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Praziquantel chewable tablets for dog or cat

A technology of praziquantel and chewable tablets, which is applied in the field of chewable tablets, can solve problems such as poor palatability, achieve the effect of reducing waste and improving the cure rate

Active Publication Date: 2010-10-13
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the physiological characteristics of dogs and cats, the inventor broke through the shortcomings of poor palatability of existing tablets, and developed a chewable tablet suitable for dogs and cats, which can be fully chewed and absorbed, effectively improving the utilization rate of therapeutic drugs , Guaranteed the dosage and improved the cure rate of dog and cat diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Praziquantel Chewable Tablets

[0019] Take 2400g of starch and bake at 100°C for 1 hour and cool to room temperature; take another 1800g of praziquantel and 60g of aspartame, dilute and mix with the cooled starch in equal incremental dilution method, then pass through 60 mesh, fine sieve Mixture A was obtained three times. Put mixture A with 600 g of oral glucose, 600 g of skimmed milk powder and 540 g of starch into a mixer and mix evenly to obtain a mixture B for use. Mix glycerin and anhydrous ethanol in a ratio of 1:10 and take 2.5L, and add 200 g of polyvinylpyrrolidone to make a polyvinylpyrrolidone glycerol-ethanol mixed solution.

[0020] Under stirring, add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B in portions until all the additions are completed, and a soft material with uniform mixing and moderate humidity is obtained. Granulate with 16 mesh sieve, ventilate and dry at 50℃. Accurately weigh 60g of magnesium stearate ...

Embodiment 2

[0028] Example 2: Praziquantel Chewable Tablets

[0029] Mix 2280g starch, 2100g praziquantel and 120g aspartame to prepare mixture A according to the method described in Example 1.

[0030] Put mixture A, 375 g of oral glucose, 1125 g of skimmed milk powder and 270 g of starch into a mixer and mix evenly to obtain mixture B, which is ready for use. Mix glycerin and anhydrous ethanol in a ratio of 1:5 and take 2.5L, add 200 g of polyvinylpyrrolidone to the mixture to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.

[0031] Under stirring, add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B in portions until all the additions are completed, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate into granules, and granulate, dry, granulate and press tablets according to the method described in Example 1. About 10,000 tablets were produced, each weighing 0.6g and containi...

Embodiment 3

[0032] Example 3: Praziquantel Chewable Tablets

[0033] Take 3300g of starch, 3000g of praziquantel and 300g of aspartame, and prepare mixture A according to the method described in Example 1. Put mixture A, 300 g of oral glucose, 900 g of skimmed milk powder, and 300 g of starch into a mixer and mix evenly to obtain mixture B, which is ready for use. Mix glycerin and absolute ethanol at a ratio of 1:10 and take 2.5L, add 200 g of polyvinylpyrrolidone to the mixture to prepare a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.

[0034] Under stirring, add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B in portions until all the additions are completed, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate into granules, and granulate, dry, granulate and press tablets according to the method described in Example 1. About 10,000 tablets were produced, each weighing 0.6g and ...

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PUM

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Abstract

The invention discloses a praziquantel chewable tablet used for dogs and cats. The invention overcomes the poor palatability defect of the existing tablet to promote the thorough chewing absorption by dogs and cats, so as to effectively guarantee the medicine-supply dose, to enhance the cure rate of diseases of dogs and cats and to reduce the medicine waste. The tablet of the invention comprises the following components represented by weight-percentage: 1 to 5 percent of aspartame; 20 to 30 percent of a mixture of oral dextrose and degreased milk powder; the ratio of 1:1 to 1:4 between the oral dextrose and degreased milk powder in the mixture; 40 to 60 percent of excipient; 0.5 to 1 percent of glidant and 30 to 50 percent of praziquantel.

Description

Technical field [0001] The invention relates to the preparation technology of veterinary drugs, in particular to a chewable tablet with good palatability for dogs and cats. Background technique [0002] Pet keeping has a long history in our country. With the improvement of living standards, the number of precious dogs, cats and pets has gradually increased, and pet owners have paid more and more attention to the quality of life of their pets. Dogs and cats are mammals and have their own common diseases. At present, the treatment of dog and cat diseases is mainly by intravenous drip and intramuscular injection. This kind of treatment plan often requires the owner to specially arrange time for the treatment of his pet. Interruption of treatment often results in a poor prognosis of the disease. If dogs and cats can take the initiative to take therapeutic drugs orally, this series of problems will be solved. However, the few veterinary tablets currently on the market are often diff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/4985A61P33/12
Inventor 李旭东鲍恩东苏建东
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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