18 results about "Zoonosis" patented technology

A method for identifying affiliation of Leptospira isolates to a specific serogroup and serovar using analysis of the percentage composition of monosaccharides in LPS of Leptospira was disclosed, it allows the identification of the affiliation of the tested strains without the use of antibody techniques, which reduces the costs of diagnosis and allows it to be carried out in less specialized research units. The method can find a particular use in veterinary diagnostics and diagnostics of zoonoses.

The invention provides a zoonosis risk prediction method coupling climatic factor time sequence characteristics and land utilization space landscape characteristics under the background of climate and land utilization change, and relates to the technical field of zoonosis space epidemiology. According to the method, land utilization types such as buildings, roads, greenbelts and water bodies are identified through high-resolution remote sensing, landscape features are constructed, weather time sequences such as air temperature, rainfall and humidity are obtained by combining a geographic space big data cloud computing platform, and climate features are extracted by adopting a long-short-term memory network; and meanwhile, spatial population distribution characteristics are formed by utilizing the population data set. And based on the multi-source spatial-temporal characteristics, constructing a multilayer perceptron to simulate and predict the propagation rate. A true propagation rate is calculated based on the case matrix and the susceptible-infected-restorer epidemiological model. And calculating a loss function of the predicted propagation rate and the real propagation rate to optimize deep learning network parameters, and realizing risk dynamic assessment of the coupling space-time propagation mechanism.

1. The name of the design product: kit (zoonosis). 2. The use of the design product: for storing various reagents for zoonosis. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.

The invention belongs to the technical field of biological medicines, and provides an S protein ancestor sequence AS mRNA of a porcine acute diarrhea syndrome coronavirus, the ancestor sequence of an SADS-CoV Spike protein is constructed through phylogenetic analysis, and the sequence aims at the existing virus and also aims at the evolution pedigree of the virus; the sequence design is used for converting target defense aiming at a single pathogen into active intervention on a virus evolution trajectory; and the prepared AS mRNA vaccine has important significance on feeding safety of animals and prevention and control of zoonosis diseases.

The invention relates to an antigen construct for rapid immune detection, in particular to an antigen molecule for realizing dimerization or trimerization through foldon or a variant thereof. The antigen construct can enhance the conformation stability and improve the antibody binding efficiency, so that the sensitivity and shelf life stability in colloidal gold, fluorescent microspheres, ELISA (enzyme-linked immuno sorbent assay) and other in-vitro diagnosis methods in immunochromatography are remarkably improved. The construct is suitable for antibody detection of rabies, influenza, coronavirus, Brucella, tuberculosis and the like in zoonosis and HIV, HBV, HCV, syphilis and the like in human infectious diseases, and can be widely applied to clinical screening, animal quarantine, family self-test and public health emergency monitoring.

Systems and methods for assessing the risk of a human-livestock disease, including salmonella, in an animal population at a production facility. A user may provide data in response to a plurality of data entry fields, which may relate, at least in part, to processes, operations, and / or devices at a production facility. For each data entry field, a value may be assigned to the data provided by the user. The value may correspond to a predetermined value of a predetermined response identified as corresponding to the user input data. The assigned value may be adjusted by a weighting factor, which may correspond to a predicted impact that the action or information reflected by the data input by the user may have on the prevention of zoonosis. The assigned and / or adjusted values may be compiled to generate a risk assessment score, which may be used to determine a food safety index score and / or a food safety plan.

The invention discloses a primer probe group, a kit, a method and application for detecting brucella. Belongs to the technical field of animal epidemic disease and zoonosis detection. The important virulence factor T4SS virB10 of Brucella is taken as a target gene, a high-specificity primer probe group is designed, and a high-sensitivity ddPCR detection kit and a detection method are constructed through optimization experiments, so that absolute quantification of Brucella is realized, the detection sensitivity is improved, false negative and false positive risks are reduced, and the kit has a good application prospect. The kit can effectively improve the detection rate of early infection or recessive infection, and can be used as a reference standard for screening and performance evaluation of clinical detection kits.

The invention discloses an intelligent management system and method for experimental animals, and belongs to the technical field of experimental animal science and automation. The animal cage underframe is arranged at the lower end of the experimental animal cage; the excrement tray is movably arranged at the lower end of the animal cage chassis; the latent jacking transfer robot is used for carrying out translation and transposition of the experimental animal cage and picking and transferring of the excrement tray; an excrement dumping system; an automatic feeding and experiment auxiliary robot; and the central control unit is used as a command center, is in signal connection with the latent jacking transfer robot, the excrement dumping system and the automatic feeding and experiment auxiliary robot, and is responsible for task planning, resource allocation, data aggregation and intelligent analysis. According to the invention, real unmanned experimental animal disposal is realized, the whole process from feeding, cleaning to health monitoring is completed by a robot cluster, and a chain of human and livestock co-disease transmission is thoroughly cut off.

