared with group S1, # P < 0.05 ## P < 0.01. Detailed Implementation

[0027] To enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be described in further detail below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present invention.

[0028] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other. The present invention will now be described in detail with reference to the embodiments.

[0029] All raw materials used in this invention were purchased through commercial channels.

[0030] Example 1

[0031] A premixed feed for improving the urinary tract health of pets contains the following components in parts by weight: 30 parts yam, 30 parts poria cocos, 20 parts dandelion, 20 parts centella asiatica, 20 parts plantain seed, 10 parts polygonatum, 10 parts cornus officinalis, and 10 parts wolfberry.

[0032] The preparation method is as follows: the prescribed amounts of Chinese herbal medicines, including yam, poria cocos, dandelion, plantain seed, centella asiatica, polygonatum sibiricum, cornus officinalis, and wolfberry, are premixed, pulverized, and sieved to obtain a premix for improving the urinary tract health of pets.

[0033] Example 2

[0034] A premixed feed for improving the urinary tract health of pets contains the following components in parts by weight: 25 parts yam, 35 parts poria cocos, 25 parts dandelion, 25 parts centella asiatica, 15 parts plantain seed, 15 parts polygonatum rhizome, 5 parts cornus officinalis, and 15 parts wolfberry.

[0035] The preparation method is the same as in Example 1.

[0036] Example 3

[0037] A premixed feed for improving the urinary tract health of pets contains the following components in parts by weight: 35 parts yam, 25 parts poria cocos, 15 parts dandelion, 15 parts centella asiatica, 25 parts plantain seed, 5 parts polygonatum, 15 parts cornus officinalis, and 5 parts wolfberry.

[0038] The preparation method is the same as in Example 1.

[0039] Example 4

[0040] A premixed feed for improving the urinary tract health of pets contains the following components in parts by weight: 28 parts of yam, 25 parts of poria cocos, 18 parts of dandelion, 16 parts of centella asiatica, 24 parts of plantain seed, 8 parts of polygonatum sibiricum, 15 parts of cornus officinalis, and 10 parts of wolfberry.

[0041] The preparation method is the same as in Example 1.

[0042] Example 5

[0043] A premixed feed for improving the urinary tract health of pets contains the following components in parts by weight: 32 parts yam, 24 parts poria cocos, 20 parts dandelion, 18 parts centella asiatica, 20 parts plantain seed, 5 parts polygonatum, 10 parts cornus officinalis, and 10 parts wolfberry.

[0044] The preparation method is the same as in Example 1.

[0045] Example 6

[0046] A premixed feed for improving the urinary tract health of pets contains the following components in parts by weight: 25 parts yam, 33 parts poria cocos, 24 parts dandelion, 22 parts centella asiatica, 18 parts plantain seed, 6 parts polygonatum sibiricum, 6 parts cornus officinalis, and 10 parts wolfberry.

[0047] The preparation method is the same as in Example 1.

[0048] Comparative Example 1

[0049] 30 parts Poria cocos, 20 parts Taraxacum mongolicum, 20 parts Centella asiatica, 20 parts Plantago asiatica, 10 parts Cornus officinalis, and 10 parts Lycium barbarum.

[0050] Compared to Example 1, the difference is that it does not contain yam and polygonatum.

[0051] The preparation method is the same as in Example 1.

[0052] Comparative Example 2

[0053] 30 parts yam, 30 parts poria cocos, 20 parts dandelion, 20 parts centella asiatica, 20 parts plantain seed, and 10 parts polygonatum.

[0054] Compared to Example 1, the difference is that it does not contain Cornus officinalis and Lycium barbarum.

[0055] The preparation method is the same as in Example 1.

[0056] Comparative Example 3

[0057] 30 parts yam, 20 parts centella asiatica, 20 parts plantain seed, 10 parts polygonatum, 10 parts cornus officinalis, and 10 parts wolfberry.

[0058] Compared with Example 1, the difference is that it does not contain Poria cocos and dandelion.

[0059] The preparation method is the same as in Example 1.

[0060] Comparative Example 4

[0061] 30 parts yam, 30 parts poria cocos, 20 parts dandelion, 10 parts polygonatum, 10 parts cornus officinalis, and 10 parts wolfberry.

[0062] Compared to Example 1, the difference is that it does not contain Centella asiatica and Plantago asiatica.

[0063] The preparation method is the same as in Example 1.

[0064] Comparative Example 5

[0065] 20 parts yam, 20 parts poria cocos, 10 parts dandelion, 10 parts centella asiatica, 10 parts plantain seed, 20 parts polygonatum, 20 parts cornus officinalis, and 20 parts wolfberry.

[0066] Compared with Example 1, the difference lies in the change of the proportion of raw materials.

[0067] Comparative Example 6

[0068] 30 parts of Chinese yam, 30 parts of Poria cocos, 20 parts of Viola yedoensis, 20 parts of Centella asiatica, 20 parts of Plantago asiatica, 10 parts of Rehmannia glutinosa, 10 parts of Cornus officinalis, and 10 parts of Lycium barbarum.

