Leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus triple inactivated vaccine

A technology for leptospirosis and leptospirosis, applied in the direction of viruses, vaccines, antiviral agents, etc., to achieve the effects of simple production process, high incidence rate and low production cost

Pending Publication Date: 2020-05-05
BEIJING HUAXIA XINGYANG BIOLOGICAL SCI & TECH +1
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] At present, there are researches and products on canine Leptospira vaccines at home and abroad, but ther...

Method used

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  • Leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus triple inactivated vaccine
  • Leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus triple inactivated vaccine
  • Leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus triple inactivated vaccine

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Embodiment Construction

[0031] 1. Isolation and identification of canine Leptospira and jaundice-hemorrhagic Leptospira

[0032] (1) Collection, cultivation and morphological identification:

[0033] The fresh dog urine of coagulated sick dogs was collected in sterilized containers in kennel farms in Hebei and Beijing respectively, filtered through a 0.45 μm microporous membrane, and added to the modified Korthof medium aseptically, and placed at 28-30°C Cultivate in an incubator, take the culture medium at 5, 7, 10, and 14 days for dark-field microscope inspection, it can be seen that the leptospira grows and transfers to fresh improved Korthof medium for further culture, and further identification is carried out when the growth is good .

[0034] After the culture characteristics and morphological identification of the isolated strain, the isolated strain is a typical shape of Leptospira, the refraction of the bacteria is consistent, both ends or one end are bent into a hook shape, the movement is...

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Abstract

The invention discloses a leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus triple inactivated vaccine. The leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus triple inactivated vaccine is prepared by inactivating leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus epidemic strains separated in China and then adding an adjuvant. The invention relates to a method for isolated culture, identification and inactivation of pathogens, a production process, vaccine preservation and an immunization method. The canine triple inactivated vaccine is used for preventing leptospira canicola, leptospira icterohaemorrhagiae and canine coronavirus diseases, high antibodies can be generated after immunizing dogs, and the triple inactivated vaccine has a good protective effect on virulent attack. Leptospira is a human and animal infectious disease, dogs are human companion animals, and pet dogs are in close contact with human beings, so that the triple inactivated vaccine has good social benefits and important public health significance.

Description

technical field [0001] The invention belongs to the field of biological products. The invention relates to the development and application of a triple inactivated vaccine against canine Leptospira, icterohemorrhagic Leptospira and canine coronavirus disease. Background technique [0002] Canine leptospirosis is a zoonotic infectious disease caused by pathogenic Leptospira. The main serotypes causing this disease in dogs are L.canicola and L.icterohemorrhagia. After the dog is infected, the main manifestations are high fever, jaundice, hemorrhagic diathesis, abortion and other symptoms. The disease mostly occurs in tropical and subtropical regions. Leptospira can infect dogs of all ages, and the incubation period is 4 to 14 days. Acute cases can occur suddenly, with no food, vomiting, elevated body temperature, depression, dyspnea, mucous membrane jaundice, hemorrhage, and generally die of body failure within 3 days of onset. Subacute symptoms are characterized by fever,...

Claims

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Application Information

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IPC IPC(8): A61K39/02A61K39/215A61K39/39A61P31/04A61P31/14C12N1/20C12N15/31C12R1/01
CPCA61K39/02A61K39/12A61K39/39A61K2039/521A61K2039/5252A61K2039/552A61K2039/70A61P31/04A61P31/14C07K14/20C12N1/20C12N2770/20034A61K2300/00
Inventor 金扩世贺亚奇张良婷李登亮胡义彬李晓亮李三鹏尚川川商云鹏赵卓王力江厚生
Owner BEIJING HUAXIA XINGYANG BIOLOGICAL SCI & TECH
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