Epsiprantel chewing tablet for cats and dogs

A technology of exetal and chewable tablets, which is applied in the field of veterinary drug preparations, can solve problems such as poor palatability, and achieve the effect of reducing waste and improving the cure rate

Inactive Publication Date: 2014-06-18
QINGDAO BOITE BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the physiological characteristics of dogs and cats, the inventor broke through the shortcomings of poor palatability of existing tablets, and developed a chewable tablet suitable for dogs and cats, which can be fully chewed and absorbed, effectively improving the utilization rate of therapeutic drugs , Guaranteed the dosage and improved the cure rate of dog and cat diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Exetal Chewable Tablets

[0019] Take 2400g of starch and bake at 100°C for 1 hour, cool to room temperature; take another 1800g of exetel and 60g of aspartame, dilute and mix with the cooled starch by equal amount incremental dilution method, pass through 60 meshes, and refine Mixture A was obtained by sieving three times. Put mixture A, 600 g of oral glucose, 600 g of skimmed milk powder and 540 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. After mixing glycerin and absolute ethanol in a ratio of 1:10, take 2.5 L, and add 200 g of polyvinylpyrrolidone to it to prepare a polyvinylpyrrolidone glycerol-ethanol mixed solution.

[0020] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Granulate with a 16-mesh sieve and ventilate and dry at 50°C. Accurately weigh 6...

Embodiment 2

[0022] Example 2 Exetal Chewable Tablets

[0023] Get starch 2280g, Exetel 2100g, aspartame 120g and prepare mixture A by the method described in Example 1.

[0024] Put mixture A, 375g of oral glucose, 1125g of skimmed milk powder and 270g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Mix glycerin and absolute ethanol evenly at a ratio of 1:5, take 2.5 L, add 200 g of polyvinylpyrrolidone to it to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.

[0025] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. A total of about 10,000 tablets were produced, each weighing 0.6g, containing 0.21g of exetyl.

Embodiment 3

[0026] Example 3 Exetal Chewable Tablets

[0027] Get starch 3300g, exetel 3000g, aspartame 300g, the method described in embodiment 1 makes mixture A. Put mixture A, 300 g of oral glucose, 900 g of skimmed milk powder and 300 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Mix glycerin and absolute ethanol uniformly at a ratio of 1:10, take 2.5 L, add 200 g of polyvinylpyrrolidone to it to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.

[0028] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. A total of about 10,000 tablets were produced, each weighing 0.6g, containing 0.3g of exetyl.

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PUM

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Abstract

The invention belongs to the technical field of veterinary drugs and discloses an epsiprantel chewing tablet for cats and dogs. The epsiprantel chewing tablet overcomes defects of poor palatability of the existing tablets, can promote full chewing and absorption of cats and dogs, effectively guarantees an administration dosage, improves a cure rate of cat and dog diseases and reduces drug waste. The epsiprantel chewing tablet comprises, by weight, 1-5% of aspartame, 20-30% of an oral glucose-skimmed milk powder mixture having a ratio of oral glucose to skimmed milk powder of 1: 1 to 1: 4, 40-60% of an excipient, 0.5-1% of a flow aid and 30-50% of epsiprantel.

Description

Technical field [0001] The present invention involves veterinary drugs, especially the chewing agent with better palatability for dogs and cats. Background technique [0002] Pets have a long history in our country.With the improvement of living standards, the number of precious dogs and cat pets gradually increases, and pet owners have paid more and more attention to the quality of life of pets.Dogs and cats are mammals and have their own common diseases. At present, the treatment of dogs and cat diseases is mainly based on intravenous dripping and muscle injection. This treatment plan often requires animal owners.Treatment interruption often causes poor prognosis of the disease.If you can take the active treatment drugs for dogs and cats, this series of problems will be solved, but the number of beast tablets on the market at present is often difficult to promote application due to poor latitivity. Invention content [0003] In response to the physiological characteristics of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/55A61P33/12A61P33/10
Inventor 郝智慧侯青青贾德强
Owner QINGDAO BOITE BIOPHARM
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