The invention relates to the technical field of biological detection, in particular to a primer probe group for detecting pathogens of milk goat-derived zoonosis and a kit and application thereof. The kit can be used for simultaneously detecting Escherichia coli, clostridium perfringens, cryptosporidium and Giardia lamblia in the same system, and has the advantages of good repeatability, high sensitivity, strong specificity, simplicity in operation and the like compared with the existing kit. The primer probe group contains any one or more specific primers and probes for detecting Escherichia coli, cryptosporidium, Giardia cyanea and clostridium perfringens respectively, and the primer probe group is used for preparing the kit for detecting the milk goat-derived zoonosis pathogen. The invention further discloses a kit for detecting the milk goat-derived zoonosis pathogen and the kit for detecting the milk goat-derived zoonosis pathogen and the kit for detecting the milk goat-derived zoonosis pathogen and the kit for detecting the milk goat-derived zoonosis pathogen.

This invention relates to a machine learning-based method for early identification and intelligent warning of zoonotic diseases in livestock and poultry, belonging to the field of machine learning technology. It includes the following steps: collecting early identification data of zoonotic diseases in livestock and poultry to construct a dataset; detecting and correcting outliers using the interquartile range method, and adaptively normalizing features based on the Shapiro-Wilk test results; constructing a model containing feature interaction and higher-order feature mining, and disease early identification modules; mining feature interactions and higher-order features to obtain an enhanced feature matrix; outputting the identification probability through dynamic heterogeneity risk scoring and time-series-aware attention aggregation; subsequently training the model, inputting the preprocessed new data into the model to obtain the identification probability, thereby achieving intelligent warning. This invention can improve the accuracy and robustness of early identification of zoonotic diseases in livestock and poultry, providing precise technical support for the prevention and control of zoonotic diseases.

The invention relates to the technical field of animal epidemic disease prevention and control, and discloses a visual interactive monitoring system for livestock and poultry health, which comprises a data acquisition module used for acquiring and structurally storing multi-source heterogeneous data from a breeding environment, livestock and poultry groups and individuals in real time; and the health assessment module is used for carrying out parallel calculation on the environmental comfort level, the regional health value and the dynamic individual health value associated with the individual historical archive based on the multi-source heterogeneous data. According to the visual interactive monitoring system for livestock and poultry health, three dimensions of environmental comfort assessment, regional group health assessment and individual dynamic health assessment are integrated, and archive information such as individual immune records and disease history is innovatively brought into a real-time analysis model; and three-dimensional monitoring of potential correlation of environmental risks, group abnormity and individual epidemic diseases is realized. The limitation that traditional monitoring only pays attention to a single physical index or behavior index is broken through, and a comprehensive data basis is provided for early discovery and blocking of a zoonosis propagation chain.

The invention discloses a rapid identification method of Brucella canis, and relates to the technical field of molecular detection. The rapid identification method comprises the following steps: extracting genome DNA of a sample to be detected; the genome DNA is used as a template, a primer and probe combination is used for fluorescence quantitative detection, signals of a fluorescence channel are collected, and whether a sample to be detected is Brucella canis or not is identified. According to the invention, a multi-channel fluorescent quantitative detection system is constructed by screening specific SNP (Single Nucleotide Polymorphism) sites of a wbdA gene of Brucella canis and designing a specific primer and probe combination. The primer and probe combination comprises a Brucella universal primer probe and a species specific primer probe, synchronous detection is achieved through different fluorescence labels, Brucella infection can be rapidly confirmed, dog species and other species of Brucella can be accurately distinguished, an efficient tool is provided for rapid identification of the dog species of Brucella, and the primer and probe combination is suitable for rapid identification of the dog species of Brucella. The method has an important practical value for the epidemiological prevention and control of brucellosis and the prevention of zoonosis.

