Method for intervening growth of echinococcus multilocularis based on diapause pheromone Ascr # 18 and application

By utilizing Ascr#18 to target and regulate the DAF-9–DA–DAF-12 signaling cascade in Echinococcus multilocularis, the problems of chemical drug resistance and toxicity in existing technologies for Echinococcus multilocularis disease have been solved, providing an efficient and safe biocontrol strategy.

CN121154652AActive Publication Date: 2025-12-19ZHEJIANG UNIV
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Patent Information

Application Number
CN202511653718.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-12
Publication Date
2025-12-19
Estimated Expiration
2045-11-12

AI Technical Summary

Technical Problem

Existing technologies for the prevention and treatment of echinococcosis suffer from problems such as drug resistance, toxicity risks, and insignificant efficacy, and lack efficient and safe biological small molecule intervention strategies.

Method used

By utilizing the naturally occurring Ascarosides#18 (Ascr#18) small molecule in Echinococcus multilocularis, the development and infectivity of the protoscolex are inhibited by targeting and regulating the DAF-9–DA–DAF-12 signaling cascade, thus blocking the life cycle of the parasite.

Benefits of technology

It achieves highly specific and safe inhibition of Echinococcus multilocularis larvae, avoiding the drug resistance and toxicity risks of chemical drugs, and provides a green and environmentally friendly biological control solution.

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Abstract

The invention discloses a method for intervening growth of echinococcus multilocularis based on diapause pheromone Ascr # 18 and application, and belongs to the technical field of prevention and control of zoonosis parasitic diseases. According to the invention, the Ascr # 18 is identified in the echinococcus multilocularis through liquid chromatography-mass spectrometry (LC-MS) for the first time, and it is verified that the Ascr # 18 can be combined with a downstream G-protein coupled receptor (GPCR) in a high-affinity manner, and a signal channel is activated. After the Ascr # 18 is treated, the expression level of development key genes daf-9 and daf-12 in the protoscolex of the echinococcus multilocularis can be remarkably reduced, and the movement activity of the development key genes daf-9 and daf-12 is inhibited, so that the development process and infection ability of parasites are blocked. The invention provides a novel biological prevention and control strategy which does not depend on traditional chemical anthelmintic drugs, is high in targeting, high in safety, environment-friendly and controllable, is suitable for comprehensive prevention and control of alveolar echinococcosis, and can also provide a theoretical basis and an application reference for prevention and control of other tapeworm and larva parasitic diseases.
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