Compositions for treating infective arterial diseases and related conditions
A composition and drug technology, applied in the fields of medicine and infectious diseases, can solve problems such as enhanced bacterial resistance
Pending Publication Date: 2020-10-09
CENT FOR DIGESTIVE DISEASES PTY LTD
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
There is also a need to effectively treat the initial infection with a combination of antibiotics to prevent it from progressing to a chronic phase that can lead to disease progression and increased bacterial resistance
Method used
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Experimental program
Comparison scheme
Effect test
example 1
[0094] A 50-year-old male patient with a 70% left anterior descending (LAD) artery occlusion with a positive stress test and sestamibi scan with reduced blood flow failed standard cardiac therapy. He started treatment with three antibiotics (clarithromycin, rifabutin and furazolidone). After three months of treatment, the patient reported complete remission of angina and methoxyisobutyronitrile tests at 6 months showed marked improvement in blood flow.
example 2
[0096] A 63-year-old woman who tested positive for methoxyisobutyronitrile and had reduced blood flow to the distal epicardial artery was initiated on three different antibiotics and supplemented with 10,000 units of vitamin D. The patient reported significant clinical improvement and improved methoxyisobutyronitrile scan results at 3 months on the combination of rifabutin, azithromycin, and doxycycline plus vitamin D.
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In alternative embodiments, provided are pharmaceutical compositions and methods for treatment, amelioration and prevention of infection-associated blood vessel diseases, and also for the treatment, amelioration and prevention of non-vessel diseases affected by infective agents which can be treated by these compositions. In alternative embodiments, one common pathogen targeted by compositions andmethods as provided herein is Chlamydia and Chlamydophila species, including pneumoniae, trachomatis and psittaci species which infect humans, including Chlamydophila pneumoniae which also infects humans. In alternative embodiments, pathogens targeted and infections (diseases) treated, ameliorated, or prevented by compositions and methods as provided herein include Mycoplasma, Listeria, Leptospirosis, Q fever or Coxiella burnetii infection, Lyme disease or Lyme borreliosis or any Borrelia infection, and Bartonella or of the family Bartonellaceae, including cat scratch disease. The compositionscomprise at least three different antibiotic agents selected with compositions comprising a rifamycin (such as rifabutin), a macrolide (such as clarithromycin or azithromycin), and a tetracycline (such as doxycycline) or a nitrofuran (such as furazolidone) being preferred.
Description
technical field [0001] The invention relates generally to medicine and infectious disease. In alternative embodiments, there are provided pharmaceutical compositions for the treatment, amelioration and prevention of vascular diseases associated with infection, and also for the treatment, amelioration and prevention of non-vascular diseases affected by infectious factors treatable by these compositions and method. In alternative embodiments, one common pathogen targeted by the compositions and methods provided herein is Chlamydia and Chlamydophila species, including pneumoniae, trachomatis, and psittacosis ( psittaci), including Chlamydophila pneumoniae, which also infects humans. In alternative embodiments, the pathogens targeted and the infections (diseases) treated, ameliorated or prevented by the compositions and methods as provided herein include Mycoplasma, Listeria, Leptospira Leptospirosis, Q fever, or Coxiella burnetii infection; Lyme disease or Lyme borreliosis, or...
Claims
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IPC IPC(8): A61K31/438A61K31/59A61K31/7048A61K31/65A61K31/7052A61P9/10A61K31/424A61P31/04
CPCA61K31/424A61K31/438A61K31/7048A61K31/7052A61K31/65A61K31/59A61P9/10A61P31/04A61K2300/00Y02A50/30A61K31/422A61K31/355A61K31/353A61K31/198A61K45/06A61K31/343A61K31/4178A61K31/429A61K31/436A61K31/454A61K31/519A61K31/52A61K31/573A61K31/593A61K31/675A61K38/13A61K38/191A61K38/212A61K38/215A61K38/217
Inventor 托马斯·朱利叶斯·波洛迪
Owner CENT FOR DIGESTIVE DISEASES PTY LTD