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Hydrochlorothiazidum chewable tablets for dog or cat

A technology of hydrochlorothiazide and chewable tablets, applied in the field of chewable tablets, can solve problems such as poor palatability, achieve the effects of reducing waste and improving the cure rate

Inactive Publication Date: 2008-06-04
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the physiological characteristics of dogs and cats, the inventor broke through the shortcomings of poor palatability of existing tablets, and developed a chewable tablet suitable for dogs and cats, which can be fully chewed and absorbed, effectively improving the utilization rate of therapeutic drugs , Guaranteed the dosage and improved the cure rate of dog and cat diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Hydrochlorothiazide Chewable Tablets

[0019] Take 2400g of starch and bake at 100°C for 1 hour, and cool to room temperature; take another 1800g of hydrochlorothiazide and 60g of aspartame, dilute and mix with the cooled starch by equal amount incremental dilution method, pass through 60 mesh, and finely sieve three times to obtain Mixture A. Put mixture A, 600 g of oral glucose, 600 g of skimmed milk powder and 540 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. After mixing glycerin and absolute ethanol in a ratio of 1:10, 2.5 L was taken, and 200 g of polyvinylpyrrolidone was added thereto to prepare a polyvinylpyrrolidone glycerol-ethanol mixed solution.

[0020] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Granulate with a 16-mesh sieve and ventilate and dry at ...

Embodiment 2

[0028] Example 2: Hydrochlorothiazide Chewable Tablets

[0029] Get starch 2370g, hydrochlorothiazide 2310g, aspartame 60g and prepare mixture A by the method described in Example 1.

[0030] Put mixture A, 375g of oral glucose, 1125g of skimmed milk powder and 30g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Mix glycerin and absolute ethanol uniformly at a ratio of 1:5, take 2.5 L, add 200 g of polyvinylpyrrolidone to it to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.

[0031] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. A total of about 10,000 tablets were produced, each weighing 0.6g, containing 0.23g of hyd...

Embodiment 3

[0032] Example 3: Hydrochlorothiazide Chewable Tablets

[0033] Get 3300g of starch, 3000g of hydrochlorothiazide, and 300g of aspartame, and prepare mixture A according to the method described in Example 1. Put mixture A, 360 g of oral glucose, 1440 g of skim milk powder and 300 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Mix glycerin and absolute ethanol uniformly at a ratio of 1:10, take 2.5 L, add polyvinylpyrrolidone 200 g to it to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.

[0034] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. A total of about 10,000 tablets were produced, each weighing 0.6g, containi...

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PUM

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Abstract

The invention discloses a hydrochlorothiazide chewable tablet used for dogs and cats. The invention can overcome the disadvantage of the poor palatability of the existing tablets, promote dogs and cats to chew and adsorb fully, effectively ensure the dosage of administration, enhance the cure rate of feline or canine diseases and reduce the waste of medicine. The tablet of the invention includes the following components represented by weight-percentage respectively: 1-5 percent of aspartame, 20-30 percent of the mixture of oral glucose and skim milk powder, in which the ratio of oral glucose and skim milk powder is 1:1-1:4, 40-60 percent of excipient, 0.5-1 percent of glidant and 30-50 percent of hydrochlorothiazide.

Description

technical field [0001] The invention relates to the preparation technology of veterinary medicine, in particular to a chewable tablet with good palatability for dogs and cats. Background technique [0002] Pet breeding has a long history in our country. With the improvement of living standards, the number of expensive dogs and cats is gradually increasing, and pet owners are paying more and more attention to the quality of life of their pets. Dogs and cats are mammals, and they also have their own common diseases. At present, the treatment of dog and cat diseases is mainly based on intravenous drip and intramuscular injection. Interruption of treatment often results in a poor prognosis of the disease. If dogs and cats can be made to actively take therapeutic drugs orally, this series of problems will be solved, but the few veterinary tablets currently on the market are often difficult to popularize because of their poor palatability. Contents of the invention [0003] A...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/5415A61P7/10
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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