[0069] Compared with Example 1, the difference is that Rehmannia glutinosa is used instead of Polygonatum sibiricum and Viola yedoensis is used instead of Taraxacum mongolicum.

[0070] Study on the effect of the premix of this invention on the urinary tract health of cats

[0071] 1. Experimental Methods

[0072] Fifty healthy cats around two years old were randomly divided into 10 groups of five. Each cat was fed 100g of basal diet daily, with unlimited water intake. Sodium oxalate was added at 1% of the diet weight to establish a feline dietary hyperoxalate model. The success of the feline dietary hyperoxalate model was determined based on body weight, hematological examination, ultrasound examination, and urinalysis.

[0073] The cats are grouped and fed as follows:

[0074] Group C served as the blank control group, fed with a basal diet.

[0075] Group M served as the model control group, fed a basal diet with 1% sodium oxalate by weight added to the basal diet.

[0076] Group S1 had 0.8% of Example 1 premix added to the basal diet and 1% sodium oxalate by weight added to the basal diet;

[0077] Group S2 had 0.8% of Example 2 premix added to the basal diet and 1% sodium oxalate by weight added to the basal diet;

[0078] Group S3 had 0.8% of Example 3 premix added to the basal diet and 1% sodium oxalate by weight added to the basal diet;

[0079] Group T1 was given 0.8% of Comparative Example 1 premix in its basal diet and 1% sodium oxalate by weight in its basal diet.

[0080] The T2 group had 0.8% of the Comparative Example 2 premix added to the basal diet and 1% sodium oxalate by weight added to the basal diet.

[0081] The T3 group had 0.8% of Comparative Example 3 premix added to the basal diet and 1% sodium oxalate by weight added to the basal diet.

[0082] The T4 group had 0.8% of the comparative example 4 premix added to the basal diet and 1% sodium oxalate by weight added to the basal diet.

[0083] The T5 group had 0.8% of Comparative Example 5 premix added to the basal diet and 1% sodium oxalate by weight added to the basal diet.

[0084] The basic diet was purchased from Shandong Shuaike Pet Products Co., Ltd., and its ingredients include: fresh chicken, corn, rice, beef meal, fish meal, duck oil, brewer's yeast powder, chicken liver powder, beet pulp granules, psyllium husk, kelp powder, and brewer's yeast cell walls; the additives include: natural steroid saponins, taurine, fructooligosaccharides, L-lysine, dl-α-tocopherol, vitamin A, vitamin D3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, folic acid, nicotinamide, D-calcium pantothenate, choline chloride, sodium chloride, antioxidants, calcium iodate, zinc glycine, iron glycine complex, copper glycine complex, and manganese methionine complex.

[0085] The experiment lasted for 28 days.

[0086] 2. Measurement Indicators

[0087] After the experiment, blood was collected from all the experimental cats using the forearm cephalic vein sampling method. The blood was placed in EDTA tubes, and the concentrations of creatinine, urea nitrogen, and oxalate in the blood were measured using creatinine, urea nitrogen, and oxalate assay kits.

[0088] 3. Data Processing

[0089] Data processing was performed using GraphPad Prism 7.0 software, with the measurement data presented in... The results indicate that one-way ANOVA was used for comparisons between groups, and a p-value < 0.05 was considered statistically significant.

[0090] 4. Test Results

[0091] Effects on feline serum creatinine, blood urea nitrogen, and serum oxalate concentrations

[0092] Blood urea nitrogen can be used to check whether the body's urination function is normal; creatinine is a muscle metabolic product, and its concentration is related to the body's glomerular filtration capacity, and is often used to determine whether the glomerular filtration rate is impaired.

[0093] As shown in Table 1, compared with group C, the serum creatinine and urea nitrogen concentrations in group M were significantly higher.

[0094] Compared with group M, the serum creatinine and urea nitrogen concentrations in groups S1, S2, and S3 were significantly lower.

[0095] The S1, S2, and S3 groups showed significantly better effects in reducing serum creatinine and urea nitrogen concentrations than the T1-T5 groups.

[0096] Table 1. Serum creatinine and blood urea nitrogen concentrations in each group

[0097]

[0098]

[0099] Note: Compared with Group C & P < 0.05 && P < 0.01;

[0100] Compared with group M, * P < 0.05 ** P < 0.01;

[0101] Compared with group S1, # P < 0.05 ## P < 0.01.

[0102] like Figure 1 As shown, compared with group C, the serum oxalate concentration in group M was significantly higher.

[0103] Compared with group M, the serum oxalate concentrations in groups S1, S2, and S3 were significantly lower.

[0104] The S1, S2, and S3 groups showed significantly better effects in reducing serum oxalate concentration than the T1-T5 groups.