The present application relates to the field of biotechnology, in particular to a fusion plasmid and its application in gene transfer and protein expression. The present application provides a novel IncI1 and IncHI2 / IncHI2A type self-transmissible fusion plasmid containing NDM-13 and OXA-10 from clinical Salmonella, which also carries other multiple drug resistance genes and shows resistance to multiple antibiotics. Salmonella is a pathogenic bacterium of zoonosis and has the ability to infect humans and livestock. Salmonella carrying the plasmid has the potential to cause outbreaks, and active research is needed to prevent the occurrence of outbreaks.

The invention discloses a method for intervening growth of echinococcus multilocularis based on diapause pheromone Ascr # 18 and application, and belongs to the technical field of prevention and control of zoonosis parasitic diseases. According to the invention, the Ascr # 18 is identified in the echinococcus multilocularis through liquid chromatography-mass spectrometry (LC-MS) for the first time, and it is verified that the Ascr # 18 can be combined with a downstream G-protein coupled receptor (GPCR) in a high-affinity manner, and a signal channel is activated. After the Ascr # 18 is treated, the expression level of development key genes daf-9 and daf-12 in the protoscolex of the echinococcus multilocularis can be remarkably reduced, and the movement activity of the development key genes daf-9 and daf-12 is inhibited, so that the development process and infection ability of parasites are blocked. The invention provides a novel biological prevention and control strategy which does not depend on traditional chemical anthelmintic drugs, is high in targeting, high in safety, environment-friendly and controllable, is suitable for comprehensive prevention and control of alveolar echinococcosis, and can also provide a theoretical basis and an application reference for prevention and control of other tapeworm and larva parasitic diseases.

The application discloses a kind of high-performance composite for pet house, for symmetrical layered structure, including sequentially arranged: first surface wear-resistant layer, first surface layer decorative paper, first bottom layer paper, first surface core layer, intermediate core layer, second surface core layer, second bottom layer paper, second surface layer decorative paper and second surface wear-resistant layer.Wherein, surface wear-resistant layer is impregnated with antibacterial anti-toxic wear-resistant glue water, decorative paper and bottom layer paper are impregnated with antibacterial anti-virus mixed glue, surface core layer is sprayed with antibacterial plant mixed oil, and intermediate core layer is antibacterial anti-tensile base material.The application is synergized by multilayer structure, constructs three-dimensional antibacterial defense line, effectively inhibits bacteria breeding, reduces the risk of zoonosis;Surface wear-resistant layer gives the board excellent anti-scratching performance at the same time, and the reinforcing structure of intermediate core layer improves tensile strength, and symmetrical design ensures that the board is flat.The application is designed for pet environment, and solves the problems of poor antibacterial property and poor scratch resistance of existing boards.

The application discloses a rapid identification method for canine Brucella, and relates to the technical field of molecular detection. The rapid identification method comprises the following steps: extracting genomic DNA of a to-be-detected sample; using the genomic DNA as a template, performing fluorescence quantitative detection by using a primer and a probe combination, collecting signals of a fluorescence channel, and identifying whether the to-be-detected sample is canine Brucella. wbdA By screening a specific SNP site of canine Brucella, designing a specific primer and probe combination, and constructing a multi-channel fluorescence quantitative detection system, the primer and the probe combination comprise Brucella universal primer and probe and species-specific primer and probe, synchronous detection is realized by different fluorescence labels, Brucella infection can be rapidly confirmed, canine Brucella can be accurately distinguished from other Brucella, an efficient tool is provided for rapid identification of canine Brucella, and the method has important practical values for epidemiological prevention and control of brucellosis and prevention of zoonosis.

The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. daf-9 With daf-12 The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. The application provides a novel biological prevention and control strategy which is independent of traditional chemical deworming drugs, has high targeting, high safety, is environment-friendly and controllable, and is suitable for comprehensive prevention and control of alveolar echinococcosis, and can also provide a theoretical basis and application reference for prevention and control of other cestode larva parasitic diseases.

The application discloses a canine leptospira, icterohaemorrhagia leptospira and canine coronavirus triple inactivated vaccine. The application is prepared by adding adjuvant after inactivation of the canine leptospira, icterohaemorrhagia leptospira and canine coronavirus epidemic strain separated in China. The application relates to a pathogen separation culture, identification, inactivation method, production process, vaccine storage and immunization method. The canine triple inactivated vaccine is used for preventing canine leptospira disease, icterohaemorrhagia leptospira disease and canine coronavirus disease, and high antibodies can be generated after immunization of the canine, and the high antibodies have a good protective effect on virulent attack. The leptospira is a zoonosis, the canine is a companion animal of human, and the pet canine is in close contact with human, so the triple inactivated vaccine has good social benefits and important public health significance.