[0105] The experimental results above show that, under the same premix dosage, changing the raw materials of the premix (Comparative Examples 1-4) and changing the dosage ratio of the premix (Comparative Example 5) will weaken the intervention effect of the premix on feline stones. The raw materials of the premix of this invention have a synergistic effect, which enhances the therapeutic effect on feline calcium oxalate stones.

[0106] Adding the premix of this invention to the cat's diet reduces serum creatinine, blood urea nitrogen, and serum oxalate concentrations, affecting oxalate absorption and excretion, and preventing the formation of calcium oxalate stones. This premix can alleviate the nephrotoxicity of sodium oxalate in cats, improve renal physiological indicators, reduce the formation of calcium oxalate stones, and provide a fundamental guarantee for the treatment of chronic urinary tract diseases. This premix can improve the health of the cat's urinary tract.

[0107] Application of the premix of this invention in the treatment of chronic urinary tract diseases in cats

[0108] Twenty cats with chronic urinary tract disease, aged 3-5 years, were selected and randomly divided into two groups: Example 1 group and Comparative Example 6 group. Each group contained 10 cats.

[0109] Inclusion criteria: The cat is in good health; the cat does not have any other types of diseases; the cat's bodily functions are normal.

[0110] Exclusion criteria: cats with organ diseases; cats with abnormal organ function; cats with allergies to the research drug; cats with abnormal states of consciousness.

[0111] Example 1 group had 1.2% of Example 1 premix added to the basal diet, and Comparative Example 6 group had 1.2% of Comparative Example 6 premix added to the basal diet. The experimental period was 30 days.

[0112] Indicator Observation

[0113] The efficacy evaluation criteria are as follows:

[0114] Highly effective: The cat's disease symptoms disappeared, the cat's physical indicators all tended to return to normal, and the cat did not experience any adverse reactions;

[0115] Significant effect: The cat's disease symptoms improved significantly, the cat's physical indicators improved effectively, and the cat experienced mild adverse reactions;

[0116] Ineffective: The cat's disease symptoms did not improve at all.

[0117] Clinical efficacy comparison

[0118] The overall effective rate of Example 1 group was better than that of Comparative Example 6 group, as shown in Table 2.

[0119] Table 2 Comparison of clinical efficacy between the two groups

[0120] Group High efficiency / only Effective / only Invalid / only Efficiency / % Example 1 Group 3 6 1 90 Comparative Example 6 Groups 2 5 3 70

[0121] The above specific embodiments are merely explanations of the present invention and are not intended to limit the present invention. After reading this specification, those skilled in the art can make modifications to these embodiments without contributing any inventive step, but as long as they are within the scope of the claims of the present invention, they are protected by patent law.

Claims

1. A premix for improving urinary tract health in pets, characterized in that, The premix is made of the following components in parts by weight: 25-35 parts of yam, 25-35 parts of poria, 15-25 parts of dandelion, 15-25 parts of gotu kola, 15-25 parts of psyllium, 5-15 parts of polygonatum, 5-15 parts of dogwood, and 5-15 parts of medlar.

2. The premix for improving urinary tract health of a pet according to claim 1, characterized by, The premix is made of the following components in parts by weight: 30 parts of yam, 30 parts of poria, 20 parts of dandelion, 20 parts of gotu kola, 20 parts of psyllium, 10 parts of polygonatum, 10 parts of dogwood, and 10 parts of medlar.

3. The premix for improving urinary tract health of a pet according to claim 1, wherein The premix is made of the following components in parts by weight: 25 parts of yam, 35 parts of poria, 25 parts of dandelion, 25 parts of gotu kola, 15 parts of psyllium, 15 parts of polygonatum, 5 parts of dogwood, and 15 parts of medlar.

4. The premix for improving urinary tract health of a pet according to claim 1, wherein The premix is made of the following components in parts by weight: 35 parts of yam, 25 parts of poria, 15 parts of dandelion, 15 parts of gotu kola, 25 parts of psyllium, 5 parts of polygonatum, 15 parts of dogwood, and 5 parts of medlar.

5. The premix for improving urinary tract health of a pet according to claim 1, wherein The preparation method is as follows: the Chinese herbal medicines yam, poria, dandelion, psyllium, gotu kola, polygonatum, dogwood, and medlar are premixed in the formula amount, ground, and sieved to obtain the premix for improving the urinary tract health of pets.

6. Use of the premix for improving the urinary tract health of pets according to any one of claims 1-4 in the preparation of pet feed.

7. Use according to claim 6, characterized in that, The pet is a cat or a dog.

8. Use according to claim 6, characterized in that, The premix reduces the formation of calcium oxalate stones.

9. Use according to claim 6, characterized in that, The premix for improving the urinary tract health of pets is used in an amount of 0.5%-1.5% of the basal daily ration.

10. Use according to claim 9, characterized in that, The premix for improving the urinary tract health of pets is used in an amount of 0.8% of the basal daily ration.

Images